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公开(公告)号：US11959101B2
公开(公告)日：2024-04-16
申请号：US17535694
申请日：2021-11-26
Applicant: Industrial Technology Research Institute
Inventor： Ting-Hsuan Chen , Kuo-Hsing Wen , Ya-Hui Chiu , Nien-Tzu Chou , Ching-Fang Lu , Cheng-Tai Chen , Ting-Shuo Chen , Pei-Shin Jiang
Abstract: A cell activation reactor and a cell activation method are provided. The cell activation reactor includes a body, a rotating part, an upper cover, a microporous film, and multiple baffles. The body has an accommodating space, which is suitable for accommodating multiple cells and multiple magnetic beads. The rotating part is disposed in the accommodating space and includes multiple impellers. The microporous film is disposed in the accommodating space and covers multiple holes of the accommodating space. The baffles are disposed in the body. When the rotating part is driven to rotate, the interaction between the baffles and the impellers separates the cells and the magnetic beads.
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公开(公告)号：US11555871B2
公开(公告)日：2023-01-17
申请号：US17136001
申请日：2020-12-29
Applicant: Industrial Technology Research Institute
Inventor： Cheng-Tai Chen , Shih-Ya Chen , Yi-Chen Liu , Ching-Fang Lu , Chia-Chen Chang , Erh-Fang Lee
Abstract: A method of detecting a biological sample includes the following steps. A magnetic sensor chip is provided, wherein the magnetic sensor chip includes a substrate and a magnetic sensing layer located on the substrate. Probes are connected to the magnetic sensor chip. A sample solution containing biological samples labeled with a first marker is provided on the magnetic sensor chip, so that the biological samples labeled with the first marker are hybridized with the probes. Magnetic beads labeled with a second marker are provided on the magnetic sensor chip, so that the magnetic beads labeled with the second marker are bound onto the biological samples labeled with the first marker. A signal sensed by the magnetic sensing layer is detected by a magnetic sensor.
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公开(公告)号：US20220205993A1
公开(公告)日：2022-06-30
申请号：US17560276
申请日：2021-12-23
Applicant: Industrial Technology Research Institute
Inventor： Wen-Ting Chiang , Chien-An Chen , Cheng-Tai Chen
IPC: G01N33/543 , G01N33/58 , G01N33/53
Abstract: A detection method of multiple analytes includes the following. A microparticle is provided. The microparticle is coupled with at least one first ligand, and includes a body and a plurality of first protrusions formed on a surface of the body. Next, the microparticle is mixed with a variety of analytes to form a first complex. Thereafter, the first complex is mixed with a variety of second ligands carrying a variety of first labels, such that the variety of second ligands bind to the variety of analytes in the first complex and form a second complex. Lastly, the variety of first labels in the variety of second ligands in the second complex are detected.
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4.发明授权公开(公告)号：US12269003B2
公开(公告)日：2025-04-08
申请号：US17134496
申请日：2020-12-28
Applicant: Industrial Technology Research Institute
Inventor： Yu-Fang Yen , Chien-An Chen , Cheng-Tai Chen
Abstract: An extracellular vesicle separation method, a colloidal particle, and a preparation method thereof are provided. The colloidal particle is used for extracellular vesicle separation, and includes 2 wt % to 6 wt % of agarose. The colloidal particle has a particle size of 25 μm to 500 μm, and is surface-modified with biocompatible molecules. The biocompatible molecules include sodium carboxymethyl cellulose (CMC), methyl cellulose (MC), glycine, aspartic acid, glutamic acid, bovine serum albumin (BSA), fetal bovine serum (FBS), or a combination thereof.
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公开(公告)号：US20240311638A1
公开(公告)日：2024-09-19
申请号：US18398161
申请日：2023-12-28
Applicant: Industrial Technology Research Institute
Inventor： Nien-Tzu Chou , Yu-Yu Lin , Ching-Fang Lu , Jian-Hao Li , Ting-Hsuan Chen , Cheng-Tai Chen
IPC: G06N3/0895 , G01N33/50 , G16B40/20
CPC classification number: G06N3/0895 , G01N33/5023 , G16B40/20 , G01N2333/70503 , G01N2333/70596 , G01N2333/7155
Abstract: A method of predicting the efficacy of natural killer cells, including: generating a plurality of training data corresponding to a plurality of donors based on a characteristic factor and a corresponding killing result against the target cancer cells of a plurality of cultured natural killer cells from the donors; obtaining a trained neural network model by inputting the plurality of training data into a neural network model; inputting a to-be-tested input vector corresponding to at least one characteristic factor of a to-be-tested natural killer cell into the trained neural network model to obtain an outputted result vector of the trained neural network model, wherein the result vector indicates a predicted killing result corresponding to the target cancer cell after applying the to-be-tested natural killer cell; and determining a quality of the to-be-tested natural killer cell based on the predicted killing result.
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Patent Agency Ranking
公开(公告)号：US11884912B2
公开(公告)日：2024-01-30
申请号：US16727057
申请日：2019-12-26
Applicant: Industrial Technology Research Institute
Inventor： Kuo-Hsing Wen , Ting-Hsuan Chen , Cheng-Tai Chen , Chien-An Chen , Su-Fung Chiu , Yung-Chi Chang , Nien-Jen Chou , Ping-Jung Wu , Shaw-Hwa Parng , Pei-Shin Jiang
Abstract: A cell culture device includes a culture unit, a gas supply unit, a first pressure unit, at least one inspecting unit and a control unit. The culture unit contains a cell culture liquid. The gas supply unit, connected with the culture unit, is used for transmitting a culture gas into the culture unit. The first pressure unit, connected with the culture unit, is used for applying a pressure to the cell culture liquid in the culture unit. The at least one inspecting unit, connected with the culture unit, is used for receiving the cell culture liquid for inspection. The control unit, electrically coupled with the culture unit, the first pressure unit, the gas supply unit and the at least one inspecting unit, is used for monitoring corresponding condition parameters to determine respective operations. In addition, a cell culture method for the cell culture device is also provided.
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公开(公告)号：US20230245808A1
公开(公告)日：2023-08-03
申请号：US18185346
申请日：2023-03-16
Applicant: Industrial Technology Research Institute
Inventor： Chien-An Chen , Cheng-Tai Chen , Pei-Shin Jiang
CPC classification number: H01F1/26 , H01F1/0054 , H01F1/37 , G01N2446/10 , G01N33/5434
Abstract: Described herein is a manufacturing method of a magnetic particle. First, deionized water, an organic solvent, a hydrophilic polymer, a lipid-soluble initiator, and at least two monomers are placed in a reactor and then stirred for polymerizing the at least two monomers into a copolymer to form a knobby copolymer core. Next, a polymer layer is formed to cover the knobby copolymer core, wherein the polymer layer has at least one functional group. Thereafter, a magnetic substance precursor is adsorbed by the knobby copolymer core covered with the polymer layer to form a magnetic substance layer. Further, a silicon-based layer may be additionally formed to cover the magnetic substance layer.
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公开(公告)号：US20220169985A1
公开(公告)日：2022-06-02
申请号：US17535694
申请日：2021-11-26
Applicant: Industrial Technology Research Institute
Inventor： Ting-Hsuan Chen , Kuo-Hsing Wen , Ya-Hui Chiu , Nien-Tzu Chou , Ching-Fang Lu , Cheng-Tai Chen , Ting-Shuo Chen , Pei-Shin Jiang
IPC: C12N5/0783 , C12M1/00 , C12M1/42 , C12M1/06
Abstract: A cell activation reactor and a cell activation method are provided. The cell activation reactor includes a body, a rotating part, an upper cover, a microporous film, and multiple baffles. The body has an accommodating space, which is suitable for accommodating multiple cells and multiple magnetic beads. The rotating part is disposed in the accommodating space and includes multiple impellers. The microporous film is disposed in the accommodating space and covers multiple holes of the accommodating space. The baffles are disposed in the body. When the rotating part is driven to rotate, the interaction between the baffles and the impellers separates the cells and the magnetic beads.
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公开(公告)号：US20210199733A1
公开(公告)日：2021-07-01
申请号：US17136001
申请日：2020-12-29
Applicant: Industrial Technology Research Institute
Inventor： Cheng-Tai Chen , Shih-Ya Chen , Yi-Chen Liu , Ching-Fang Lu , Chia-Chen Chang , Erh-Fang Lee
Abstract: A method of detecting a biological sample includes the following steps. A magnetic sensor chip is provided, wherein the magnetic sensor chip includes a substrate and a magnetic sensing layer located on the substrate. Probes are connected to the magnetic sensor chip. A sample solution containing biological samples labeled with a first marker is provided on the magnetic sensor chip, so that the biological samples labeled with the first marker are hybridized with the probes. Magnetic beads labeled with a second marker are provided on the magnetic sensor chip, so that the magnetic beads labeled with the second marker are bound onto the biological samples labeled with the first marker. A signal sensed by the magnetic sensing layer is detected by a magnetic sensor.
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10.发明申请公开(公告)号：US20210197162A1
公开(公告)日：2021-07-01
申请号：US17134496
申请日：2020-12-28
Applicant: Industrial Technology Research Institute
Inventor： Yu-Fang Yen , Chien-An Chen , Cheng-Tai Chen
Abstract: An extracellular vesicle separation method, a colloidal particle, and a preparation method thereof are provided. The colloidal particle is used for extracellular vesicle separation, and includes 2 wt % to 6 wt % of agarose. The colloidal particle has a particle size of 25 μm to 500 μm, and is surface-modified with biocompatible molecules. The biocompatible molecules include sodium carboxymethyl cellulose (CMC), methyl cellulose (MC), glycine, aspartic acid, glutamic acid, bovine serum albumin (BSA), fetal bovine serum (FBS), or a combination thereof.
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