公开(公告)号：US20160257964A1

公开(公告)日：2016-09-08

申请号：US15069057

申请日：2016-03-14

申请人： Intrexon Corporation

发明人： Subba Reddy PALLI ,  Mohan Basavaraju Kumar ,  Dean Ervin Cress ,  Ted Tsutomu Fujimoto

IPC分类号： C12N15/63 ,  C12N7/00 ,  C12N15/86

CPC分类号： C12N15/635 ,  C07K14/70567 ,  C07K14/721 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10043 ,  C12P21/02

摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

公开(公告)号：US10190124B2

公开(公告)日：2019-01-29

申请号：US15069057

申请日：2016-03-14

申请人： Intrexon Corporation

发明人： Subba Reddy Palli ,  Mohan Basavaraju Kumar ,  Dean Ervin Cress ,  Ted Tsutomu Fujimoto

IPC分类号： C12P21/06 ,  C12N15/63 ,  C07K14/705 ,  C07K14/72 ,  C12P21/02 ,  C12N7/00 ,  C12N15/86

摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.