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公开(公告)号：US20110129484A1
公开(公告)日：2011-06-02
申请号：US12988445
申请日：2009-04-17
IPC分类号： A61K39/395 , A61K38/02 , A61K35/00 , A61K35/76 , A61K35/74 , A61K36/06 , A61K35/68 , A61K39/00 , A61K39/12 , A61K39/02 , A61P37/04
CPC分类号： C07K16/18 , A61K38/164 , A61K38/1709 , C07K14/35 , C07K16/28 , C07K2317/21 , C07K2317/622 , C07K2319/00 , C07K2319/22
摘要： Provided herein are self-assembling pharmaceutical compositions comprising a heat shock protein fused to a biotin-binding protein, wherein the biotin-binding protein is non-covalently bound to four biotinylated components, and further wherein at least two of the four biotinylated components are not identical.
摘要翻译： 本文提供了包含与生物素结合蛋白融合的热休克蛋白的自组装药物组合物，其中生物素结合蛋白与四个生物素化组分非共价结合，并且其中四个生物素化组分中的至少两个不是 相同。
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公开(公告)号：US09527906B2
公开(公告)日：2016-12-27
申请号：US12988445
申请日：2009-04-17
IPC分类号： A61K39/395 , A61K38/02 , A61K35/00 , A61K35/76 , A61K35/74 , A61K36/06 , A61K39/00 , A61K39/12 , A61K39/02 , A61P37/04 , C07K16/18 , A61K38/16 , A61K38/17 , C07K14/35 , C07K16/28
CPC分类号： C07K16/18 , A61K38/164 , A61K38/1709 , C07K14/35 , C07K16/28 , C07K2317/21 , C07K2317/622 , C07K2319/00 , C07K2319/22
摘要： Provided herein are self-assembling pharmaceutical compositions comprising a heat shock protein fused to a biotin-binding protein, wherein the biotin-binding protein is non-covalently bound to four biotinylated components, and further wherein at least two of the four biotinylated components are not identical.
摘要翻译： 本文提供了包含与生物素结合蛋白融合的热休克蛋白的自组装药物组合物，其中生物素结合蛋白与四个生物素化组分非共价结合，并且其中四个生物素化组分中的至少两个不是 相同。
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公开(公告)号：US08435494B2
公开(公告)日：2013-05-07
申请号：US13107624
申请日：2011-05-13
申请人： Jeffrey A. Gelfand
发明人： Jeffrey A. Gelfand
CPC分类号： C07K14/35 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K16/46 , C07K2319/00
摘要： The invention relates to fusion proteins comprising a stress protein fused with an engineered antibody or fragment that binds to mesothelin, or a stress protein fused with a biotin-binding protein in combination with a biotinylated engineered antibody or fragment that binds to mesothelin. The invention also relates to fusion proteins comprising a stress protein fused with an antibody binding protein in combination with an engineered antibody or fragment that binds to mesothelin. The invention also relates to fusion proteins comprising an engineered antibody or fragment that binds specifically to mesothelin fused in frame with a biotin binding protein. The invention also provides fusion proteins comprising an engineered antibody or fragment, that binds to mesothelin, fused with an antibody binding protein. The invention also relates to methods of using fusion proteins of the invention to induce an immune response to mesothelin and to treat disease.
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公开(公告)号：US06652456B2
公开(公告)日：2003-11-25
申请号：US09731101
申请日：2000-12-06
IPC分类号： A61B500
CPC分类号： G01N15/1475 , G01N2015/1488 , Y10S128/92
摘要： Mass medical, e.g., cervical cancer, screening is provided to areas of the world where a lack of sufficient laboratory infrastructure and technical skills presently compromises the effectiveness of screening or even makes mass screening impossible. These methods are cost-effective and provide excellent sensitivity and specificity in cervical cancer screening.
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公开(公告)号：US08143387B2
公开(公告)日：2012-03-27
申请号：US12783186
申请日：2010-05-19
申请人： Jeffrey A. Gelfand
发明人： Jeffrey A. Gelfand
CPC分类号： C07K16/00 , A61K2039/505 , C07K14/35 , C07K16/468 , C07K2317/626 , C07K2319/00
摘要： Provided are fusion polypeptides comprising an engineered antibody and a stress protein that bind to antigens with high affinity, are highly immunogenic, exhibit MHC class I priming and are able to be produced in non-mammalian cells, such as E. coli.
摘要翻译： 提供了包含工程化抗体和与高亲和力结合抗原的应激蛋白的融合多肽，是高度免疫原性的，表现出MHC I类引发，并能够在非哺乳动物细胞如大肠杆菌中产生。
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公开(公告)号：US07943133B2
公开(公告)日：2011-05-17
申请号：US12291104
申请日：2008-11-06
申请人： Jeffrey A. Gelfand
发明人： Jeffrey A. Gelfand
IPC分类号： A61K39/00
CPC分类号： C07K14/35 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K16/46 , C07K2319/00
摘要： The invention relates to fusion proteins comprising a stress protein fused with an engineered antibody or fragment that binds to mesothelin, or a stress protein fused with a biotin-binding protein in combination with a biotinylated engineered antibody or fragment that binds to mesothelin. The invention also relates to fusion proteins comprising a stress protein fused with an antibody binding protein in combination with an engineered antibody or fragment that binds to mesothelin. The invention also relates to fusion proteins comprising an engineered antibody or fragment that binds specifically to mesothelin fused in frame with a biotin binding protein. The invention also provides fusion proteins comprising an engineered antibody or fragment, that binds to mesothelin, fused with an antibody binding protein. The invention also relates to methods of using fusion proteins of the invention to induce an immune response to mesothelin and to treat disease.
摘要翻译： 本发明涉及包含与工程化抗体或与间皮素结合的片段融合的应激蛋白或与生物素结合蛋白融合的应激蛋白与融合了间皮素的生物素化工程化抗体或片段的融合蛋白。 本发明还涉及包含与抗体结合蛋白融合的应激蛋白与融合于间皮素的工程化抗体或片段组合的融合蛋白。 本发明还涉及包含与生物素结合蛋白框架融合的间皮素的特异性结合的工程化抗体或片段的融合蛋白。 本发明还提供融合蛋白，其包含与抗体结合蛋白融合的间皮素的工程化抗体或片段。 本发明还涉及使用本发明的融合蛋白诱导对间皮素的免疫应答并治疗疾病的方法。
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公开(公告)号：US07749501B2
公开(公告)日：2010-07-06
申请号：US12185631
申请日：2008-08-04
申请人： Jeffrey A. Gelfand
发明人： Jeffrey A. Gelfand
IPC分类号： A61K39/00
CPC分类号： C07K16/00 , A61K2039/505 , C07K14/35 , C07K16/468 , C07K2317/626 , C07K2319/00
摘要： Provided are fusion polypeptides comprising an engineered antibody and a stress protein that bind to antigens with high affinity, are highly immunogenic, exhibit MHC class I priming and are able to be produced in non-mammalian cells, such as E. coli.
摘要翻译： 提供了包含工程化抗体和与高亲和力结合抗原的应激蛋白的融合多肽，是高度免疫原性的，表现出MHC I类引发，并能够在非哺乳动物细胞如大肠杆菌中产生。
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公开(公告)号：US20090155269A1
公开(公告)日：2009-06-18
申请号：US12291104
申请日：2008-11-06
申请人： Jeffrey A. Gelfand
发明人： Jeffrey A. Gelfand
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , C12N5/06
CPC分类号： C07K14/35 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K16/46 , C07K2319/00
摘要： The invention relates to fusion proteins comprising a stress protein fused with an engineered antibody or fragment that binds to mesothelin, or a stress protein fused with a biotin-binding protein in combination with a biotinylated engineered antibody or fragment that binds to mesothelin. The invention also relates to fusion proteins comprising a stress protein fused with an antibody binding protein in combination with an engineered antibody or fragment that binds to mesothelin. The invention also relates to fusion proteins comprising an engineered antibody or fragment that binds specifically to mesothelin fused in frame with a biotin binding protein. The invention also provides fusion proteins comprising an engineered antibody or fragment, that binds to mesothelin, fused with an antibody binding protein. The invention also relates to methods of using fusion proteins of the invention to induce an immune response to mesothelin and to treat disease.
摘要翻译： 本发明涉及包含与工程化抗体或与间皮素结合的片段融合的应激蛋白或与生物素结合蛋白融合的应激蛋白与融合了间皮素的生物素化工程化抗体或片段的融合蛋白。 本发明还涉及包含与抗体结合蛋白融合的应激蛋白与融合于间皮素的工程化抗体或片段组合的融合蛋白。 本发明还涉及包含与生物素结合蛋白框架融合的间皮素的特异性结合的工程化抗体或片段的融合蛋白。 本发明还提供融合蛋白，其包含与抗体结合蛋白融合的间皮素的工程化抗体或片段。 本发明还涉及使用本发明的融合蛋白诱导对间皮素的免疫应答并治疗疾病的方法。
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公开(公告)号：US20090068184A1
公开(公告)日：2009-03-12
申请号：US12185631
申请日：2008-08-04
申请人： Jeffrey A. Gelfand
发明人： Jeffrey A. Gelfand
CPC分类号： C07K16/00 , A61K2039/505 , C07K14/35 , C07K16/468 , C07K2317/626 , C07K2319/00
摘要： Provided are fusion polypeptides comprising an engineered antibody and a stress protein that bind to antigens with high affinity, are highly immunogenic, exhibit MHC class I priming and are able to be produced in non-mammalian cells, such as E. coli.
摘要翻译： 提供了包含工程化抗体和与高亲和力结合抗原的应激蛋白的融合多肽，是高度免疫原性的，表现出MHC I类引发，并能够在非哺乳动物细胞如大肠杆菌中产生。
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10.发明授权Methods and compositions for treatment of infection by intracellular parasites 失效用于治疗细胞内寄生虫感染的方法和组合物
公开(公告)号：US5270052A
公开(公告)日：1993-12-14
申请号：US689709
申请日：1991-04-19
CPC分类号： A61K31/70 , A61K9/1271 , C07K14/4737 , C07K14/52 , Y10S436/829
摘要： A method for treating an infection caused by an intracellular parasite in a patient. The method includes administering to the patient liposomes coated with C-reactive protein, wherein the liposomes include phosphatidylcholine or phosphorylcholine.
摘要翻译： 一种治疗患者细胞内寄生虫引起的感染的方法。 该方法包括向患者施用涂有C-反应蛋白的脂质体，其中脂质体包括磷脂酰胆碱或磷酸胆碱。
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