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    DEVICE FOR THE CHROMATOGRAPHIC SEPARATION OF A SUBSTANCE MIXTURE AND USE THEREOF
    3.
    发明申请
    DEVICE FOR THE CHROMATOGRAPHIC SEPARATION OF A SUBSTANCE MIXTURE AND USE THEREOF 有权
    物质混合物的色谱分离装置及其用途

    公开(公告)号：US20130220929A1

    公开(公告)日：2013-08-29

    申请号：US13881831

    申请日：2011-10-18

    申请人： Hans-Peter Leinenbach ,  Franz-Josef Gerner ,  Stefan Kuhn ,  Patrick Priesnitz

    发明人： Hans-Peter Leinenbach ,  Franz-Josef Gerner ,  Stefan Kuhn ,  Patrick Priesnitz

    IPC分类号： B01D15/22

    CPC分类号： B01D15/22 ,  G01N30/6004 ,  G01N30/6017 ,  G01N30/6091

    摘要： The invention relates to a multifunctional device and its use for chromatographic separation, in particular for affinity chromatographic separation of a substance mixture, which allows a uniform fluid distribution on the separation medium and a uniform flow through the stationary phase, in that the fluid to be separated is passed through a radial inlet line in the upper partial region of the device to its center, such that the radial inlet line is enlarged in the form of a cupola at the center.

    摘要翻译： 本发明涉及多功能装置及其用于色谱分离的用途，特别是用于物质混合物的亲和色谱分离，其允许在分离介质上均匀的流体分布和通过固定相的均匀流动，其中流体为 分离的装置通过装置的上部部分区域中的径向入口管线到达其中心，使得径向入口管线在中心以圆顶形式扩大。

    Method and arrangement for sterilization, in particular for the sterilization of an adsorber
    5.
    发明授权
    Method and arrangement for sterilization, in particular for the sterilization of an adsorber 有权
    用于灭菌的方法和装置，特别是用于吸附器的灭菌

    公开(公告)号：US09011765B2

    公开(公告)日：2015-04-21

    申请号：US13125344

    申请日：2009-10-22

    申请人： Holger Rahn ,  Hans-Peter Leinenbach ,  Stefan Kuhn ,  Franz-Josef Gerner

    发明人： Holger Rahn ,  Hans-Peter Leinenbach ,  Stefan Kuhn ,  Franz-Josef Gerner

    IPC分类号： A61L2/08 ,  A61L2/00 ,  A61M1/16

    CPC分类号： A61L2/007 ,  A61L2/0035 ,  A61L2/08 ,  A61L2202/122 ,  A61M1/168 ,  A61M1/169

    摘要： A method and an arrangement for sterilizing, in particular for sterilizing an adsorber, which has an adsorber housing that is to be filled with an adsorbent, are such that, instead of the adsorbent-filled adsorber housing being sterilized, the adsorbent is sterilized in a separate container, which is dimensioned such that the adsorbent spreads out in a thin layer in the container. Together with the adsorber housing, the container for sterilizing the adsorbent forms a closed system, such that the adsorbent can be transferred into the adsorber housing without the need for an aseptic environment. The container for receiving the adsorbent is preferably a bag, in which the adsorbent spreads out in a thin layer when the bag is lying flat on a plane surface. Since the adsorbent in the bag spreads out in a thin layer, the sterilization requires only a relatively small dose of radiation, which cannot damage the adsorbent. The bag is irradiated with high-energy radiation, in particular ionizing radiation. The adsorbent is then transferred from the bag into the adsorber housing. During the transfer of the adsorbent into the adsorber housing, the air and/or excess liquid present in the adsorber housing is removed from the adsorber housing preferably into one or more empty bags.

    摘要翻译： 特别是消毒吸附器的方法和装置，其特征在于，具有吸附器壳体的要被填充吸附剂的灭菌器是这样的：代替吸附剂填充的吸附器壳体被消毒，吸附剂在 分离的容器的尺寸使得吸附剂在容器中的薄层中展开。 与吸附器壳体一起，用于消毒吸附剂的容器形成封闭系统，使得吸附剂可以被转移到吸附器壳体中，而不需要无菌环境。 用于接收吸附剂的容器优选为袋，当袋平躺在平面上时，吸附剂以薄层展开。 由于袋中的吸附剂散布在薄层中，所以灭菌只需要较小剂量的辐射，这不会损伤吸附剂。 用高能量辐射照射袋子，特别是电离辐射。 然后将吸附剂从袋中转移到吸附器壳体中。 在将吸附剂转移到吸附器壳体期间，存在于吸附器壳体中的空气和/或多余的液体优选地从吸附器壳体移除到一个或多个空袋中。