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公开(公告)号：US09791460B2
公开(公告)日：2017-10-17
申请号：US14105891
申请日：2013-12-13
Applicant: Industrial Technology Research Institute
Inventor： Tzu-Ling Tseng , Hung-Yi Li , Yen-Peng Li , Angelina Huai-Lo Lee , Yi-Chen Liu , Ping-Fu Cheng , Wei-Ya Lin , Hong-Zen Yeh
IPC: G01N33/53 , G01N33/49 , G01N33/50 , G01N33/576 , G01N33/487 , G01N33/68
CPC classification number: G01N33/6893 , G01N33/487 , G01N33/49 , G01N33/50 , G01N33/5067 , G01N33/53 , G01N33/576 , G01N2333/70539 , G01N2333/96494 , G01N2333/9723 , G01N2800/085
Abstract: Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and β-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing liver fibrosis.
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Patent Agency Ranking
公开(公告)号：US20140106370A1
公开(公告)日：2014-04-17
申请号：US14105891
申请日：2013-12-13
Applicant: Industrial Technology Research Institute
Inventor： Tzu-Ling Tseng , Hong-Yi Li , Ye-Peng Li , Angelina Huai-Lo Lee , Yi-Chen Liu , Ping-Fu Cheng , Wei-Ya Lin , Hong-Zen Yeh
IPC: G01N33/68
CPC classification number: G01N33/6893 , G01N33/487 , G01N33/49 , G01N33/50 , G01N33/5067 , G01N33/53 , G01N33/576 , G01N2333/70539 , G01N2333/96494 , G01N2333/9723 , G01N2800/085
Abstract: Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and β-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing liver fibrosis.
Abstract translation: 鉴定尿激酶型纤溶酶原，基质金属蛋白酶9和＆bgr.2-微球蛋白作为与肝纤维化相关的新型生物标志物及其在诊断肝纤维化中的用途。
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公开(公告)号：US20210199733A1
公开(公告)日：2021-07-01
申请号：US17136001
申请日：2020-12-29
Applicant: Industrial Technology Research Institute
Inventor： Cheng-Tai Chen , Shih-Ya Chen , Yi-Chen Liu , Ching-Fang Lu , Chia-Chen Chang , Erh-Fang Lee
Abstract: A method of detecting a biological sample includes the following steps. A magnetic sensor chip is provided, wherein the magnetic sensor chip includes a substrate and a magnetic sensing layer located on the substrate. Probes are connected to the magnetic sensor chip. A sample solution containing biological samples labeled with a first marker is provided on the magnetic sensor chip, so that the biological samples labeled with the first marker are hybridized with the probes. Magnetic beads labeled with a second marker are provided on the magnetic sensor chip, so that the magnetic beads labeled with the second marker are bound onto the biological samples labeled with the first marker. A signal sensed by the magnetic sensing layer is detected by a magnetic sensor.
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公开(公告)号：US11555871B2
公开(公告)日：2023-01-17
申请号：US17136001
申请日：2020-12-29
Applicant: Industrial Technology Research Institute
Inventor： Cheng-Tai Chen , Shih-Ya Chen , Yi-Chen Liu , Ching-Fang Lu , Chia-Chen Chang , Erh-Fang Lee
Abstract: A method of detecting a biological sample includes the following steps. A magnetic sensor chip is provided, wherein the magnetic sensor chip includes a substrate and a magnetic sensing layer located on the substrate. Probes are connected to the magnetic sensor chip. A sample solution containing biological samples labeled with a first marker is provided on the magnetic sensor chip, so that the biological samples labeled with the first marker are hybridized with the probes. Magnetic beads labeled with a second marker are provided on the magnetic sensor chip, so that the magnetic beads labeled with the second marker are bound onto the biological samples labeled with the first marker. A signal sensed by the magnetic sensing layer is detected by a magnetic sensor.
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公开(公告)号：US09983216B2
公开(公告)日：2018-05-29
申请号：US15706011
申请日：2017-09-15
Applicant: Industrial Technology Research Institute
Inventor： Tzu-Ling Tseng , Hung-Yi Li , Yen-Peng Li , Angelina Huai-Lo Lee , Yi-Chen Liu , Ping-Fu Cheng , Wei-Ya Lin , Hong-Zen Yeh
IPC: G01N33/53 , G01N33/49 , G01N33/576 , G01N33/487 , G01N33/68 , G01N33/50
CPC classification number: G01N33/6893 , G01N33/487 , G01N33/49 , G01N33/50 , G01N33/5067 , G01N33/53 , G01N33/576 , G01N2333/70539 , G01N2333/96494 , G01N2333/9723 , G01N2800/085
Abstract: Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and β-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing and staging liver fibrosis.
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公开(公告)号：US20180003722A1
公开(公告)日：2018-01-04
申请号：US15706011
申请日：2017-09-15
Applicant: Industrial Technology Research Institute
Inventor： Tzu-Ling Tseng , Hung-Yi Li , Yen-Peng Li , Angelina Huai-Lo Lee , Yi-Chen Liu , Ping-Fu Cheng , Wei-Ya Lin , Hong-Zen Yeh
IPC: G01N33/68 , G01N33/487 , G01N33/50 , G01N33/53 , G01N33/576 , G01N33/49
CPC classification number: G01N33/6893 , G01N33/487 , G01N33/49 , G01N33/50 , G01N33/5067 , G01N33/53 , G01N33/576 , G01N2333/70539 , G01N2333/96494 , G01N2333/9723 , G01N2800/085
Abstract: Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and β-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing and staging liver fibrosis.
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