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20 条记录 (耗时 0.023 秒)

    Process for the preparation of pterin derivatives
    3.
    发明授权
    Process for the preparation of pterin derivatives 失效
    蝶呤衍生物的制备方法

    公开(公告)号：US5043446A

    公开(公告)日：1991-08-27

    申请号：US485274

    申请日：1990-02-23

    申请人： Haruhiko Kikuchi ,  Kenji Mori

    发明人： Haruhiko Kikuchi ,  Kenji Mori

    IPC分类号： C07D475/04 ,  C07H5/04 ,  C07H9/04 ,  C07H15/203

    CPC分类号： C07D475/04

    摘要： A process of preparing l-biopterin is disclosed which comprises the steps of:Subjecting to selective Grignard reaction D-ribose having the hydroxyl groups in the 2- and 3-positions protected by an acetal group to give 6-deoxy-3,4-O-alkylidene allitol;subjecting the 1- and 2-positions of said allitol to oxidative cleavage to form 5-deoxy-2,3-O-alkylidene-L-ribose followed by deacetalization to give 5-deoxy-L-ribose;reacting 5-deoxy-L-ribose with a hydrazine compound to form a 5-deoxy-L-ribose hydrazone compound; andsubjecting said hydrazone compound to condensation reaction with an acid addition salt of 4-hydroxy-2,5,6-triaminopyrimidine followed by oxidation.

    LUBRICATION-CONDITION DETECTOR, LUBRICANT FEEDER, INJECTION MOLDING MACHINE AND METHOD OF DETECTING LUBRICATION-CONDITION
    4.
    发明申请
    LUBRICATION-CONDITION DETECTOR, LUBRICANT FEEDER, INJECTION MOLDING MACHINE AND METHOD OF DETECTING LUBRICATION-CONDITION 有权
    润滑条件检测器，润滑剂进料器，注射成型机和检测润滑条件的方法

    公开(公告)号：US20080271949A1

    公开(公告)日：2008-11-06

    申请号：US12100825

    申请日：2008-04-10

    申请人： HARUMICHI TOKUYAMA ,  Masahiko Mori ,  Makoto Takami ,  Haruhiko Kikuchi ,  Akira Yoshinaga ,  Noriyuki Sasaki ,  Shinya Itani

    发明人： HARUMICHI TOKUYAMA ,  Masahiko Mori ,  Makoto Takami ,  Haruhiko Kikuchi ,  Akira Yoshinaga ,  Noriyuki Sasaki ,  Shinya Itani

    IPC分类号： F01M1/18

    CPC分类号： G01N33/2888 ,  B29C45/83 ,  G01F23/0046 ,  G01F23/22

    摘要： A lubrication-condition detector detects a lubricant shortage of a target portion that repeats a predetermined operation at a predetermined cycle. The lubrication-condition detector includes: a physical-quantity measuring unit for continuously measuring a physical quantity related to the target portion; and a computer for determining a presence of a lubricant shortage based on the physical quantity. The computer includes: a cycle extractor for extracting a cycle datum per an operational cycle from continuous data including the physical quantity and its measuring time; a representative-value calculator for calculating a representative value for each of plural cycle data; and determining unit for determining a presence of a lubricant shortage based on the plural representative values.

    摘要翻译： 润滑条件检测器检测以预定周期重复预定操作的目标部分的润滑剂不足。 润滑条件检测器包括：物理量测量单元，用于连续测量与目标部分相关的物理量; 以及用于基于物理量确定润滑剂短缺的存在的计算机。 计算机包括：循环提取器，用于从包括物理量和其测量时间的连续数据中提取每个操作周期的循环数据; 用于计算多个周期数据中的每一个的代表值的代表值计算器; 以及基于所述多个代表值来确定润滑剂不足的存在的确定单元。

    Diazabicyclo derivatives
    5.
    发明授权
    Diazabicyclo derivatives 失效
    二氮杂双环衍生物

    公开(公告)号：US5344831A

    公开(公告)日：1994-09-06

    申请号：US10145

    申请日：1993-01-28

    申请人： Hiroaki Satoh ,  Haruhiko Kikuchi ,  Kazuhiko Yamada ,  Ruta Fukutomi ,  Masashi Suzuki ,  Koichiro Hagihara ,  Toru Hayakawa ,  Takeo Arai ,  Setsuko Mino

    发明人： Hiroaki Satoh ,  Haruhiko Kikuchi ,  Kazuhiko Yamada ,  Ruta Fukutomi ,  Masashi Suzuki ,  Koichiro Hagihara ,  Toru Hayakawa ,  Takeo Arai ,  Setsuko Mino

    IPC分类号： C07D471/08 ,  C07D247/02 ,  A61K31/495 ,  C07D487/08

    CPC分类号： C07D471/08

    摘要： Diazabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, oxoalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyl, dialkylaminoalkyl, hydroxyalkyl, haloalkyl, cyanoalkyl, heterocycloalkyl, aryl, heteroarylalkyl or arylalkyl, the aryl group and the aryl moiety being optionally substituted by alkoxy, nitro, alkyl, amino or halo;R.sup.2 is hydrogen or alkyl;R.sup.3 and R.sup.4 may be the same or different and each is hydrogen, alkyl, alkenyl, acyl, alkoxyalkyl or arylalkyl wherein the aryl moiety is optionally substituted by alkoxy, nitro, alkyl, amino or halo;with the proviso that when R.sup.2 is hydrogen and both R.sup.3 and R.sup.4 are methyl, R.sup.1 does not represent hydrogen, alkyl, unsubstituted benzyl or dimethylaminoethyl; having 5-HT.sub.3 receptor antagonist activity.

    摘要翻译： 式（I）的二氮杂双环衍生物及其药学上可接受的盐：其中R是氢，烷基，烯基，炔基，环烷基，环烷基烷基，烷氧基烷基，氧代烷基，烷氧基羰基烷基，烷氧基羰基，酰基，二烷基氨基烷基，羟基烷基，卤代烷基， 氰基烷基，杂环烷基，芳基，杂芳基烷基或芳烷基，芳基和芳基部分任选被烷氧基，硝基，烷基，氨基或卤素取代; R2是氢或烷基; R 3和R 4可以相同或不同，各自为氢，烷基，烯基，酰基，烷氧基烷基或芳烷基，其中芳基部分任选被烷氧基，硝基，烷基，氨基或卤素取代; 条件是当R 2是氢并且R 3和R 4都是甲基时，R 1不代表氢，烷基，未取代的苄基或二甲基氨基乙基; 具有5-HT 3受体拮抗剂活性。

    Process for preparing 4-(4-biphenylyl)-4-oxo-butanoic acid
    6.
    发明授权
    Process for preparing 4-(4-biphenylyl)-4-oxo-butanoic acid 失效
    制备4-（4-联苯基）-4-氧代 - 丁酸的方法

    公开(公告)号：US4621154A

    公开(公告)日：1986-11-04

    申请号：US668335

    申请日：1984-11-05

    申请人： Haruhiko Kikuchi

    发明人： Haruhiko Kikuchi

    IPC分类号： C07C59/84 ,  B01J27/00 ,  C07B61/00 ,  C07C51/00 ,  C07C51/347 ,  C07C51/373 ,  C07C67/00 ,  C07C59/86

    CPC分类号： C07C51/347

    摘要： An improved process for preparing 4-(4-biphenylyl)-4-oxo-butanoic acid which is useful as anti-inflammatory and analgesic agents. The process comprises reacting biphenyl with succinic anhydride in chlorobenzene in the presence of anhydrous aluminum chloride. No 4-(4-chlorophenyl)-4-oxo-butanoic acid is produced as by-product.

    摘要翻译： 用于制备4-（4-联苯基）-4-氧代 - 丁酸的改进方法，其可用作抗炎和止痛剂。 该方法包括在无水氯化铝存在下将联苯与琥珀酸酐在氯苯中反应。 不产生副产物4-（4-氯苯基）-4-氧代 - 丁酸。

    Lubrication-condition detector, lubricant feeder, injection molding machine and method of detecting lubrication-condition
    7.
    发明授权
    Lubrication-condition detector, lubricant feeder, injection molding machine and method of detecting lubrication-condition 有权
    润滑条件检测器，润滑剂给料机，注塑机及检测润滑条件的方法

    公开(公告)号：US08479886B2

    公开(公告)日：2013-07-09

    申请号：US12100825

    申请日：2008-04-10

    申请人： Harumichi Tokuyama ,  Masahiko Mori ,  Makoto Takami ,  Haruhiko Kikuchi ,  Akira Yoshinaga ,  Noriyuki Sasaki ,  Shinya Itani

    发明人： Harumichi Tokuyama ,  Masahiko Mori ,  Makoto Takami ,  Haruhiko Kikuchi ,  Akira Yoshinaga ,  Noriyuki Sasaki ,  Shinya Itani

    IPC分类号： F01M1/18

    CPC分类号： G01N33/2888 ,  B29C45/83 ,  G01F23/0046 ,  G01F23/22

    摘要： A lubrication-condition detector detects a lubricant shortage of a target portion that repeats a predetermined operation at a predetermined cycle. The lubrication-condition detector includes: a physical-quantity measuring unit for continuously measuring a physical quantity related to the target portion; and a computer for determining a presence of a lubricant shortage based on the physical quantity. The computer includes: a cycle extractor for extracting a cycle datum per an operational cycle from continuous data including the physical quantity and its measuring time; a representative-value calculator for calculating a representative value for each of plural cycle data; and determining unit for determining a presence of a lubricant shortage based on the plural representative values.

    摘要翻译： 润滑条件检测器检测以预定周期重复预定操作的目标部分的润滑剂不足。 润滑条件检测器包括：物理量测量单元，用于连续测量与目标部分相关的物理量; 以及用于基于物理量确定润滑剂短缺的存在的计算机。 计算机包括：循环提取器，用于从包括物理量和其测量时间的连续数据中提取每个操作周期的循环数据; 用于计算多个周期数据中的每一个的代表值的代表值计算器; 以及基于所述多个代表值来确定润滑剂不足的存在的确定单元。

    Method and system for temperature control of hydraulic oil
    9.
    发明授权
    Method and system for temperature control of hydraulic oil 失效
    液压油温度控制方法及系统

    公开(公告)号：US5971068A

    公开(公告)日：1999-10-26

    申请号：US792235

    申请日：1997-01-31

    申请人： Akira Ochiai ,  Kazuo Nagashima ,  Chikara Watanabe ,  Haruhiko Kikuchi

    发明人： Akira Ochiai ,  Kazuo Nagashima ,  Chikara Watanabe ,  Haruhiko Kikuchi

    IPC分类号： F16C32/06 ,  G05D23/19 ,  G05D23/00

    CPC分类号： G05D23/1904

    摘要： A combination of setting a correction value of an atmospheric temperature for each temporal section in response to a predicted value of a variation of the atmospheric temperature in a day and a delayed variation of a temperature of hydraulic oil due to thermal inertia and correcting a command value for a temperature regulation of the hydraulic oil at a supply source of the hydraulic oil in response to the correction value of the atmospheric temperature, performing a feed forward compensation of the temperature of the hydraulic oil with respect to the variation of the atmospheric temperature for the day as a cyclic period, permits a working body of hydraulic oil to be kept at an adequate temperature, even under working conditions subjected to significant influences of atmospheric temperature variations and thermal inertia.

    摘要翻译： 响应于一天中的大气温度的变化的预测值和由于热惯性引起的液压油的温度的延迟变化以及修正指令值，设定每个时间段的大气温度的校正值的组合 为了响应于大气温度的校正值对液压油的供给源上的液压油进行温度调节，对于液压油的大气温度的变化，对液压油的温度进行前馈补偿 一天作为循环周期，即使在受到大气温度变化和热惯性的显着影响的工作条件下，也允许液压油的工作体保持在适当的温度。