公开(公告)号：US5726288A

公开(公告)日：1998-03-10

申请号：US102942

申请日：1993-08-02

申请人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman ,  Wendy Bruening ,  Andre Darveau

发明人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman ,  Wendy Bruening ,  Andre Darveau

IPC分类号： C07K14/47 ,  C07K16/30 ,  G01N33/574 ,  C07K14/435

CPC分类号： C07K16/30 ,  C07K14/47 ,  G01N33/57438

摘要： The Wilms' tumor gene associated with 11p3 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in predominantly in kidney and gonadal tissue. The gene is alternative spliced producing four very similar mRNA transcripts. The polypeptides encoded by the Wilms' tumor DNA includes four "zinc fingers" and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.

公开(公告)号：US06316599B1

公开(公告)日：2001-11-13

申请号：US09037179

申请日：1998-03-09

申请人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman ,  Wendy Breuning ,  Andre Darveau

发明人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman ,  Wendy Breuning ,  Andre Darveau

IPC分类号： C07K1600

CPC分类号： C07K16/30 ,  C07K14/47 ,  G01N33/57438

摘要： The Wilms' tumor gene associated with 11p3 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in predominantly in kidney and gonadal tissue. The gene is alternative spliced producing four very similar mRNA transcripts. The polypeptides encoded by the Wilms' tumor DNA includes four “zinc fingers” and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.

摘要翻译： 描述和表征了与人类染色体上的11p3基因座相关的Wilms肿瘤基因以及分析细胞的基因的方法。 该基因编码大小约50kb的转录单位和大约3kb的mRNA，其主要在肾和性腺组织中表达。 该基因是选择性剪接产生四个非常相似的mRNA转录物。 由Wilms肿瘤DNA编码的多肽包括四个“锌指”和富含脯氨酸和谷氨酰胺的区域，表明该多肽在转录调控中起作用。

公开(公告)号：US06943011B2

公开(公告)日：2005-09-13

申请号：US09929315

申请日：2001-08-14

申请人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry M. Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman ,  Wendy Bruening ,  André Darveau

发明人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry M. Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman ,  Wendy Bruening ,  André Darveau

IPC分类号： C07K14/47 ,  C07K16/30 ,  G01N33/574 ,  C12N15/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K16/30 ,  C07K14/47 ,  G01N33/57438

摘要： The Wilms' tumor gene associated with 11p3 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in predominantly in kidney and gonadal tissue. The gene is alternative spliced producing four very similar mRNA transcripts. The polypeptides encoded by the Wilms' tumor DNA includes four “zinc fingers” and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.

摘要翻译： 描述和表征了与人类染色体上的11p3基因座相关的Wilms肿瘤基因以及分析细胞的基因的方法。 该基因编码大小约50kb的转录单位和大约3kb的mRNA，其主要在肾和性腺组织中表达。 该基因是选择性剪接产生四个非常相似的mRNA转录物。 由Wilms肿瘤DNA编码的多肽包括四个“锌指”和富含脯氨酸和谷氨酰胺的区域，表明该多肽在转录调控中起作用。

公开(公告)号：US5350840A

公开(公告)日：1994-09-27

申请号：US795323

申请日：1991-11-20

申请人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman

发明人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman

IPC分类号： C12P21/00 ,  A61K38/00 ,  A61K39/395 ,  A61K51/00 ,  A61P35/00 ,  C07K14/47 ,  C07K16/30 ,  C12N15/09 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/19 ,  C12R1/91 ,  G01N33/574 ,  G01N33/577 ,  C07H21/02 ,  C07H21/04

CPC分类号： G01N33/57438 ,  C07K14/47 ,  C07K16/30

摘要： The Wilms' tumor gene associated with the 11p13 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in a limited number of cell types (e.g., predominantly kidney cells and ja subset of hematopoietic cells). The polypeptide encoded by the Wilms' tumor DNA includes four "zinc fingers" and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.

摘要翻译： 描述和表征了与人染色体上的11p13基因座相关的Wilms肿瘤基因以及分析细胞的基因的方法。 该基因编码大小约为50kb的转录单位和约3kb的mRNA，其在有限数量的细胞类型（例如，主要是肾细胞和造血细胞的ja子集）中表达。 由Wilms肿瘤DNA编码的多肽包括四个“锌指”和富含脯氨酸和谷氨酰胺的区域，表明该多肽在转录调控中起作用。