-
1.发明申请Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors 有权用作丙二酰辅酶A脱羧酶抑制剂的基于氰基胍的唑类化合物公开(公告)号：US20050032824A1
公开(公告)日：2005-02-10
申请号：US10900706
申请日：2004-07-28
申请人： Jie Cheng , Bin Liu , Thomas Arrhenius , Mark Wilson , Alex Nadzan , Gary Lopaschuk , Jason Dyck , Rossy Serafimov
发明人： Jie Cheng , Bin Liu , Thomas Arrhenius , Mark Wilson , Alex Nadzan , Gary Lopaschuk , Jason Dyck , Rossy Serafimov
IPC分类号： A61K31/428 , A61K31/4439 , A61K31/4745 , A61K31/506 , C07D277/70 , C07D417/12
CPC分类号： C07D277/70 , A61K31/428 , A61K31/4439 , A61K31/4745 , A61K31/506 , C07D417/12
摘要： The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
摘要翻译： 本发明提供了使用结构I所示化合物的方法，含有该化合物的药物组合物，以及预防，治疗和治疗由MCD抑制调节的代谢疾病和疾病的方法。 本发明公开的化合物可用于预防，管理和治疗涉及丙二酰辅酶A调节的葡萄糖/脂肪酸代谢途径的疾病。 特别地，这些化合物和含有它们的药物组合物在心血管疾病，糖尿病，癌症和肥胖症的预防，治疗和治疗中被指出。
-
2.发明申请公开(公告)号：US20080070869A1
公开(公告)日：2008-03-20
申请号：US11855984
申请日：2007-09-14
申请人： Thomas Arrhenius , Mi Chen , Jie Fei Cheng , Yujin Huang , Alex Nadzan , Sovouthy Tith , David Wallace , Bin Liu , Masahiro Nishimoto , Gary Lopaschuk , Jason Dyck
发明人： Thomas Arrhenius , Mi Chen , Jie Fei Cheng , Yujin Huang , Alex Nadzan , Sovouthy Tith , David Wallace , Bin Liu , Masahiro Nishimoto , Gary Lopaschuk , Jason Dyck
IPC分类号： A61K31/66 , A61K31/155 , A61K31/185 , A61P3/10 , A61P9/00 , A61P35/00 , A61P3/04 , A61K31/277
CPC分类号： C07D231/06 , A61K31/16 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/44 , A61K31/5375 , C07C33/46 , C07C257/22 , C07C279/18 , C07C307/10 , C07C335/18 , C07D231/14 , C07D233/64 , C07D233/90 , C07D261/04 , C07D261/08 , C07D261/14 , C07D261/18 , C07D295/13 , C07D295/194 , C07D295/21 , C07D295/215 , C07D295/32 , C07D307/52 , C07D401/12 , C07F9/247 , C07F9/4021
摘要： The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.
摘要翻译： 本发明涉及新型化合物（I），其前药和药学上可接受的盐以及含有这样的化合物的药物组合物，其可用于治疗某些代谢疾病和通过抑制酶丙二酰辅酶A脱羧酶（丙二酰 - CoA脱羧酶，MCD）。 特别地，本发明涉及通过抑制丙二酰辅酶A脱羧酶来预防，治疗和治疗心血管疾病，糖尿病，酸中毒，癌症和肥胖的化合物和组合物和方法。
-
3.发明授权Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors 有权用作丙二酰辅酶A脱羧酶抑制剂的基于氰基胍的唑类化合物公开(公告)号：US07786145B2
公开(公告)日：2010-08-31
申请号：US10900706
申请日：2004-07-28
申请人： Jie Fei Cheng , Bin Liu , Thomas Arrhenius , Mark E. Wilson , Alex M. Nadzan , Gary D. Lopaschuk , Jason R. Dyck , Rossy Serafimov
发明人： Jie Fei Cheng , Bin Liu , Thomas Arrhenius , Mark E. Wilson , Alex M. Nadzan , Gary D. Lopaschuk , Jason R. Dyck , Rossy Serafimov
IPC分类号： A61K31/4406 , A61K31/428 , A61K31/4025 , C07D417/12 , C07D277/72 , C07D207/14
CPC分类号： C07D277/70 , A61K31/428 , A61K31/4439 , A61K31/4745 , A61K31/506 , C07D417/12
摘要： The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
摘要翻译： 本发明提供了使用结构I所示化合物的方法，含有该化合物的药物组合物，以及预防，治疗和治疗由MCD抑制调节的代谢疾病和疾病的方法。 本发明公开的化合物可用于预防，管理和治疗涉及丙二酰辅酶A调节的葡萄糖/脂肪酸代谢途径的疾病。 特别地，这些化合物和含有它们的药物组合物在心血管疾病，糖尿病，癌症和肥胖症的预防，治疗和治疗中被指出。
-
公开(公告)号：US07279477B2
公开(公告)日：2007-10-09
申请号：US10466926
申请日：2002-01-22
申请人： Thomas Arrhenius , Mi Chen , Jie Fei Cheng , Yujin Huang , Alex Michael Nadzan , Sovouthy Tith , David Mark Wallace , Bin Liu , Masahiro Nishimoto , Gary D. Lopaschuk , Jason R. Dyck
发明人： Thomas Arrhenius , Mi Chen , Jie Fei Cheng , Yujin Huang , Alex Michael Nadzan , Sovouthy Tith , David Mark Wallace , Bin Liu , Masahiro Nishimoto , Gary D. Lopaschuk , Jason R. Dyck
IPC分类号： A61K31/5375 , C07D265/30
CPC分类号： C07D231/06 , A61K31/16 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/44 , A61K31/5375 , C07C33/46 , C07C257/22 , C07C279/18 , C07C307/10 , C07C335/18 , C07D231/14 , C07D233/64 , C07D233/90 , C07D261/04 , C07D261/08 , C07D261/14 , C07D261/18 , C07D295/13 , C07D295/194 , C07D295/21 , C07D295/215 , C07D295/32 , C07D307/52 , C07D401/12 , C07F9/247 , C07F9/4021
摘要： The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.
摘要翻译： 本发明涉及新型化合物（I），其前药和药学上可接受的盐以及含有这样的化合物的药物组合物，其可用于治疗某些代谢疾病和通过抑制酶丙二酰辅酶A脱羧酶（丙二酰 - CoA脱羧酶，MCD）。 特别地，本发明涉及通过抑制丙二酰辅酶A脱羧酶来预防，治疗和治疗心血管疾病，糖尿病，酸中毒，癌症和肥胖的化合物和组合物和方法。
-
-
-
-
公开(公告)号：US10753941B2
公开(公告)日：2020-08-25
申请号：US14342074
申请日：2012-09-03
申请人： Benzhong Tang , Wei Qin , Jianzhao Liu , Sijie Chen , Tsz Kin Kwok , Bin Liu , Kai Li , Dan Ding , Haibin Shi , Jun Long Geng , Jingzhi Sun , Anjun Qin , Qiuli Zhao
发明人： Benzhong Tang , Wei Qin , Jianzhao Liu , Sijie Chen , Tsz Kin Kwok , Bin Liu , Kai Li , Dan Ding , Haibin Shi , Jun Long Geng , Jingzhi Sun , Anjun Qin , Qiuli Zhao
摘要： The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.
-
公开(公告)号：US20190024246A1
公开(公告)日：2019-01-24
申请号：US14692886
申请日：2015-04-22
申请人： Peidong Yang , Chong Liu , Jinyao Tang , Hao Ming Chen , Bin Liu
发明人： Peidong Yang , Chong Liu , Jinyao Tang , Hao Ming Chen , Bin Liu
摘要： This disclosure provides systems, methods, and apparatus related to solar water splitting. In one aspect, a structure includes a plurality of first nanowires, the plurality of first nanowires comprising an n-type semiconductor or a p-type semiconductor. The structure further includes a second nanowire, the second nanowire comprising the n-type semiconductor or the p-type semiconductor, the second nanowire being a different composition than the plurality of first nanowires. The second nanowire includes a first region and a second region, with the first region having a conductive layer disposed thereon, and each of the plurality of first nanowires being disposed on the conductive layer.
-
公开(公告)号：US09636021B2
公开(公告)日：2017-05-02
申请号：US14740914
申请日：2015-06-16
IPC分类号： A61B5/00 , A61B5/02 , C07D311/30 , G01N33/50 , G01N33/58
CPC分类号： A61B5/0071 , A61B5/02007 , A61B2503/02 , A61B2503/40 , A61K49/0021 , C07D311/30 , G01N33/5088 , G01N33/582 , G01N2333/4603
摘要： Flavonoid compounds that are selective for a protein, a portion or a living cell, or a portion of an organism may be used as biological imaging agents. The flavonoid compounds are useful for methods of imaging organisms such as zebrafish embryos and zebra fish. Flavonoid compounds may also be used to detect protein. Advantageously, flavonoids that selectively bind protein, a portion of a living cell, or a portion of an organism may exhibit a florescence “turn-on” mechanism, where the flavonoids that are selectively bound exhibit a florescence response when excited.
-
-
-
-
-
-
-
-
-
搜索结果
190 条记录 (耗时 0.04 秒)
