公开(公告)号：US5061730A

公开(公告)日：1991-10-29

申请号：US143942

申请日：1988-01-14

申请人： Itsuo Uchida ,  Hiroshi Hatanaka ,  Kumiko Nitta ,  Seiji Hashimoto ,  Masakuni Okuhara ,  Hidetsugu Murai ,  Masashi Hashimoto

发明人： Itsuo Uchida ,  Hiroshi Hatanaka ,  Kumiko Nitta ,  Seiji Hashimoto ,  Masakuni Okuhara ,  Hidetsugu Murai ,  Masashi Hashimoto

IPC分类号： C07D211/94 ,  A01N37/36 ,  A61K31/19 ,  A61P43/00 ,  C07C67/00 ,  C07C239/00 ,  C07C259/06 ,  C12N9/99 ,  C12P13/00 ,  C12R1/465

CPC分类号： A61K31/19

摘要： This invention relates to new carboxylic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or aryl, and pharmaceutically acceptable salt thereof which inhibit activity of DHP-I, to a process for preparing them and to an antibacterial composition comprising them and carbapenem antibiotics.

公开(公告)号：US5502033A

公开(公告)日：1996-03-26

申请号：US218883

申请日：1994-03-28

申请人： Toshiro Iwamoto ,  Akihiko Fujie ,  Kumiko Nitta ,  Yasuhisa Tsurumi ,  Nobuharu Shigematsu ,  Chiyoshi Kasahara ,  Motohiro Hino ,  Masakuni Okuhara

发明人： Toshiro Iwamoto ,  Akihiko Fujie ,  Kumiko Nitta ,  Yasuhisa Tsurumi ,  Nobuharu Shigematsu ,  Chiyoshi Kasahara ,  Motohiro Hino ,  Masakuni Okuhara

IPC分类号： C12N1/14 ,  A61K38/00 ,  A61P31/04 ,  A61P31/10 ,  C07K1/20 ,  C07K5/12 ,  C07K7/56 ,  C07K14/195 ,  C07K14/41 ,  C12P21/04 ,  C12R1/645 ,  C07K7/00 ,  C07K7/06

CPC分类号： C07K7/56 ,  A61K38/00

摘要： A compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or hydroxy, R.sup.2 is hydrogen or hydroxy, R.sup.3 is hydroxy or hydroxysulfonyloxy, with proviso that when R.sup.1 is hydrogen, R.sup.2 is hydrogen, or a phamaceutically acceptable salt thereof. The compound can be used in a method for treating infectious diseases caused by pathogenic microorganism.

摘要翻译： 具有以下通式的抗微生物活性的化合物：其中R 1是氢或羟基，R 2是氢或羟基，R 3是羟基或羟基磺酰氧基，条件是当R 1是氢时，R 2是氢或药学上可接受的盐 其中。 该化合物可用于治疗由病原微生物引起的感染性疾病的方法。

公开(公告)号：US5376634A

公开(公告)日：1994-12-27

申请号：US715961

申请日：1991-06-17

申请人： Toshiro Iwamoto ,  Akihiko Fujie ,  Kumiko Nitta ,  Yasuhisa Tsurumi ,  Nobuharu Shigematsu ,  Chiyoshi Kasahara ,  Motohiro Hino ,  Masakuni Okuhara ,  Kazuo Sakane ,  Kohji Kawabata ,  Hidenori Ohki

发明人： Toshiro Iwamoto ,  Akihiko Fujie ,  Kumiko Nitta ,  Yasuhisa Tsurumi ,  Nobuharu Shigematsu ,  Chiyoshi Kasahara ,  Motohiro Hino ,  Masakuni Okuhara ,  Kazuo Sakane ,  Kohji Kawabata ,  Hidenori Ohki

IPC分类号： A61K38/00 ,  A61K38/12 ,  A61P31/04 ,  A61P31/10 ,  C07C309/43 ,  C07K1/06 ,  C07K7/56 ,  C07K7/64 ,  C12P21/04 ,  C12R1/645 ,  C07K5/12 ,  A61K37/02 ,  C07K7/06

CPC分类号： C07K7/56 ,  A61K38/00

摘要： A polypeptide compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or acyl group, R.sup.2 is hydroxy or acyloxy,R.sup.3 is hydroxysulfonyloxy, andR.sup.4 is hydrogen or carbamoyl,with proviso thatR.sup.1 is not palmitoyl, when R.sup.2 is hydroxy,R.sup.3 is hydroxysulfonyloxy andR.sup.4 is carbamoyl,and a pharmaceutically acceptable salt thereof.

摘要翻译： 具有以下通式的抗微生物活性的多肽化合物：其中R1是氢或酰基，R2是羟基或酰氧基，R3是羟基磺酰氧基，R4是氢或氨基甲酰基，条件是R1不是棕榈酰基，当R2 是羟基，R3是羟基磺酰氧基，R4是氨基甲酰基，及其药学上可接受的盐。

公开(公告)号：USH1638H

公开(公告)日：1997-03-04

申请号：US311434

申请日：1994-09-26

申请人： Takahisa Furuta ,  Toshiro Iwamoto ,  Akihiko Fujie ,  Kumiko Nitta ,  Yasuhisa Tsurumi ,  Nobuharu Shigematsu ,  Chiyoshi Kasahara ,  Motohiro Hino ,  Masakuni Okuhara

发明人： Takahisa Furuta ,  Toshiro Iwamoto ,  Akihiko Fujie ,  Kumiko Nitta ,  Yasuhisa Tsurumi ,  Nobuharu Shigematsu ,  Chiyoshi Kasahara ,  Motohiro Hino ,  Masakuni Okuhara

IPC分类号： A61K38/12 ,  C07K7/56 ,  A61K38/00

CPC分类号： A61K38/12 ,  C07K7/56

摘要： A pharmaceutical composition comprising an amount of a polypeptide of the formula: ##STR1## wherein R.sup.1 is hydrogen or an acyl group, R.sup.2 is hydroxy or an acyloxy group, R.sup.3 is hydrogen, hydroxy or hydroxysulfonyloxy, R.sup.4 is hydrogen or carbamoyl, and R.sup.5 and R.sup.6 are each hydrogen or hydroxy, with the proviso that (i) R.sup.2 is acyloxy when R.sup.3 is hydrogen, and (ii) R.sup.5 is hydrogen when R.sup.6 is hydrogen, or a pharmaceutically acceptable salt thereof, is useful in the prevention or treatment of Pneumocystis carinii infection.

摘要翻译： 一种药物组合物，其包含一定量下式的多肽：其中R 1是氢或酰基，R 2是羟基或酰氧基，R 3是氢，羟基或羟基磺酰氧基，R 4是氢或氨基甲酰基，和R 5和 R6各自为氢或羟基，条件是当R 3为氢时，（ⅰ）R 2为酰氧基，和（ⅱ）R 6为氢时R 5为氢或其药学上可接受的盐可用于预防或治疗肺孢子虫 卡利尼病感染。