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    Heterocyclic compounds, their production and use as tachykinin reactor antagonists
    5.
    发明授权
    Heterocyclic compounds, their production and use as tachykinin reactor antagonists 失效
    杂环化合物，它们的生产和用作速激肽反应器拮抗剂

    公开(公告)号：US5585385A

    公开(公告)日：1996-12-17

    申请号：US338762

    申请日：1994-11-10

    申请人： Hideaki Natsugari ,  Takenori Ishimaru ,  Takayuki Doi

    发明人： Hideaki Natsugari ,  Takenori Ishimaru ,  Takayuki Doi

    IPC分类号： C07D215/16 ,  A61K31/47 ,  A61K31/4709 ,  A61P23/00 ,  A61P29/00 ,  C07D401/04 ,  C07D409/04 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04 ,  A61C31/44 ,  A61C31/435 ,  A61C31/47

    CPC分类号： C07D401/04 ,  C07D409/04 ,  C07D471/04 ,  C07D495/04

    摘要： A novel compound represented by the formula: ##STR1## wherein Ring A and Ring B respectively stands for an optionally substituted homo- or hetero-cyclic ring, and at least one of them stands for an optionally substituted heterocyclic ring stand; Ring C stands for an optionally substituted benzene ring; R stands for a hydrogen atom or an optionally substituted hydrocarbon residue; one of X and Y stands for --NR.sup.1 -- (R.sup.1 stands for a hydrogen atom or an optionally substituted hydrocarbon residue) or --O--, and the other stands for--CO-- or --CS--, or one of them stands for --N.dbd. and the other stands for .dbd.CR.sup.2 -- (R.sup.2 stands for a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon residue, an optionally substituted amino group or an optionally substituted hydroxyl group); n denotes 1 or 2 or salts thereof which have an excellent tachykinin receptor antagonistic action and inhibitory action on plasma extravasation.

    摘要翻译： 由下式表示的新化合物：其中环A和环B分别代表任选取代的同 - 或杂环环，并且其中至少一个代表任选取代的杂环环; 环C代表任选取代的苯环; R代表氢原子或任选取代的烃残基; X和Y之一代表-NR1-（R1代表氢原子或任选取代的烃残基）或-O-，另一个代表-CO-或-CS-，或其中一个代表-N =和另一个代表= CR2-（R2代表氢原子，卤原子，任选取代的烃残基，任选取代的氨基或任选取代的羟基）; n表示1或2或其盐，其具有优异的速激肽受体拮抗作用和对血浆外渗的抑制作用。

    Labeling substance and chimeric substance and method for preparing the same and method for capturing, structurally analyzing and/or identifying biological substance by means of the labeling substance
    10.
    发明授权
    Labeling substance and chimeric substance and method for preparing the same and method for capturing, structurally analyzing and/or identifying biological substance by means of the labeling substance 失效
    标记物质和嵌合物质及其制备方法以及通过标记物质捕获，结构分析和/或识别生物物质的方法

    公开(公告)号：US08053194B2

    公开(公告)日：2011-11-08

    申请号：US10594119

    申请日：2005-03-30

    申请人： Kazuo Shinya ,  Tohru Natsume ,  Takayuki Doi

    发明人： Kazuo Shinya ,  Tohru Natsume ,  Takayuki Doi

    IPC分类号： G01N33/00 ,  G01N33/53 ,  G01N33/566 ,  C07K5/00

    CPC分类号： G01N33/532 ,  Y10T436/13

    摘要： Disclosed is a labeling substance capable of reversibly immobilizing (reversible detachment) to a solid surface and to reliably and accurately identify a target biological substance interacting with a probe substance bound to the labeling substance. A chimeric compound is provided, which includes a labeling substance L including (1) an organic compound S with a chemical structure capable of binding to a probe substance P, which can interact with a biological substance B and (2) a peptide bound to the organic compound S and specifically recognized by an antibody A, peptide and a probe substance P at least except a peptide or protein. In addition, a method for preparing the labeling substance L and a method for capturing, structurally analyzing and/or identifying the biological substance using the labeling substance L are provided.

    摘要翻译： 公开了一种能够可靠地固定（可逆分离）到固体表面并且可靠和准确地识别与结合到标记物质的探针物质相互作用的靶生物物质的标记物质。 提供嵌合化合物，其包括标记物质L，其包括（1）具有能够结合探针物质P的化学结构的有机化合物S，其可与生物物质B相互作用;和（2）与 有机化合物S，并且至少除了肽或蛋白质之外，被抗体A，肽和探针物质P特别识别。 此外，提供了制备标记物质L的方法和使用标记物质L捕获，结构分析和/或识别生物物质的方法。