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1.发明申请THIAZOLE OR THIADIZALOE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS 审中-公开用作磷酸1-磷酸1（S1P1）受体激动剂的噻唑或十二烷基衍生物公开(公告)号：US20120094979A1
公开(公告)日：2012-04-19
申请号：US13378809
申请日：2010-06-17
申请人： James Matthew Bailey , Emmanuel Hubert Demont , Xichen Lin , Feng Ren , Christian Alan Paul Smethurst
发明人： James Matthew Bailey , Emmanuel Hubert Demont , Xichen Lin , Feng Ren , Christian Alan Paul Smethurst
IPC分类号： A61K31/55 , A61K31/4725 , A61K31/433 , A61P25/00 , A61P37/06 , A61P29/00 , A61P11/06 , A61P19/02 , A61P1/00 , A61P17/06 , A61P9/10 , A61P35/00 , A61P35/04 , A61P9/00 , A61P31/12 , A61P3/10 , C07D417/10
CPC分类号： C07D417/04
摘要： Thiazole or thiadizaloe derivatives of formula (I) or pharmaceutical salts thereof having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptor are disclosed.
摘要翻译： 公开了具有药理活性的式（I）的噻唑或噻二唑衍生物或其药用盐，其制备方法，含有它们的药物组合物及其在治疗由S1P1受体介导的各种疾病中的用途。
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2.发明申请THIADIAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF DISORDERS MEDIATED BY S1P1 RECEPTORS 审中-公开三唑衍生物及其用于治疗由S1P1受体介导的疾病的用途公开(公告)号：US20120101086A1
公开(公告)日：2012-04-26
申请号：US13379110
申请日：2010-06-17
申请人： James Matthew Bailey , John Alexander Brown , Emmanuel Hubert Demont , Lee Andrew Harrison , Gail Astra Lorraine Seal , Christian Alan Paul Smethurst , Jason Witherington
发明人： James Matthew Bailey , John Alexander Brown , Emmanuel Hubert Demont , Lee Andrew Harrison , Gail Astra Lorraine Seal , Christian Alan Paul Smethurst , Jason Witherington
IPC分类号： A61K31/55 , C07D487/04 , C07D471/04 , A61P25/00 , A61P37/00 , A61P29/00 , A61P11/06 , A61P19/02 , A61P41/00 , A61P1/00 , A61P35/00 , A61P35/04 , A61P7/00 , A61P31/12 , A61P3/10 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译： 本发明涉及具有药理活性的新化合物，其制备方法，含有它们的药物组合物及其在治疗各种疾病中的用途。
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公开(公告)号：US20120101083A1
公开(公告)日：2012-04-26
申请号：US13379059
申请日：2010-06-17
申请人： James Matthew Bailey , Rino Antonio Bit , Emmanuel Hubert Demont , Lee Andrew Harrison , Katherine Louise Jones , Christian Alan Paul Smethurst , Jason Witherington
发明人： James Matthew Bailey , Rino Antonio Bit , Emmanuel Hubert Demont , Lee Andrew Harrison , Katherine Louise Jones , Christian Alan Paul Smethurst , Jason Witherington
IPC分类号： A61K31/55 , C07D417/10 , C07D413/14 , A61K31/4725 , A61P25/00 , A61P29/00 , A61P11/06 , A61P19/02 , A61P17/06 , A61P35/00 , A61P35/04 , A61P9/00 , A61P31/12 , A61P3/10 , C07D413/10
CPC分类号： C07D413/04 , C07D413/14 , C07D417/04
摘要： The present invention relates to novel compounds of formula (I) having S1P1 agonist activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译： 本发明涉及具有S1P1激动剂活性的新型式（I）化合物，其制备方法，含有它们的药物组合物及其在治疗各种疾病中的用途。
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公开(公告)号：US08993554B2
公开(公告)日：2015-03-31
申请号：US14111625
申请日：2012-04-19
IPC分类号： C07D215/42 , C07D401/12 , C07D401/14 , C07D215/44 , C07D401/04
CPC分类号： C07D215/42 , C07D215/44 , C07D401/04 , C07D401/12 , C07D401/14
摘要： Tetrahydroquinoline compounds, pharmaceutical compositions containing such compounds and their use in therapy.
摘要翻译： 四氢喹啉化合物，含有这些化合物的药物组合物及其在治疗中的用途。
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公开(公告)号：US20120208814A1
公开(公告)日：2012-08-16
申请号：US13503947
申请日：2010-11-03
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/47 , C07D401/14 , C07D401/10 , C07D215/38 , A61P35/00 , A61P29/00 , A61K31/4709 , A61K31/496 , C07D413/10
CPC分类号： C07D401/12 , C07D215/44 , C07D401/14 , C07D405/10 , C07D409/10 , C07D413/04
摘要： Tetrahydroquinoline compounds of formula (I) or a salt thereof, pharmaceutical compositions containing such compounds and their use in therapy, in particular in the treatment of diseases or conditions for which a bromodomain inhibitor is indicted.
摘要翻译： 式（I）的四氢喹啉化合物或其盐，含有这些化合物的药物组合物及其在治疗中的用途，特别是治疗被指示溴结构域抑制剂的疾病或病症。
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公开(公告)号：US20100273771A1
公开(公告)日：2010-10-28
申请号：US12747205
申请日：2008-12-19
申请人： Emmanuel Hubert Demont , Jag Paul Heer , John Skidmore , Ian David Wall , Jason Witherington , Thomas Daniel Heightman , David Nigel Hurst , Christopher Norbert Johnson
发明人： Emmanuel Hubert Demont , Jag Paul Heer , John Skidmore , Ian David Wall , Jason Witherington , Thomas Daniel Heightman , David Nigel Hurst , Christopher Norbert Johnson
IPC分类号： A61K31/553 , C07D413/10 , A61K31/55 , A61P37/00
CPC分类号： C07D223/16 , C07D267/14 , C07D271/06 , C07D413/04 , C07D413/14
摘要： The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
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公开(公告)号：US09029395B2
公开(公告)日：2015-05-12
申请号：US14111580
申请日：2012-04-19
IPC分类号： C07D215/44 , C07D215/42 , C07D401/12
CPC分类号： C07D215/44 , C07D215/42 , C07D401/12
摘要： Tetrahydroquinoline derivatives, pharmaceutical compositions containing such compounds and to their use in therapy.
摘要翻译： 四氢喹啉衍生物，含有这些化合物的药物组合物及其在治疗中的应用。
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公开(公告)号：US08697725B2
公开(公告)日：2014-04-15
申请号：US13501159
申请日：2010-11-03
申请人： Emmanuel Hubert Demont , Neil Stuart Garton , Romain Luc Marie Gosmini , Thomas George Christopher Hayhow , Jonathan Seal , David Matthew Wilson , Michael David Woodrow
发明人： Emmanuel Hubert Demont , Neil Stuart Garton , Romain Luc Marie Gosmini , Thomas George Christopher Hayhow , Jonathan Seal , David Matthew Wilson , Michael David Woodrow
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D215/42
摘要： Tetrahydroquinoline compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.
摘要翻译： 式（I）的四氢喹啉化合物及其盐，含有这些化合物的药物组合物及其在治疗中的用途。
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公开(公告)号：US20140031336A1
公开(公告)日：2014-01-30
申请号：US14111625
申请日：2012-04-19
IPC分类号： C07D215/42 , C07D401/14 , C07D401/12
CPC分类号： C07D215/42 , C07D215/44 , C07D401/04 , C07D401/12 , C07D401/14
摘要： Tetrahydroquinoline compounds, pharmaceutical compositions containing such compounds and their use in therapy.
摘要翻译： 四氢喹啉化合物，含有这些化合物的药物组合物及其在治疗中的用途。
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10.发明申请N-(Phenylmethyl)-2-(1H-Pyrazol-4-yl) Acetamide Derivatives as P2X7 Antagonists for the Treatment of Pain, Inflammation and Neurodegeneration 审中-公开N-（苯基甲基）-2-（1H-吡唑-4-基）乙酰胺衍生物作为P2X7拮抗剂用于治疗疼痛，炎症和神经退行性疾病公开(公告)号：US20090149524A1
公开(公告)日：2009-06-11
申请号：US12303260
申请日：2007-06-05
申请人： Paul John Beswick , Laura J. Chambers , David John Davies , David Kenneth Dean , Emmanuel Hubert Demont , Susan Roomans , Daryl Simon Walter
发明人： Paul John Beswick , Laura J. Chambers , David John Davies , David Kenneth Dean , Emmanuel Hubert Demont , Susan Roomans , Daryl Simon Walter
IPC分类号： A61K31/415 , C07D231/10 , A61P25/28
CPC分类号： C07D231/12
摘要： The present invention relates to novel pyrazole derivatives of formula (I) which bind to the P2X7 receptor and are capable of interfering with the effects of ATP at the P2X7 receptor: and the use of such compounds or pharmaceutical compositions thereof in the treatment of disorders mediated by the P2X7 receptor, for example pain, inflammation and neurodegeneration.
摘要翻译： 本发明涉及结合P2X7受体并能够干扰ATP在P2X7受体上的作用的式（I）的吡唑衍生物，以及这些化合物或其药物组合物在治疗疾病介导中的用途 通过P2X7受体，例如疼痛，炎症和神经变性。
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