摘要:
The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
摘要:
The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
摘要:
The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
摘要:
Novel compounds composition capable of inhibiting TNFα and having anti immunoinflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.
摘要:
Novel compounds composition capable of inhibiting TNFα and having antiimmunoinflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.
摘要:
A novel solution phase and solid phase synthesis of 4-N-acyl-Δ5-2-oxopiperazine (I) is described via a Ugi four-component condensation of an acid, an ketone or aldehyde, a protected α-aminoaldehyde or α-aminoketone and an isocyanide followed by an N-acyliminium ion cyclization facilitated by an acid, which also cleaves the product from the polymer when the reaction is conducted in the solid phase.
摘要:
Tetra-alkylated phenylenediamine compounds useful as ashless TBN sources for lubricating oil compositions that are compatible with fluoroelastomeric engine seal materials and meet copper corrosion requirements, and lubricating oil compositions containing such phenylenediamine compounds.
摘要:
A plug connector includes an insulative housing (1) including a base portion (10) and a mating portion (12) extending from the base portion in a first direction, a number of contacts (2) received in the insulative housing, and a number of wires (3) including a number of signal wires (31) and a number of power wires (32) respectively electrically connecting with the contacts. The signal wires and the power wires are both arranged to extend along a second direction perpendicular to the first direction of the mating portion. The power wires are arranged into two groups respectively symmetrically arranged relative to the base portion along the second direction and electrically connect to the same contacts.
摘要:
A plug connector includes an insulative housing (1) including a base portion (10) and a mating portion (12) extending from the base portion in a first direction, a number of contacts (2) received in the insulative housing, and a number of wires (3) including a number of signal wires (31) and a number of power wires (32) respectively electrically connecting with the contacts. The signal wires and the power wires are both arranged to extend along a second direction perpendicular to the first direction of the mating portion. The power wires are arranged into two groups respectively symmetrically arranged relative to the base portion along the second direction and electrically connect to the same contacts.
摘要:
A computer-implemented method for extracting peak information including providing a data spectrum, normalizing the data spectrum, binning features for reducing the resolution of the data spectrum and filtering noise from a normalized data spectrum, identifying at least one peak in the normalized data spectrum, performing a baseline correction of the at least one peak, and performing data mining on the at least one peak to determine a pathology.