公开(公告)号：US08475825B2

公开(公告)日：2013-07-02

申请号：US12786896

申请日：2010-05-25

申请人： Hongbo Liu

发明人： Hongbo Liu

IPC分类号： A61F2/00

CPC分类号： C09J4/00 ,  A61L24/06 ,  C08K3/40 ,  C08F222/32 ,  C08L35/04

摘要： The present invention is directed to curable compositions that comprise a non-porous substrate, one or more cyanoacrylate polymerization initiators and a prepolymer composition comprising at least one liquid cyanoacrylate monomer or mixture of such monomers (solid or liquid) and/or cyanoacrylate oligomers. The non-porous substrate is a collection of individual particulates that are not bound, bonded or fixed to one another. At least one initiator is deposited on the surface of the individual particulates to form a plurality of initiator carriers. The prepolymer composition receives the plurality of initiator carriers to begin a controlled and consistent polymerization or curing of the liquid cyanoacrylate monomer in order to produce a biocompatible adhesive composition for use on living tissue. The present invention also provides for methods of making and using and devices for such a curable compositions, particularly in treating living tissue by applying to living tissue a biocompatible adhesive composition.

摘要翻译： 本发明涉及包含无孔底物，一种或多种氰基丙烯酸酯聚合引发剂和包含至少一种液体氰基丙烯酸酯单体或这些单体（固体或液体）和/或氰基丙烯酸酯低聚物的混合物的预聚物组合物的可固化组合物。 无孔基材是不结合，结合或彼此固定的单个颗粒的集合。 至少一个引发剂沉积在各个颗粒的表面上以形成多个引发剂载体。 预聚物组合物接收多个引发剂载体以开始可控和一致地聚合或固化液体氰基丙烯酸酯单体以产生用于活组织的生物相容性粘合剂组合物。 本发明还提供了制备和使用这些可固化组合物的方法，特别是通过向生物体组织施用生物相容性粘合剂组合物来治疗生物体组织。

公开(公告)号：US20100051813A1

公开(公告)日：2010-03-04

申请号：US12515018

申请日：2007-11-12

申请人： Shoujun Xiao ,  Hongbo Liu

发明人： Shoujun Xiao ,  Hongbo Liu

IPC分类号： G01N21/01 ,  G01N21/25

CPC分类号： G01N21/031 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01N21/3563 ,  G01N2021/0339

摘要： A measurement accessory with multiple transmission-reflections uses for an infrared spectrometer, laid accessory is arranged in the sample cavity of the infrared spectrometer. Said accessory includes two parallel plane mirrors (7, 8) and a sample holder fixed between the two mirrors (7, 8). Said sample holder can fix the sample piece (9) between the two plane mirrors (7, 8) and make the sample piece parallel with plane mirrors (7, 8). During measuring, the infrared ray emitted from infrared spectrometer (17) forms a certain angle incident to the space between said plane mirrors and reflects for several times between the two parallel plane mirrors (7, 8) and the sample piece (9) is measured with multiple transmission-reflections by the infrared spectrometer. Then the infrared spectrometer (20) enters into the detector of infrared spectrometer.

摘要翻译： 具有多次透射反射的测量附件用于红外光谱仪，铺设的附件布置在红外光谱仪的样品腔中。 所述附件包括固定在两个反射镜（7,8）之间的两个平行平面镜（7,8）和样品保持架。 所述样品保持器可将样品片（9）固定在两个平面镜（7,8）之间，并使样品片与平面镜（7,8）平行。 在测量期间，从红外光谱仪（17）发射的红外线形成入射到所述平面镜之间的一定角度，并在两个平行平面镜（7,8）之间反射若干次，并测量样品片（9） 通过红外光谱仪进行多次透射反射。 然后红外光谱仪（20）进入红外光谱仪的检测器。

公开(公告)号：US07238828B2

公开(公告)日：2007-07-03

申请号：US11088587

申请日：2005-03-24

申请人： Hongbo Liu

发明人： Hongbo Liu

IPC分类号： C07C255/19 ,  C08G63/91 ,  C08G63/48 ,  A61K31/785

CPC分类号： C07C255/23 ,  A61L24/06 ,  C09D4/00 ,  C08L35/04

摘要： A monomer composition comprising at least one polymerizable alkyl ester α-cyanoacrylate monomer. Specifically, the α-cyanoacrylate monomer is an alkyl ester α-cyanoacrylate monomer of the general formula having a spacer R1: wherein n is from 2 to 12; R3 and R4 are each an alkyl group or a hydrogen, and at least one of R3 or R4 is an alkyl group (e.g. linear or branched, or cyclic) having from 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 and 13 carbon atoms; R2 is an alkyl group (e.g. linear or branched, or cyclic) having from 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 and 13 carbon atoms; and the combined number of carbon atoms (N) in the spacer R1 is at least n+1.

摘要翻译： 包含至少一种可聚合的烷基酯α-氰基丙烯酸酯单体的单体组合物。 具体地，α-氰基丙烯酸酯单体是具有间隔基R1的通式的具有通式的烷基酯α-氰基丙烯酸酯单体：其中n为2至12; R3和R4各自为烷基或氢，R3或R4中的至少一个为具有1,2,3,4,5,6,7,8位的烷基（例如直链或支链或环状） ，9,10,11,12和13个碳原子; R2是具有1,2,3,4,5,6,7,8,9,10,11,12和13个碳原子的烷基（例如直链或支链或环状）; 并且间隔物R1中的​​碳原子（N）的合数为至少n + 1。

公开(公告)号：US07919480B2

公开(公告)日：2011-04-05

申请号：US11743815

申请日：2007-05-03

申请人： Hongbo Liu ,  Xintian Ming

发明人： Hongbo Liu ,  Xintian Ming

IPC分类号： A61K31/717 ,  C07H15/20

CPC分类号： A01N43/16 ,  A01N33/12

摘要： An antimicrobial composition comprising: a complex of a polysaccharide covalently bonded with an antibiotic. A medical device having an antimicrobial composition comprising: a complex of an oxidized regenerated cellulose covalently bonded with gentamicin.

摘要翻译： 一种抗微生物组合物，其包含：与抗生素共价结合的多糖的复合物。 一种具有抗微生物组合物的医疗装置，包括：与庆大霉素共价结合的氧化再生纤维的复合物。

公开(公告)号：US20100168885A1

公开(公告)日：2010-07-01

申请号：US12642733

申请日：2009-12-18

申请人： Zhaozao Li ,  Hongbo Liu ,  Shen Qu

发明人： Zhaozao Li ,  Hongbo Liu ,  Shen Qu

IPC分类号： G06F17/00 ,  G06F15/16

CPC分类号： H04N21/6543 ,  H04N21/44218 ,  H04N21/44222

摘要： A method and a device for sending and playing the streaming data are disclosed in embodiments of the present invention. The method for playing the streaming data includes: receiving the streaming data from the client and buffering the data; and exporting the buffered streaming data according to the predefined rhythm. The statistics about the streaming data in the buffer is collected; and the rhythm is adjusted according to the amount of streaming data. The transmitting end can send the streaming data to the client as soon as possible and buffer only a little data; the client controls the rhythm to reduce the effect of network jitter on delay, thus shortening the delay of streaming play.

摘要翻译： 在本发明的实施例中公开了用于发送和播放流数据的方法和装置。 播放流数据的方法包括：从客户端接收流数据并缓存数据; 以及根据预定义的节奏导出缓冲的流数据。 收集缓冲区中流数据的统计信息; 并根据流数据量来调节节奏。 发送端可以尽快将流数据发送给客户端，只缓存少量数据; 客户端控制节奏，减少网络抖动对延迟的影响，从而缩短了流媒体播放的延迟。

公开(公告)号：US20090075283A1

公开(公告)日：2009-03-19

申请号：US12179782

申请日：2008-07-25

申请人： Hongbo Liu ,  Min He

发明人： Hongbo Liu ,  Min He

IPC分类号： C12Q1/68 ,  C12N15/00 ,  C12P21/04

CPC分类号： C12N15/76

摘要： The present invention relates to a shuttle BAC vector for facilitating the cloning, transfer and heterologous expression of streptomycete secondary metabolite biosynthetic gene clusters. The invention also relates to a plasmid rescue method using this vector for enhancing the process of cloning biosynthetic gene clusters for secondary metabolites from streptomycetes without sophisticated generation and screening of cosmids or BAC libraries. The cloned DNA can then be used for sequencing or heterologous expression of putative secondary metabolic gene clusters.

摘要翻译： 本发明涉及用于促进链霉菌次生代谢物生物合成基因簇的克隆，转移和异源表达的穿梭BAC载体。 本发明还涉及一种使用该载体的质粒拯救方法，用于增强克隆来自链霉菌的次生代谢物的生物合成基因簇的过程，而不需要复杂的生成和筛选粘粒或BAC文库。 克隆的DNA可用于测序或异源表达推定的次级代谢基因簇。

公开(公告)号：US20110105225A1

公开(公告)日：2011-05-05

申请号：US12911414

申请日：2010-10-25

申请人： Yasong Huang ,  Hongbo Liu ,  Zhaozao Li

发明人： Yasong Huang ,  Hongbo Liu ,  Zhaozao Li

IPC分类号： A63F13/00 ,  A63F13/06 ,  A63F9/24

CPC分类号： G11B27/105 ,  G11B27/034

摘要： A device for positioning a playing video is provided. The device includes: a receiving engine, configured to generate a control signal according to a user instruction; and a user interface engine, configured to respond to the control signal from the receiving engine, define a display interface, present a video playing progress indicator on the display interface according to the control signal, and adjust a scale of the video playing progress indicator to determine a display range of the playing video. Meanwhile, a method and a system for positioning a playing video are provided. A video playing progress indicator is presented on a display interface according to a control signal, and a play scale of the progress indicator is adjusted to determine a display range of the playing video, so as to enhance flexibility in the detailed operation of a video progress.

摘要翻译： 提供了一种用于定位播放视频的设备。 该装置包括：接收引擎，被配置为根据用户指令生成控制信号; 以及用户接口引擎，被配置为响应来自所述接收引擎的所述控制信号，定义显示界面，根据所述控制信号在所述显示界面上呈现视频播放进度指示符，并且将所述视频播放进度指示符的比例调整为 确定播放视频的显示范围。 同时，提供了一种用于定位播放视频的方法和系统。 视频播放进度指示符根据控制信号呈现在显示界面上，并且调整进度指示符的播放比例以确定播放视频的显示范围，从而提高视频进度的详细操作的灵活性 。

公开(公告)号：US07713544B2

公开(公告)日：2010-05-11

申请号：US10343408

申请日：2001-07-30

申请人： Elliot L. Chaikof ,  June Feng ,  Janine M. Orban ,  Hongbo Liu ,  Xue Long Sun ,  Keith M. Faucher

发明人： Elliot L. Chaikof ,  June Feng ,  Janine M. Orban ,  Hongbo Liu ,  Xue Long Sun ,  Keith M. Faucher

IPC分类号： A61L27/00 ,  A61F13/00 ,  A61K9/127

CPC分类号： C07F9/6552 ,  A61K9/1273 ,  A61K9/5031 ,  A61K9/5073 ,  A61L15/32 ,  A61L27/222 ,  A61L27/227 ,  A61L27/24 ,  A61L27/507 ,  A61L33/0082 ,  B82Y5/00 ,  B82Y30/00 ,  C08F220/28 ,  C08F220/36 ,  C12N1/00

摘要： A biocompatible biological component is provided comprising a membrane-mimetic surface film covering a substrate. Suitable substrates include hydrated substrates, e.g. hydrogels which may contain drugs for delivery to a patient through the membrane-mimetic film, or may be made up of cells, such as islet cells, for transplantation. The surface may present exposed bioactive molecules or moieties for binding to target molecules in vivo, for modulating host response when implanted into a patient (e.g. the surface may be antithrombogenic or antiinflammatory) and the surface may have pores of selected sizes to facilitate transport of substances therethrough. An optional hydrophilic cushion or spacer between the substrate and the membrane-mimetic surface allows transmembrane proteins to extend from the surface through the hydrophilic cushion, mimicking the structure of naturally-occurring cells. An alkylated layer directly beneath the membrane-mimetic surface facilates bonding of the surface to the remainder of the biological component. Alkyl chains may extend entirely through the hydrophilic cushion when present. To facilitate binding, the substrate may optionally be treated with a polyelectrolyte or alternating layers of oppositely-charged polyelectrolytes to facilitate charged binding of the membrane-mimetic film or alkylated layer beneath the membrane-mimetic film to the substrate. The membrane-mimetic film is preferably made by in situ polymerization of phospholipid vesicles.

摘要翻译： 提供生物相容的生物组分，其包含覆盖基质的膜模拟表面膜。 合适的底物包括水合底物，例如 水凝胶，其可以含有通过膜模拟膜递送到患者的药物，或者可以由用于移植的细胞如胰岛细胞组成。 表面可以在体内呈现暴露的生物活性分子或结合靶向分子的部分，用于当植入患者时调节宿主反应（例如表面可能是抗血栓形成或抗炎性的），并且该表面可以具有选定尺寸的孔以促进物质的运输 通过。 衬底和膜模拟表面之间的可选的亲水垫或间隔物允许跨膜蛋白从表面延伸穿过亲水垫，模仿天然存在的细胞的结构。 直接在膜 - 模拟表面下面的烷基化层促进了表面与生物组分的其余部分的结合。 当存在时，烷基链可以完全延伸穿过亲水性垫。 为了便于结合，底物可以任选地用聚电解质或交替的相反电荷的聚电解质层处理，以促进膜 - 模拟膜下面的膜模拟膜或烷基化层与底物的带电结合。 膜模拟膜优选通过磷脂囊泡的原位聚合来制备。

公开(公告)号：US07534907B2

公开(公告)日：2009-05-19

申请号：US11755093

申请日：2007-05-30

申请人： Hongbo Liu

发明人： Hongbo Liu

IPC分类号： A61K31/785 ,  C07C255/19 ,  C08G63/91 ,  C08G63/48

CPC分类号： C07C255/23 ,  A61L24/06 ,  C09D4/00 ,  C08L35/04

摘要： A monomer composition comprising at least one polymerizable alkyl ester α-cyanoacrylate monomer. Specifically, the α-cyanoacrylate monomer is an alkyl ester α-cyanoacrylate monomer of the general formula having a spacer R1: n is from 2 to 12; R3 and R4 are each an alkyl group or a hydrogen, and at least one of R3 or R4 is an alkyl group (e.g. linear or branched, or cyclic) having from 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 and 13 carbon atoms; R2 is an alkyl group (e.g. linear or branched, or cyclic) having from 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 and 13 carbon atoms; and the combined number of carbon atoms (N) in the spacer R1 is at least n+1.

摘要翻译： 包含至少一种可聚合的烷基酯α-氰基丙烯酸酯单体的单体组合物。 具体地，α-氰基丙烯酸酯单体是具有间隔基R1的通式的具有通式的烷基酯α-氰基丙烯酸酯单体：n为2至12; R3和R4各自为烷基或氢，R3或R4中的至少一个为具有1,2,3,4,5,6,7,8位的烷基（例如直链或支链或环状） ，9,10,11,12和13个碳原子; R2是具有1,2,3,4,5,6,7,8,9,10,11,12和13个碳原子的烷基（例如直链或支链或环状）; 并且间隔物R1中的​​碳原子（N）的合数为至少n + 1。

公开(公告)号：US20080275230A1

公开(公告)日：2008-11-06

申请号：US11743815

申请日：2007-05-03

申请人： Hongbo Liu ,  Xintian Ming

发明人： Hongbo Liu ,  Xintian Ming

IPC分类号： C07D315/00 ,  C07H1/00 ,  C08B1/00

CPC分类号： A01N43/16 ,  A01N33/12

摘要： An antimicrobial composition comprising: a complex of a polysaccharide covalently bonded with an antibiotic. A medical device having an antimicrobial composition comprising: a complex of an oxidized regenerated cellulose covalently bonded with gentamicin.

摘要翻译： 一种抗微生物组合物，其包含：与抗生素共价结合的多糖的复合物。 一种具有抗微生物组合物的医疗装置，包括：与庆大霉素共价结合的氧化再生纤维的复合物。