公开(公告)号：US20100094006A1

公开(公告)日：2010-04-15

申请号：US12568243

申请日：2009-09-28

申请人： Ghilsoo NAM ,  Kyung Il Choi ,  Hye Ran Kim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Hyunah Choo ,  Hyewhon Rhim ,  Yong Seo Cho ,  Eun Joo Roh ,  Gyo Chang Keum ,  Kee Hyun Choi ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Chan Seong Cheong ,  Jae Kyun Lee ,  Kee Dal Nam ,  Yong Koo Kang ,  Youngsoo Kim ,  Woong Seo Park ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Dong Yun Shin ,  Chi man Song

发明人： Ghilsoo NAM ,  Kyung Il Choi ,  Hye Ran Kim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Hyunah Choo ,  Hyewhon Rhim ,  Yong Seo Cho ,  Eun Joo Roh ,  Gyo Chang Keum ,  Kee Hyun Choi ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Chan Seong Cheong ,  Jae Kyun Lee ,  Kee Dal Nam ,  Yong Koo Kang ,  Youngsoo Kim ,  Woong Seo Park ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Dong Yun Shin ,  Chi man Song

IPC分类号： C07D403/12 ,  C07D241/04 ,  C07D231/12

CPC分类号： C07D231/12 ,  C07D401/04 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12

摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.

摘要翻译： 本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。 本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

公开(公告)号：US08299072B2

公开(公告)日：2012-10-30

申请号：US12568243

申请日：2009-09-28

申请人： Ghilsoo Nam ,  Kyung Il Choi ,  Hye Ran Kim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Hyunah Choo ,  Hyewhon Rhim ,  Yong Seo Cho ,  Eun Joo Roh ,  Gyo Chang Keum ,  Kee Hyun Choi ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Chan Seong Cheong ,  Jae Kyun Lee ,  Kee Dal Nam ,  Yong Koo Kang ,  Youngsoo Kim ,  Woong Seo Park ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Dong Yun Shin ,  Chi man Song

发明人： Ghilsoo Nam ,  Kyung Il Choi ,  Hye Ran Kim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Hyunah Choo ,  Hyewhon Rhim ,  Yong Seo Cho ,  Eun Joo Roh ,  Gyo Chang Keum ,  Kee Hyun Choi ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Chan Seong Cheong ,  Jae Kyun Lee ,  Kee Dal Nam ,  Yong Koo Kang ,  Youngsoo Kim ,  Woong Seo Park ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Dong Yun Shin ,  Chi man Song

IPC分类号： A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  C07D231/12 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/10

CPC分类号： C07D231/12 ,  C07D401/04 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12

摘要： The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.

摘要翻译： 本发明涉及作为钙通道调节剂有效的吡唑基甲胺 - 哌嗪衍生物及其药学上可接受的盐及其制备方法。 本发明还涉及由于其作为钙通道调节剂的作用而使上述化合物作为疾病的治疗性治疗的药物用途。

公开(公告)号：US20090325979A1

公开(公告)日：2009-12-31

申请号：US12492615

申请日：2009-06-26

申请人： Kyung Il CHOI ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

发明人： Kyung Il CHOI ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

IPC分类号： A61K31/497 ,  C07D403/06 ,  C07D233/54

CPC分类号： C07D233/60 ,  C07D209/48 ,  C07D233/54 ,  C07D233/61 ,  C07D403/06

摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.

摘要翻译： 公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。 还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

公开(公告)号：US08492384B2

公开(公告)日：2013-07-23

申请号：US12492615

申请日：2009-06-26

申请人： Kyung Il Choi ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

发明人： Kyung Il Choi ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

IPC分类号： A61K31/496 ,  C07D233/64

CPC分类号： C07D233/60 ,  C07D209/48 ,  C07D233/54 ,  C07D233/61 ,  C07D403/06

摘要： Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.

摘要翻译： 公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。 还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

公开(公告)号：US09012481B2

公开(公告)日：2015-04-21

申请号：US13142313

申请日：2009-12-29

申请人： Hoh-Gyu Hahn ,  Kee-Dal Nam ,  Dong-Yun Shin ,  Chan-Ho Park ,  Sung-Woo Cho ,  Eun-A Kim ,  Ghil-Soo Nam ,  Kyung-Il Chol ,  Seon-Hee Seo ,  Hee-Sup Shin ,  Dong-Jin Kim ,  Ae-Nim Pae ,  Hye-Jin Chung ,  Hyun-Ah Choo ,  Hye-Whon Rhim ,  Yong-Seo Cho ,  Eun-Joo Roh ,  Gyo-Chang Keum ,  Kee-Hyun Choi ,  Kye-Jung Shin ,  Chan-Seong Cheong ,  Jae-Kyun Lee ,  Yong-Koo Kang ,  Young-Soo Kim ,  Woong-Seo Park ,  Key-Sun Kim ,  He-Sson Chung ,  Chi-Man Song ,  Sun-Joon Min ,  Eunice Eun-Kyeong Kim ,  Cheol-Ju Lee ,  Soon-Bang Kang

发明人： Hoh-Gyu Hahn ,  Kee-Dal Nam ,  Dong-Yun Shin ,  Chan-Ho Park ,  Sung-Woo Cho ,  Eun-A Kim ,  Ghil-Soo Nam ,  Kyung-Il Chol ,  Seon-Hee Seo ,  Hee-Sup Shin ,  Dong-Jin Kim ,  Ae-Nim Pae ,  Hye-Jin Chung ,  Hyun-Ah Choo ,  Hye-Whon Rhim ,  Yong-Seo Cho ,  Eun-Joo Roh ,  Gyo-Chang Keum ,  Kee-Hyun Choi ,  Kye-Jung Shin ,  Chan-Seong Cheong ,  Jae-Kyun Lee ,  Yong-Koo Kang ,  Young-Soo Kim ,  Woong-Seo Park ,  Key-Sun Kim ,  He-Sson Chung ,  Chi-Man Song ,  Sun-Joon Min ,  Eunice Eun-Kyeong Kim ,  Cheol-Ju Lee ,  Soon-Bang Kang

IPC分类号： C07D235/22 ,  C07D263/58 ,  C07D333/06 ,  C07D327/04 ,  C07D277/82

CPC分类号： C07D277/82 ,  C07D235/22 ,  C07D263/58 ,  C07D327/04 ,  C07D333/06

摘要： Novel benzoarylureido compounds and a use thereof for prevention and/or treatment of the neurodegenerative brain disease are provided. The neurodegenerative brain diseases may include Alzheimer's disease, dementia, Parkinson's disease, stroke, amyloidosis, Pick's disease, Lou Gehrig's disease, Huntington's disease, Creutzfeld-Jakob disease, and the like.

摘要翻译： 提供了新的苯甲酰脲基化合物及其用于预防和/或治疗神经退行性脑病的用途。 神经变性脑疾病可包括阿尔茨海默病，痴呆，帕金森病，中风，淀粉样变性，皮克病，卢格里希氏病，亨廷顿舞蹈病，克雅氏病，雅各布病等。

公开(公告)号：US08507540B2

公开(公告)日：2013-08-13

申请号：US13314706

申请日：2011-12-08

申请人： Gyo-Chang Keum ,  Eunice Eun-Kyeong Kim ,  Ae-Nim Pae ,  Kyung-Il Choi ,  Soon-Bang Kang ,  Seon-Hee Seo ,  Deepak Bhattaral ,  Ju-Hyeon Lee

发明人： Gyo-Chang Keum ,  Eunice Eun-Kyeong Kim ,  Ae-Nim Pae ,  Kyung-Il Choi ,  Soon-Bang Kang ,  Seon-Hee Seo ,  Deepak Bhattaral ,  Ju-Hyeon Lee

IPC分类号： A61K31/422 ,  A61P31/04 ,  C07D413/14

CPC分类号： C07D413/10 ,  A61K31/422 ,  C07D413/14 ,  Y02A50/473 ,  Y02A50/481

摘要： The present invention relates to oxazolidinone derivatives containing new bicyclic group, having antibacterial activity, or a pharmaceutically acceptable salt thereof, a method for preparing the same, an antibacterial composition comprising the oxazolidinone derivative or a pharmaceutically acceptable salt thereof as an active ingredient, and a method for treating an infectious disease caused by pathogen using the same. The oxazolidinone derivative or a pharmaceutically acceptable salt thereof may exhibit excellent antibacterial activity against gram positive bacteria including various resistant strains.

摘要翻译： 本发明涉及含有具有抗菌活性的新二环基的恶唑烷酮衍生物或其药学上可接受的盐，其制备方法，包含恶唑烷酮衍生物或其药学上可接受的盐作为活性成分的抗菌组合物，和 用于治疗由使用其的病原体引起的感染性疾病的方法。 恶唑烷酮衍生物或其药学上可接受的盐可以对包括各种抗性菌株的革兰氏阳性细菌表现出优异的抗菌活性。

公开(公告)号：US20130012554A1

公开(公告)日：2013-01-10

申请号：US13314706

申请日：2011-12-08

申请人： Gyo-Chang KEUM ,  Eunice Eun-Kyeong Kim ,  Ae-Nim Pae ,  Kyung-II Choi ,  Soon-Bang Kang ,  Seon-Hee Seo ,  Deepak Bhattaral ,  Ju-Hyeon Lee

发明人： Gyo-Chang KEUM ,  Eunice Eun-Kyeong Kim ,  Ae-Nim Pae ,  Kyung-II Choi ,  Soon-Bang Kang ,  Seon-Hee Seo ,  Deepak Bhattaral ,  Ju-Hyeon Lee

IPC分类号： A61K31/422 ,  A61P31/04 ,  C07D413/14 ,  C07D413/10

CPC分类号： C07D413/10 ,  A61K31/422 ,  C07D413/14 ,  Y02A50/473 ,  Y02A50/481

摘要： The present invention relates to oxazolidinone derivatives containing new bicyclic group, having antibacterial activity, or a pharmaceutically acceptable salt thereof, a method for preparing the same, an antibacterial composition comprising the oxazolidinone derivative or a pharmaceutically acceptable salt thereof as an active ingredient, and a method for treating an infectious disease caused by pathogen using the same. The oxazolidinone derivative or a pharmaceutically acceptable salt thereof may exhibit excellent antibacterial activity against gram positive bacteria including various resistant strains.

摘要翻译： 本发明涉及含有具有抗菌活性的新二环基的恶唑烷酮衍生物或其药学上可接受的盐，其制备方法，包含恶唑烷酮衍生物或其药学上可接受的盐作为活性成分的抗菌组合物，和 用于治疗由使用其的病原体引起的感染性疾病的方法。 恶唑烷酮衍生物或其药学上可接受的盐可以对包括各种抗性菌株的革兰氏阳性细菌表现出优异的抗菌活性。

公开(公告)号：US09422274B2

公开(公告)日：2016-08-23

申请号：US14539472

申请日：2014-11-12

申请人： Sung Key Jang ,  Gyo Chang Keum ,  Eunice Eun-Kyeong Kim ,  Soon Bang Kang ,  Suyeon Yeom ,  Juhyeon Lee ,  SeungGi Lee ,  Hee Sun Kim

发明人： Sung Key Jang ,  Gyo Chang Keum ,  Eunice Eun-Kyeong Kim ,  Soon Bang Kang ,  Suyeon Yeom ,  Juhyeon Lee ,  SeungGi Lee ,  Hee Sun Kim

IPC分类号： C07D413/14 ,  A61K31/422

CPC分类号： C07D413/14

摘要： The present invention relates to oxazolidinone compounds represented by Chemical Formula 1, pharmaceutically acceptable salts thereof or hydrates, a method of preparing the same, and a pharmaceutical composition for preventing or treating Hepatitis C infection: Wherein R1, R7 and X are defined in the detailed description.

摘要翻译： 本发明涉及由化学式1表示的恶唑烷酮化合物，其药学上可接受的盐或水合物，其制备方法和用于预防或治疗丙型肝炎感染的药物组合物：其中R1，R7和X定义在详细的 描述。

公开(公告)号：US07797112B2

公开(公告)日：2010-09-14

申请号：US11965989

申请日：2007-12-28

申请人： Eunice Eun-Kyeong Kim ,  Byung Hak Ha

发明人： Eunice Eun-Kyeong Kim ,  Byung Hak Ha

IPC分类号： G01N31/00 ,  G06G7/58 ,  C12Q1/26

CPC分类号： C12N9/001 ,  C07K2299/00 ,  C12Y103/01009 ,  G01N2333/90206 ,  G01N2500/20

摘要： The present invention relates to a FabK (enoyl-acyl carrier protein reductase) protein derived from a Thermotoga maritima strain. In the present invention, the active site and the three-dimensional crystal structure of the protein are determined, a novel inhibitor against the FabK protein is screened and/or designed using the three-dimensional crystal structure thereof, and thereby developing a novel active compound, namely active-controlling material with excellent antibiotic activities against strains having a resistance to previous antibiotics.

摘要翻译： 本发明涉及来源于海栖热带菌的FabK（烯酰基 - 酰基载体蛋白还原酶）蛋白质。 在本发明中，测定蛋白质的活性部位和三维晶体结构，使用其三维晶体结构筛选和/或设计对FabK蛋白质的新型抑制剂，从而开发新的活性化合物 即对具有对先前抗生素的抗性的菌株具有优异的抗生素活性的主动控制材料。

公开(公告)号：US06747050B1

公开(公告)日：2004-06-08

申请号：US10088288

申请日：2002-03-15

申请人： Eunice Eun-Kyeong Kim ,  Mi-Jeong Park ,  Tae-Hee Lee ,  Hye-Kyung Chang ,  Tae-Kyo Park ,  Chang-Yuil Kang ,  Young-Myeong Kim ,  Kwang-Yul Moon ,  Young-Leem Oh ,  Chang-Hee Min ,  Hyun-Ho Chung

发明人： Eunice Eun-Kyeong Kim ,  Mi-Jeong Park ,  Tae-Hee Lee ,  Hye-Kyung Chang ,  Tae-Kyo Park ,  Chang-Yuil Kang ,  Young-Myeong Kim ,  Kwang-Yul Moon ,  Young-Leem Oh ,  Chang-Hee Min ,  Hyun-Ho Chung

IPC分类号： A61K3142

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D261/18 ,  C07D413/12

摘要： The present invention provides to an isoxazoline derivative of formula (I), the pharmaceutically acceptable salts, esters and stereochemically isomeric forms thereof, and the use of the derivative in inhibiting the activity of caspases. The present invention also provides a pharmaceutical composition for preventing inflammation and apoptosis which comprise the isoxazoline derivative, pharmaceutically acceptable salts, esters and stereochemically isomeric forms thereof and the process for preparing the same. The derivative according to the present invention can be effectively used in treating diseases due to caspases, such as, for example the disease in which cells are abnormally died, dementia, cerebral stroke, AIDS, diabetes, gastric ulcer, hepatic injury by hepatitis, sepsis, organ transplantation rejection reaction and anti-inflammation.

摘要翻译： 本发明提供了式（I）的异恶唑啉衍生物，其药学上可接受的盐，酯和立体化学异构形式，以及该衍生物在抑制胱天蛋白酶活性方面的用途。 本发明还提供了包含异恶唑啉衍生物，其药学上可接受的盐，酯和立体化学异构形式的用于预防炎症和细胞凋亡的药物组合物及其制备方法。 根据本发明的衍生物可以有效地用于治疗由于胱天蛋白酶引起的疾病，例如细胞异常死亡的疾病，痴呆，脑卒中，艾滋病，糖尿病，胃溃疡，肝炎肝损伤，败血症 器官移植排斥反应和抗炎。