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公开(公告)号：US12275953B2
公开(公告)日：2025-04-15
申请号：US17564729
申请日：2021-12-29
Applicant: Industrial Technology Research Institute
Inventor： Yen-Ju Lin , Mei-Wei Lin , Min-Yuan Chou
Abstract: A method for screening host cells expressing a target protein is provided. The method includes the following steps: providing an expression vector, the expression vector including a promoter, a gene encoding a target protein and an FTH1 gene; transfecting the host cells with the expression vector; culturing the host cells in a medium; and adding iron ions to the medium, and screening the surviving host cells to obtain the host cells expressing the target protein. An expression vector and a method for establishing a cell line stably expressing an exogenous recombinant gene are also provided.
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公开(公告)号：US11667709B2
公开(公告)日：2023-06-06
申请号：US16948563
申请日：2020-09-23
Applicant: Industrial Technology Research Institute
Inventor： Min-Yuan Chou , Li-Tsen Lin , Chung-Yuan Sun , Ya-Ping Lai , Chin-Pen Lai , Ssu-Yuan Wu , Mei-Wei Lin
CPC classification number: C07K16/2803 , A61P35/00 , A61K45/06 , C07K2317/565 , C07K2317/567
Abstract: Antibodies and antigen-binding fragments that bind to TIGIT are disclosed. The disclosure further relates to methods and compositions for use in treating an immune-related disease (e.g., a cancer or an infection or infectious disease) by administering a composition disclosed herein.
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Patent Agency Ranking
3.发明申请公开(公告)号：US20180142214A1
公开(公告)日：2018-05-24
申请号：US15861625
申请日：2018-01-03
Applicant: Industrial Technology Research Institute
Inventor： Mei-Wei Lin , Dian-Kun Li , Ling-Mei Wang , Ching-Huai Ko , Chin-Pen Lai , Chun-Min Liu , Hsiang-Wen Tseng
CPC classification number: C12N5/0693 , C12N5/067 , G01N33/5011 , G01N33/5067
Abstract: An in vitro method for screening a testing compound to evaluate its potential as a liver drug of the disclosure is provided. The method includes applying the testing compound to cells of an isolated human liver tumor cell line, named as ITRI-H28, measuring a cell viability of the cells and determining the effect of the testing compound on the cells by calculating a half maximal inhibitory concentration (IC50) of the testing compound.
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公开(公告)号：US20150160195A1
公开(公告)日：2015-06-11
申请号：US14513174
申请日：2014-10-13
Applicant: Industrial Technology Research Institute
Inventor： Mei-Wei Lin , Dian-Kun Li , Ling-Mei Wang , Ching-Huai Ko , Chin-Pen Lai , Chun-Chung Wang , Hsiang-Wen Tseng
CPC classification number: G01N33/5067 , C12N5/067 , C12N5/0693 , G01N33/5011
Abstract: An isolated human liver tumor cell line is provided and is named as ITRI-H16, and which was deposited in the Food Industry Research and Development Institute with the accession number BCRC960432 on Nov. 7, 2011. A method of an agent screening is also provided. The method includes providing the isolated human liver tumor cell line ITRI-H16 and treating an interest compound to the ITRI-H16 cell line to determine an effect of the interesting compound on the ITRI-H16 cell line.
Abstract translation: 提供了一种分离的人肝肿瘤细胞系，并命名为ITRI-H16，并于2011年11月7日保藏于食品工业研究开发研究所，登记号为BCRC960432。还提供了一种试剂筛选方法 。 该方法包括提供分离的人肝肿瘤细胞系ITRI-H16并将感兴趣的化合物处理到ITRI-H16细胞系以确定感兴趣的化合物对ITRI-H16细胞系的影响。
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5.发明申请公开(公告)号：US20180143181A1
公开(公告)日：2018-05-24
申请号：US15861613
申请日：2018-01-03
Applicant: Industrial Technology Research Institute
Inventor： Mei-Wei Lin , Dian-Kun Li , Ling-Mei Wang , Ching-Huai Ko , Chin-Pen Lai , Chun-Chung Wang , Hsiang-Wen Tseng
CPC classification number: G01N33/5067 , C12N5/067 , C12N5/0693 , G01N33/5011
Abstract: An in vitro method for screening a testing compound to evaluate its potential as a liver drug is provided. The method includes applying the testing compound to cells of an isolated human liver tumor cell line, named as ITRI-H16, measuring a cell viability of the cells and determining the effect of the testing compound on the cells by calculating a half maximal inhibitory concentration (IC50) of the testing compound.
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公开(公告)号：US09682062B2
公开(公告)日：2017-06-20
申请号：US14133213
申请日：2013-12-18
Applicant: Industrial Technology Research Institute
Inventor： I-Horng Pan , Hsin-Jan Yao , Mei-Wei Lin , I-Huang Lu , Hsin-Chieh Wu , Hsiang-Wen Tseng , Ching-Huai Ko , Chun-Chung Wang , Zong-Keng Kuo , Shyh-Horng Lin , Yi-Cheng Cheng , Tien-Soung Tong
IPC: A61K36/15 , A61K36/185 , A61K31/365 , A61K36/14 , A61K31/7048
CPC classification number: A61K31/365 , A61K31/7048 , A61K36/14 , A61K2300/00
Abstract: The disclosure provides a pharmaceutical composition for inhibiting angiogenesis, including an effective amount of an extract of Juniperus chinensis or an effective amount of a lignan as an effective ingredient. The pharmaceutical composition may further include a pharmaceutically acceptable carrier or salt. The disclosure also provides a method for inhibiting angiogenesis, including administering an effective amount of an extract of Juniperus chinensis or an effective amount of a lignan as an effective ingredient for inhibiting angiogenesis to a subject in need thereof.
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公开(公告)号：US20150159141A1
公开(公告)日：2015-06-11
申请号：US14510136
申请日：2014-10-09
Applicant: Industrial Technology Research Institute
Inventor： Mei-Wei Lin , Dian-Kun Li , Ling-Mei Wang , Ching-Huai Ko , Chin-Pen Lai , Chun-Min Liu , Hsiang-Wen Tseng
CPC classification number: C12N5/0693 , C12N5/067 , G01N33/5011 , G01N33/5067
Abstract: An isolated human liver tumor cell line is provided, which was named as ITRI-H28 and deposited in the Food Industry Research and Development Institute with the accession number BCRC960457 on Dec. 14, 2012. A method of an agent screening is also provided. The method includes providing the isolated human liver tumor cell line ITRI-H28 and adding an interest compound into the ITRI-H28 cell line to determine an effect on the ITRI-H28 cell line.
Abstract translation: 提供了一种分离的人肝肿瘤细胞系，被命名为ITRI-H28，并于2012年12月14日保藏于食品工业研究开发研究所，登记号为BCRC960457。还提供了一种试剂筛选方法。 该方法包括提供分离的人肝肿瘤细胞系ITRI-H28并将兴趣化合物加入到ITRI-H28细胞系中以确定对ITRI-H28细胞系的影响。
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