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公开(公告)号：US20230219953A1
公开(公告)日：2023-07-13
申请号：US18068360
申请日：2022-12-19
发明人： Andrew Simon Bell , Jérémy Besnard , Anthony Richard Bradley , Luke Green , Wolfgang Haap , Buelent Kocer , Andreas Kuglstatter , Xavier Lucas , Patrizio Mattei , Dmitry Mazunin , Claus Riemer , Willem Paul Van Hoorn
IPC分类号： C07D471/04 , C07D231/56 , C07D209/08
CPC分类号： C07D471/04 , C07D231/56 , C07D209/08
摘要： The present invention provides compounds of formula I
wherein X1, X2, X3, X4, R1, R1a, R1b, R2′, R2″, R3′, R3″, R6 and R7 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.-
公开(公告)号：US11034687B2
公开(公告)日：2021-06-15
申请号：US16903616
申请日：2020-06-17
发明人： Bjoern Bartels , Cosimo Dolente , Wolfgang Guba , Wolfgang Haap , Ulrike Obst Sander , Jens-Uwe Peters , Thomas Woltering
IPC分类号： C07D417/14
摘要： The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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公开(公告)号：US20200308166A1
公开(公告)日：2020-10-01
申请号：US16903616
申请日：2020-06-17
发明人： Bjoern Bartels , Cosimo Dolente , Wolfgang Guba , Wolfgang Haap , Ulrike Obst Sander , Jens-Uwe Peters , Thomas Woltering
IPC分类号： C07D417/14
摘要： The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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公开(公告)号：US10723729B2
公开(公告)日：2020-07-28
申请号：US16512905
申请日：2019-07-16
发明人： Bjoern Bartels , Cosimo Dolente , Wolfgang Guba , Wolfgang Haap , Ulrike Obst Sander , Jens-Uwe Peters , Thomas Woltering
IPC分类号： C07D417/14
摘要： The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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公开(公告)号：US20180057485A1
公开(公告)日：2018-03-01
申请号：US15558273
申请日：2016-03-16
发明人： Bjoern Bartels , Cosimo Dolente , Wolfgang Guba , Wolfgang Haap , Ulrike Obst Sander , Jens-Uwe Peters , Thomas Woltering
IPC分类号： C07D417/14
CPC分类号： C07D417/14
摘要： The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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![5-aryl-1-imino-1-oxo-[1,2,4]thiadiazines](/abs-image/US/2017/03/28/US09605006B2/abs.jpg.150x150.jpg)
公开(公告)号：US09605006B2
公开(公告)日：2017-03-28
申请号：US15105725
申请日：2014-12-17
发明人： Wolfgang Guba , Wolfgang Haap , Andreas Kuglstatter , Jens-Uwe Peters , Ulrike Obst Sander , Christian Schnider , Roger Wermuth , Thomas Woltering
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： The present invention provides a compound of formula I′ having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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公开(公告)号：US20130217665A1
公开(公告)日：2013-08-22
申请号：US13767031
申请日：2013-02-14
发明人： David Banner , Wolfgang Haap , Thomas Luebbers , Jens-Uwe Peters
IPC分类号： C07D417/14 , C07D405/14 , C07D207/10 , C07D409/14 , C07D417/08 , C07D403/08 , C07D403/06 , C07D401/14
CPC分类号： C07D417/14 , C07D207/10 , C07D401/14 , C07D403/06 , C07D403/08 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/08
摘要： The invention relates to a compound of formula (I) wherein A1 to A3 and R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译： 本发明涉及式（I）化合物，其中A 1至A 3和R 1至R 3如在说明书和权利要求书中所定义。 式（I）化合物可以用作药物。
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公开(公告)号：US20190352312A1
公开(公告)日：2019-11-21
申请号：US16527307
申请日：2019-07-31
发明人： Bjoern Bartels , Cosimo Dolente , Wolfgang Guba , Wolfgang Haap , Andreas Kuglstatter , Ulrike Obst Sander , Jens-Uwe Peters , Mark Rogers-Evans , Thomas Woltering , Christian Schnider , Roger Wermuth
IPC分类号： C07D513/04 , A61P25/28
摘要： The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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公开(公告)号：US20190307737A1
公开(公告)日：2019-10-10
申请号：US16179122
申请日：2018-11-02
发明人： Wolfgang Haap , Holger Kuehne , Harald Mauser
IPC分类号： A61K31/4523 , C07D471/04 , C07D265/02 , C07C19/08 , C07C317/02 , C07D233/20 , C07D401/14 , A61K31/38 , C07D417/14 , C07D403/14 , C07D413/14
摘要： The invention relates to a compound of formula (I) wherein A1, A2 and R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
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公开(公告)号：US20170266175A1
公开(公告)日：2017-09-21
申请号：US15612123
申请日：2017-06-02
发明人： Wolfgang Haap , Holger Kuehne , Harald Mauser
IPC分类号： A61K31/4523 , C07C19/08 , C07D265/02 , A61K31/38 , C07D471/04 , C07C317/02 , C07D233/20
CPC分类号： A61K31/4523 , A61K31/38 , A61K31/445 , C07C19/08 , C07C317/02 , C07D233/20 , C07D265/02 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The invention relates to a compound of formula (I) wherein A1, A2 and R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
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