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    1,3-dioxoisoindole derivatives having selective antagonism of T-type calcium channel
    7.
    发明授权
    1,3-dioxoisoindole derivatives having selective antagonism of T-type calcium channel 失效
    具有T型钙通道选择性拮抗作用的1,3-二氧代异吲哚衍生物

    公开(公告)号：US07319098B2

    公开(公告)日：2008-01-15

    申请号：US11600391

    申请日：2006-11-16

    申请人： Yong Seo Cho ,  Hyunah Choo ,  Ae Nim Pae ,  Joo Hwan Cha ,  Hun Yeong Koh ,  Hwa-Sil Kim ,  Hyewhon Rhim ,  Seon Hee Seo

    发明人： Yong Seo Cho ,  Hyunah Choo ,  Ae Nim Pae ,  Joo Hwan Cha ,  Hun Yeong Koh ,  Hwa-Sil Kim ,  Hyewhon Rhim ,  Seon Hee Seo

    IPC分类号： A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  A61K31/4025 ,  C07D413/12 ,  C07D403/12 ,  C07D401/12 ,  C07D207/06

    CPC分类号： C07D209/48

    摘要： The present invention relates to 1,3-dioxoisoindole derivatives of Formula (1) or pharmaceutically acceptable salts thereof, a preparation method thereof and use thereof as a T-type calcium channel antagonist, based on the fact that 1,3-dioxoisoindole derivatives of Formula (1) show selective antagonistic activity against T-type calcium channel, thus being effective in treating brain diseases, cardiac diseases and neurogenic pains: wherein R1 is a phenyl or a benzyl group, optionally substituted with a moiety selected from the group consisting of a halogen atom, a C1-C6 alkoxy, a C1-C6 alkyl, and a cyano group; R2 is a heterocyclic group selected from the group consisting of piperidinyl, pyrrolidinyl, morpholinyl, and piperazinyl groups, wherein the heterocyclic group is optionally substituted with a C1-C6 alkyl group; and n is 1 or 2.

    摘要翻译： 本发明涉及式（1）的1,3-二氧代异吲哚衍生物或其药学上可接受的盐，其制备方法及其作为T型钙通道拮抗剂的用途，基于以下事实： 式（1）表示对T型钙通道的选择性拮抗活性，因此有效治疗脑疾病，心脏病和神经源性疼痛：其中R 1是苯基或苄基，任选被 选自卤素原子，C 1 -C 6烷氧基，C 1 -C 6烷基的部分 烷基和氰基; R 2是选自哌啶基，吡咯烷基，吗啉基和哌嗪基的杂环基，其中杂环基任选被C 1 -C 6烷基取代， C 1-6烷基; n为1或2。

    1,3-DIOXOISOINDOLE DERIVATIVES HAVING SELECTIVE ANTAGONISM OF T-TYPE CALCIUM CHANNEL
    8.
    发明申请
    1,3-DIOXOISOINDOLE DERIVATIVES HAVING SELECTIVE ANTAGONISM OF T-TYPE CALCIUM CHANNEL 失效
    具有T型钙通道选择性拮抗剂的1,3-二氧化物衍生物

    公开(公告)号：US20070259867A1

    公开(公告)日：2007-11-08

    申请号：US11600391

    申请日：2006-11-16

    申请人： Yong Seo Cho ,  Hyunah Choo ,  Ae Nim Pae ,  Joo Hwan Cha ,  Hun Yeong Koh ,  Hwa-Sil Kim ,  Hyewhon Rhim ,  Seon Hee Seo

    发明人： Yong Seo Cho ,  Hyunah Choo ,  Ae Nim Pae ,  Joo Hwan Cha ,  Hun Yeong Koh ,  Hwa-Sil Kim ,  Hyewhon Rhim ,  Seon Hee Seo

    IPC分类号： A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  A61K31/4035 ,  C07D413/02 ,  C07D403/02

    CPC分类号： C07D209/48

    摘要： The present invention relates to 1,3-dioxoisoindole derivatives of Formula (1) or pharmaceutically acceptable salts thereof, a preparation method thereof and use thereof as a T-type calcium channel antagonist, based on the fact that 1,3-dioxoisoindole derivatives of Formula (1) show selective antagonistic activity against T-type calcium channel, thus being effective in treating brain diseases, cardiac diseases and neurogenic pains: wherein R1 is a phenyl or a benzyl group, optionally substituted with a moiety selected from the group consisting of a halogen atom, a C1-C6 alkoxy, a C1-C6 alkyl, and a cyano group; R2 is a heterocyclic group selected from the group consisting of piperidinyl, pyrrolidinyl, morpholinyl, and piperazinyl groups, wherein the heterocyclic group is optionally substituted with a C1-C6 alkyl group; and n is 1 or 2.

    摘要翻译： 本发明涉及式（1）的1,3-二氧代异吲哚衍生物或其药学上可接受的盐，其制备方法及其作为T型钙通道拮抗剂的用途，基于以下事实： 式（1）表示对T型钙通道的选择性拮抗活性，因此有效治疗脑疾病，心脏病和神经源性疼痛：其中R 1是苯基或苄基，任选被 选自卤素原子，C 1 -C 6 - 烷氧基，C 1 -C 6烷氧基，C 1 -C 6 - 烷基和氰基; R 2是选自哌啶基，吡咯烷基，吗啉基和哌嗪基的杂环基，其中杂环基任选被C 1 -C 6烷基取代， C 1-6烷基; n为1或2。