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公开(公告)号：US20160138004A1
公开(公告)日：2016-05-19
申请号：US14877475
申请日：2015-10-07
发明人： Herbert Andres , David Casagolda Vallribera , Hartmut Duefel , Michael Gerg , Christian Scholz , Michael Schraeml
IPC分类号： C12N9/90 , G01N33/573 , C07K14/65 , C07K14/475 , C07K16/40 , C07K16/22
CPC分类号： C07K16/22 , C07K14/475 , C07K14/65 , C07K16/1203 , C07K16/40 , C07K2317/34 , C07K2317/565 , C07K2317/92 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/23 , C07K2319/24 , C07K2319/35 , C07K2319/41 , C07K2319/43 , C12N9/90 , C12Y502/01008 , G01N33/573 , G01N33/74 , G01N2333/99
摘要： Herein is reported a fusion polypeptide according to formula I NH2—S2—X1—S1—COOH (formula I) wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and — denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.
摘要翻译： 本文报道了根据式I的融合多肽，NH2-S2-X1-S1-COOH（式I），其中X1包含随机氨基酸序列或衍生自第一多肽的氨基酸序列，S2和S1不重叠 衍生自第二多肽的氨基酸序列和 - 表示肽键，其中第二多肽是具有肽基 - 脯氨酰顺/反异构酶活性（PPIase活性）或衍生自FKBP-折叠域家族的多肽，其中X1 被插入代替第二多肽的插入片段结构域。
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2.发明申请公开(公告)号：US20130344059A1
公开(公告)日：2013-12-26
申请号：US13744140
申请日：2013-01-17
发明人： Herbert Andres , Sanne Lysbet De Haas , Rebecca Elliott , Johann Karl , Yu-Ju Gloria Meng , Gregory D. Plowman , Stefan Scherer , Norbert Wild
IPC分类号： G01N33/68 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K31/337 , A61K31/513 , A61K31/517 , A61K31/70 , A61K31/7068 , A61K33/00 , A61K33/24 , A61K38/43 , A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57434 , G01N33/57492 , G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
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公开(公告)号：US10647765B2
公开(公告)日：2020-05-12
申请号：US15924110
申请日：2018-03-16
发明人： Herbert Andres , David Casagolda Vallribera , Hartmut Duefel , Michael Gerg , Christian Scholz , Michael Schraeml
IPC分类号： A61K39/00 , C07K16/22 , C07K16/12 , C12N9/90 , G01N33/74 , C07K16/40 , G01N33/573 , C07K14/475 , C07K14/65
摘要： Herein is reported a fusion polypeptide according to formula I NH2—S2—X1—S1—COOH (formula I) wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and — denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.
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4.发明申请公开(公告)号：US20140056874A1
公开(公告)日：2014-02-27
申请号：US13802282
申请日：2013-03-13
发明人： Herbert Andres , Sanne Lysbet De Haas , Rebecca Elliott , Johann Karl , Yu-Ju Gloria Meng , Gregory D. Plowman , Stefan Scherer , Norbert Wild
IPC分类号： G01N33/68 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K31/337 , A61K31/513 , A61K31/517 , A61K31/70 , A61K31/7068 , A61K33/00 , A61K33/24 , A61K38/43 , A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57434 , G01N33/57492 , G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
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5.发明申请公开(公告)号：US20140017231A1
公开(公告)日：2014-01-16
申请号：US13802356
申请日：2013-03-13
发明人： Herbert Andres , Sanne Lysbet De Haas , Rebecca Elliott , Johann Karl , Yu-Ju Gloria Meng , Gregory D. Plowman , Stefan Scherer , Norbert Wild
IPC分类号： G01N33/74 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K31/337 , A61K31/513 , A61K31/517 , A61K31/70 , A61K31/7068 , A61K33/00 , A61K33/24 , A61K38/43 , A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57434 , G01N33/57492 , G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
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6.发明申请公开(公告)号：US20130344060A1
公开(公告)日：2013-12-26
申请号：US13744372
申请日：2013-01-17
IPC分类号： G01N33/68 , A61K45/06 , A61K39/395
CPC分类号： A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57484 , G01N33/57488 , G01N33/6893 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
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7.发明申请公开(公告)号：US20130336960A1
公开(公告)日：2013-12-19
申请号：US13744131
申请日：2013-01-17
发明人： Herbert Andres , Sanne Lysbet De Haas , Rebecca Elliott , Johann Karl , Yu-Ju Gloria Meng , Gregory D. Plowman , Stefan Scherer , Norbert Wild
IPC分类号： G01N33/68 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K31/337 , A61K31/513 , A61K31/517 , A61K31/70 , A61K31/7068 , A61K33/00 , A61K33/24 , A61K38/43 , A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57434 , G01N33/57492 , G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
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8.发明申请公开(公告)号：US20140017232A1
公开(公告)日：2014-01-16
申请号：US13802394
申请日：2013-03-13
发明人： Herbert Andres , Sanne Lysbet De Haas , Rebecca Elliott , Johann Karl , Yu-Ju Gloria Meng , Gregory D. Plowman , Stefan Scherer , Norbert Wild
IPC分类号： G01N33/74 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K31/337 , A61K31/513 , A61K31/517 , A61K31/70 , A61K31/7068 , A61K33/00 , A61K33/24 , A61K38/43 , A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57434 , G01N33/57492 , G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
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9.发明申请公开(公告)号：US20140023640A1
公开(公告)日：2014-01-23
申请号：US13802521
申请日：2013-03-13
IPC分类号： G01N33/574 , A61K45/06 , A61K39/395
CPC分类号： A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57484 , G01N33/57488 , G01N33/6893 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
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10.发明申请Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy 审中-公开识别患有抗癌治疗反应可能性增加的患者的方法公开(公告)号：US20130336959A1
公开(公告)日：2013-12-19
申请号：US13744014
申请日：2013-01-17
发明人： Herbert Andres , Sanne Lysbet De Haas , Rebecca Elliott , Johann Karl , Yu-Ju Gloria Meng , Gregory D. Plowman , Stefan Scherer , Norbert Wild
IPC分类号： G01N33/68 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K31/337 , A61K31/513 , A61K31/517 , A61K31/70 , A61K31/7068 , A61K33/00 , A61K33/24 , A61K38/43 , A61K39/3955 , A61K39/39558 , A61K45/06 , G01N33/57434 , G01N33/57492 , G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2800/52
摘要： The invention provides methods for identifying patient who may benefit from treatment with an anti-cancer therapy comprising a VEGF antagonist. The invention also provides methods for monitoring a patients' response to the anti-cancer therapy. The invention also provides kits and articles of manufacture for use in the methods.
摘要翻译： 本发明提供了用于鉴定可能受益于包含VEGF拮抗剂的抗癌疗法治疗的患者的方法。 本发明还提供了用于监测患者对抗癌疗法的反应的方法。 本发明还提供用于该方法的试剂盒和制品。
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