公开(公告)号：US20180085489A1

公开(公告)日：2018-03-29

申请号：US15830528

申请日：2017-12-04

Applicant: KCI Licensing, Inc.

Inventor： Douglas Philip HANSON ,  James COURAGE

IPC: A61L26/00 ,  C08G18/32 ,  A61F13/00 ,  A61L15/26 ,  C08G18/08 ,  C08J9/36 ,  C08J9/00 ,  C08G18/84 ,  C08G18/83 ,  C08G18/76

CPC classification number: A61L26/0066 ,  A61F13/00017 ,  A61F13/00063 ,  A61F13/00068 ,  A61F2013/0017 ,  A61K9/12 ,  A61K38/4873 ,  A61K47/34 ,  A61K47/55 ,  A61K47/59 ,  A61K47/60 ,  A61L15/26 ,  A61L15/32 ,  A61L15/38 ,  A61L15/425 ,  A61L15/44 ,  A61L26/0085 ,  A61L2300/254 ,  A61L2300/404 ,  A61L2300/406 ,  C08G18/14 ,  C08G18/3293 ,  C08G18/40 ,  C08G18/6415 ,  C08G18/7621 ,  C08G18/833 ,  C08G18/84 ,  C08G2101/0083 ,  C08J9/00 ,  C08J9/36 ,  C08J2205/05 ,  C08J2207/10 ,  C08J2375/12 ,  C12Y304/22004 ,  C08L75/04

Abstract: The present disclosure provides amine-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include a covalently attached molecule comprising free amine groups. Such amine groups can be used, for instance, to conjugate biologically active polypeptides and/or linkers. Methods for using modified polymers are also provided.

公开(公告)号：US20200085628A1

公开(公告)日：2020-03-19

申请号：US16618950

申请日：2018-06-12

Applicant: KCI Licensing, Inc.

Inventor： Timothy Mark ROBINSON ,  Christopher Brian LOCKE ,  Diwi L. ALLEN ,  Justin Alexander LONG ,  James COURAGE

IPC: A61F13/00 ,  A61F13/02 ,  A61M1/00

Abstract: A method may include forming a mesh comprising a plurality of strands meshed together. Each of the plurality of strands may include a polymeric film. The method may include perforating the mesh to form a perforated mesh having one or more perforations. The method may further include texturing the perforated mesh to form at textured and perforated mesh having at least one of a dimple or a channel. A system may include a cover configured to form a seal over the tissue site. The system may also include a reduced-pressure source configured to provide reduced pressure through the cover at the tissue site. The system may further include a tissue interface configured to be disposed underneath the cover at the tissue site. The tissue interface may include a textured mat having a plurality of strands of polymeric film matted together and at least one of a dimple or a channel.

公开(公告)号：US20220347017A1

公开(公告)日：2022-11-03

申请号：US17861074

申请日：2022-07-08

Applicant: KCI Licensing, Inc.

Inventor： Timothy Mark ROBINSON ,  Christopher Brian LOCKE ,  Benjamin Andrew PRATT ,  Larry Tab RANDOLPH ,  Justin Alexander LONG ,  James COURAGE ,  Diwi L. ALLEN ,  Kristine M. KIESWETTER

IPC: A61F13/00 ,  A61F13/02 ,  A61F13/14 ,  A61L27/16 ,  A61L27/18 ,  A61L27/34 ,  A61L27/54 ,  A61M1/00

Abstract: An apparatus for filling a wound can include an array of at least four truncated ellipsoids interconnected to define at least one fluid path through, for example perpendicular to, the array. The longest principal axis of each ellipsoid may be perpendicular to the array. Each truncated ellipsoid may be a spheroid and/or may include an approximately elliptical contact surface at each contact surface between two interconnected ellipsoids. Each fluid pathway may have four continuously-curved concave sides and may have a parallelogram-shaped cross-section with continuously-curved concave edges. A dressing may include the apparatus, a dressing layer coupled to the apparatus, a backing layer disposed over a surface of the dressing layer opposite the apparatus, and an attachment device disposed on at least a margin of the backing layer. Methods of treating various tissue sites using the apparatus or dressing with negative-pressure therapy are also disclosed.

公开(公告)号：US20210161723A1

公开(公告)日：2021-06-03

申请号：US16618844

申请日：2018-06-12

Applicant: KCI Licensing, Inc.

Inventor： Timothy Mark ROBINSON ,  Christopher Brian LOCKE ,  Diwi L. ALLEN ,  James COURAGE

IPC: A61F13/00 ,  A61F13/02

Abstract: A method of manufacturing a tissue interface for a reduced pressure tissue treatment system is provided. The method includes foaming a plurality of polymer particles to form a porous polymer. The method also includes sintering the porous polymer to form a sintered porous polymer. The method further includes texturing the sintered porous polymer. A system to provide reduced pressure at a tissue site is provided. The system includes a cover configured to form a seal over the tissue site. The system also includes a reduced-pressure source configured to provide reduced pressure through the cover at the tissue site. The system further includes a tissue interface configured to be disposed underneath the cover at the tissue site and comprising a porous polymer that is formed from one or more polymer particles that may be foamed and textured.

公开(公告)号：US20200375805A1

公开(公告)日：2020-12-03

申请号：US16757343

申请日：2018-10-22

Applicant: KCI Licensing, Inc.

Inventor： Timothy Mark ROBINSON ,  Christopher Brian LOCKE ,  Benjamin Andrew PRATT ,  Larry Tab RANDOLPH ,  Justin Alexander LONG ,  James COURAGE ,  Diwi L. ALLEN ,  Kristine M. KIESWETTER

IPC: A61F13/14 ,  A61L27/18 ,  A61L27/34 ,  A61L27/54 ,  A61M1/00 ,  A61F13/02 ,  A61F13/00 ,  A61L27/16

Abstract: An apparatus for filling a wound can include an array of at least four truncated ellipsoids interconnected to define at least one fluid path through, for example perpendicular to, the array. The longest principal axis of each ellipsoid may be perpendicular to the array. Each truncated ellipsoid may be a spheroid and/or may include an approximately elliptical contact surface at each contact surface between two interconnected ellipsoids. Each fluid pathway may have four continuously-curved concave sides and may have a parallelogram-shaped cross-section with continuously-curved concave edges. A dressing may include the apparatus, a dressing layer coupled to the apparatus, a backing layer disposed over a surface of the dressing layer opposite the apparatus, and an attachment device disposed on at least a margin of the backing layer. Methods of treating various tissue sites using the apparatus or dressing with negative-pressure therapy are also disclosed.

公开(公告)号：US20210169701A1

公开(公告)日：2021-06-10

申请号：US16768614

申请日：2018-11-29

Applicant: KCI Licensing, Inc.

Inventor： Diwi L. ALLEN ,  James COURAGE ,  Prathamesh KHARKAR

IPC: A61F13/02 ,  A61L15/32 ,  A61L15/24 ,  A61L15/58 ,  A61B17/322

Abstract: In one aspect, a dressing for transferring skin grafts from a donor site to a recipient site is disclosed, which comprises a substrate having a surface configured for contact with one or more epidermal skin grafts, a plurality of capture sites distributed across said substrate surface, wherein each of said capture sites is configured for capturing at least one epidermal skin graft, and a plurality of topographical features distributed over said substrate surface and coupled to at least one of said capture sites so as to provide at least one of inducing proliferation and facilitating migration of keratinocytes in the captured epidermal skin grafts to surrounding tissue.

公开(公告)号：US20190038473A1

公开(公告)日：2019-02-07

申请号：US16073863

申请日：2017-03-06

Applicant: KCI Licensing, Inc.

Inventor： James A. LUCKEMEYER ,  James COURAGE ,  Timothy Mark ROBINSON ,  Christopher Brian LOCKE

IPC: A61F13/02 ,  A61M1/00 ,  A61F13/00 ,  A61L15/26 ,  A61L15/40 ,  A61L15/44 ,  A61L15/32 ,  A61F15/00 ,  A61N1/10

Abstract: A treatment system for applying negative-pressure therapy to a wound site is disclosed. The treatment system may include a non-adherent material for applying to the perimeter of the wound site. In some embodiments, the treatment system may include a tape, a tissue interface, a sealing member, and a negative-pressure subsystem. The tape material may provide a smooth surface along the perimeter of the wound site for protecting the wound edges from stresses and for promoting epithelialization.

公开(公告)号：US20170246341A1

公开(公告)日：2017-08-31

申请号：US15491228

申请日：2017-04-19

Applicant: KCI Licensing, Inc.

Inventor： Douglas Philip HANSON ,  James COURAGE

IPC: A61L26/00 ,  C08G18/76 ,  C08G18/32 ,  A61F13/00 ,  C08J9/00 ,  C08J9/36 ,  C08G18/83 ,  C08G18/84 ,  A61L15/26 ,  C08G18/08

CPC classification number: A61L26/0066 ,  A61F13/00017 ,  A61F13/00063 ,  A61F13/00068 ,  A61F2013/0017 ,  A61K9/12 ,  A61K38/4873 ,  A61K47/34 ,  A61K47/55 ,  A61K47/59 ,  A61K47/60 ,  A61L15/26 ,  A61L15/32 ,  A61L15/38 ,  A61L15/425 ,  A61L15/44 ,  A61L26/0085 ,  A61L2300/254 ,  A61L2300/404 ,  A61L2300/406 ,  C08G18/14 ,  C08G18/3293 ,  C08G18/40 ,  C08G18/6415 ,  C08G18/7621 ,  C08G18/833 ,  C08G18/84 ,  C08G2101/0083 ,  C08J9/00 ,  C08J9/36 ,  C08J2205/05 ,  C08J2207/10 ,  C08J2375/12 ,  C12Y304/22004 ,  C08L75/04

Abstract: The present disclosure provides amine-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include a covalently attached molecule comprising free amine groups. Such amine groups can be used, for instance, to conjugate biologically active polypeptides and/or linkers. Methods for using modified polymers are also provided.