公开(公告)号：US08299072B2

公开(公告)日：2012-10-30

申请号：US12568243

申请日：2009-09-28

申请人： Ghilsoo Nam ,  Kyung Il Choi ,  Hye Ran Kim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Hyunah Choo ,  Hyewhon Rhim ,  Yong Seo Cho ,  Eun Joo Roh ,  Gyo Chang Keum ,  Kee Hyun Choi ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Chan Seong Cheong ,  Jae Kyun Lee ,  Kee Dal Nam ,  Yong Koo Kang ,  Youngsoo Kim ,  Woong Seo Park ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Dong Yun Shin ,  Chi man Song

发明人： Ghilsoo Nam ,  Kyung Il Choi ,  Hye Ran Kim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Hyunah Choo ,  Hyewhon Rhim ,  Yong Seo Cho ,  Eun Joo Roh ,  Gyo Chang Keum ,  Kee Hyun Choi ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Chan Seong Cheong ,  Jae Kyun Lee ,  Kee Dal Nam ,  Yong Koo Kang ,  Youngsoo Kim ,  Woong Seo Park ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Dong Yun Shin ,  Chi man Song

IPC分类号： A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  C07D231/12 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/10

CPC分类号： C07D231/12 ,  C07D401/04 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12

摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.

摘要翻译： 本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。 本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

公开(公告)号：US20100094006A1

公开(公告)日：2010-04-15

申请号：US12568243

申请日：2009-09-28

申请人： Ghilsoo NAM ,  Kyung Il Choi ,  Hye Ran Kim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Hyunah Choo ,  Hyewhon Rhim ,  Yong Seo Cho ,  Eun Joo Roh ,  Gyo Chang Keum ,  Kee Hyun Choi ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Chan Seong Cheong ,  Jae Kyun Lee ,  Kee Dal Nam ,  Yong Koo Kang ,  Youngsoo Kim ,  Woong Seo Park ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Dong Yun Shin ,  Chi man Song

发明人： Ghilsoo NAM ,  Kyung Il Choi ,  Hye Ran Kim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Hyunah Choo ,  Hyewhon Rhim ,  Yong Seo Cho ,  Eun Joo Roh ,  Gyo Chang Keum ,  Kee Hyun Choi ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Chan Seong Cheong ,  Jae Kyun Lee ,  Kee Dal Nam ,  Yong Koo Kang ,  Youngsoo Kim ,  Woong Seo Park ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Dong Yun Shin ,  Chi man Song

IPC分类号： C07D403/12 ,  C07D241/04 ,  C07D231/12

CPC分类号： C07D231/12 ,  C07D401/04 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12

摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.

摘要翻译： 本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。 本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

公开(公告)号：US20090325979A1

公开(公告)日：2009-12-31

申请号：US12492615

申请日：2009-06-26

申请人： Kyung Il CHOI ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

发明人： Kyung Il CHOI ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

IPC分类号： A61K31/497 ,  C07D403/06 ,  C07D233/54

CPC分类号： C07D233/60 ,  C07D209/48 ,  C07D233/54 ,  C07D233/61 ,  C07D403/06

摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.

摘要翻译： 公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。 还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

公开(公告)号：US08492384B2

公开(公告)日：2013-07-23

申请号：US12492615

申请日：2009-06-26

申请人： Kyung Il Choi ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

发明人： Kyung Il Choi ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

IPC分类号： A61K31/496 ,  C07D233/64

CPC分类号： C07D233/60 ,  C07D209/48 ,  C07D233/54 ,  C07D233/61 ,  C07D403/06

摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.

摘要翻译： 公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。 还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。