公开(公告)号：US20220089761A1

公开(公告)日：2022-03-24

申请号：US17288234

申请日：2019-10-30

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Pavel Andreevich IAKOVLEV ,  Natalia Eugenievna PESTOVA ,  Arina Vitalevna ANIKINA ,  Anna Alexandrovna TRUDOVISHNIKOVA ,  Mariia Aleksandrovna SHCHEMELEVA ,  Nina Grachyaevna KHARATIAN ,  Valery Vladimirovich SOLOVYEV ,  Alexey Konstantinovich MISORIN ,  Sergei Vasilyevich DIDUK ,  Anna Vladimirovna EROSHOVA ,  Veronika Sergeevna USATOVA ,  Elena Andreevna KRENDELEVA ,  Iakov Iurevich USTIUGOV ,  Aleksei Aleksandrovich ALEKSANDROV ,  Iana Andreevna SMIRNOVA ,  Svetlana Vladimirovna KOSKOVA ,  Roman Alekseevich IVANOV ,  Dmitry Valentinovich MOROZOV

IPC: C07K16/28 ,  A61P35/02 ,  C12N15/63

Abstract: The present invention relates to biotechnology and provides a monoclonal antibody that specifically binds to CD20. The invention also relates to DNA encoding said antibody, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibody.

公开(公告)号：US20190127478A1

公开(公告)日：2019-05-02

申请号：US16095800

申请日：2017-07-04

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Viktoriia Mikhailovna EKIMOVA ,  Dmitry Valeryevich KORZHAVIN ,  Yulia Sergeevna CHERNYKH ,  Timofey Aleksandrovich NEMANKIN ,  Valery Vladimirovich SOLOVYEV ,  Anna Konstantinovna VLADIMIROVA ,  Irina Andreevna BULANKINA ,  Sergei Vasilyevich DIDUK ,  Olga Vladimirovna GONCHAROVA ,  Anna Vladimirovna EROSHOVA ,  Iakov Iurevich USTIUGOV ,  Marina Vladimirovna ARTIUKHOVA ,  Andrei Borisovich ULITIN ,  Roman Alekseevich IVANOV ,  Dmitry Valentinovich MOROZOV

IPC: C07K16/28 ,  A61P35/00 ,  C12N15/63 ,  A61P31/00

Abstract: The present invention relates to biotechnology and comprises isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind to PD-1 with high affinity. The antibodies according to the invention may be chimeric, humanized or human antibodies, or antigen-binding fragments thereof, and may be used as a medicinal agent in oncology and immuno-oncology, for treating diseases associated with various cell proliferation or development disorders. The invention also relates to methods for producing said antibodies and a method for treating human diseases using said antibodies.