公开(公告)号：US4692444A

公开(公告)日：1987-09-08

申请号：US836402

申请日：1986-03-05

申请人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe ,  Yousuke Katsura

发明人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe ,  Yousuke Katsura

IPC分类号： A61K31/415 ,  A61P7/10 ,  A61P9/12 ,  A61P19/06 ,  C07D495/04

CPC分类号： C07D495/04

摘要： This invention provides a benzene-fused heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy or acylamino,X is --S--, ##STR2## n is an integer of 1 or 2 and A is a group of the formula: ##STR3## in which R.sup.2 is hydrogen, lower alkyl, lower alkynyl, carboxy(lower)alkyl or protected carboxy(lower)alkyl, or pharmaceutically acceptable salts thereof. This compound possesses diuretic, uricosuric, and vasodilative activities and therefore is useful as a diuretic agent, uricosuric agent and anti-hypertensive agent. This invention further provides processes for the preparation of this compound and pharmaceutical composition comprising compound of the above formula.

摘要翻译： 本发明提供下式的苯稠稠杂环化合物：其中R1是卤素，硝基，氨基，羟基，低级烷基，低级烷氧基或酰基氨基，X是-S-，n是 其中R 2为氢，低级烷基，低级炔基，羧基（低级）烷基或被保护的羧基（低级）烷基）或其药学上可接受的盐。 该化合物具有利尿，尿酸和血管扩张活性，因此可用作利尿剂，尿酸血症药和抗高血压药。 本发明还提供了制备该化合物的方法和包含上式化合物的药物组合物。

公开(公告)号：US4675324A

公开(公告)日：1987-06-23

申请号：US780582

申请日：1985-09-26

申请人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe ,  Yousuke Katsura

发明人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe ,  Yousuke Katsura

IPC分类号： C07D311/22 ,  A61K31/415 ,  A61K31/4162 ,  A61K31/435 ,  A61K31/47 ,  A61K31/4745 ,  A61P7/10 ,  A61P9/02 ,  A61P9/08 ,  A61P9/12 ,  A61P19/06 ,  C07D215/22 ,  C07D215/233 ,  C07D215/38 ,  C07D311/56 ,  C07D471/04 ,  C07D491/04 ,  C07D491/052 ,  A61K31/395

CPC分类号： C07D215/233 ,  C07D311/56 ,  C07D471/04 ,  C07D491/04

摘要： This invention provides a benezene-fused heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy substituted by carboxy or protected carboxy, acylamino which may have lower alkyl on the amino moiety, or aryloxy which may have halogen,R.sup.2 is hydrogen or halogen,X is --O-- or ##STR2## in which R.sup.3 is hydrogen, lower alkyl or acyl and A is a group of the formula: ##STR3## in which R.sup.4 is hydrogen, lower alkenyl, lower alkynyl or alkyl which may have suitable substituent(s) selected from the groups consisting of hydroxy, acyl, lower alkoxy, di(lower)alkylamino, carboxy, protected carboxy and aryl; orR.sup.1 is hydrogen or lower alkoxy,R.sup.2 is hydrogen,X is ##STR4## in which R.sub.a.sup.3 is lower alkanoyl and A is a group of the formula: ##STR5## and pharmaceutically acceptable salts thereof. This compound possesses diuretic activity, uricosuric activity and vasodilative activity and are useful as a diuretic agent, uricosuric agent and anti-hypertensive agent. The invention further relates to processes for the preparation of this compound and pharmaceutical composition comprising compound of the above formula.

摘要翻译： 本发明提供了下式的有益稠合的杂环化合物：其中R 1是卤素，硝基，氨基，羟基，低级烷基，被羧基或被保护的羧基取代的低级烷氧基，在氨基部分上可以具有低级烷基的酰基氨基， 或可具有卤素的芳氧基，R 2是氢或卤素，X是-O-或者其中R 3是氢，低级烷基或酰基，和A是下式的基团：其中R 4是氢， 低级烯基，低级炔基或烷基，其可以具有选自羟基，酰基，低级烷氧基，二（低级）烷基氨基，羧基，保护的羧基和芳基的合适取代基。 或R 1为氢或低级烷氧基，R 2为氢，X为R a为低级烷酰基，A为下式基团：及其药学上可接受的盐。 该化合物具有利尿活性，尿酸活性和血管舒张活性，可用作利尿剂，尿酸血症药和抗高血压药。 本发明还涉及制备该化合物的方法和包含上式化合物的药物组合物。

公开(公告)号：US4767780A

公开(公告)日：1988-08-30

申请号：US42299

申请日：1987-04-24

申请人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe ,  Yousuke Katsura

发明人： Ikuo Ueda ,  Youichi Shiokawa ,  Takashi Manabe ,  Yousuke Katsura

IPC分类号： C07D311/22 ,  A61K31/415 ,  A61K31/4162 ,  A61K31/435 ,  A61K31/47 ,  A61K31/4745 ,  A61P7/10 ,  A61P9/02 ,  A61P9/08 ,  A61P9/12 ,  A61P19/06 ,  C07D215/22 ,  C07D215/233 ,  C07D215/38 ,  C07D311/56 ,  C07D471/04 ,  C07D491/04 ,  C07D491/052 ,  A61K31/35 ,  C07D487/04

CPC分类号： C07D215/233 ,  C07D311/56 ,  C07D471/04 ,  C07D491/04

摘要： This invention provides a benezene-fused heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy substituted by carboxy or protected carboxy, acylamino which may have lower alkyl on the amino moiety, or aryloxy which may have halogen,R.sup.2 is hydrogen or halogen,X is --O-- or ##STR2## in which R.sup.3 is hydrogen, lower alkyl or acyl and A is a group of the formula: ##STR3## in which R.sup.4 is hydrogen, lower, alkenyl, lower alkynyl or alkyl which may have suitable substituent(s) selected from the groups consisting of hydroxy, acyl, lower alkoxy, di(lower)alkylamino, carboxy, protected carboxy and aryl; orR.sup.1 is hydrogen or lower alkoxy,R.sup.2 is hydrogen,X is ##STR4## in which R.sub.a.sup.3 is lower alkanoyl and A is a group of the formula: ##STR5## and pharmaceutically acceptable salts thereof. This compound possesses diuretic activity, uricosuric activity and vasodilative activity and are useful as a diuretic agent, uricosuric agent and anti-hypertensive agent. The invention further relates to processes for the preparation of this compound and pharmaceutical composition comprising compound of the above formula.

公开(公告)号：US4764514A

公开(公告)日：1988-08-16

申请号：US855904

申请日：1986-04-24

申请人： Ikuo Ueda ,  Yousuke Katsura

发明人： Ikuo Ueda ,  Yousuke Katsura

IPC分类号： A61K31/425 ,  A61K31/426 ,  A61K31/435 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/55 ,  A61P25/00 ,  A61P25/28 ,  C07D243/00 ,  C07D277/14 ,  C07D333/00 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D521/00

CPC分类号： C07D417/06 ,  C07D277/14 ,  C07D417/12 ,  C07D417/14

摘要： This invention provides a oxothiazolidine compound of the formula: ##STR1## wherein R.sup.1 is acyl;di(lower)alkylamino(lower)alkylcarbamoyl(lower)alkyl; arylcarbamoyl(lower)alkyl;ar(lower)alkylcarbamoyl(lower)alkyl;heterocyclic carbamoyl(lower)alkyl;heterocyclic(lower)alkylcarbamoyl(lower)alkyl;thiazolidinylcarbonyl(lower)alkyl;morpholinylcarbonyl(lower)alkyl or a group of the formula: ##STR2## in which A is lower alkylene;n is an integer of 0 or 1;m is an integer of 2 or 3;X is --N--, ##STR3## or --CH-- and R.sup.2 is hydroxy;lower alkyl which may have hydroxy;ar(lower)alkyl which may have halogen;arylthio which may have halogen;acyl or heterocyclic group andY is --S--, ##STR4## or pharmaceutically acceptable salt thereof. This compound is useful as cognition activator. This invention further provides processes for the preparation of this compound and pharmaceutical composition comprising compound of the above formula.

摘要翻译： 本发明提供下式的氧代噻唑烷化合物：其中R 1是酰基; 二（低级）烷基氨基（低级）烷基氨基甲酰基（低级）烷基; 芳基氨基甲酰基（低级）烷基; 芳（低级）烷基氨基甲酰基（低级）烷基; 杂环氨基甲酰基（低级）烷基; （低级）烷基氨基甲酰基（低级）烷基; 噻唑烷基羰基（低级）烷基; 吗啉基羰基（低级）烷基或下式的基团：其中A是低级亚烷基; n为0或1的整数; m为2或3的整数; X是-N-，或-CH-，R 2是羟基; 可具有羟基的低级烷基; 可以具有卤素的芳基（低级）烷基; 可以具有卤素的芳硫基; 酰基或杂环基，Y是-S-，其中或其药学上可接受的盐。 该化合物可用作认知激活剂。 本发明还提供了制备该化合物的方法和包含上式化合物的药物组合物。

公开(公告)号：US4562190A

公开(公告)日：1985-12-31

申请号：US627612

申请日：1984-07-03

申请人： Ikuo Ueda ,  Kiyoshi Taniguchi ,  Yousuke Katsura

发明人： Ikuo Ueda ,  Kiyoshi Taniguchi ,  Yousuke Katsura

IPC分类号： A61K31/50 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D237/00 ,  C07D277/68 ,  C07D417/04 ,  C07D417/02 ,  C07D417/06 ,  C07D417/10 ,  C07D417/14

CPC分类号： C07D277/68 ,  C07D417/04

摘要： A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl, andR.sup.2 is hydrogen lower alkyl, carboxy(lower)alkyl, lower alkoxy(lower)alkyl, aliphatic acyl (lower)alkyl, aromatic acyl(lower)alkyl or heterocyclic acyl(lower)alkyl,and pharmaceutically acceptable salts thereof are useful for treatment of hypertension, heart disease and thrombosis.

摘要翻译： 下式的化合物，其中R 1是低级烷基，R 2是氢低级烷基，羧基（低级）烷基，低级烷氧基（低级）烷基，脂族酰基（低级）烷基，芳族酰基（低级）烷基或杂环 酰基（低级）烷基及其可药用盐可用于治疗高血压，心脏病和血栓形成。

公开(公告)号：US08205644B2

公开(公告)日：2012-06-26

申请号：US12733482

申请日：2008-10-06

申请人： Ikuo Ueda

发明人： Ikuo Ueda

IPC分类号： D21F1/10 ,  D21F7/08 ,  D03D25/00

CPC分类号： D21F1/0036 ,  Y10T428/24612

摘要： An industrial two-layer fabric constituted by at least one upper surface side warp to be woven with at least one upper surface side weft, at least one lower surface side warp to be woven with at least one lower surface side weft, and at least one warp binding yarn to be woven with the at least one upper surface side weft and the at least one lower surface side weft having at least one pair of upper and lower warps in which the upper and lower surface side warps are located to be upper and lower, respectively, and at least one pair of warp binding yarns in which at least one yarn constitutes a warp binding yarn.

摘要翻译： 一种工业双层织物，由至少一个上表面侧经纱与至少一个上表面侧纬纱组成，至少一个下表面侧经纱与至少一个下表面侧纬纱织造，至少一个 具有至少一个上表面侧纬纱和至少一个下表面侧纬纱的经编结合纱线具有至少一对上下翘曲，其中上表面侧经线和下表面侧经线位于其上下 以及至少一对经纱结合纱线，其中至少一根纱线构成经纱结合纱线。

公开(公告)号：US20100252137A1

公开(公告)日：2010-10-07

申请号：US12591704

申请日：2009-11-30

申请人： Ikuo Ueda

发明人： Ikuo Ueda

IPC分类号： D03D11/00

CPC分类号： D21F1/0036

摘要： A two layer fabric has first, second, third and fourth upper side wefts contiguously and repeatedly arranged. Each of three contiguously arranged warps forms a knuckle over second, over third, and over second upper side wefts respectively to form a separation portion. At both sides of the separation portion, both the second and third upper side wefts form a float portion by passing over two or more warps. Adjacent to the float portion, one warp passes over the second and third upper side wefts successively and one or two warps adjacent thereto pass over the second or the third upper side weft to form an approach portion where the second and third upper side wefts approach. Crimp portions are formed to sandwich the separation portion where the first and fourth upper side wefts pass over warps which are common to those of the separation portion.

摘要翻译： 双层织物具有连续重复布置的第一，第二，第三和第四上侧纬纱。 三个连续布置的经纱中的每一个分别在第二，第三和第二上侧纬纱上形成转向节，以形成分离部分。 在分离部分的两侧，第二和第三上侧纬纱都经过两个或多个经纱而形成浮子部分。 相邻于浮子部分，一个经纱依次穿过第二和第三上侧纬纱，并且与其相邻的一个或两个经纱穿过第二或第三上侧纬纱，以形成第二和第三上侧纬纱接近的接近部分。 压接部形成为夹着第一和第四上侧纬纱经过与分离部的纬纱共同的经纱的分离部。

公开(公告)号：US07357156B2

公开(公告)日：2008-04-15

申请号：US11431007

申请日：2006-05-10

申请人： Ikuo Ueda ,  Masakazu Murakami

发明人： Ikuo Ueda ,  Masakazu Murakami

IPC分类号： D21F7/08 ,  D03D25/00

CPC分类号： D21F1/0036 ,  Y10S162/902

摘要： An industrial two-layer fabric having eight upper side warps and eight lower warps are stacked vertically forming upper and lower layers which are bound by a warp binding yarn of these warps. In a repeating unit of the upper layer, one of the warps has repetition of a design in which it passes over one upper side weft, passes under four successive upper side wefts, passes over one upper side weft, and passes under two upper side wefts, and an upper side weft has a design in which it passes over three upper side warps and then passes under one upper side warp to form, on the upper side, a weft long crimp corresponding to three warps, whereby forming an industrial fabric excellent in running stability, surface property and wear resistance.

摘要翻译： 具有八个上侧经纱和八个下经纱的工业双层织物垂直地堆叠形成由这些经纱的经纱结合纱线结合的上层和下层。 在上层的重复单元中，一个经纱具有重复的设计，其中它经过一个上侧纬纱，经过四个连续的上侧纬纱，经过一个上侧纬纱，并经过两个上侧纬纱 并且上侧纬纱具有其经过三个上侧经纱然后经过一个上侧经纱的设计，在上侧形成对应于三个经纱的纬纱长卷曲，由此形成优异的工业织物 运行稳定性，表面性能和耐磨性。

公开(公告)号：US20060278295A1

公开(公告)日：2006-12-14

申请号：US11435095

申请日：2006-05-17

申请人： Ikuo Ueda ,  Hiromi Tsutsue

发明人： Ikuo Ueda ,  Hiromi Tsutsue

IPC分类号： D03D25/00

CPC分类号： D21F1/0036

摘要： An industrial two-layer fabric comprises pairs of warps obtained by vertically stacking an upper side warp to be woven with an upper side weft and a lower side warp to be woven with a lower side weft and having, as at least one of the pairs. A pair of binding warps composed of warp binding yarns to be woven with both an upper side weft and a lower side weft constitutes a portion of an upper side surface design and a portion of a lower side surface design. As a lower side surface warp design formed by the weaving of a warp binding yarn and a lower side warp with a lower side weft, two or three designs different from each other and has, as a weft design, a design of passing over two warps adjacent to each other and then passing under a plurality of warps to form a long crimp on the lower side surface.

摘要翻译： 工业双层织物包括通过垂直地堆叠上下纬纱的上侧经纱和下侧纬纱编织的下侧经纱而获得的经纱，并且具有至少一对成对。 由与上侧纬纱和下侧纬纱两者编织的经纱结合纱组成的一对装订经线构成上侧面设计的一部分和下侧面设计的一部分。 作为通过编织经向结合纱和具有下侧纬纱的下侧经纱形成的下侧面经纱设计，两个或三个不同的设计彼此不同，并且具有作为纬纱设计的经过两个经纱的设计 彼此相邻，然后在多个经纱下通过，以在下侧表面上形成长卷曲。

公开(公告)号：US5521292A

公开(公告)日：1996-05-28

申请号：US389079

申请日：1995-02-13

申请人： Ikuo Ueda ,  Nomura Tadanori

发明人： Ikuo Ueda ,  Nomura Tadanori

IPC分类号： C08B13/00 ,  C08B37/08 ,  C08L1/32 ,  C08L35/06 ,  C09D101/32 ,  A61K31/715 ,  C07H13/02 ,  C08B5/02 ,  C08B37/00

CPC分类号： C08L1/32 ,  C08B13/00 ,  C08B37/003 ,  C09D101/32 ,  C08L35/06

摘要： The present invention provides:(1) a polysaccharide derivative having hydrophilic functional groups and nitrate groups per one repeating unit in the following range:0.2.ltoreq.X.ltoreq.1.5, 0.4.ltoreq.Y.ltoreq.2.2, X+Y

摘要翻译： 本发明提供：（1）每一个重复单元具有亲水性官能团和硝酸根的多糖衍生物，其范围为：0.2≤X≤1.5,0.4≤Y≤2.2，X + Y <3; 其中X和Y分别表示亲水官能团和硝酸根基团的数目; （2）中和的多糖衍生物; （3）用作含有中和的多糖和水的粘合剂的组合物; 和（4）作为含有中和的多糖，树脂，有机溶剂和水的载体的组合物。 车辆组合物具有优异的性能，如干燥特性，颜料分散性，与水溶性树脂的相容性和触变性，并且可以形成具有优异的耐热性和抗粘连性的透明连续膜。