公开(公告)号：US20220133835A1

公开(公告)日：2022-05-05

申请号：US17518799

申请日：2021-11-04

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob HAM ,  Taejung KIM ,  Young Tae PARK ,  Pilju CHOI ,  Ji-yool KIM ,  Cheol Hee YOON ,  Haneul JU

IPC: A61K36/906 ,  A61P3/10

Abstract: Provided are a pharmaceutical composition for preventing or treating diabetes and a method of preventing or treating diabetes in a subject by using the pharmaceutical composition, the pharmaceutical composition including a ginger extract, as an active ingredient, obtained by microwave irradiation, under pressure, of ginger, an extract thereof, or a combination thereof.

公开(公告)号：US20200331863A1

公开(公告)日：2020-10-22

申请号：US16852820

申请日：2020-04-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Taejung KIM ,  Jungyeob HAM ,  Young Tae PARK

IPC: C07D235/02

Abstract: The present invention relates to a method of preparing pactalactam represented by Formula 5 below using a total synthesis method:

公开(公告)号：US20210196608A1

公开(公告)日：2021-07-01

申请号：US17138312

申请日：2020-12-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob HAM ,  Taejung KIM ,  Bong Chul CHUNG ,  Sungdo HA ,  Seok LEE ,  Jin-Chul KIM ,  Pilju CHOI ,  Bong Geun SONG

IPC: A61K8/49 ,  C07D311/80 ,  A23L33/105 ,  A23L5/30

Abstract: Provided are: a method of preparing a Cannabis processed product having an increased CBN content in an efficient and economic manner, through cyclization of CBD and aromatization of THC by continuous microwave irradiation of a Cannabis extract; and use of a processed product having an increased CBN content prepared by the method, a fraction thereof, and a single ingredient of CBN, in foods, drugs, and cosmetics.

公开(公告)号：US20140120188A1

公开(公告)日：2014-05-01

申请号：US13661205

申请日：2012-10-26

Applicant: Korea Institute of Science and Technology

Inventor： Hyun Ok YANG ,  Hak Cheol KWON ,  Joon Ki KIM ,  Jin Wook CHA ,  Young-Joo KIM ,  Jungyeob HAM

IPC: A61K36/489 ,  A61P25/32

CPC classification number: A61K36/489 ,  A23L33/105 ,  A23V2002/00 ,  A61K2236/30 ,  A23V2200/334 ,  A23V2250/21

Abstract: A method of preventing or alleviating alcohol hangover, which comprises administering one or more selected from the group consisting of Sophora flavescens extracts, dried products of the extracts, and concentrates of the extracts to a subject in need of preventing or alleviating alcohol hangover is provided.

Abstract translation: 提供了一种预防或减轻酒精宿醉的方法，其包括向需要预防或减轻酒精宿醉的受试者施用一种或多种选自苦参提取物，提取物的干燥产物和提取物的浓缩物的一种或多种。

公开(公告)号：US20140087008A1

公开(公告)日：2014-03-27

申请号：US14038378

申请日：2013-09-26

Applicant: COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH (CSIR) ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Ok YANG ,  Sung-Kwon CHUNG ,  Hak Cheol KWON ,  Jin Wook CHA ,  Vinesh Jaichand MAHARAJ ,  Rudzani NTHAMBELENI ,  Dashnie NAIDOO ,  Young-Joo KIM ,  Jungyeob HAM ,  Jeremiah SENABE ,  Gerda FOUCHE ,  Eric KHOROMBI ,  Joon Ki KIM

IPC: A61K36/185 ,  A23L2/52 ,  A23L1/30

CPC classification number: A61K36/185 ,  A23L2/52 ,  A23L33/105 ,  A61K2236/39

Abstract: The present invention relates to a pharmaceutical composition for preventing and/or treating dementia comprising extracts of Monsonia sp.; a food composition for preventing and/or improving dementia comprising extracts of Monsonia sp.; and a method of preparing an extract of Monsonia sp. with excellent inhibitory effect on the formation of β-amyloid. The plant extract can inhibit the formation of β-amyloid which has been known as a factor causing the dementia, especially Alzheimer's disease, thereby being used for preventing, improving and/or treating the dementia.

Abstract translation: 本发明涉及一种用于预防和/或治疗痴呆症的药物组合物，其包含麻黄属植物提取物。 一种用于预防和/或改善痴呆症的食物组合物，其包含孟山药的提取物。 和一种制备麻黄提取物的方法 对淀粉样蛋白的形成具有优异的抑制作用。 植物提取物可以抑制已知作为引起痴呆的因素，特别是阿尔茨海默氏病的β-淀粉样蛋白的形成，从而用于预防，改善和/或治疗痴呆。

公开(公告)号：US20220096425A1

公开(公告)日：2022-03-31

申请号：US17465847

申请日：2021-09-03

Applicant: RESEARCH COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jintae LEE ,  Jungyeob HAM ,  Taejung KIM

IPC: A61K31/352 ,  A61K31/192 ,  A61K31/05 ,  A61K31/513 ,  A61K31/4706 ,  A61K31/675 ,  A61P31/14 ,  A61K36/185 ,  G01N33/94 ,  G01N33/569

Abstract: The present invention relates to an antiviral composition and a screening method thereof for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that occurred in Wuhan, China in 2019. An extract from leaves or unfertilized female flowers of Cannabis sativa L. or its fraction, and the cannabinoids (CBDs) molecules isolated from it have high binding strength and stability to SARS-CoV-2 Mpro, thereby inhibiting its action as the main protease, to provide a useful lead molecule that can be used alone or in combination with other drugs to treat SARS-CoV-2.

公开(公告)号：US20210308648A1

公开(公告)日：2021-10-07

申请号：US17221591

申请日：2021-04-02

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob HAM ,  Taejung KIM ,  Bong Chul CHUNG ,  Sungdo HA ,  Seok LEE ,  Young Tae PARK ,  Pilju CHOI

IPC: B01J19/12

Abstract: A large capacity natural material composition conversion apparatus using a microwave with a preset pressure function includes a chamber including a sealed reaction space accommodating a material, an radiator configured to heat the material by radiating a microwave into the reaction space, a pressure regulator configured to regulate a pressure of the reaction space by supplying a gas into the reaction space, and a controller configured to control the pressure regulator and the radiator, and preliminarily increase a pressure of the reaction space by controlling the pressure regulator before heating the material.

公开(公告)号：US20190254989A1

公开(公告)日：2019-08-22

申请号：US16282203

申请日：2019-02-21

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob HAM ,  Young Tae PARK ,  Taejung KIM ,  Young seok KIM ,  Pilju CHOI ,  Kyusun KIM ,  SeonJun CHOI ,  BongGeun SONG ,  Kisung KANG ,  Buyng Su HWANG ,  Dahae LEE ,  Jihoon SONG

IPC: A61K31/122 ,  A61K33/243 ,  A61P13/12 ,  A61K31/09 ,  A61K36/062 ,  A61K31/05

Abstract: A composition for preventing or reducing nephrotoxicity, and use thereof are provided, the composition including a Hypoxylon truncatum extract or an active component thereof.

公开(公告)号：US20170007653A1

公开(公告)日：2017-01-12

申请号：US15201819

申请日：2016-07-05

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob HAM ,  Taejung KIM ,  Kwantae KIM ,  Pilju CHOI ,  Buyng Su HWANG ,  Young Seok KIM

IPC: A61K36/258

CPC classification number: A61K36/258 ,  A61K9/00 ,  A61K2236/00

Abstract: Provided are a pharmaceutical composition for preventing or treating skin cancer and a method of preventing or treating skin cancer in a subject by using the pharmaceutical composition, wherein the pharmaceutical composition includes a Panax spp. plant extract as an active ingredient.

Abstract translation: 本发明提供一种用于预防或治疗皮肤癌的药物组合物，以及通过使用药物组合物预防或治疗受试者的皮肤癌的方法，其中所述药物组合物包括Panax spp。 植物提取物作为活性成分。

公开(公告)号：US20220314191A1

公开(公告)日：2022-10-06

申请号：US17590292

申请日：2022-02-01

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Taejung KIM ,  Jungyeob HAM ,  Young Tae PARK ,  Pilju CHOI ,  Joonyeon CHANG

IPC: B01J19/12 ,  B01J19/24

Abstract: According to an aspect of the disclosure, there is provided a microwave reactor including a container for storing a bath fluid, a tube including an inlet at one end through which a target fluid is introduced, an outlet at another end through which the target fluid is discharged, wherein at least a portion of the tube is submerged in the bath fluid, and at least one radiator located outside the container and configured to irradiate microwaves into the container.