公开(公告)号：US5762904A

公开(公告)日：1998-06-09

申请号：US786617

申请日：1997-01-17

申请人： Junichi Okada ,  Smadar Cohen ,  Robert S. Langer

发明人： Junichi Okada ,  Smadar Cohen ,  Robert S. Langer

IPC分类号： A61K9/127 ,  A61K39/00 ,  A61M36/12

CPC分类号： A61K9/1273 ,  Y10S424/812 ,  Y10T428/2984

摘要： Polymerized liposomes, methods of preparing the polymerized liposomes and incorporating biologically active substances within the polymerized liposomes, and methods of administering polymerized liposomes containing a biologically active substance to be delivered to a patient are disclosed. The polymerized liposomes are prepared by polymerizing double bond-containing liposomes. The polymerization can be initiated with a source of radiation and/or a free radical initiator. Biologically active substances can be incorporated into both the hydrophilic and hydrophobic layers of the liposomes, either during or after polymerization. The polymerized liposomes can be administered orally to a patient in need of the biologically active substance to be delivered. Examples demonstrate enhanced stability.

摘要翻译： 聚合的脂质体，制备聚合的脂质体并将生物活性物质并入聚合的脂质体内的方法，以及施用含有待递送给患者的生物活性物质的聚合脂质体的方法。 通过聚合含双键的脂质体制备聚合的脂质体。 可以用辐射源和/或自由基引发剂引发聚合。 在聚合过程中或之后，生物活性物质可以并入脂质体的亲水层和疏水层中。 聚合的脂质体可以口服给予需要递送的生物活性物质的患者。 实例表明增强的稳定性。

公开(公告)号：US08963070B2

公开(公告)日：2015-02-24

申请号：US14110013

申请日：2012-04-03

申请人： Junichi Okada ,  Kouichi Kobayashi ,  Fumitaka Kume

发明人： Junichi Okada ,  Kouichi Kobayashi ,  Fumitaka Kume

IPC分类号： G01D18/00 ,  G12B13/00 ,  G01J3/42 ,  G01N21/3563 ,  G01N21/27

CPC分类号： G01J3/42 ,  G01N21/274 ,  G01N21/3563

摘要： The present invention provides a method for making it possible to easily and simply measure approximate concentration of substitutional carbon impurities in a desired position in a polycrystalline silicon rod. A polycrystalline silicon plate is sliced out from a polycrystalline silicon rod and both surfaces of the polycrystalline silicon plate are mirror-polished to reduce the polycrystalline silicon plate to thickness of 2.12±0.01 mm. A calibration curve is created according to an infrared absorption spectroscopy and on the basis of a standard measurement method using a single crystal silicon standard sample having known substitutional carbon concentration and thickness of 2.00±0.01 mm, an infrared absorption spectrum in a frequency domain including an absorption zone peak of substitutional carbon of the polycrystalline silicon plate after the mirror polishing is calculated under conditions same as conditions during the calibration curve creation, and substitutional carbon concentration is calculated without performing thickness correction.

摘要翻译： 本发明提供了一种使得可以容易且简单地测量多晶硅棒中期望位置中的取代碳杂质的近似浓度的方法。 将多晶硅板从多晶硅棒切出，并将多晶硅板的两个表面进行镜面抛光以将多晶硅板的厚度减小到2.12±0.01mm。 根据红外吸收光谱法和基于使用具有已知的取代碳浓度和厚度为2.00±0.01mm的单晶硅标准样品的标准测量方法产生校准曲线，在频域中的红外吸收光谱包括 在与校准曲线生成期间的条件相同的条件下计算镜面抛光后的多晶硅板的取代碳的吸收峰的峰值，并且计算替代碳浓度而不进行厚度校正。

公开(公告)号：US20110288834A1

公开(公告)日：2011-11-24

申请号：US13104495

申请日：2011-05-10

申请人： Takashi Yamazaki ,  Yoshimasa Kadooka ,  Toshiaki Hisada ,  Seiryo Sugiura ,  Takumi Washio ,  Junichi Okada

发明人： Takashi Yamazaki ,  Yoshimasa Kadooka ,  Toshiaki Hisada ,  Seiryo Sugiura ,  Takumi Washio ,  Junichi Okada

IPC分类号： G06F17/10

CPC分类号： G06F17/5009 ,  G06F17/5018 ,  G06F2217/16

摘要： A fluid structure interaction simulation method includes a graph information forming process to form graph information of nodes obtained by discretising a computing region for each of a fluid and a structure that are represented by meshes, and a main time development loop process to simulate a physical phenomenon. The loop process includes arranging IMEs (Interaction Mediating Elements) that move with a displacement of the structure, on a boundary of the structure, defining, within the IME, correcting functions of a pressure and a velocity of the fluid that interact with the pressure and the velocity of the fluid and the displacement of the structure, and executing a simulation based on the correcting functions, in a state in which the meshes of the fluid are mismatched to the meshes of the structure.

摘要翻译： 流体结构相互作用模拟方法包括图形信息形成处理，以形成通过离散流体和由网格表示的结构中的每一个离散计算区域获得的节点的图形信息，以及用于模拟物理现象的主要时间开发循环过程 。 循环过程包括排列与结构位移一起移动的IME（交互中介元素），在该结构的边界上，在IME内限定与压力相互作用的流体的压力和速度的校正函数，以及 流体的速度和结构的位移，并且在流体的网格与结构的网格不匹配的状态下，基于校正功能执行模拟。

公开(公告)号：US07930826B2

公开(公告)日：2011-04-26

申请号：US11930424

申请日：2007-10-31

申请人： Koji Inoue ,  Yasushi Watanabe ,  Koji Marumo ,  Junichi Okada

发明人： Koji Inoue ,  Yasushi Watanabe ,  Koji Marumo ,  Junichi Okada

IPC分类号： B21D53/88 ,  B21D41/02 ,  B21D41/04 ,  B21C37/30

CPC分类号： B62D1/16 ,  B21K1/12 ,  B21K1/762 ,  B21K1/763 ,  B21K21/16 ,  B62D1/20 ,  F16D1/0864 ,  F16D2250/00 ,  Y10T29/49622 ,  Y10T29/49805 ,  Y10T29/49995

摘要： When an outer circumference of a clamping portion 25 and an outer circumference of a circular outer circumference 26 are restrained by a die 6 while inserting a non-circular punch 5 into a circular hole 28, paddings 27, 27 are pressed by a semi-circular inner circumference of the die 6 to thereby be forced into interior of the circular hole 28. The volume of the paddings 27, 27 is set to be substantially the same as a volume obtained by subtracting the volume of a non-circular hole 23 in an extension shaft 2 from the volume of the circular hole 28. The circular hole 28 is deformed, and the paddings 27, 27 forced into the circular hole 28 abut with inclined planes 52, 52 of the punch 5, whereby the non-circular hole 23 is formed in the extension shaft 2.

摘要翻译： 当将非圆形冲头5插入圆形孔28中时，夹持部25的外周和圆形外周26的外周被模具6约束，将填充物27,27按半圆 模具6的内周，从而被迫进入圆形孔28的内部。填充物27,27的体积被设定为与通过减去非圆形孔23的体积而获得的体积基本相同 延伸轴2从圆形孔28的体积变形。圆形孔28变形，被迫进入圆形孔28的垫圈27,27与冲头5的倾斜平面52,52抵接，由此非圆形孔23 形成在延伸轴2中。

公开(公告)号：US07735359B2

公开(公告)日：2010-06-15

申请号：US11795081

申请日：2005-11-14

申请人： Shuichi Umezawa ,  Junichi Okada

发明人： Shuichi Umezawa ,  Junichi Okada

IPC分类号： G01M15/00

CPC分类号： G01M15/14 ,  F02C9/28 ,  F02C9/44 ,  F05D2270/30 ,  F05D2270/301 ,  F05D2270/303 ,  F05D2270/304 ,  Y02E20/16

摘要： A process quantity measurement method with which an engine output is accurately measured in a relatively simple manner. Torque of an engine is measured based on the amount of torsion of the output shaft of the engine, and an engine output is obtained based on the measured torque. On the other hand, an engine output is calculated based on input and output heat quantity, and a difference between the engine output based on the torque and the engine output based on the input and output heat quantity is obtained in advance. When the engine is operated, the previously obtained difference is added to the engine output that is based on the calculated input and output heat quantity to obtain the engine output.

摘要翻译： 以相对简单的方式准确地测量发动机输出的过程量测量方法。 发动机的扭矩基于发动机的输出轴的扭转量来测量，并且基于所测量的扭矩获得发动机输出。 另一方面，基于输入和输出热量计算发动机输出，并且预先获得基于输入和输出热量的基于扭矩的发动机输出和发动机输出之间的差。 当发动机运转时，将先前获得的差值加到基于所计算的输入和输出热量的发动机输出中以获得发动机输出。

公开(公告)号：US07488955B2

公开(公告)日：2009-02-10

申请号：US11726577

申请日：2007-03-22

申请人： Junichi Okada ,  Makio Ueno ,  Yasunari Matsukawa

发明人： Junichi Okada ,  Makio Ueno ,  Yasunari Matsukawa

IPC分类号： G02B21/06

CPC分类号： G01N21/6458

摘要： The invention provides a multiphoton-excitation observation apparatus comprising a light-source unit for emitting pulsed laser light; an observation apparatus main unit for irradiating a specimen with laser light emitted from the light-source unit and observing fluorescence emitted from the specimen; an incidence adjusting device, disposed between the light-source unit and the observation apparatus main unit, for adjusting the beam diameter of the laser light emitted from the light-source unit; and a control apparatus for controlling the incidence-adjusting unit according to the depth of an observation plane in the specimen.

摘要翻译： 本发明提供了一种多光子激发观测装置，包括用于发射脉冲激光的光源单元; 观察装置主单元，用于从从所述光源单元发射的激光照射样本并观察从所述样本发射的荧光; 入射调节装置，设置在所述光源单元和所述观察装置主单元之间，用于调节从所述光源单元发射的所述激光的光束直径; 以及控制装置，用于根据样本中观察平面的深度来控制入射调节单元。

公开(公告)号：US07160731B2

公开(公告)日：2007-01-09

申请号：US10241645

申请日：2002-09-12

申请人： Kazuhiro Takagi ,  Junichi Okada

发明人： Kazuhiro Takagi ,  Junichi Okada

IPC分类号： G01N31/16

CPC分类号： G01N33/84

摘要： To provide a simple examination method of buffer capacity of saliva without influence by examiner's subjectivity and an examination instrument to carry out suitably the examination method, an examination instrument, in which two to ten kinds of chemical liquids each containing a pH indicator having a transition interval within a pH range of 3.0 to 7.0 and capable of easily discriminating its indicated color at two or more stages and an acid in an amount so as to exhibit a different pH value within a pH range of 1.5 or more but lower than 3.0 when water in the same amount as that of saliva to be examined is added at a temperature of 25° C. and a humidity of 50% are each immersed in a water-absorptive material, or are in a liquid or gel state and are accommodated within a constant-volume container, is prepared; saliva of a subject in a volume to be examined is added to each of the chemical liquids; after lapsing a predetermined time, the color of each chemical liquid is measured as a readily discriminable indicated color; and the buffer capacity of saliva is determined by overall evaluation from the readily discriminable indicated color as exhibited by the chemical liquid.

摘要翻译： 为了提供唾液的缓冲能力的检查方法，不受检查者的主观性的影响，检查仪器适当地进行检查方法，检查仪器，其中两至十种各自含有具有过渡间隔的pH指示剂的化学液体 在3.0至7.0的pH范围内，并且能够容易地在两个或多个阶段区分其指示的颜色，并且酸的量可以在1.5以上且低于3.0的pH范围内显示不同的pH值 在25℃的温度和50％的湿度下加入与待检查的唾液相同的量浸渍在吸水材料中，或者处于液体或凝胶状态，并且容纳在恒定的 体积容器，准备; 将待检体积的受检者的唾液加入到每种化学液体中; 在经过预定时间之后，每个化学液体的颜色被测量为容易识别的指示颜色; 唾液的缓冲能力由化学液体显示的容易辨别的指示颜色的总体评价来确定。

公开(公告)号：US4364067A

公开(公告)日：1982-12-14

申请号：US201104

申请日：1980-10-28

申请人： Haruhiko Koto ,  Junichi Okada

发明人： Haruhiko Koto ,  Junichi Okada

IPC分类号： B41J2/15 ,  G01D15/16

CPC分类号： B41J2/15

摘要： A head for an ink-on-demand jet dot printer is highly integrated to provide a large plurality of closely spaced dots by combining more than one head of lesser dot density as components of a single unit. The dots from the separate component heads are interspaced on the print recording medium to provide characters of high quality. Commonality of elements provides for a miniaturized head. In another embodiment independent pressure chambers, channels and nozzles are formed on opposite sides of a common baseplate.

摘要翻译： 用于喷墨点阵打印机的头部被高度集成以通过组合多于一个较小点密度的头部作为单个单元的部件来提供大量多个紧密间隔的点。 来自分离的组件头的点间隔在打印记录介质上以提供高质量的字符。 元素的共同性提供了一个小型化的头。 在另一个实施例中，独立的压力室，通道和喷嘴形成在公共基板的相对侧上。

公开(公告)号：US07160689B2

公开(公告)日：2007-01-09

申请号：US10163614

申请日：2002-06-07

申请人： Yuko Matsumoto ,  Yumiko Kobayashi ,  Junichi Okada

发明人： Yuko Matsumoto ,  Yumiko Kobayashi ,  Junichi Okada

IPC分类号： G01N33/53

CPC分类号： G01N1/10 ,  A61B10/0051 ,  B01L3/5029 ,  B01L3/505 ,  G01N2001/028 ,  G01N2333/315

摘要： In a pretreatment instrument and a pretreatment method of saliva, used for identification and quantitation of Streptococcus mutans in saliva by the immunochromatographic method utilizing an antigen-antibody reaction, the instrument includes a swab and a mixing container for saliva and a treatment liquid, the swab having a stick and a soft synthetic resin-made sponge capable of absorbing a predetermined amount or more of saliva, and the mixing container being made of a transparent or translucent soft synthetic resin and comprising a bag-like portion formed integrally with and continuously to a constricted portion as the end of a tapering introduction portion having an opening thoroughly larger than the sponge, wherein the constricted portion and the bag-like portion have elasticity such that the sponge can be squashed by a finger pressure in a state that the sponge is inserted therein; the constricted portion has a width such that a pressure can be applied by fingers and has a shape such that when the sponge is taken out in a squashed state by the finger pressure, a minimum amount necessary for the pretreatment or more of the saliva can be squeezed out.

摘要翻译： 在使用抗原 - 抗体反应的免疫色谱法在唾液的预处理仪器和预处理方法中，用于鉴别和定量唾液中的变形链球菌，仪器包括用于唾液和处理液的拭子和混合容器，拭子 具有能够吸收规定量以上的唾液的棒状物和软质合成树脂制海棉，所述混合容器由透明或半透明的软质合成树脂制成，并且包括一体形成的袋状部分， 收缩部分作为具有比海绵充分大的开口的锥形引入部分的端部，其中收缩部分和袋状部分具有弹性，使得海绵可以在海绵被插入的状态下被手指压力挤压 其中 收缩部分具有能够通过手指施加压力的宽度，并且具有这样的形状，使得当通过手指压力以压扁状态取出海绵时，预处理所需的最小量或更多的唾液可以是 挤出。

公开(公告)号：US20060084595A1

公开(公告)日：2006-04-20

申请号：US11254836

申请日：2005-10-21

申请人： Shinichi Yamamoto ,  Junichi Okada ,  Atsushi Kurihara ,  Taku Numazawa ,  Junichi Kondo ,  Eisuke Tsuda ,  Shinichi Mochizuki ,  Hirotaka Nishi ,  Hideki Miyazaki

发明人： Shinichi Yamamoto ,  Junichi Okada ,  Atsushi Kurihara ,  Taku Numazawa ,  Junichi Kondo ,  Eisuke Tsuda ,  Shinichi Mochizuki ,  Hirotaka Nishi ,  Hideki Miyazaki

IPC分类号： A61K38/18 ,  C07K14/475 ,  A61K31/715

CPC分类号： A61K47/61

摘要： A complex comprising at least one substance selected from the group consisting of an osteoclastogenesis inhibitory factor, an analogue thereof and a variant thereof, which is bound to at least one substance selected from the group consisting of a polysaccharide and a polysaccharide derivative. The complex has a prolonged retention in the bloodstream after administration, making it useful in the treatment and prophylaxis of bone metabolic diseases.