公开(公告)号：US06943011B2

公开(公告)日：2005-09-13

申请号：US09929315

申请日：2001-08-14

申请人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry M. Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman ,  Wendy Bruening ,  André Darveau

发明人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry M. Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman ,  Wendy Bruening ,  André Darveau

IPC分类号： C07K14/47 ,  C07K16/30 ,  G01N33/574 ,  C12N15/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K16/30 ,  C07K14/47 ,  G01N33/57438

摘要： The Wilms' tumor gene associated with 11p3 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in predominantly in kidney and gonadal tissue. The gene is alternative spliced producing four very similar mRNA transcripts. The polypeptides encoded by the Wilms' tumor DNA includes four “zinc fingers” and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.

摘要翻译： 描述和表征了与人类染色体上的11p3基因座相关的Wilms肿瘤基因以及分析细胞的基因的方法。 该基因编码大小约50kb的转录单位和大约3kb的mRNA，其主要在肾和性腺组织中表达。 该基因是选择性剪接产生四个非常相似的mRNA转录物。 由Wilms肿瘤DNA编码的多肽包括四个“锌指”和富含脯氨酸和谷氨酰胺的区域，表明该多肽在转录调控中起作用。

公开(公告)号：US5726288A

公开(公告)日：1998-03-10

申请号：US102942

申请日：1993-08-02

申请人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman ,  Wendy Bruening ,  Andre Darveau

发明人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman ,  Wendy Bruening ,  Andre Darveau

IPC分类号： C07K14/47 ,  C07K16/30 ,  G01N33/574 ,  C07K14/435

CPC分类号： C07K16/30 ,  C07K14/47 ,  G01N33/57438

摘要： The Wilms' tumor gene associated with 11p3 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in predominantly in kidney and gonadal tissue. The gene is alternative spliced producing four very similar mRNA transcripts. The polypeptides encoded by the Wilms' tumor DNA includes four "zinc fingers" and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.

公开(公告)号：US5350840A

公开(公告)日：1994-09-27

申请号：US795323

申请日：1991-11-20

申请人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman

发明人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman

IPC分类号： C12P21/00 ,  A61K38/00 ,  A61K39/395 ,  A61K51/00 ,  A61P35/00 ,  C07K14/47 ,  C07K16/30 ,  C12N15/09 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/19 ,  C12R1/91 ,  G01N33/574 ,  G01N33/577 ,  C07H21/02 ,  C07H21/04

CPC分类号： G01N33/57438 ,  C07K14/47 ,  C07K16/30

摘要： The Wilms' tumor gene associated with the 11p13 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in a limited number of cell types (e.g., predominantly kidney cells and ja subset of hematopoietic cells). The polypeptide encoded by the Wilms' tumor DNA includes four "zinc fingers" and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.

摘要翻译： 描述和表征了与人染色体上的11p13基因座相关的Wilms肿瘤基因以及分析细胞的基因的方法。 该基因编码大小约为50kb的转录单位和约3kb的mRNA，其在有限数量的细胞类型（例如，主要是肾细胞和造血细胞的ja子集）中表达。 由Wilms肿瘤DNA编码的多肽包括四个“锌指”和富含脯氨酸和谷氨酰胺的区域，表明该多肽在转录调控中起作用。

公开(公告)号：US06316599B1

公开(公告)日：2001-11-13

申请号：US09037179

申请日：1998-03-09

申请人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman ,  Wendy Breuning ,  Andre Darveau

发明人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman ,  Wendy Breuning ,  Andre Darveau

IPC分类号： C07K1600

CPC分类号： C07K16/30 ,  C07K14/47 ,  G01N33/57438

摘要： The Wilms' tumor gene associated with 11p3 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in predominantly in kidney and gonadal tissue. The gene is alternative spliced producing four very similar mRNA transcripts. The polypeptides encoded by the Wilms' tumor DNA includes four “zinc fingers” and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.

摘要翻译： 描述和表征了与人类染色体上的11p3基因座相关的Wilms肿瘤基因以及分析细胞的基因的方法。 该基因编码大小约50kb的转录单位和大约3kb的mRNA，其主要在肾和性腺组织中表达。 该基因是选择性剪接产生四个非常相似的mRNA转录物。 由Wilms肿瘤DNA编码的多肽包括四个“锌指”和富含脯氨酸和谷氨酰胺的区域，表明该多肽在转录调控中起作用。

公开(公告)号：US06383792B1

公开(公告)日：2002-05-07

申请号：US09454818

申请日：1999-12-03

申请人： Maxine J. Allen ,  Marc Rutter ,  Alan J. Buckler

发明人： Maxine J. Allen ,  Marc Rutter ,  Alan J. Buckler

IPC分类号： C12N914

CPC分类号： C07K14/82 ,  A01K2217/05

摘要： The invention features polynucleotides encoding novel GTP-binding polypeptides, hereinafter referred to as RAQ polypeptides; expression vectors comprising a RAQ polynucleotide of the invention; isolated cells comprising a RAQ-encoding vector; a transgenic non-human animal comprising an alteration in a RAQ gene; and the use of RAQ polynucleotides in detecting in an individual the presence of a genetic polymorphism of a RAQ gene. The invention further features novel RAQ polypeptides; monoclonal antibodies specific for RAQ polypeptides; and a method for making RAQ polypeptides.

摘要翻译： 本发明的特征在于编码新型GTP结合多肽的多核苷酸，以下称为RAQ多肽; 包含本发明的RAQ多核苷酸的表达载体; 包含RAQ编码载体的分离的细胞; 包含RAQ基因改变的转基因非人动物; 以及使用RAQ多核苷酸在个体中检测RAQ基因的遗传多态性的存在。 本发明还特征在于新型RAQ多肽; RAQ多肽特异性单克隆抗体; 和制备RAQ多肽的方法。

公开(公告)号：US6100058A

公开(公告)日：2000-08-08

申请号：US909954

申请日：1997-08-12

申请人： Maxine J. Allen ,  Alan J. Buckler

发明人： Maxine J. Allen ,  Alan J. Buckler

IPC分类号： C07K14/47 ,  C12P21/06 ,  C07H21/02 ,  C07H21/04 ,  C12N9/00

CPC分类号： C07K14/4706 ,  A01K2217/075

摘要： Methods for isolating GAP12 genes are provided. The GAP12 nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.

摘要翻译： 提供了分离GAP12基因的方法。 GAP12核酸组合物用于鉴定同源或相关蛋白质和编码此类蛋白质的DNA序列; 在制备调节蛋白质的表达或功能的组合物中; 并研究相关的生理学途径。 此外，体内基因活性的调节用于预防和治疗目的，例如基于表达的细胞类型的鉴定等。

公开(公告)号：US6017710A

公开(公告)日：2000-01-25

申请号：US078317

申请日：1998-05-13

申请人： Maxine J. Allen ,  Marc Rutter ,  Alan J. Buckler

发明人： Maxine J. Allen ,  Marc Rutter ,  Alan J. Buckler

IPC分类号： C07K14/82 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/02 ,  C12N5/00 ,  C12N15/00 ,  C12P21/06

CPC分类号： C07K14/82 ,  A01K2217/05

摘要： The invention features polynucleotides encoding novel GTP-binding polypeptides, hereinafter referred to as RAQ polypeptides; expression vectors comprising a RAQ polynucleotide of the invention; isolated cells comprising a RAQ-encoding vector; a transgenic non-human animal comprising an alteration in a RAQ gene; and the use of RAQ polynucleotides in detecting in an individual the presence of a genetic polymorphism of a RAQ gene. The invention further features novel RAQ polypeptides; monoclonal antibodies specific for RAQ polypeptides; and a method for making RAQ polypeptides.