公开(公告)号：US20090325979A1

公开(公告)日：2009-12-31

申请号：US12492615

申请日：2009-06-26

申请人： Kyung Il CHOI ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

发明人： Kyung Il CHOI ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

IPC分类号： A61K31/497 ,  C07D403/06 ,  C07D233/54

CPC分类号： C07D233/60 ,  C07D209/48 ,  C07D233/54 ,  C07D233/61 ,  C07D403/06

摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.

摘要翻译： 公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。 还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

公开(公告)号：US08492384B2

公开(公告)日：2013-07-23

申请号：US12492615

申请日：2009-06-26

申请人： Kyung Il Choi ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

发明人： Kyung Il Choi ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

IPC分类号： A61K31/496 ,  C07D233/64

CPC分类号： C07D233/60 ,  C07D209/48 ,  C07D233/54 ,  C07D233/61 ,  C07D403/06

摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.

摘要翻译： 公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。 还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

公开(公告)号：US08299072B2

公开(公告)日：2012-10-30

申请号：US12568243

申请日：2009-09-28

申请人： Ghilsoo Nam ,  Kyung Il Choi ,  Hye Ran Kim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Hyunah Choo ,  Hyewhon Rhim ,  Yong Seo Cho ,  Eun Joo Roh ,  Gyo Chang Keum ,  Kee Hyun Choi ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Chan Seong Cheong ,  Jae Kyun Lee ,  Kee Dal Nam ,  Yong Koo Kang ,  Youngsoo Kim ,  Woong Seo Park ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Dong Yun Shin ,  Chi man Song

发明人： Ghilsoo Nam ,  Kyung Il Choi ,  Hye Ran Kim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Hyunah Choo ,  Hyewhon Rhim ,  Yong Seo Cho ,  Eun Joo Roh ,  Gyo Chang Keum ,  Kee Hyun Choi ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Chan Seong Cheong ,  Jae Kyun Lee ,  Kee Dal Nam ,  Yong Koo Kang ,  Youngsoo Kim ,  Woong Seo Park ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Dong Yun Shin ,  Chi man Song

IPC分类号： A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  C07D231/12 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/10

CPC分类号： C07D231/12 ,  C07D401/04 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12

摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.

摘要翻译： 本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。 本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

公开(公告)号：US20100094006A1

公开(公告)日：2010-04-15

申请号：US12568243

申请日：2009-09-28

申请人： Ghilsoo NAM ,  Kyung Il Choi ,  Hye Ran Kim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Hyunah Choo ,  Hyewhon Rhim ,  Yong Seo Cho ,  Eun Joo Roh ,  Gyo Chang Keum ,  Kee Hyun Choi ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Chan Seong Cheong ,  Jae Kyun Lee ,  Kee Dal Nam ,  Yong Koo Kang ,  Youngsoo Kim ,  Woong Seo Park ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Dong Yun Shin ,  Chi man Song

发明人： Ghilsoo NAM ,  Kyung Il Choi ,  Hye Ran Kim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Hyunah Choo ,  Hyewhon Rhim ,  Yong Seo Cho ,  Eun Joo Roh ,  Gyo Chang Keum ,  Kee Hyun Choi ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Chan Seong Cheong ,  Jae Kyun Lee ,  Kee Dal Nam ,  Yong Koo Kang ,  Youngsoo Kim ,  Woong Seo Park ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Dong Yun Shin ,  Chi man Song

IPC分类号： C07D403/12 ,  C07D241/04 ,  C07D231/12

CPC分类号： C07D231/12 ,  C07D401/04 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12

摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.

摘要翻译： 本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。 本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

公开(公告)号：US07939672B2

公开(公告)日：2011-05-10

申请号：US12429004

申请日：2009-04-23

申请人： Kye Jung Shin ,  Hyung Kook Lee ,  Eun Joo Roh ,  Dong Jin Kim ,  Kyung Il Choi ,  Hyewhon Rhim ,  Hye Jin Chung ,  Seon Hee Seo

发明人： Kye Jung Shin ,  Hyung Kook Lee ,  Eun Joo Roh ,  Dong Jin Kim ,  Kyung Il Choi ,  Hyewhon Rhim ,  Hye Jin Chung ,  Seon Hee Seo

IPC分类号： C07D235/08

CPC分类号： C07D211/34 ,  C07D211/14 ,  C07D211/18 ,  C07D211/22 ,  C07D211/70 ,  C07D235/14 ,  C07D235/16 ,  C07D295/145 ,  C07D295/15

摘要： Disclosed herein are a new phenylacetate derivative represented by Chemical Formula 1 or pharmaceutically acceptable salt thereof, a preparation method thereof, and a composition for prevention or treatment of diseases induced by the activation of T-type calcium ion channels containing the same. The composition containing the phenylacetate derivative according to the present invention effectively inhibits the activation of T-type calcium ion channels and may be useful in the prevention or treatment of diseases such as hypertension, cancer, epilepsy, and neurogenic pains induced by the activation of T-type calcium ion channels. wherein, X, R1, and R3 are as defined herein.

摘要翻译： 本文公开了由化学式1表示的新的苯乙酸酯衍生物或其药学上可接受的盐，其制备方法，以及用于预防或治疗由含有其的T型钙离子通道活化引起的疾病的组合物。 含有本发明的苯乙酸酯衍生物的组合物有效地抑制T型钙离子通道的活化，并且可用于预防或治疗诸如高血压，癌症，癫痫和T激活诱导的神经源性疼痛等疾病 型钙离子通道。 其中X，R 1和R 3如本文所定义。

公开(公告)号：US07674596B2

公开(公告)日：2010-03-09

申请号：US11162487

申请日：2005-09-12

申请人： Seong-Woo Jeong ,  Jung-Ha Lee ,  Byong-Gon Park ,  Edward Perez-Reyes ,  Dong Jin Kim ,  Hee Sup Shin ,  Taehyun Kim ,  Hyewhon Rhim

发明人： Seong-Woo Jeong ,  Jung-Ha Lee ,  Byong-Gon Park ,  Edward Perez-Reyes ,  Dong Jin Kim ,  Hee Sup Shin ,  Taehyun Kim ,  Hyewhon Rhim

IPC分类号： C12N5/10 ,  G01N33/53

CPC分类号： G01N33/5008 ,  G01N33/502 ,  G01N33/6872 ,  G01N2333/705

摘要： The present invention relates to a cell line in which a potassium channel is introduced. More specifically, it is a cell line capable of activating the T-type α1H calcium channel by depolarization wherein a vector encoding a potassium channel is introduced. Since the cell line of the present invention is available for a high throughput screening of candidate T-type α1H calcium channel inhibitors, it may accelerate the development of therapeutic agents for diseases related to T-type α1H calcium channels.

摘要翻译： 本发明涉及引入钾通道的细胞系。 更具体地说，它是能够通过去极化激活T型α1H钙通道的细胞系，其中引入编码钾通道的载体。 由于本发明的细胞系可用于候选T型α1H钙通道抑制剂的高通量筛选，因此可加速用于与T型α1H钙通道相关的疾病的治疗剂的开发。

公开(公告)号：US20080039438A1

公开(公告)日：2008-02-14

申请号：US11570468

申请日：2005-06-14

申请人： Kyung Ho Yoo ,  Dong Jin Kim ,  Yong Koo Kang ,  Kyung Seok Lee ,  Gwan Lee ,  Maeng Sup Kim ,  Jae Hoon Kang

发明人： Kyung Ho Yoo ,  Dong Jin Kim ,  Yong Koo Kang ,  Kyung Seok Lee ,  Gwan Lee ,  Maeng Sup Kim ,  Jae Hoon Kang

IPC分类号： A61K31/397 ,  A61P31/04 ,  C07D205/12 ,  C07D261/18

CPC分类号： C07D477/20

摘要： The present invention relates to a novel 1β-methylcarbapenem derivative, a process for the preparation thereof and a pharmaceutical composition comprising the 1β-methylcarbapenem derivative or a pharmaceutically acceptable salt thereof as an active antibacterial ingredient.

摘要翻译： 本发明涉及一种新型的β-甲基碳青霉烯类衍生物，其制备方法和药物组合物，其包含作为活性抗菌成分的β-甲基碳青霉烯衍生物或其药学上可接受的盐。

公开(公告)号：US20110124888A1

公开(公告)日：2011-05-26

申请号：US12997397

申请日：2009-06-12

申请人： Dong Jin Kim ,  Kyung Ho Yoo ,  Ji Hun Byun ,  YoungSoo Kim ,  Hye Yun Kim ,  Gwan Sun Lee ,  Maeng Sup Kim ,  Young Gil Ahn ,  Ji Hoon Lee ,  Myoung-Hwan Lee ,  Hana Hwang ,  Jiyeon Ryu

发明人： Dong Jin Kim ,  Kyung Ho Yoo ,  Ji Hun Byun ,  YoungSoo Kim ,  Hye Yun Kim ,  Gwan Sun Lee ,  Maeng Sup Kim ,  Young Gil Ahn ,  Ji Hoon Lee ,  Myoung-Hwan Lee ,  Hana Hwang ,  Jiyeon Ryu

IPC分类号： C07D307/81 ,  C07D307/80

CPC分类号： C07D307/81 ,  C07D307/80

摘要： The present invention relates to a novel compound which efficiently inhibits the formation of beta-amyloid fibrils in the brain to be useful for preventing or treating a degenerative brain disease, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient.

摘要翻译： 本发明涉及有效抑制脑中β-淀粉样蛋白原纤维形成以用于预防或治疗退行性脑病的新型化合物，其制备方法和含有该衍生物作为活性成分的药物组合物。

公开(公告)号：US08536178B2

公开(公告)日：2013-09-17

申请号：US12960977

申请日：2010-12-06

申请人： Dong Jin Kim ,  YoungSoo Kim ,  Hye Yun Kim

发明人： Dong Jin Kim ,  YoungSoo Kim ,  Hye Yun Kim

IPC分类号： A61K31/497 ,  C07D241/04 ,  C07D295/00

CPC分类号： A61K31/495 ,  A61K31/5375

摘要： Disclosed herein is a method for treating diseases associated with beta amyloid accumulation, including administering to a patient a therapeutically effective amount of morpholine or piperazine based compounds including a sulfuric or carboxylic acid structure represented by the following chemical formula 1 or a pharmaceutically acceptable salt thereof: (wherein Z, R1 and R2 are as defined in the specification).

摘要翻译： 本文公开了一种治疗与β淀粉样蛋白积累相关疾病的方法，包括向患者施用治疗有效量的吗啉或哌嗪基化合物，包括由以下化学式1表示的硫酸或羧酸结构或其药学上可接受的盐： （其中Z，R1和R2如说明书中所定义）。

公开(公告)号：US08906254B2

公开(公告)日：2014-12-09

申请号：US13484715

申请日：2012-05-31

申请人： Sa Heum Kim ,  Dong Gun Kim ,  Young Jun Kim ,  Jun Ho Song ,  Woo Suk Cho ,  Jeom Soo Kim ,  Dong Jin Kim

发明人： Sa Heum Kim ,  Dong Gun Kim ,  Young Jun Kim ,  Jun Ho Song ,  Woo Suk Cho ,  Jeom Soo Kim ,  Dong Jin Kim

IPC分类号： H01M4/88

CPC分类号： C01B25/45 ,  C01B25/455

摘要： Disclosed are a cathode material for a secondary battery, and a manufacturing method of the same. The cathode material includes a lithium manganese phosphate LiMnPO4/sodium manganese fluorophosphate Na2MnPO4F composite, in which the LiMnPO4 and Na2MnPO4F have different crystal structures. Additionally, the method of manufacturing the cathode material may be done in a single step through a hydrothermal synthesis, which greatly reduces the time and cost of production. Additionally, the disclosure provides that the electric conductivity of the cathode material may be improved through carbon coating, thereby providing a cathode material with excellent electrochemical activity.

摘要翻译： 公开了二次电池用阴极材料及其制造方法。 正极材料包括磷酸锰锂LiMnPO4 /锰锰磷酸钠Na2MnPO4F复合材料，其中LiMnPO4和Na2MnPO4F具有不同的晶体结构。 此外，制造阴极材料的方法可以通过水热合成的一个步骤进行，这大大降低了生产的时间和成本。 此外，本公开内容提供了通过碳涂覆可以改善阴极材料的电导率，从而提供具有优异的电化学活性的阴极材料。