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公开(公告)号：US06867006B2
公开(公告)日：2005-03-15
申请号：US10141965
申请日：2002-05-10
申请人： Haodong Li , Steven M. Ruben , Granger Sutton, III
发明人： Haodong Li , Steven M. Ruben , Granger Sutton, III
IPC分类号： A61K38/00 , C07K14/52 , C12N15/12 , C12N15/19 , C07K16/00 , C07K16/18 , C07K16/22 , C07K16/24 , C07K16/26
CPC分类号： C07K14/523 , A61K38/00
摘要： A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.
摘要翻译： 公开了人趋化多肽，编码它的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了将多肽用于多种目的的方法，包括：干细胞动员，髓过保护，神经元保护，治疗肿瘤，伤口愈合，治疗寄生虫感染和调节造血。 还公开了多肽拮抗剂和用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。
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公开(公告)号：US06419917B1
公开(公告)日：2002-07-16
申请号：US09453416
申请日：1999-12-03
申请人： Haodong Li , Steven M. Ruben , Granger Sutton, III
发明人： Haodong Li , Steven M. Ruben , Granger Sutton, III
IPC分类号： A61K3816
CPC分类号： C07K14/523 , A61K38/00
摘要： A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.
摘要翻译： 公开了人趋化多肽，编码它的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了将多肽用于多种目的的方法，包括：干细胞动员，髓过保护，神经元保护，治疗肿瘤，伤口愈合，治疗寄生虫感染和调节造血。 还公开了多肽拮抗剂和用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。
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公开(公告)号：US06075124A
公开(公告)日：2000-06-13
申请号：US44856
申请日：1998-03-20
申请人： Haodong Li , Steven M. Ruben , Granger Sutton, III
发明人： Haodong Li , Steven M. Ruben , Granger Sutton, III
IPC分类号： A61K38/00 , C07K14/52 , C07K14/435 , C07K14/00
CPC分类号： C07K14/523 , A61K38/00
摘要： A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.
摘要翻译： 公开了人趋化多肽，编码它的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了将多肽用于多种目的的方法，包括：干细胞动员，髓过保护，神经元保护，治疗肿瘤，伤口愈合，治疗寄生虫感染和调节造血。 还公开了多肽拮抗剂和用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。
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公开(公告)号：US6100389A
公开(公告)日：2000-08-08
申请号：US44855
申请日：1998-03-20
申请人： Haodong Li , Steven M. Ruben , Granger Sutton, III
发明人： Haodong Li , Steven M. Ruben , Granger Sutton, III
CPC分类号： C07K14/523 , A61K38/00
摘要： A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.
摘要翻译： 公开了人趋化多肽，编码它的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了将多肽用于多种目的的方法，包括：干细胞动员，髓过保护，神经元保护，治疗肿瘤，伤口愈合，治疗寄生虫感染和调节造血。 还公开了多肽拮抗剂和用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。
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公开(公告)号：US07364865B2
公开(公告)日：2008-04-29
申请号：US11381977
申请日：2006-05-05
申请人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
发明人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
CPC分类号： G01N33/6863 , A61K38/00 , A61K48/00 , C07K1/113 , C07K1/36 , C07K14/50 , C07K14/521 , C07K14/523 , C07K16/24 , C07K2319/00 , C12N15/72 , C12N2799/026 , G01N2333/52
摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1(CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译： 公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子β8（CKbeta8或ckb-8））的分离的核酸分子的治疗组合物和方法。 人单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ和趋化因子β1（CKbeta1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4）以及MPIF-1 ，M-CIF和/或MIP-4多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。
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公开(公告)号：US07851596B2
公开(公告)日：2010-12-14
申请号：US12111079
申请日：2008-04-28
申请人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
发明人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
IPC分类号： C07K14/52
CPC分类号： G01N33/6863 , A61K38/00 , A61K48/00 , C07K1/113 , C07K1/36 , C07K14/50 , C07K14/521 , C07K14/523 , C07K16/24 , C07K2319/00 , C12N15/72 , C12N2799/026 , G01N2333/52
摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译： 公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子8（CK＆bgr; 8或ckb-8））的分离的核酸分子的治疗组合物和方法; 人类单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ和趋化因子1（CK＆bgr; 1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4） 作为MPIF-1，M-CIF和/或MIP-4多肽本身，载体，宿主细胞和用于制备它们的重组方法也是如此。
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公开(公告)号：US07041460B2
公开(公告)日：2006-05-09
申请号：US10626530
申请日：2003-07-25
申请人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
发明人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
CPC分类号： G01N33/6863 , A61K38/00 , A61K48/00 , C07K1/113 , C07K1/36 , C07K14/50 , C07K14/521 , C07K14/523 , C07K16/24 , C07K2319/00 , C12N15/72 , C12N2799/026 , G01N2333/52
摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译： 公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子β8（CKbeta8或ckb-8））的分离的核酸分子的治疗组合物和方法。 人单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ和趋化因子β1（CKbeta1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4）以及MPIF-1 ，M-CIF和/或MIP-4多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。
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公开(公告)号：US06919433B2
公开(公告)日：2005-07-19
申请号：US09853161
申请日：2001-05-11
申请人： Steven M. Ruben , Craig A. Rosen , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie L. Fischer , Haodong Li , Daniel R. Soppet , Reiner L. Gentz , Ying-Fei Wei , Paul A. Moore , Paul E. Young , John M. Greene , Ann M. Ferrie , Gregg A. Hastings
发明人： Steven M. Ruben , Craig A. Rosen , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie L. Fischer , Haodong Li , Daniel R. Soppet , Reiner L. Gentz , Ying-Fei Wei , Paul A. Moore , Paul E. Young , John M. Greene , Ann M. Ferrie , Gregg A. Hastings
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US5880263A
公开(公告)日：1999-03-09
申请号：US726830
申请日：1996-10-08
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K39/395 , A61K48/00 , A61P3/06 , A61P7/00 , A61P29/00 , A61P33/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07K14/52 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/19 , C12P21/02 , C12R1/19 , C12R1/91 , C07K14/00
CPC分类号： C07K14/523 , A61K38/00
摘要： A human chemotactic protein polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating for stem cell mobilization, myeloprotection and neuronal protection, to treat tumors, to promote wound healing, to combat parasitic infection and to regulate hematopoiesis. Also disclosed are antagonists against such polypeptides which may be employed to treat rheumatoid arthritis, lung inflammation, allergy, infectious diseases and to prevent inflammation and atherosclerosis. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.
摘要翻译： 公开了人类趋化蛋白多肽和编码这种多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种多肽预防和/或治疗干细胞移动，骨髓保护和神经元保护，治疗肿瘤，促进伤口愈合，抵抗寄生虫感染和调节造血作用的方法。 还公开了抗这种多肽的拮抗剂，其可用于治疗类风湿性关节炎，肺部炎症，变态反应，感染性疾病和预防炎症和动脉粥样硬化。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。
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10.发明申请Myeloid Progenitor Inhibitory Factor-1 (MPIF-1), Monocyte Colony Inhibitory Factor (M-CIF), and Macrophage Inhibitory Factor-4 (MIP-4) 失效髓系祖细胞抑制因子-1（MPIF-1），单核细胞集落抑制因子（M-CIF）和巨噬细胞抑制因子-4（MIP-4）公开(公告)号：US20080274109A1
公开(公告)日：2008-11-06
申请号：US12111079
申请日：2008-04-28
申请人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
发明人： Reiner L. Gentz , Brent L. Kreider , Jun Zhang , Michael Antonaccio , Donna Mendrick , Pablo Jimenez , Vikram Patel , Craig A. Rosen , Mark D. Adams , Haodong Li , Steven M. Ruben
IPC分类号： A61K39/395 , C07H21/04 , C12Q1/68 , C07K14/00 , G01N33/53 , A61P43/00 , A61K38/00 , C12Q1/00 , C07K16/18
CPC分类号： G01N33/6863 , A61K38/00 , A61K48/00 , C07K1/113 , C07K1/36 , C07K14/50 , C07K14/521 , C07K14/523 , C07K16/24 , C07K2319/00 , C12N15/72 , C12N2799/026 , G01N2333/52
摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
摘要翻译： 公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子β8（CKbeta8或ckb-8））的分离的核酸分子的治疗组合物和方法。 人单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ和趋化因子β1（CKbeta1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4）以及MPIF-1 ，M-CIF和/或MIP-4多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。
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