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1.发明申请METHODS OF DETECTING A FRAGMENT OF NEUROSECRETORY PROTEIN VGF FOR DIAGNOSING ALZHEIMER'S DISEASE 审中-公开检测神经病毒蛋白VGF片段用于诊断阿尔茨海默病的方法公开(公告)号：US20110294865A1
公开(公告)日：2011-12-01
申请号：US12829630
申请日：2010-07-02
IPC分类号： A61K31/7088 , C07K17/00 , C07K16/18 , G06F19/10 , G01N33/566 , G01N33/53 , C12N5/02 , A61P25/28 , C07K14/435 , C07K19/00
CPC分类号： G01N33/6896 , G01N33/6842 , G01N33/6848 , G01N33/6851 , G01N2800/2821
摘要： The present invention provides a neurosecretory protein VGF peptide useful in qualifying Alzheimer's disease status in a patient. In particular, this peptide and modified forms thereof may be used to classify a subject sample as Alzheimer's disease or non-Alzheimer's disease. The peptide biomarker can be detected by SELDI mass spectrometry.
摘要翻译： 本发明提供了可用于评估患者中阿尔茨海默病状态的神经分泌蛋白VGF肽。 特别地，该肽及其修饰形式可用于将受试者样品分类为阿尔茨海默病或非阿尔茨海默氏病。 肽生物标志物可以通过SELDI质谱法检测。
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公开(公告)号：US20110129920A1
公开(公告)日：2011-06-02
申请号：US12845025
申请日：2010-07-28
CPC分类号： G01N33/6896 , G01N33/6842 , G01N33/6848 , G01N33/6851 , G01N2800/2821
摘要： The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Alzheimer's disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as Alzheimer's or non-Alzheimer's dementia or normal. The biomarkers can be detected by SELDI mass spectrometry. In addition, the invention provides appropriate treatment interventions and methods for measuring response to treatment. Certain biomarkers of the invention may also be suitable for employment as radio-labeled ligands in non-invasive imaging techniques such as Positron Emission Tomography (PET).
摘要翻译： 本发明提供了可用于评估患者中的阿尔茨海默病状态的基于蛋白质的生物标志物和生物标志物组合。 特别地，本发明的生物标志物可用于将受试者样品分类为阿尔茨海默病或非阿尔茨海默氏痴呆或正常。 生物标志物可以通过SELDI质谱检测。 此外，本发明提供适当的治疗干预措施和测量治疗反应的方法。 本发明的某些生物标志物也可适用于诸如正电子发射断层扫描（PET）的非侵入性成像技术中的放射性标记的配体。
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公开(公告)号：US07794948B2
公开(公告)日：2010-09-14
申请号：US10982545
申请日：2004-11-06
IPC分类号： G01N33/50
CPC分类号： G01N33/6896 , G01N33/6842 , G01N33/6848 , G01N33/6851 , G01N2800/2821
摘要： The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Alzheimer's disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as Alzheimer's or non-Alzheimer's dementia or normal. The biomarkers can be detected by SELDI mass spectrometry. In addition, the invention provides appropriate treatment interventions and methods for measuring response to treatment. Certain biomarkers of the invention may also be suitable for employment as radio-labeled ligands in non-invasive imaging techniques such as Positron Emission Tomography (PET).
摘要翻译： 本发明提供了可用于评估患者中的阿尔茨海默病状态的基于蛋白质的生物标志物和生物标志物组合。 特别地，本发明的生物标志物可用于将受试者样品分类为阿尔茨海默病或非阿尔茨海默氏痴呆或正常。 生物标志物可以通过SELDI质谱检测。 此外，本发明提供适当的治疗干预措施和测量治疗反应的方法。 本发明的某些生物标志物也可适用于诸如正电子发射断层扫描（PET）的非侵入性成像技术中的放射性标记的配体。
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4.发明授权Methods of detecting a fragment of neurosecretory protein VGF for diagnosing alzheimer's disease 失效检测神经分泌蛋白VGF片段用于诊断阿尔茨海默病的方法公开(公告)号：US07749716B2
公开(公告)日：2010-07-06
申请号：US11452477
申请日：2006-06-13
IPC分类号： G01N33/543
CPC分类号： G01N33/6896 , G01N33/6842 , G01N33/6848 , G01N33/6851 , G01N2800/2821
摘要： The present invention provides a neurosecretory protein VGF peptide useful in qualifying Alzheimer's disease status in a patient. In particular, this peptide and modified forms thereof may be used to classify a subject sample as Alzheimer's disease or non-Alzheimer's disease. The peptide biomarker can be detected by SELDI mass spectrometry.
摘要翻译： 本发明提供了可用于评估患者中阿尔茨海默病状态的神经分泌蛋白VGF肽。 特别地，该肽及其修饰形式可用于将受试者样品分类为阿尔茨海默病或非阿尔茨海默氏病。 肽生物标志物可以通过SELDI质谱法检测。
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5.发明申请Fragment of neurosecretory protein VGF as a biomarker for Alzheimer's disease 失效神经分泌蛋白VGF片段作为阿尔茨海默病的生物标志物公开(公告)号：US20070015221A1
公开(公告)日：2007-01-18
申请号：US11452477
申请日：2006-06-13
申请人： Huw Davies , Kaj Blennow , James McGuire , Vladimir Podust , Anja Simonsen
发明人： Huw Davies , Kaj Blennow , James McGuire , Vladimir Podust , Anja Simonsen
IPC分类号： G01N33/567 , A61K38/54
CPC分类号： G01N33/6896 , G01N33/6842 , G01N33/6848 , G01N33/6851 , G01N2800/2821
摘要： The present invention provides a neurosecretory protein VGF peptide useful in qualifying Alzheimer's disease status in a patient. In particular, this peptide and modified forms thereof may be used to classify a subject sample as Alzheimer's disease or non-Alzheimer's disease. The peptide biomarker can be detected by SELDI mass spectrometry.
摘要翻译： 本发明提供了可用于评估患者中阿尔茨海默病状态的神经分泌蛋白VGF肽。 特别地，该肽及其修饰形式可用于将受试者样品分类为阿尔茨海默病或非阿尔茨海默氏病。 肽生物标志物可以通过SELDI质谱法检测。
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公开(公告)号：US20050244890A1
公开(公告)日：2005-11-03
申请号：US10982545
申请日：2004-11-06
申请人： Huw Davies , James McGuire , Anja Simonsen , Kaj Blennow , Vladimir Podust
发明人： Huw Davies , James McGuire , Anja Simonsen , Kaj Blennow , Vladimir Podust
CPC分类号： G01N33/6896 , G01N33/6842 , G01N33/6848 , G01N33/6851 , G01N2800/2821
摘要： The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Alzheimer's disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as Alzheimer's or non-Alzheimer's dementia or normal. The biomarkers can be detected by SELDI mass spectrometry. In addition, the invention provides appropriate treatment interventions and methods for measuring response to treatment. Certain biomarkers of the invention may also be suitable for employment as radio-labeled ligands in non-invasive imaging techniques such as Positron Emission Tomography (PET).
摘要翻译： 本发明提供了可用于评估患者中的阿尔茨海默病状态的基于蛋白质的生物标志物和生物标志物组合。 特别地，本发明的生物标志物可用于将受试者样品分类为阿尔茨海默病或非阿尔茨海默氏痴呆或正常。 生物标志物可以通过SELDI质谱检测。 此外，本发明提供适当的治疗干预措施和测量治疗反应的方法。 本发明的某些生物标志物也可适用于诸如正电子发射断层扫描（PET）的非侵入性成像技术中的放射性标记的配体。
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公开(公告)号：US20120017467A1
公开(公告)日：2012-01-26
申请号：US13126101
申请日：2009-10-26
申请人： Kendrick Whitney , James McGuire , Richard Posoff
发明人： Kendrick Whitney , James McGuire , Richard Posoff
IPC分类号： A43B13/14
CPC分类号： A43B13/20 , A43B3/0031 , A43B7/144 , A43B7/1445 , A43B7/1465 , A43B13/187 , A43B17/02
摘要： An orthotic shoe sole assembly and an orthotic insole are disclosed herein. The orthotic shoe assembly includes a shoe sole having an exposed surface and at least one exposed cavity accessible via the exposed surface. The at least one exposed cavity includes a central region and a plurality of channels extending from the central region. A resilient member is removably positioned within the central region of the exposed cavity. The resilient member is configured to resiliently expand into at least one of the plurality of channels of the exposed cavity. The orthotic insole is removably positioned to selectively conceal the exposed cavity of the shoe sole and the resilient member. The orthotic insole includes a central axis member for supporting a foot along its central axis.
摘要翻译： 本文公开了矫正鞋底组件和矫正内底。 矫正鞋组件包括具有暴露表面的鞋底和经由暴露表面可接近的至少一个暴露腔。 所述至少一个暴露的空腔包括中心区域和从中心区域延伸的多个通道。 弹性构件可移除地定位在暴露腔的中心区域内。 弹性构件被配置成弹性地扩展到暴露腔的多个通道中的至少一个。 矫正鞋垫可拆卸地定位成选择性地隐藏鞋底和弹性构件的暴露腔体。 矫正内底包括用于沿着其中心轴线支撑脚的中心轴构件。
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8.发明申请公开(公告)号：US20070115840A1
公开(公告)日：2007-05-24
申请号：US10070339
申请日：2001-10-17
申请人： Wayne Feick , Sean Finn , Mansour Karam , Michael Lloyd , Herbert Madan , James McGuire , Jose-Miguel Pulido , Omar Baldonado
发明人： Wayne Feick , Sean Finn , Mansour Karam , Michael Lloyd , Herbert Madan , James McGuire , Jose-Miguel Pulido , Omar Baldonado
CPC分类号： H04L43/50 , H04L41/0813 , H04L43/08 , H04L43/10
摘要： Methods and apparatuses for communicating data within measurement traffic are described. Embodiments that send, receive and both send and receive are described. Some embodiments are described that compute statistics based at least partly on measurement traffic. Some embodiments are described that communicate computed statistics within measurement traffic. Some embodiments are described that rank and select paths based at least in part on computed statistics.
摘要翻译： 描述用于在测量业务内传送数据的方法和装置。 描述发送，接收和发送和接收的实施例。 描述了一些实施例，其至少部分地基于测量业务来计算统计。 描述了在测量业务中传送计算的统计信息的一些实施例。 描述了一些实施例，其至少部分地基于所计算的统计量来对路径进行排序和选择。
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公开(公告)号：US20070024971A1
公开(公告)日：2007-02-01
申请号：US11442673
申请日：2006-05-26
IPC分类号： G02B27/28
CPC分类号： G02B6/0038 , G02B6/0008 , G02B6/0018 , G02B6/0068 , G02B6/0096 , G02B6/4298 , G02B27/0994
摘要： Various embodiments described herein comprise mixers comprising a light pipe having input and output ends and a central region therebetween. An optical path extends in a longitudinal direction from the input end through the central region to the output end. The central region of the light pipe comprises one or more rippled reflective sidewalls having a plurality of elongate ridges and valleys and sloping surfaces therebetween. Light from the input end propagating along the optical path reflects from the sloping surfaces and is redirected at a different azimuthal direction toward the output end thereby mixing the light at the output end. Illuminance and/or color mixing can therefore be provided.
摘要翻译： 本文描述的各种实施例包括具有输入和输出端的光管和其间的中心区域的混合器。 光路沿着纵向方向从输入端穿过中心区延伸到输出端。 光管的中心区域包括一个或多个波纹反射侧壁，其具有多个细长的脊和谷以及它们之间的倾斜表面。 沿着光路传播的输入端的光从倾斜表面反射，并以不同的方位角方向朝向输出端重定向，从而将输出端的光混合。 因此可以提供照度和/或混色。
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10.发明申请Analyzing an access control list for a router to identify a subsumption relation between elements in the list 有权分析路由器的访问控制列表，以识别列表中元素之间的包含关系公开(公告)号：US20050102423A1
公开(公告)日：2005-05-12
申请号：US11006995
申请日：2004-12-07
申请人： Richard Pelavin , James McGuire , Herbert Madan
发明人： Richard Pelavin , James McGuire , Herbert Madan
IPC分类号： H04L12/56 , G06F15/173
摘要： Methods are described for analyzing access list subsumption in routing devices of a computer network and for identifying computer network integrity violations, by producing structured data that includes stored router names and access lists that include elements with address/mask pairs, or patterns used to filter data into and out of a routing device, respectively; determining whether access lists in the structured data include elements in which a first element in the access list has a more general or equal address/mask pair, or pattern, respectively, than a second or subsequent element, or pattern; and storing in electronic memory a report of elements or a list of patterns, respectively, in which a first element or pattern is more general than or equal to a second or subsequent element or pattern.
摘要翻译： 描述了用于分析计算机网络的路由设备中的访问列表包含以及用于识别计算机网络完整性违例的方法，其通过生成包括存储的路由器名称和包括具有地址/掩码对的元素的访问列表或者用于过滤数据的模式的结构化数据 分别进出路由设备; 确定结构化数据中的访问列表是否包括元素，其中访问列表中的第一元素分别具有比第二或后续元素或模式更一般或相等的地址/掩码对或模式; 以及分别在电子存储器中存储元件或模式列表的报告，其中第一元件或图案比第二或随后的元件或图案更一般。
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