公开(公告)号：US5736550A

公开(公告)日：1998-04-07

申请号：US737335

申请日：1996-11-15

申请人： Haruhiko Kikuchi ,  Hiroaki Satoh ,  Ruta Fukutomi ,  Kohei Inomata ,  Masashi Suzuki ,  Koichiro Hagihara ,  Takeo Arai ,  Setsuko Mino ,  Haruko Eguchi

发明人： Haruhiko Kikuchi ,  Hiroaki Satoh ,  Ruta Fukutomi ,  Kohei Inomata ,  Masashi Suzuki ,  Koichiro Hagihara ,  Takeo Arai ,  Setsuko Mino ,  Haruko Eguchi

IPC分类号： C07D239/48 ,  C07D239/56 ,  C07D239/58 ,  C07D239/60 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/08 ,  C07D498/08 ,  C07D239/02 ,  A01N43/54 ,  C07D239/00 ,  C07D241/02

CPC分类号： C07D239/48 ,  C07D239/56 ,  C07D239/58 ,  C07D239/60 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/08 ,  C07D498/08

摘要： Pyrimidine derivatives useful as a gastrointestinal prokinetic agent, represented by formula ##STR1## wherein X is O or NR.sup.5, Y is O, S or NR.sup.5 wherein R.sup.5 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or the like; R.sup.1 and R.sup.2 may be the same or different and each is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or the like; R.sup.3 is CN, or COOR.sup.6 wherein R.sup.6 is a C.sub.1 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 cycloalkyl group, an aryl group or the like; R.sup.4 is --SR.sup.7 or --NR.sup.8 R.sup.9 wherein R.sup.7 is a C.sub.1 -C.sub.6 alkyl group; R.sup.8 is a C.sub.1 -C.sub.6 alkyl group or the like; R.sup.9 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or the like, or R.sup.8 and R.sup.9 may represent, together with the nitrogen atom to which they are attached, an N-substituted piperazine ring of formula (X) ##STR2## wherein R.sup.10 represents a C.sub.1 -C.sub.6 alkyl group or the like or a pharmacologically acceptable salt thereof. The above-mentioned compounds are useful as a gastrointestinal prokinetic agent used for the therapy of digestive tract diseases.

摘要翻译： PCT No.PCT / JP95 / 00937 371日期1996年11月15日 102（e）日期1996年11月15日PCT提交1995年5月17日PCT公布。 公开号WO95 / 31442 日期1997年11月23日可用作胃肠促动力的嘧啶衍生物，由式R NR5表示，其中R5是氢原子，C1-C6烷基等; R1和R2可以相同或不同，各自为氢原子，C1-C6烷基等; R3是CN或COOR6，其中R6是C1-C6烷基，C3-C6环烷基，芳基等; R4是-SR7或-NR8R9，其中R7是C1-C6烷基; R8是C1-C6烷基等; R 9是氢原子，C 1 -C 6烷基等，或者R 8和R 9可以与它们所连接的氮原子一起代表式（X）的N-取代哌嗪环。 ）其中R 10表示C1-C6烷基等或其药理学上可接受的盐。 上述化合物可用作用于治疗消化道疾病的胃肠促动力剂。

公开(公告)号：US5753654A

公开(公告)日：1998-05-19

申请号：US737133

申请日：1996-11-07

申请人： Haruhiko Kikuchi ,  Hiroaki Satoh ,  Ruta Fukutomi ,  Kohei Inomata ,  Masashi Suzuki ,  Koichiro Hagihara ,  Takeo Arai ,  Setsuko Mino ,  Haruko Eguchi

发明人： Haruhiko Kikuchi ,  Hiroaki Satoh ,  Ruta Fukutomi ,  Kohei Inomata ,  Masashi Suzuki ,  Koichiro Hagihara ,  Takeo Arai ,  Setsuko Mino ,  Haruko Eguchi

IPC分类号： A61K31/535 ,  C07D265/30 ,  C07D265/36 ,  C07D413/00

CPC分类号： A61K31/535 ,  C07D265/30 ,  C07D265/36 ,  C07D413/00

摘要： Novel diaminomethylidene derivatives represented by formula (I) ##STR1## wherein R.sup.1 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 cycloalkyl group and others, R.sup.2 is a group of the following formula ##STR2## and others, R.sup.3 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group and others, X is O, S, CHNO.sub.2, C(COOR.sup.4).sub.2, C(COOR.sup.4)CN or C(CN).sub.2) or pharmacologically acceptable salts thereof. The above-mentioned compounds are useful as a gastrointestinal prokinetic agent to be used for the treatment of digestive tract diseases.

公开(公告)号：US5684003A

公开(公告)日：1997-11-04

申请号：US543853

申请日：1995-10-12

申请人： Haruhiko Kikuchi ,  Hiroaki Satoh ,  Masashi Suzuki ,  Ruta Fukutomi ,  Masahiro Ueno ,  Koichiro Hagihara ,  Takeo Arai ,  Setsuko Mino ,  Yumiko Noguchi

发明人： Haruhiko Kikuchi ,  Hiroaki Satoh ,  Masashi Suzuki ,  Ruta Fukutomi ,  Masahiro Ueno ,  Koichiro Hagihara ,  Takeo Arai ,  Setsuko Mino ,  Yumiko Noguchi

IPC分类号： C07D498/08 ,  A61K31/535 ,  C07D413/12

CPC分类号： C07D498/08

摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof are selective agonists for 5-HT.sub.4 receptors. ##STR1## wherein Ak is a C.sub.3 -C.sub.6 alkyl group, and R is a C.sub.2 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 alkenyl group, a C.sub.3 -C.sub.6 alkynyl group, a C.sub.3 -C.sub.7 cycloalkyl group or a C.sub.3 -C.sub.6 cycloalkylmethyl group.

摘要翻译： 式（I）化合物及其药学上可接受的盐是5-HT 4受体的选择性激动剂。 （I）其中Ak是C3-C6烷基，R是C2-C6烷基，C3-C6烯基，C3-C6炔基，C3-C7环烷基或C3- C6环烷基甲基。

公开(公告)号：US5344831A

公开(公告)日：1994-09-06

申请号：US10145

申请日：1993-01-28

申请人： Hiroaki Satoh ,  Haruhiko Kikuchi ,  Kazuhiko Yamada ,  Ruta Fukutomi ,  Masashi Suzuki ,  Koichiro Hagihara ,  Toru Hayakawa ,  Takeo Arai ,  Setsuko Mino

发明人： Hiroaki Satoh ,  Haruhiko Kikuchi ,  Kazuhiko Yamada ,  Ruta Fukutomi ,  Masashi Suzuki ,  Koichiro Hagihara ,  Toru Hayakawa ,  Takeo Arai ,  Setsuko Mino

IPC分类号： C07D471/08 ,  C07D247/02 ,  A61K31/495 ,  C07D487/08

CPC分类号： C07D471/08

摘要： Diazabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, oxoalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyl, dialkylaminoalkyl, hydroxyalkyl, haloalkyl, cyanoalkyl, heterocycloalkyl, aryl, heteroarylalkyl or arylalkyl, the aryl group and the aryl moiety being optionally substituted by alkoxy, nitro, alkyl, amino or halo;R.sup.2 is hydrogen or alkyl;R.sup.3 and R.sup.4 may be the same or different and each is hydrogen, alkyl, alkenyl, acyl, alkoxyalkyl or arylalkyl wherein the aryl moiety is optionally substituted by alkoxy, nitro, alkyl, amino or halo;with the proviso that when R.sup.2 is hydrogen and both R.sup.3 and R.sup.4 are methyl, R.sup.1 does not represent hydrogen, alkyl, unsubstituted benzyl or dimethylaminoethyl; having 5-HT.sub.3 receptor antagonist activity.

摘要翻译： 式（I）的二氮杂双环衍生物及其药学上可接受的盐：其中R是氢，烷基，烯基，炔基，环烷基，环烷基烷基，烷氧基烷基，氧代烷基，烷氧基羰基烷基，烷氧基羰基，酰基，二烷基氨基烷基，羟基烷基，卤代烷基， 氰基烷基，杂环烷基，芳基，杂芳基烷基或芳烷基，芳基和芳基部分任选被烷氧基，硝基，烷基，氨基或卤素取代; R2是氢或烷基; R 3和R 4可以相同或不同，各自为氢，烷基，烯基，酰基，烷氧基烷基或芳烷基，其中芳基部分任选被烷氧基，硝基，烷基，氨基或卤素取代; 条件是当R 2是氢并且R 3和R 4都是甲基时，R 1不代表氢，烷基，未取代的苄基或二甲基氨基乙基; 具有5-HT 3受体拮抗剂活性。

公开(公告)号：US6096746A

公开(公告)日：2000-08-01

申请号：US274885

申请日：1999-03-23

申请人： Masashi Suzuki ,  Masahiro Ueno ,  Ryuta Fukutomi ,  Hiroaki Satoh ,  Haruhiko Kikuchi ,  Koichiro Hagihara ,  Takeo Arai ,  Sugure Taniguchi ,  Setsuko Mino ,  Yumiko Noguchi

发明人： Masashi Suzuki ,  Masahiro Ueno ,  Ryuta Fukutomi ,  Hiroaki Satoh ,  Haruhiko Kikuchi ,  Koichiro Hagihara ,  Takeo Arai ,  Sugure Taniguchi ,  Setsuko Mino ,  Yumiko Noguchi

IPC分类号： C07D231/56 ,  C07D401/12 ,  A61K31/496 ,  C07D403/12

CPC分类号： C07D231/56 ,  C07D401/12

摘要： An indazole compound having a piperazinyl moiety in the structure thereof, which is a 5-HT.sub.4 receptor agonist which is useful in the treatment of digestive tract disorders.

摘要翻译： 在其结构中具有哌嗪基部分的吲唑化合物，其是可用于治疗消化道疾病的5-HT 4受体激动剂。

公开(公告)号：US5945434A

公开(公告)日：1999-08-31

申请号：US952509

申请日：1997-11-28

申请人： Masashi Suzuki ,  Masahiro Ueno ,  Ryuta Fukutomi ,  Hiroaki Satoh ,  Haruhiko Kikuchi ,  Koichiro Hagihara ,  Takeo Arai ,  Sugure Taniguchi ,  Setsuko Mino ,  Yumiko Noguchi

发明人： Masashi Suzuki ,  Masahiro Ueno ,  Ryuta Fukutomi ,  Hiroaki Satoh ,  Haruhiko Kikuchi ,  Koichiro Hagihara ,  Takeo Arai ,  Sugure Taniguchi ,  Setsuko Mino ,  Yumiko Noguchi

IPC分类号： C07D231/56 ,  C07D401/12 ,  A61K31/445

CPC分类号： C07D231/56 ,  C07D401/12

摘要： An indazole compound having the formula (I): wherein:R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl or C.sub.3 -C.sub.6 cycloalkyl;Q is carbonyl, thiocarbonyl or methylene; andR.sub.2 is a group of the formula (II) or (IV); ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl or benzyl, of which a phenyl group thereof is optionally mono- or di-substituted by the same or different halogen or methoxy; m is 0 to 2; n and o is 1 or 2. The compound exhibits 5-HT.sub.4 receptor agonist activity.

摘要翻译： PCT No.PCT / JP96 / 01475第 371日期1997年11月28日 102（e）1997年11月28日日期PCT提交1996年5月31日PCT公布。 WO96 / 38420 PCT出版物 日期：1996年12月5日具有式（I）的吲唑化合物：其中：R1为氢，C1-C6烷基，C3-C6烯基或C3-C6环烷基; Q是羰基，硫代羰基或亚甲基; 并且R 2是式（II）或（IV）的基团; 其中R 1是C 1 -C 6烷基，C 3 -C 6烯基或苄基，其中苯基任选被相同或不同的卤素或甲氧基单取代或二取代; m为0〜2; n和o是1或2.化合物显示5-HT 4受体激动剂活性。

公开(公告)号：US6011069A

公开(公告)日：2000-01-04

申请号：US767624

申请日：1996-12-17

申请人： Kohei Inomata ,  Toshihiro Takahashi ,  Hitoshi Inoue ,  Makoto Yanai ,  Hiroyuki Yamazaki ,  Masashi Suzuki ,  Tsutomu Takasawa ,  Kouji Kawamura ,  Norio Oshida ,  Hiroyuki Ikemoto ,  Takao Kishiye

发明人： Kohei Inomata ,  Toshihiro Takahashi ,  Hitoshi Inoue ,  Makoto Yanai ,  Hiroyuki Yamazaki ,  Masashi Suzuki ,  Tsutomu Takasawa ,  Kouji Kawamura ,  Norio Oshida ,  Hiroyuki Ikemoto ,  Takao Kishiye

IPC分类号： A61K31/137 ,  A01N33/02

CPC分类号： A61K31/137

摘要： There is disclosed a multidrug resistance inhibitor for overcoming a multidrug resistance of cancer, or an agent for enhancing the activity of anti-cancer agents, which comprises as an active ingredient a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein n is an integer of 5 to 12,R.sub.1 and R.sub.2 are each independently benzyl, of which a phenyl ring may be substituted by 1 to 5 substituents selected from hydroxy, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy and halogen, and/or by methylenedioxy, with the proviso that R.sub.1 and R.sub.2 are simultaneously not a compound of formula (II) ##STR2##

摘要翻译： 公开了用于克服癌症的多药耐药性的多药耐药性抑制剂或增强抗癌剂活性的药剂，其包含作为活性成分的式（I）化合物或其药学上可接受的盐：其中n 为5〜12的整数，R 1和R 2各自独立地为苄基，其中苯环可被1〜5个选自羟基，（C 1 -C 4）烷基，（C 1 -C 4）烷氧基和卤素的取代基取代， /或亚甲二氧基，条件是R1和R2不是式（II）的化合物，

公开(公告)号：US5756475A

公开(公告)日：1998-05-26

申请号：US791165

申请日：1997-01-30

申请人： Kohei Inomata ,  Toshihiro Takahashi ,  Hitoshi Inoue ,  Makoto Yanai ,  Hiroyuki Yamazaki ,  Masashi Suzuki ,  Tsutomu Takasawa ,  Kouji Kawamura ,  Norio Oshida ,  Hiroyuki Ikemoto ,  Takao Kishiye

发明人： Kohei Inomata ,  Toshihiro Takahashi ,  Hitoshi Inoue ,  Makoto Yanai ,  Hiroyuki Yamazaki ,  Masashi Suzuki ,  Tsutomu Takasawa ,  Kouji Kawamura ,  Norio Oshida ,  Hiroyuki Ikemoto ,  Takao Kishiye

IPC分类号： C07C211/29 ,  C07C217/58 ,  C07D207/14 ,  C07D295/13 ,  C07D498/08 ,  A01N43/04 ,  A01N33/02 ,  C07C211/00

CPC分类号： C07D295/13 ,  C07C211/29 ,  C07C217/58 ,  C07D207/14 ,  C07C2101/04 ,  C07C2103/18 ,  Y10S514/937 ,  Y10S514/938

摘要： Isoprene derivatives of formula (I) ##STR1## wherein m is an integer of 0 to 3, n is an integer of 5 to 12, A is cyclo(C.sub.3 -C.sub.6)alkylene, phenylene, fluorenylene, pyrrolidinylene, piperazinylene, 9-aza-3-oxabicyclo�3.3.1!-nonylene, R.sub.1 and R.sub.2 are each independently benzyl, of which a phenyl ring may be substituted by 1 to 5 substituents selected from the group consisting of hydroxy, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy and halogen, X is a single bond or a divalent radical of --(CH.sub.2).sub.p NH--, p is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof. Those compounds are useful as multidrug resistance inhibitors for overcoming multidrug resistance of cancer and agents for enhancing an activity of anti-cancer agents.

摘要翻译： 式（I）的异戊二烯衍生物其中m为0〜3的整数，n为5〜12的整数，A为环（C 3〜C 6）亚烷基，亚苯基，亚芴基，吡咯烷基， 9-氮杂-3-氧杂双环[3.3.1] - 亚芳基，R 1和R 2各自独立地为苄基，其中苯环可被1至5个选自羟基，（C 1 -C 4）烷基 ，（C1-C4）烷氧基和卤素，X是 - （CH2）pNH-的单键或二价基团，p是0-3的整数，或其药学上可接受的盐。 那些化合物可用作克服癌症多药耐药性和增强抗癌药活性的药物的多药耐药性抑制剂。

公开(公告)号：US20180356759A1

公开(公告)日：2018-12-13

申请号：US15990317

申请日：2018-05-25

申请人： Susumu Narita ,  Yoshinobu Sakaue ,  Ryo Sato ,  Koichi Murota ,  Masashi Suzuki ,  Takuma Nishio ,  Hiroaki Nishina

发明人： Susumu Narita ,  Yoshinobu Sakaue ,  Ryo Sato ,  Koichi Murota ,  Masashi Suzuki ,  Takuma Nishio ,  Hiroaki Nishina

IPC分类号： G03G15/00 ,  G03G15/043

CPC分类号： G03G15/5062 ,  G03G15/043 ,  G03G15/6529 ,  G03G2215/00042

摘要： An image forming apparatus includes a latent image bearer, a latent image writing device, a developing device, a conveyance unit to convey a recording medium, a transfer device, a length data acquisition unit to obtain a length of the recording medium in a conveyance direction of the recording medium, an image forming processor to form a test pattern, and a light quantity correction calculator that acquires image density data of the test pattern and calculates a light quantity correction value to correct a light quantity. The image forming processor sets a position of the test pattern on the recording medium in the conveyance direction of the recording medium and a length of the test pattern in the conveyance direction of the recording medium based on the length of the recording medium in the conveyance direction of the recording medium obtained by the length data acquisition unit.

公开(公告)号：US09242478B2

公开(公告)日：2016-01-26

申请号：US14102738

申请日：2013-12-11

申请人： Masashi Suzuki ,  Katsuhiko Maeda ,  Yoshio Kanzaki ,  Masahiko Oikawa ,  Yasuhiro Abe ,  Hiroaki Nishina ,  Yuuki Honda

发明人： Masashi Suzuki ,  Katsuhiko Maeda ,  Yoshio Kanzaki ,  Masahiko Oikawa ,  Yasuhiro Abe ,  Hiroaki Nishina ,  Yuuki Honda

IPC分类号： B41J2/47 ,  B41J2/435 ,  G06K15/12

CPC分类号： B41J2/435 ,  B41J2/471 ,  G06K15/1209

摘要： The invention is concerning the writing controlling apparatus that includes an acquiring unit configured to acquire a plurality of light amounts of a light source driven while changing an input current in non-effective scanning periods during which an image carrier is not irradiated with light from the light source, as a plurality of output results; a detecting unit configured to detect characteristics of the light source using the output results thus acquired; and a correcting unit configured to correct a current to be applied to the light source based on the characteristics thus detected.

摘要翻译： 本发明涉及一种写入控制装置，该写入控制装置包括获取单元，该获取单元被配置为在图像载体未被来自光的光照射的非有效扫描周期中改变输入电流，从而获取驱动的多个光量 源，作为多个输出结果; 检测单元，被配置为使用如此获取的输出结果来检测光源的特性; 以及校正单元，其被配置为基于所检测的特性来校正要施加到光源的电流。