公开(公告)号：US20220220529A1

公开(公告)日：2022-07-14

申请号：US17485606

申请日：2021-09-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hak Suk CHUNG ,  Jinsu AN ,  Eun Gyeong YANG ,  So Yeon KIM

IPC: C12Q1/02 ,  C12N9/64

Abstract: Provided are a method of screening an inhibitor of caspase activity by lipopolysaccharide and a method of screening a therapeutic agent for inflammatory diseases or sepsis using the same. Accordingly, it is possible to develop a caspase-4-specific inhibitor.

公开(公告)号：US20190338265A1

公开(公告)日：2019-11-07

申请号：US16244361

申请日：2019-01-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hak Suk CHUNG ,  Jinsu AN ,  Eun Gyeong YANG ,  So Yeon KIM

IPC: C12N9/50 ,  C12N15/70

Abstract: Provided is a method of producing monomeric caspase activation and recruitment domains (CARDs) in bacteria. According to this method, CARD domains may be easily produced in a monomeric form. Monomeric CARDs may be applied to studies on the mechanism of action of caspase, the development of new drugs, detection and elimination of endotoxins, development of cosmetics, etc.

公开(公告)号：US20170191037A1

公开(公告)日：2017-07-06

申请号：US15224499

申请日：2016-07-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： So Yeon KIM ,  Eun Gyeong YANG ,  Myung-Han YOON ,  Hyunju KIM

IPC: C12N5/074 ,  C12N5/00

CPC classification number: C12N5/0696 ,  C12N5/0075 ,  C12N2501/60 ,  C12N2506/1307 ,  C12N2510/00 ,  C12N2531/00 ,  C12N2535/00

Abstract: Provided are a method of culturing an induced pluripotent stem cell and a method of forming a spheroid of the induced pluripotent stem cell. According to an embodiment of the present inventive concept, the induced pluripotent stem cell may have improved stemness.

公开(公告)号：US20170030913A1

公开(公告)日：2017-02-02

申请号：US15220521

申请日：2016-07-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  SAMSUNG LIFE PUBLIC WELFARE FOUNDATION

Inventor： Ji Eun LEE ,  Dong Huey CHEON ,  Cheolju LEE ,  Eun Gyeong YANG ,  Jihye SHIN ,  Hee Cheol KIM ,  Ji Hye HAN

IPC: G01N33/574

CPC classification number: G01N33/57419 ,  G01N2333/521

Abstract: Provided are a composition or a kit for diagnosing colorectal cancer including a CXCL7-measuring agent, and a method of diagnosing colorectal cancer using the same. According to the composition or the kit, and the method, colorectal cancer may be simply diagnosed with high diagnostic accuracy and specificity for colorectal cancer.

Abstract translation: 提供了用于诊断包括CXCL7测定剂的结肠直肠癌的组合物或试剂盒，以及使用该组合物或试剂盒诊断结肠直肠癌的方法。 根据组合物或试剂盒和方法，可以简单地诊断结肠直肠癌对结肠直肠癌具有高诊断准确性和特异性。

公开(公告)号：US20220186186A1

公开(公告)日：2022-06-16

申请号：US17387782

申请日：2021-07-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： So Yeon KIM ,  Eun Gyeong YANG ,  HyeRan GWAK

IPC: C12N5/0786 ,  A61K35/15

Abstract: Provided are: a composition for inducing direct conversion from somatic cells into common myeloid progenitor cells, the composition including a chemical cocktail; a method of direct conversion of somatic cells into common myeloid progenitor cells and macrophages by using the composition; common myeloid progenitor cells or macrophages prepared by the method; a pharmaceutical composition for preventing or treating fibrosis or scars, cell therapeutics, a composition for screening drugs, and a 3D printable biomaterial composition for fabricating artificial tissues, each using the common myeloid progenitor cells or the macrophages.

公开(公告)号：US20170191071A1

公开(公告)日：2017-07-06

申请号：US15378681

申请日：2016-12-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hak Suk CHUNG ,  Eun Gyeong YANG ,  Dohyeon HWANG

IPC: C12N15/70 ,  C12N15/52 ,  C12N9/10 ,  C12P19/12 ,  C12N9/16

CPC classification number: C12N15/70 ,  C12N9/1029 ,  C12N9/16 ,  C12N15/52 ,  C12N15/74 ,  C12P19/12

Abstract: A bacterium producing monophosphoryl lipid A (MLA) comprising a genetic modification that increases expression of a gene encoding LpxE polypeptide and a method of producing MLA are provided. According to the present invention, MLA may be produced in a simple manner without acid hydrolysis and/or base hydrolysis.

公开(公告)号：US20200248141A1

公开(公告)日：2020-08-06

申请号：US16601853

申请日：2019-10-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： So Yeon KIM ,  HyeRan GWAK ,  Eun Gyeong YANG

IPC: C12N5/0786 ,  A61K35/15

Abstract: Provided are a composition and a kit for reprogramming cancer associated fibroblasts (CAFs) into macrophages, and a method of using the same. According to a method of reprogramming CAFs according to an aspect, macrophages may be prepared with a high yield in a short period of time, and the tumor microenvironment may be suppressed and macrophages produced by reprogramming CAF may elimininate cancer cells. Therefore, the macrophages may be usefully applied as an anticancer agent or an anticancer adjuvant.