公开(公告)号：US20190135765A1

公开(公告)日：2019-05-09

申请号：US16090072

申请日：2017-03-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY

Inventor： Tae Bo SIM ,  Woo Young HUR ,  Ho Jong YOON ,  Chi Man SONG ,  In Jae SHUN ,  Byeong Yun LIM ,  HanNa CHO ,  Seung Hye CHOI ,  Gu KONG ,  Jeong Yeon LEE

IPC: C07D239/42 ,  A61P35/00 ,  C07D405/12 ,  C07D409/12 ,  C07D403/12

Abstract: The present invention relates to a novel pyrimidine-4-carboxylic acid derivative having an anticancer activity, and the compound of the present invention is useful as a drug for treating and preventing tumor diseases.

公开(公告)号：US20180065969A1

公开(公告)日：2018-03-08

申请号：US15672987

申请日：2017-08-09

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Han Na CHO ,  Eun Hye JU ,  Woo Young HUR ,  Ho Jong YOON ,  Chi Man SONG

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention provides a therapeutic agent of acute myeloid leukemia containing a 1,3,7-trisubstituted 3,4-dihydropyrimido[4,5-d]pyrimidine-2(1H)-one compound as an active ingredient, which has proliferation inhibitory activity for a human acute myeloid leukemia cell line OCI-AML3 having a NRAS mutant gene while having low inhibitory activity for wild type NRAS and has activity of inhibiting GCK and ACK1 protein kinases at the same time.

公开(公告)号：US20230263792A1

公开(公告)日：2023-08-24

申请号：US18006584

申请日：2021-07-30

Applicant: PHAROS IBIO CO., LTD ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Seung Hye CHOI ,  Han Na CHO ,  Woo Young HUR ,  Chi Man SONG ,  Ky Youb NAM ,  Jeong Hyeok YOON

IPC: A61K31/4535 ,  A61P35/02 ,  A61P29/00

CPC classification number: A61K31/4535 ,  A61P35/02 ,  A61P29/00

Abstract: The present invention relates to the use of a 2,3,5-substituted thiophene compound for the prevention, amelioration or treatment of mastocytosis. The 2,3,5-substituted thiophene compound has excellent inhibitory activity against the growth of mastocytosis cells and against an inflammatory response caused by mastocytosis, and thus may be effectively used for the prevention, amelioration or treatment of mastocytosis.

公开(公告)号：US20180065970A1

公开(公告)日：2018-03-08

申请号：US15674023

申请日：2017-08-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Woo Young HUR ,  Ho Jong YOON ,  Chi Man SONG ,  Eun Hye JU ,  Han na CHO ,  Hwan Geun CHOI

IPC: C07D487/04 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D487/04 ,  A61K31/519 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14

Abstract: The present invention provides a pharmaceutical composition, as an effective ingredient, a urea compound having a protein kinase inhibitory activity and containing a 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one skeleton, and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230270733A1

公开(公告)日：2023-08-31

申请号：US18006582

申请日：2021-07-30

Applicant: PHAROS IBIO CO., LTD. ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Seung Hye CHOI ,  Han Na CHO ,  Nam Kyoung KIM ,  Woo Young HUR ,  Chi Man SONG ,  Ky Youb NAM ,  Jeong Hyeok YOON

IPC: A61K31/4535 ,  A23L33/10 ,  A61P35/00

CPC classification number: A61K31/4535 ,  A23L33/10 ,  A61P35/00

Abstract: The present invention relates to the use of a 2,3,5-substituted thiophene compound for the prevention, amelioration or treatment of gastrointestinal stromal tumor. The 2,3,5-substituted thiophene compound exhibits high inhibitory activity against the growth of gastrointestinal stromal tumor, and thus may be effectively used for the prevention, amelioration or treatment of gastrointestinal stromal tumor.

公开(公告)号：US20220135559A1

公开(公告)日：2022-05-05

申请号：US17431591

申请日：2020-02-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： TAE BO SIM ,  Woo Young HUR ,  Chi Man SONG ,  Sandip SENGUPTA ,  Chan Sun PARK ,  Seung Hye CHOI ,  Han Na CHO ,  In Jae SHIN

IPC: C07D471/04

Abstract: The present disclosure relates to a pyrido[3,4-d]pyrimidin-8-one derivative compound exhibiting excellent anti-proliferative effects against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative disease containing the same as an active ingredient, and an anticancer composition against cancer cells. The compound exhibits excellent cancer cell inhibitory activity and anti-proliferative effects, and thus is effective in inhibiting cancer cells, preventing cancer metastasis and proliferative diseases or treating cancer.