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    System and method for distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device
    3.
    发明授权
    System and method for distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device 有权
    使用可植入医疗器械区分心脏缺血，低血糖和高血糖的系统和方法

    公开(公告)号：US08180441B2

    公开(公告)日：2012-05-15

    申请号：US12360822

    申请日：2009-01-27

    申请人： Jong Gill ,  Peter Boileau ,  Rupinder Bharmi ,  Xiaoyi Min ,  Joseph J. Florio ,  Michael E. Benser ,  Gene A. Bornzin

    发明人： Jong Gill ,  Peter Boileau ,  Rupinder Bharmi ,  Xiaoyi Min ,  Joseph J. Florio ,  Michael E. Benser ,  Gene A. Bornzin

    IPC分类号： A61B5/0468

    CPC分类号： A61N1/3962 ,  A61B5/0452 ,  A61B5/0468 ,  A61B5/14532 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36557 ,  A61N1/3925

    摘要： Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.

    摘要翻译： 描述了基于心内电描记图（IEGM）信号检测缺血，低血糖或高血糖的技术。 基于QRS复合体与T波结束（QTmax）之间的间隔的缩短单独或与ST段抬高的变化相结合来检测局部缺血。 或者，基于ST段抬高的变化结合QRS复合体与T波结束（QTend）之间的间隔的最小变化来检测局部缺血。 基于ST段抬高的变化以及QTmax或QTend的延长来检测低血糖。 基于ST段抬高的变化以及QTmax和QTend中的最小变化来检测高血糖。 通过利用QTmax和QTend与ST段抬高相结合，可以将由低/高血糖引起的ST段抬高的变化与缺血引起的变化进行适当区分。

    Systems and methods for distinguishing cardiac ischemia from systemic influences on IEGM morphology using an implantable medical device
    4.
    发明授权
    Systems and methods for distinguishing cardiac ischemia from systemic influences on IEGM morphology using an implantable medical device 有权
    使用可植入医疗器械区分心脏缺血与对IEGM形态的全身影响的系统和方法

    公开(公告)号：US08265739B1

    公开(公告)日：2012-09-11

    申请号：US12016166

    申请日：2008-01-17

    申请人： Peter Boileau ,  Xiaoyi Min ,  Jong Gill ,  Rupinder Bharmi ,  Joseph J. Florio ,  Michael E. Benser ,  Gene A. Bornzin

    发明人： Peter Boileau ,  Xiaoyi Min ,  Jong Gill ,  Rupinder Bharmi ,  Joseph J. Florio ,  Michael E. Benser ,  Gene A. Bornzin

    IPC分类号： A61B5/0402 ,  A61B5/0428 ,  A61B5/0452

    CPC分类号： A61B5/0452 ,  A61B5/0428 ,  A61B5/0468 ,  A61B5/0472 ,  A61B5/14532 ,  A61B5/7282

    摘要： Techniques are provided for use in a pacemaker or implantable cardioverter/defibrillator (ICD) for distinguishing cardiac ischemia from other conditions affecting the morphology of electrical cardiac signals sensed within a patient, such as hypoglycemia, hyperglycemia or other systemic conditions. In one example, the device detects changes in morphological features of cardiac signals indicative of possible cardiac ischemia within the patient, such as changes in ST segment elevation within an intracardiac electrogram (IEGM). The device determines whether the changes in the morphological features are the result of spatially localized changes within a portion of the heart and then distinguishes cardiac ischemia from other conditions affecting the morphology of electrical cardiac signals based on that determination. In another example, the device exploits the interval between the peak of a T-wave (Tmax) and the end of the T-wave (Tend). A significant increase in the Tend−Tmax interval is indicative of ischemia rather than a systemic condition.

    摘要翻译： 提供了用于起搏器或植入式心律转复除颤器（ICD）的技术，用于区分心脏缺血与影响患者体内感测的电心电信号形态的其他状况，如低血糖，高血糖或其他系统性疾病。 在一个示例中，该装置检测指示患者可能的心脏缺血的心脏信号的形态学特征的变化，例如心内电描记图（IEGM）内ST段抬高的变化。 该装置确定形态特征的变化是否是心脏部分内的空间局部变化的结果，然后基于该确定将心脏缺血与影响电心电信号形态的其它状况区分开。 在另一个例子中，器件利用了T波峰值（Tmax）和T波（Tend）结束之间的间隔。 Tend-Tmax间期的显着增加指示缺血而不是全身状况。

    SYSTEM AND METHOD FOR DISTINGUISHING AMONG CARDIAC ISCHEMIA, HYPOGLYCEMIA AND HYPERGLYCEMIA USING AN IMPLANTABLE MEDICAL DEVICE
    5.
    发明申请
    SYSTEM AND METHOD FOR DISTINGUISHING AMONG CARDIAC ISCHEMIA, HYPOGLYCEMIA AND HYPERGLYCEMIA USING AN IMPLANTABLE MEDICAL DEVICE 审中-公开
    使用可植入医疗器械评估心脏病，高血压和高血压的系统和方法

    公开(公告)号：US20120197149A1

    公开(公告)日：2012-08-02

    申请号：US13444733

    申请日：2012-04-11

    申请人： Jong Gill ,  Peter Boileau ,  Rupinder Bharmi ,  Xiaoyi Min ,  Joseph J. Florio ,  Michael E. Benser ,  Gene A. Bornzin

    发明人： Jong Gill ,  Peter Boileau ,  Rupinder Bharmi ,  Xiaoyi Min ,  Joseph J. Florio ,  Michael E. Benser ,  Gene A. Bornzin

    IPC分类号： A61B5/0468 ,  A61B5/0452

    CPC分类号： A61N1/3962 ,  A61B5/0452 ,  A61B5/0468 ,  A61B5/14532 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36557 ,  A61N1/3925

    摘要： Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.

    摘要翻译： 描述了基于心内电描记图（IEGM）信号检测缺血，低血糖或高血糖的技术。 基于QRS复合体与T波结束（QTmax）之间的间隔的缩短单独或与ST段抬高的变化相结合来检测局部缺血。 或者，基于ST段抬高的变化结合QRS复合体与T波结束（QTend）之间的间隔的最小变化来检测局部缺血。 基于ST段抬高的变化以及QTmax或QTend的延长来检测低血糖。 基于ST段抬高的变化以及QTmax和QTend中的最小变化来检测高血糖。 通过利用QTmax和QTend与ST段抬高相结合，可以将由低/高血糖引起的ST段抬高的变化与缺血引起的变化进行适当区分。

    System and Method for Distinguishing Among Cardiac Ischemia, Hypoglycemia and Hyperglycemia Using an Implantable Medical Device
    6.
    发明申请
    System and Method for Distinguishing Among Cardiac Ischemia, Hypoglycemia and Hyperglycemia Using an Implantable Medical Device 有权
    使用植入式医疗器械区分心脏缺血，低血糖和高血糖的系统和方法

    公开(公告)号：US20090177104A1

    公开(公告)日：2009-07-09

    申请号：US12360822

    申请日：2009-01-27

    申请人： Jong Gill ,  Peter Boileau ,  Rupinder Bharmi ,  Xiaoyi Min ,  Joseph J. Florio ,  Michael E. Benser ,  Gene A. Bornzin

    发明人： Jong Gill ,  Peter Boileau ,  Rupinder Bharmi ,  Xiaoyi Min ,  Joseph J. Florio ,  Michael E. Benser ,  Gene A. Bornzin

    IPC分类号： A61B5/0472

    CPC分类号： A61N1/3962 ,  A61B5/0452 ,  A61B5/0468 ,  A61B5/14532 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36557 ,  A61N1/3925

    摘要： Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.

    摘要翻译： 描述了基于心内电描记图（IEGM）信号检测缺血，低血糖或高血糖的技术。 基于QRS复合体与T波结束（QTmax）之间的间隔的缩短单独或与ST段抬高的变化相结合来检测局部缺血。 或者，基于ST段抬高的变化结合QRS复合体与T波结束（QTend）之间的间隔的最小变化来检测局部缺血。 基于ST段抬高的变化以及QTmax或QTend的延长来检测低血糖。 基于ST段抬高的变化以及QTmax和QTend中的最小变化来检测高血糖。 通过利用QTmax和QTend与ST段抬高相结合，可以将由低/高血糖引起的ST段抬高的变化与缺血引起的变化进行适当区分。

    CARDIAC ANALYSIS SYSTEM FOR COMPARING CLINICAL AND INDUCED VENTRICULAR TACHYCARDIA EVENTS
    8.
    发明申请
    CARDIAC ANALYSIS SYSTEM FOR COMPARING CLINICAL AND INDUCED VENTRICULAR TACHYCARDIA EVENTS 有权
    用于比较临床和诱发的心室TACHYCARDIA事件的心脏分析系统

    公开(公告)号：US20110282226A1

    公开(公告)日：2011-11-17

    申请号：US12820879

    申请日：2010-06-22

    申请人： Michael E. Benser ,  Gene A. Bornzin ,  Euljoon Park ,  Kyungmoo Ryu ,  Michael Hardage

    发明人： Michael E. Benser ,  Gene A. Bornzin ,  Euljoon Park ,  Kyungmoo Ryu ,  Michael Hardage

    IPC分类号： A61B5/04

    CPC分类号： A61B5/0422 ,  A61B5/0031 ,  A61B5/0464 ,  A61B18/1492 ,  A61N1/3621

    摘要： A cardiac analysis system is provided that includes an implantable medical device (IMD), at least one sensor, and an external device. The IMD has electrodes positioned proximate to a heart that sense first cardiac signals of the heart and associated with a clinical ventricular tachycardia (VT) event and second cardiac signals associated with an induced VT event. The sensor measures first and second cardiac parameters of the heart associated with the clinical and induced VT events, respectively. The external device is configured to receive the first and second cardiac signals associated with the clinical and the induced VT events and the first and second cardiac parameters associated with the clinical and the induced VT events. The external device compares the first and second cardiac signals and compares the first and second cardiac parameters to determine if the clinical and induced VT events are a common type of VT event.

    摘要翻译： 提供了包括可植入医疗装置（IMD），至少一个传感器和外部装置的心脏分析系统。 IMD具有位于心脏附近的电极，其感测心脏的第一心脏信号并与临床心室性心动过速（VT）事件和与诱导的VT事件相关联的第二心脏信号相关联。 该传感器分别测量与临床和诱导VT事件相关的心脏的第一和第二心脏参数。 外部设备被配置为接收与临床和诱导的VT事件相关联的第一和第二心脏信号以及与临床和诱导的VT事件相关联的第一和第二心脏参数。 外部设备比较第一和第二心脏信号，并比较第一和第二心脏参数以确定临床和诱导的VT事件是否是常见类型的VT事件。

    Cardiac analysis system for comparing clinical and induced ventricular tachycardia events
    9.
    发明授权
    Cardiac analysis system for comparing clinical and induced ventricular tachycardia events 有权
    用于比较临床和诱导性室性心动过速事件的心脏分析系统

    公开(公告)号：US08634902B2

    公开(公告)日：2014-01-21

    申请号：US12820879

    申请日：2010-06-22

    申请人： Michael E. Benser ,  Gene A. Bornzin ,  Euljoon Park ,  Kyungmoo Ryu ,  Michael Hardage

    发明人： Michael E. Benser ,  Gene A. Bornzin ,  Euljoon Park ,  Kyungmoo Ryu ,  Michael Hardage

    IPC分类号： A61B5/04

    CPC分类号： A61B5/0422 ,  A61B5/0031 ,  A61B5/0464 ,  A61B18/1492 ,  A61N1/3621

    摘要： A cardiac analysis system is provided that includes an implantable medical device (IMD), at least one sensor, and an external device. The IMD has electrodes positioned proximate to a heart that sense first cardiac signals of the heart and associated with a clinical ventricular tachycardia (VT) event and second cardiac signals associated with an induced VT event. The sensor measures first and second cardiac parameters of the heart associated with the clinical and induced VT events, respectively. The external device is configured to receive the first and second cardiac signals associated with the clinical and the induced VT events and the first and second cardiac parameters associated with the clinical and the induced VT events. The external device compares the first and second cardiac signals and compares the first and second cardiac parameters to determine if the clinical and induced VT events are a common type of VT event.

    摘要翻译： 提供了包括可植入医疗装置（IMD），至少一个传感器和外部装置的心脏分析系统。 IMD具有位于心脏附近的电极，其感测心脏的第一心脏信号并与临床心室性心动过速（VT）事件和与诱导的VT事件相关联的第二心脏信号相关联。 该传感器分别测量与临床和诱导VT事件相关的心脏的第一和第二心脏参数。 外部设备被配置为接收与临床和诱导的VT事件相关联的第一和第二心脏信号以及与临床和诱导的VT事件相关联的第一和第二心脏参数。 外部设备比较第一和第二心脏信号，并比较第一和第二心脏参数以确定临床和诱导的VT事件是否是常见类型的VT事件。

    Implantable cardiac stimulation device providing reduced defibrillation thresholds and method
    10.
    发明授权
    Implantable cardiac stimulation device providing reduced defibrillation thresholds and method 有权
    植入式心脏刺激装置提供降低的除颤阈值和方法

    公开(公告)号：US07856266B1

    公开(公告)日：2010-12-21

    申请号：US11756283

    申请日：2007-05-31

    申请人： Gene A. Bornzin ,  Michael E. Benser ,  Euljoon Park ,  Taraneh Ghaffari Farazi

    发明人： Gene A. Bornzin ,  Michael E. Benser ,  Euljoon Park ,  Taraneh Ghaffari Farazi

    IPC分类号： A61N1/39

    CPC分类号： A61N1/3962 ,  A61N1/3622 ,  A61N1/36521 ,  A61N1/3943

    摘要： An implantable cardiac defibrillation device provides pre-shock stimuli to reduce the defibrillation threshold (DFT). The device includes an arrhythmia detector that detects fibrillation of a fibrillating chamber of a heart and a pulse generator that provides a fibrillation therapy output responsive to the arrhythmia detector detecting fibrillation of the fibrillating chamber of the heart. The therapy output includes a defibrillating shock having an output magnitude exceeding a temporary defibrillation threshold of the fibrillating chamber and at least one pre-defibrillating shock output pulse that reduces an initial defibrillation threshold of the fibrillating chamber to the temporary defibrillation threshold. An electrode system having at least two defibrillation electrodes delivers both the at least one pre-defibrillating shock output pulse to the heart and the defibrillating shock to the fibrillating chamber of the heart.

    摘要翻译： 植入式心脏除颤装置提供预冲击刺激以减少除颤阈值（DFT）。 该装置包括心律失常检测器，其检测心脏的原纤化室的原纤维和脉冲发生器，其提供响应于心律失常检测器检测心脏原纤化室的纤颤的原纤维化治疗输出。 治疗输出包括具有超过原纤化室的暂时除颤阈值的输出量值的至少一个除纤颤前冲击输出脉冲，其将原纤化室的初始除颤阈值降低到临时除颤阈值。 具有至少两个除颤电极的电极系统将至少一个除颤前的冲击输出脉冲和心脏的去纤维化颤动传递给心脏的原纤维室。