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公开(公告)号：US20100311641A1
公开(公告)日：2010-12-09
申请号：US12837525
申请日：2010-07-16
申请人： JOHN P. O'BRIEN , Hong Wang , Ying Wu
发明人： JOHN P. O'BRIEN , Hong Wang , Ying Wu
CPC分类号： A61K8/64 , A61K2800/43 , A61K2800/57 , A61K2800/94 , A61Q3/00 , A61Q5/065 , A61Q11/00 , A61Q19/04
摘要： Peptides have been identified that bind with high affinity to body surfaces, such as, hair, skin, nails, teeth, gums, and oral cavity surfaces. Peptide-based body surface coloring reagents, preferably tooth coloring reagents, are formed by coupling a tooth binding peptide to a pigment binding peptide, either directly or through a spacer. The peptide-based body coloring reagents may be used in conjunction with pigments to color body surfaces.
摘要翻译： 已经鉴定出已经以高亲和力结合到身体表面，例如头发，皮肤，指甲，牙齿和口腔表面的肽。 通过将牙结合肽直接或通过间隔物偶联到颜料结合肽而形成基于肽的体表着色剂，优选牙齿着色剂。 基于肽的身体着色剂可以与颜料结合使用以使身体表面着色。
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公开(公告)号：US20100189670A1
公开(公告)日：2010-07-29
申请号：US12754630
申请日：2010-04-06
申请人： WILLIAM A. BECK , JOHN P. O'BRIEN , HONG WANG
发明人： WILLIAM A. BECK , JOHN P. O'BRIEN , HONG WANG
IPC分类号： A61K8/64 , C07K14/00 , A61K8/89 , A61K8/92 , A61K8/98 , A61K8/87 , A61Q5/12 , A61Q5/10 , A61Q5/00 , A61Q19/00 , A61Q1/02
CPC分类号： A61K8/64 , A61K2800/94 , A61Q3/00 , A61Q5/10 , A61Q17/005 , A61Q17/04 , A61Q19/00 , A61Q19/04 , C07K2319/00
摘要： Methods are provided for enhancing the longevity of the binding of various benefit agents to hair and skin. Applications of traditional and non-traditional colorants and conditioners to hair and skin are amended with compositions of hair or skin-binding peptides respectively. The presence of the hair or skin-binding peptide compositions act to increase the longevity of the applied colorant or conditioner on the hair or skin.
摘要翻译： 提供了用于增强各种有益剂与头发和皮肤结合的寿命的方法。 传统和非传统着色剂和调理剂对毛发和皮肤的应用分别用头发或皮肤结合肽的组合物修饰。 头发或皮肤结合肽组合物的存在用于增加所施用的着色剂或护发素在头发或皮肤上的寿命。
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公开(公告)号：US20080280810A1
公开(公告)日：2008-11-13
申请号：US11877692
申请日：2007-10-24
申请人： JOHN P. O'BRIEN , Hong Wang
发明人： JOHN P. O'BRIEN , Hong Wang
CPC分类号： C07K7/08 , A61K8/64 , A61K2800/94 , A61Q3/00 , A61Q3/02 , A61Q5/065 , A61Q5/12 , A61Q11/00 , A61Q19/00 , C07K7/06 , C07K14/001
摘要： Peptides having affinity for a body surface are provided. The peptides comprise a body surface-binding peptide block and at least one charged, terminal peptide block. These peptides have enhanced affinity for body surfaces and deposit more rapidly onto body surfaces than peptides lacking the charged terminal groups. The peptides are used to deliver and/or to seal benefit agents to body surfaces, thereby providing enhanced durability.
摘要翻译： 提供了对身体表面具有亲和力的肽。 肽包含身体表面结合肽嵌段和至少一个带电荷的末端肽嵌段。 这些肽对于身体表面具有增强的亲和性，并且比缺乏带电端基的肽更快地沉积在体表上。 这些肽用于将有益剂递送和/或密封到身体表面，从而提供增强的耐久性。
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公开(公告)号：US20090143295A1
公开(公告)日：2009-06-04
申请号：US12273778
申请日：2008-11-19
CPC分类号： C07K14/463 , A61K31/085 , A61K31/60 , A61K47/64 , C07K7/06 , C07K7/08 , C07K2319/01
摘要： Peptide-based antiacne reagents, formed by coupling a skin-binding peptide with an antiacne agent, are described. The skin-binding peptide portion of the peptide-based antiacne reagent binds strongly to the skin, thus keeping the antiacne agent coupled to the skin for a long lasting effect. Skin care compositions comprising the peptide-based antiacne reagents are also provided as well as a method of treating or preventing skin acne.
摘要翻译： 描述了通过将皮肤结合肽与抗痤疮剂偶联而形成的基于肽的抗痤疮试剂。 基于肽的抗痤疮剂的皮肤结合肽部分强烈地与皮肤结合，从而保持抗皮肤剂与皮肤偶联以获得持久的效果。 还提供了包含基于肽的抗痤疮试剂的护肤组合物以及治疗或预防皮肤痤疮的方法。
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5.发明申请公开(公告)号：US20100186633A1
公开(公告)日：2010-07-29
申请号：US12754636
申请日：2010-04-06
申请人： JOHN P. O'BRIEN , Jianjun Yang
发明人： JOHN P. O'BRIEN , Jianjun Yang
IPC分类号： C09B67/22
CPC分类号： C07K7/06 , B01F17/005 , B01F17/0057 , C07K7/08 , C09D5/027 , C09D7/45 , C09D11/037
摘要： Peptides have been identified that bind with high affinity to common ink pigments and to various print media, including paper and fabrics. These peptides were used to prepare diblock and triblock dispersants for coating applications, including ink jet printing, and diblock polymers for treating paper and fabrics. The diblock dispersants consist of a pigment-binding peptide coupled to a hydrophilic linker, a pigment-binding peptide coupled to a print medium-binding peptide or a print medium-binding peptide coupled to a hydrophobic linker. The diblock polymers consist of a print medium-binding peptide coupled to a hydrophilic linker or a benefit agent. The triblock dispersants consist of a pigment-binding peptide coupled to a hydrophilic linker, which is coupled to a print medium-binding peptide.
摘要翻译： 已经鉴定了与常见的油墨颜料和各种印刷介质（包括纸和织物）以高亲和力结合的肽。 这些肽用于制备用于涂布应用的二嵌段和三嵌段分散剂，包括喷墨印刷和用于处理纸和织物的二嵌段聚合物。 二嵌段分散剂由耦合到亲水接头的颜料结合肽，偶联至印刷介质结合肽的颜料结合肽或与疏水性连接体偶联的印刷介质结合肽组成。 二嵌段聚合物由与亲水接头或有益试剂偶联的印迹介质结合肽组成。 三嵌段分散剂由与亲水接头偶联的颜料结合肽组成，其与印刷介质结合肽偶联。
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公开(公告)号：US20130244287A1
公开(公告)日：2013-09-19
申请号：US13606373
申请日：2012-09-07
申请人： JOHN P. O'BRIEN , Mark S. Payne
发明人： JOHN P. O'BRIEN , Mark S. Payne
IPC分类号： C12P19/18
CPC分类号： C12P19/18 , C08B37/0009 , C08L5/00 , C12N9/1051 , C12P19/04
摘要： A process for enzymatic preparation of a highly linear poly(α 1, 3 glucan) from sucrose is disclosed. The glucosyltransferase enzyme (gtfJ) from Streptococcus salivarius is used to convert sucrose to a highly linear poly(α 1, 3 glucan) in high titers. Hydrolyzed poly(α 1, 3 glucan) is used as the primer for the gtfJ enzyme reaction resulting in the formation of highly linear poly(α 1, 3 glucan).
摘要翻译： 公开了从蔗糖酶制备高度线性的聚（α1,3葡聚糖）的方法。 来自唾液链球菌的葡糖基转移酶（gtfJ）用于以高滴度将蔗糖转化为高度线性的聚（α1,3葡聚糖）。 水解的聚（α1,3葡聚糖）用作gtfJ酶反应的引物，导致形成高度线性的聚（α1,3葡聚糖）。
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公开(公告)号：US20110274639A1
公开(公告)日：2011-11-10
申请号：US12945969
申请日：2010-11-15
申请人： JOHN P. O'BRIEN
发明人： JOHN P. O'BRIEN
CPC分类号： A61K8/64 , A61K8/19 , A61K8/25 , A61K2800/57 , A61K2800/621 , A61K2800/94 , A61Q5/065
摘要： Peptide-based coloring reagents are described in which a body surface-binding peptide is covalently attached to a pigment, the surface of which is coated with a layer containing at least 3 atom percent of silicon. The peptide-based coloring reagents are useful for coloring body surfaces such as hair, skin, nails, and teeth.
摘要翻译： 描述了基于肽的着色剂，其中体表面结合肽共价连接到颜料上，其表面涂覆有含有至少3原子％硅的层。 基于肽的着色剂可用于使身体表面如头发，皮肤，指甲和牙齿着色。
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