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    Piperazinylalkylpyrazole derivatives useful as selective T-type calcium channel blockers and preparation method thereof
    4.
    发明申请
    Piperazinylalkylpyrazole derivatives useful as selective T-type calcium channel blockers and preparation method thereof 失效
    可用作选择性T型钙通道阻滞剂的哌嗪基烷基吡唑衍生物及其制备方法

    公开(公告)号：US20070049604A1

    公开(公告)日：2007-03-01

    申请号：US11509769

    申请日：2006-08-25

    申请人： Ghilsoo Nam ,  Kyung Choi ,  Hun Koh ,  Ae Pae ,  Hyewhon Rhim ,  In-Sung Choi

    发明人： Ghilsoo Nam ,  Kyung Choi ,  Hun Koh ,  Ae Pae ,  Hyewhon Rhim ,  In-Sung Choi

    IPC分类号： A61K31/496 ,  C07D403/02

    CPC分类号： C07D231/12 ,  C07D405/04

    摘要： The present invention provides for novel piperazinylalkylpyrazole derivatives, the preparation method thereof and the selective T-type calcium channel blocking activity thereof. Particularly, it provides a piperazinylalkylpyrazole derivative as represented by the formula set forth below or its pharmaceutically acceptable salts, and its preparation method thereof. The compound of Formula 1 is a novel piperazinylalkylpyrazole derivative, which particulary has T-type Ca2+ channel blocking effect and thus can be useful as a therapeutic agent for nerve and muscle pain.

    摘要翻译： 本发明提供新的哌嗪基烷基吡唑衍生物，其制备方法和选择性T型钙通道阻断活性。 特别地，其提供如下式所示的哌嗪基烷基吡唑衍生物或其药学上可接受的盐及其制备方法。 式1的化合物是新型的哌嗪基烷基吡唑衍生物，特别是具有T型Ca 2+通道阻断效应，因此可用作神经和肌肉疼痛的治疗剂。