公开(公告)号：US07585495B2

公开(公告)日：2009-09-08

申请号：US11251715

申请日：2005-10-17

申请人： John P. O'Brien ,  Hong Wang ,  Antoinette E. Wilkins ,  Ying Wu

发明人： John P. O'Brien ,  Hong Wang ,  Antoinette E. Wilkins ,  Ying Wu

IPC分类号： A61K8/64 ,  A61K8/65 ,  A61K38/00 ,  C12Q1/68 ,  A01N37/18

CPC分类号： A61K8/29 ,  A61K8/64 ,  A61K2800/413 ,  A61K2800/57 ,  A61K2800/94 ,  A61Q1/10 ,  A61Q5/065 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q17/04 ,  B82Y5/00

摘要： A method for identifying shampoo-resistant hair-binding peptides is described. The shampoo-resistant hair-binding peptides bind strongly to hair from a shampoo matrix and are stable therein. Peptide-based benefit agents, such as peptide-based hair conditioners and hair colorants, based on the shampoo-resistant hair binding peptides are described. The peptide-based hair conditioners and hair colorants consist of a shampoo-resistant hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. Hair care and hair coloring product compositions comprising these peptide-based hair conditioners and colorants are also described.

摘要翻译： 描述了一种用于鉴定洗发剂抗性头发结合肽的方法。 洗发剂抗性的头发结合肽与洗发剂基质的头发强烈结合并且在其中是稳定的。 描述了基于洗发剂抗性的头发结合肽的基于肽的有益试剂，例如基于肽的护发素和毛发着色剂。 基于肽的护发素和头发着色剂分别由与头发调理剂或着色剂偶联的洗发剂抗性头发结合肽组成。 还描述了包含这些基于肽的头发调理剂和着色剂的头发护理和头发着色产品组合物。

公开(公告)号：US20080292576A1

公开(公告)日：2008-11-27

申请号：US12144907

申请日：2008-06-24

申请人： HONG WANG ,  Ying Wu ,  John P. O'Brien

发明人： HONG WANG ,  Ying Wu ,  John P. O'Brien

IPC分类号： A61K8/64 ,  C40B30/04 ,  C07K2/00 ,  A61Q5/12 ,  C07K14/00 ,  C07K7/00

CPC分类号： A61Q1/10 ,  A61K8/64 ,  A61Q5/065 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001 ,  C12Q1/6809

摘要： A method for identifying hair conditioner-resistant hair-binding peptides is described. The hair conditioner-resistant hair-binding peptides bind strongly to hair from a hair conditioner matrix and are stable therein. Peptide-based benefit agents, such as hair conditioners and hair colorants, based on the hair conditioner-resistant hair binding peptides are described. The peptide-based hair conditioners and hair colorants consist of a hair conditioner-resistant hair-binding peptide coupled to a hair conditioning agent or a coloring agent, either directly or through an optional spacer. Hair care and hair coloring product compositions comprising these peptide-based hair conditioners and colorants are also described.

摘要翻译： 描述了一种用于鉴定头发护发素抗性的头发结合肽的方法。 头发护发素的头发结合肽强力地与头发调理剂基质的头发结合并且在其中是稳定的。 描述了基于护发素抗性头发结合肽的基于肽的有益剂，例如头发调理剂和头发着色剂。 基于肽的护发素和头发着色剂由直接或通过任选的间隔物与头发调理剂或着色剂偶联的头发护发素抗性发束结合肽组成。 还描述了包含这些基于肽的头发调理剂和着色剂的头发护理和头发着色产品组合物。

公开(公告)号：US07285264B2

公开(公告)日：2007-10-23

申请号：US11389948

申请日：2006-03-27

申请人： John P. O'Brien ,  Hong Wang ,  Ying Wu

发明人： John P. O'Brien ,  Hong Wang ,  Ying Wu

IPC分类号： A61K8/64 ,  A61K38/02 ,  A61Q5/10 ,  C07K2/00

CPC分类号： A61K8/64 ,  A61K2800/42 ,  A61K2800/57 ,  A61K2800/94 ,  A61Q1/02 ,  A61Q3/00 ,  A61Q5/065 ,  A61Q11/00 ,  A61Q19/04 ,  C07K7/06 ,  C07K7/08

摘要： Peptides have been identified that bind with high affinity to body surfaces, such as, hair, skin, nails, teeth, gums, and oral cavity surfaces. Diblock and triblock peptide-based body surface coloring reagents formed by coupling a body surface binding peptide to a pigment binding peptide, either directly or through a spacer, are described. The peptide-based body surface coloring reagents may be used in conjunction with pigments to color body surfaces.

摘要翻译： 已经鉴定出已经以高亲和力结合到身体表面，例如头发，皮肤，指甲，牙齿和口腔表面的肽。 描述了通过直接或通过间隔物将身体表面结合肽偶联到颜料结合肽而形成的二嵌段和基于三嵌段肽的体表着色试剂。 基于肽的体表着色剂可以与颜料结合使用以使身体表面着色。

公开(公告)号：US20100311641A1

公开(公告)日：2010-12-09

申请号：US12837525

申请日：2010-07-16

申请人： JOHN P. O'BRIEN ,  Hong Wang ,  Ying Wu

发明人： JOHN P. O'BRIEN ,  Hong Wang ,  Ying Wu

IPC分类号： A61K38/02 ,  C07K2/00 ,  C07K7/00 ,  C07K14/00 ,  A61Q11/00 ,  A61P31/00

CPC分类号： A61K8/64 ,  A61K2800/43 ,  A61K2800/57 ,  A61K2800/94 ,  A61Q3/00 ,  A61Q5/065 ,  A61Q11/00 ,  A61Q19/04

摘要： Peptides have been identified that bind with high affinity to body surfaces, such as, hair, skin, nails, teeth, gums, and oral cavity surfaces. Peptide-based body surface coloring reagents, preferably tooth coloring reagents, are formed by coupling a tooth binding peptide to a pigment binding peptide, either directly or through a spacer. The peptide-based body coloring reagents may be used in conjunction with pigments to color body surfaces.

摘要翻译： 已经鉴定出已经以高亲和力结合到身体表面，例如头发，皮肤，指甲，牙齿和口腔表面的肽。 通过将牙结合肽直接或通过间隔物偶联到颜料结合肽而形成基于肽的体表着色剂，优选牙齿着色剂。 基于肽的身体着色剂可以与颜料结合使用以使身体表面着色。

公开(公告)号：US20070269394A1

公开(公告)日：2007-11-22

申请号：US11778699

申请日：2007-07-17

申请人： John O'Brien ,  Hong Wang ,  Ying Wu

发明人： John O'Brien ,  Hong Wang ,  Ying Wu

IPC分类号： A61K8/64 ,  C12P21/06 ,  C08G63/91

CPC分类号： A61K8/64 ,  A61K2800/42 ,  A61K2800/57 ,  A61K2800/94 ,  A61Q1/02 ,  A61Q3/00 ,  A61Q5/065 ,  A61Q11/00 ,  A61Q19/04 ,  C07K7/06 ,  C07K7/08

摘要： Peptides have been identified that bind with high affinity to body surfaces, such as, hair, skin, nails, teeth, gums, and oral cavity surfaces. Diblock and triblock peptide-based body surface coloring reagents formed by coupling a body surface binding peptide to a pigment binding peptide, either directly or through a spacer, are described. The peptide-based body surface coloring reagents may be used in conjunction with pigments to color body surfaces.

摘要翻译： 已经鉴定出已经以高亲和力结合到身体表面，例如头发，皮肤，指甲，牙齿和口腔表面的肽。 描述了通过直接或通过间隔物将身体表面结合肽偶联到颜料结合肽而形成的二嵌段和基于三嵌段肽的体表着色试剂。 基于肽的体表着色剂可以与颜料结合使用以使身体表面着色。

公开(公告)号：US20050226839A1

公开(公告)日：2005-10-13

申请号：US11074473

申请日：2005-03-08

申请人： Xueying Huang ,  Ying Wu ,  Hong Wang ,  John O'Brien

发明人： Xueying Huang ,  Ying Wu ,  Hong Wang ,  John O'Brien

IPC分类号： A61K8/29 ,  A61K8/64 ,  A61Q1/10 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q17/04 ,  C07K14/47 ,  A61K7/06 ,  A61K7/11

CPC分类号： A61K8/64 ,  A61K8/29 ,  A61K2800/413 ,  A61K2800/42 ,  A61K2800/57 ,  A61K2800/94 ,  A61Q1/02 ,  A61Q1/10 ,  A61Q3/00 ,  A61Q5/065 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/04 ,  B82Y5/00 ,  C07K7/06 ,  C07K7/08

摘要： Peptides have been identified that bind with high affinity to body surfaces, such as, hair, skin, nails, teeth, gums, corneal tissue, and oral cavity surfaces. Peptide-based body surface reagents formed by coupling a body surface binding peptide to a benefit agent are described. The peptide-based body surface reagents include peptide-based hair conditioners, hair colorants, skin conditioners, skin colorants, nail colorants, and oral care reagents. The peptide-based hair conditioners and hair colorants are comprised of a hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based skin conditioners and skin colorants are comprised of a skin-binding peptide coupled to a skin conditioning agent or a colorant, respectively. The peptide-based nail colorants are comprised of a nail-binding peptide coupled to a coloring agent. The peptide-based oral care reagents are comprised of an oral cavity surface-binding peptide coupled to an oral care benefit agent. In all these compositions, the peptide may be directly coupled to the active agent or the coupling may be via a spacer. Personal care compositions containing these peptide-based body surface reagents are also described.

摘要翻译： 已经鉴定出已经以高亲和力结合身体表面，例如头发，皮肤，指甲，牙齿，牙龈，角膜组织和口腔表面的肽。 描述了通过将身体表面结合肽偶联到有益剂形成的基于肽的体表试剂。 基于肽的体表试剂包括基于肽的头发调理剂，毛发着色剂，皮肤调理剂，皮肤着色剂，指甲着色剂和口腔护理试剂。 基于肽的护发素和毛发着色剂分别由与头发调理剂或着色剂偶联的毛发结合肽组成。 基于肽的皮肤调理剂和皮肤着色剂分别由与皮肤调理剂或着色剂偶联的皮肤结合肽组成。 基于肽的指甲着色剂由与着色剂偶联的指甲结合肽组成。 基于肽的口腔护理试剂由与口腔护理有益剂偶联的口腔表面结合肽组成。 在所有这些组合物中，肽可以直接与活性剂偶联，或者偶联可以经由间隔物。 还描述了含有这些基于肽的体表试剂的个人护理组合物。

公开(公告)号：US20080152612A1

公开(公告)日：2008-06-26

申请号：US11716161

申请日：2007-03-09

申请人： Xueying Huang ,  Ying Wu ,  Hong Wang

发明人： Xueying Huang ,  Ying Wu ,  Hong Wang

IPC分类号： A61K8/64 ,  A61Q5/12

CPC分类号： C07K7/08 ,  A61K8/64 ,  A61K2800/57 ,  A61K2800/94 ,  A61Q3/00 ,  A61Q5/065 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/04 ,  C07K7/06

摘要： Peptides have been identified that bind with high affinity to hair, skin, and nails. Peptide-based hair conditioners, hair colorants, skin conditioners, skin colorants, and nail colorants are described. The peptide-based hair conditioners and hair colorants consist of a hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based skin conditioners and skin colorants consist of a skin-binding peptide coupled to a skin conditioning agent or a colorant, respectively. The peptide-based nail colorants consist of a nail-binding peptide coupled to a coloring agent. In all these compositions, the peptide may be directly coupled to the active agent or the coupling may be via a spacer. Personal care compositions containing these peptide-based conditioners and colorants are also described.

摘要翻译： 已经鉴定出以高亲和力结合头发，皮肤和指甲的肽。 描述了基于肽的护发素，头发着色剂，皮肤调理剂，皮肤着色剂和指甲着色剂。 基于肽的头发调理剂和毛发着色剂分别由与头发调理剂或着色剂偶联的毛发结合肽组成。 基于肽的皮肤调理剂和皮肤着色剂分别由与皮肤调理剂或着色剂偶联的皮肤结合肽组成。 基于肽的指甲着色剂由与着色剂偶联的指甲结合肽组成。 在所有这些组合物中，肽可以直接偶联到活性剂上，或者偶联可以通过间隔物。 还描述了含有这些基于肽的调理剂和着色剂的个人护理组合物。

公开(公告)号：US20070196305A1

公开(公告)日：2007-08-23

申请号：US11359163

申请日：2006-02-22

申请人： Hong Wang ,  Ying Wu ,  John O'Brien

发明人： Hong Wang ,  Ying Wu ,  John O'Brien

IPC分类号： A61Q5/12 ,  C07K7/08 ,  G01N33/566

CPC分类号： A61Q1/10 ,  A61K8/64 ,  A61Q5/065 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001 ,  C12Q1/6809

摘要： A method for identifying hair conditioner-resistant hair-binding peptides is described. The hair conditioner-resistant hair-binding peptides bind strongly to hair from a hair conditioner matrix and are stable therein. Peptide-based benefit agents, such as hair conditioners and hair colorants, based on the hair conditioner-resistant hair binding peptides are described. The peptide-based hair conditioners and hair colorants consist of a hair conditioner-resistant hair-binding peptide coupled to a hair conditioning agent or a coloring agent, either directly or through an optional spacer. Hair care and hair coloring product compositions comprising these peptide-based hair conditioners and colorants are also described.

摘要翻译： 描述了一种用于鉴定头发护发素抗性的头发结合肽的方法。 头发护发素的头发结合肽强力地与头发调理剂基质的头发结合并且在其中是稳定的。 描述了基于护发素抗性头发结合肽的基于肽的有益剂，例如头发调理剂和头发着色剂。 基于肽的护发素和头发着色剂由直接或通过任选的间隔物与头发调理剂或着色剂偶联的头发护发素抗性发束结合肽组成。 还描述了包含这些基于肽的头发调理剂和着色剂的头发护理和头发着色产品组合物。

公开(公告)号：US20060199206A1

公开(公告)日：2006-09-07

申请号：US11359162

申请日：2006-02-22

申请人： Hong Wang ,  Ying Wu ,  John O'Brien

发明人： Hong Wang ,  Ying Wu ,  John O'Brien

IPC分类号： C40B40/10 ,  C40B40/08

CPC分类号： A61K8/64 ,  A61K2800/57 ,  A61K2800/94 ,  A61Q1/02 ,  A61Q5/065 ,  A61Q19/00 ,  G01N33/6845

摘要： A method for identifying skin care composition-resistant skin-binding peptides is described. The skin care composition-resistant skin-binding peptides bind strongly to skin from a skin care composition matrix and are stable therein. Peptide-based skin benefit agents, such as skin conditioners and skin colorants, based on the skin care composition-resistant skin binding peptides are described. The peptide-based skin conditioners and skin colorants consist of skin care composition-resistant skin-binding peptide coupled to a skin conditioning agent or a coloring agent, either directly or through an optional spacer. Skin care and skin coloring product compositions comprising these peptide-based skin conditioners and colorants are also described.

摘要翻译： 描述了一种鉴定皮肤护理组合物抗性皮肤结合肽的方法。 皮肤护理组合物抗性皮肤结合肽从皮肤护理组合物基质强烈地与皮肤结合并且在其中是稳定的。 描述了基于皮肤护理组合物抗性皮肤结合肽的基于肽的皮肤有益剂，例如皮肤调理剂和皮肤着色剂。 基于肽的皮肤调理剂和皮肤着色剂由直接或通过任选的间隔物与皮肤调理剂或着色剂偶联的护肤组合物抗性皮肤结合肽组成。 还描述了包含这些基于肽的皮肤调理剂和着色剂的皮肤护理和皮肤着色产品组合物。

公开(公告)号：US20050050656A1

公开(公告)日：2005-03-10

申请号：US10935642

申请日：2004-09-07

申请人： Xueying Huang ,  Ying Wu ,  Hong Wang

发明人： Xueying Huang ,  Ying Wu ,  Hong Wang

IPC分类号： A61K8/64 ,  A61Q3/00 ,  A61Q3/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/04 ,  A61K7/06 ,  A61K7/11 ,  A61K7/13

CPC分类号： C07K7/08 ,  A61K8/64 ,  A61K2800/57 ,  A61K2800/94 ,  A61Q3/00 ,  A61Q5/065 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/04 ,  C07K7/06

摘要： Peptides have been identified that bind with high affinity to hair, skin, and nails. Peptide-based hair conditioners, hair colorants, skin conditioners, skin colorants, and nail colorants based are described. The peptide-based hair conditioners and hair colorants consist of a hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based skin conditioners and skin colorants consist of a skin-binding peptide coupled to a skin conditioning agent or a colorant, respectively. The peptide-based nail colorants consist of a nail-binding peptide coupled to a coloring agent. In all these compositions, the peptide may be directly coupled to the active agent or the coupling may be via a spacer. Personal care compositions containing these peptide-based conditioners and colorants are also described.

摘要翻译： 已经鉴定出以高亲和力结合头发，皮肤和指甲的肽。 描述了基于肽的护发素，头发着色剂，皮肤调理剂，皮肤着色剂和指甲着色剂。 基于肽的头发调理剂和毛发着色剂分别由与头发调理剂或着色剂偶联的毛发结合肽组成。 基于肽的皮肤调理剂和皮肤着色剂分别由与皮肤调理剂或着色剂偶联的皮肤结合肽组成。 基于肽的指甲着色剂由与着色剂偶联的指甲结合肽组成。 在所有这些组合物中，肽可以直接与活性剂偶联，或者偶联可以经由间隔物。 还描述了含有这些基于肽的调理剂和着色剂的个人护理组合物。