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38 条记录 (耗时 0.039 秒)

    Two-chamber blood pump
    6.
    发明授权
    Two-chamber blood pump 有权
    双室血泵

    公开(公告)号：US09234514B2

    公开(公告)日：2016-01-12

    申请号：US12199593

    申请日：2008-08-27

    申请人： Kenneth A. Jones

    发明人： Kenneth A. Jones

    IPC分类号： F04B1/02 ,  A61M1/00 ,  F04B9/04 ,  F04B43/02 ,  A61M1/10 ,  F04B7/00 ,  F04B23/06 ,  F04B53/14

    CPC分类号： F04B43/02 ,  A61M1/1006 ,  A61M1/1037 ,  A61M1/1046 ,  A61M1/1081 ,  A61M1/1086 ,  A61M2202/047 ,  A61M2205/12 ,  F04B7/00 ,  F04B23/06 ,  F04B43/026 ,  F04B53/14

    摘要： A fluid pump for medical applications. The pump includes a flexible cassette containing two pump chambers of differing volume, each chamber having a dedicated piston. The first piston pushes fluid from the first chamber to the second, and the second piston pushes fluid from the second chamber and out of the pump. Three valves are coordinated with the action of the pistons to control fluid flow into and out of the pump chambers by applying and releasing pressure to and from specific points of the flexible cassette. A control system controls the operation of the pistons and valves and directs the pistons to be advanced according to a time-varying velocity profile. The first pump chamber passively fills and then rapidly expels the collected fluid into the second chamber at low pressure. The second chamber, once filled, expels the fluid downstream at high pressure, producing a pulsatile pressure profile.

    摘要翻译： 用于医疗应用的流体泵。 该泵包括一个含有两个不同体积的泵室的柔性盒，每个室具有专用的活塞。 第一活塞将流体从第一腔室推动到第二活塞，第二活塞将流体从第二腔室推出泵出。 三个阀门与活塞的作用协调起来，以通过向和从该软管盒的特定点施加和释放压力来控制流入和流出泵室的流体。 控制系统控制活塞和阀的操作，并根据时变速度分布指示要提前的活塞。 第一泵室被动填充，然后在低压下将收集的流体快速排出到第二室中。 一旦装满了第二个室，高压下排出流体，产生脉动压力分布。

    Methods for preparing compositions using a SNORF33 receptor
    7.
    发明授权
    Methods for preparing compositions using a SNORF33 receptor 失效
    使用SNORF33受体制备组合物的方法

    公开(公告)号：US07517658B2

    公开(公告)日：2009-04-14

    申请号：US11227855

    申请日：2005-09-15

    申请人： Beth E. Borowsky ,  Kristine L. Ogozalek ,  Kenneth A. Jones

    发明人： Beth E. Borowsky ,  Kristine L. Ogozalek ,  Kenneth A. Jones

    IPC分类号： G01N33/567 ,  G01N33/53 ,  C07K14/47

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.

    摘要翻译： 本发明提供编码哺乳动物SNORF33受体的分离的核酸，纯化的哺乳动物SNORF33受体，包含编码哺乳动物SNORF33受体的核酸的载体，包含此类载体的细胞，针对哺乳动物SNORF33受体的抗体，用于检测编码哺乳动物SNORF33受体的核酸的核酸探针， 与编码哺乳动物SNORF33受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变的哺乳动物SNORF33受体的DNA的转基因非人动物，分离哺乳动物SNORF33受体的方法，治疗与哺乳动物的活性相关的异常的方法 SNORF33受体以及确定化合物与哺乳动物SNORF33受体的结合的方法，识别SNORF33受体的激动剂和拮抗剂的方法，以及所鉴定的激动剂和拮抗剂。

    DNA encoding mammalian neuropeptide FF (NPFF) receptors and uses thereof
    8.
    发明授权
    DNA encoding mammalian neuropeptide FF (NPFF) receptors and uses thereof 失效
    编码哺乳动物神经肽FF（NPFF）受体的DNA及其用途

    公开(公告)号：US06709831B1

    公开(公告)日：2004-03-23

    申请号：US09405558

    申请日：1999-09-24

    申请人： Christophe P. G. Gerald ,  Kenneth A. Jones ,  James A. Bonini ,  Beth E. Borowsky ,  Douglas A. Craig

    发明人： Christophe P. G. Gerald ,  Kenneth A. Jones ,  James A. Bonini ,  Beth E. Borowsky ,  Douglas A. Craig

    IPC分类号： G01N33566

    CPC分类号： C07K14/70571 ,  A01K2217/075

    摘要： This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.

    摘要翻译： 本发明提供编码哺乳动物NPFF受体的分离的核酸，纯化的哺乳动物NPFF受体，包含编码哺乳动物NPFF受体的核酸的载体，包含该载体的细胞，针对哺乳动物NPFF受体的抗体，用于检测编码哺乳动物NPFF受体的核酸的核酸探针， 与编码哺乳动物NPFF受体的核酸的独特序列互补的反义寡核苷酸，其表达编码正常或突变型哺乳动物NPFF受体的DNA的转基因非人动物，分离哺乳动物NPFF受体的方法，治疗与哺乳动物活性相关的异常的方法 NPFF受体，以及确定化合物与哺乳动物NPFF受体的结合的方法，识别NPFF受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。

    DNA encoding mammalian neuropeptides FF (NPFF) receptors and uses thereof
    9.
    发明授权
    DNA encoding mammalian neuropeptides FF (NPFF) receptors and uses thereof 失效
    编码哺乳动物神经肽FF（NPFF）受体的DNA及其用途

    公开(公告)号：US06262246B1

    公开(公告)日：2001-07-17

    申请号：US09255368

    申请日：1999-02-22

    申请人： Christophe P. G. Gerald ,  Kenneth A. Jones ,  James A. Bonini ,  Beth Borowsky

    发明人： Christophe P. G. Gerald ,  Kenneth A. Jones ,  James A. Bonini ,  Beth Borowsky

    IPC分类号： C07H2104

    CPC分类号： C07K14/70571 ,  A01K2217/075

    摘要： This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.

    摘要翻译： 本发明提供编码哺乳动物NPFF受体的分离的核酸，纯化的哺乳动物NPFF受体，包含编码哺乳动物NPFF受体的核酸的载体，包含该载体的细胞，针对哺乳动物NPFF受体的抗体，用于检测编码哺乳动物NPFF受体的核酸的核酸探针， 与编码哺乳动物NPFF受体的核酸的独特序列互补的反义寡核苷酸，其表达编码正常或突变型哺乳动物NPFF受体的DNA的转基因非人动物，分离哺乳动物NPFF受体的方法，治疗与哺乳动物活性相关的异常的方法 NPFF受体，以及确定化合物与哺乳动物NPFF受体的结合的方法，识别NPFF受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。

    Method of making a selective compositional disordering of a GaAs based heterostructure by the in-diffusion of Au through a single crystal, epitaxially grown Ge film
    10.
    发明授权
    Method of making a selective compositional disordering of a GaAs based heterostructure by the in-diffusion of Au through a single crystal, epitaxially grown Ge film 失效
    通过单晶，外延生长的Ge膜通过Au的扩散形成GaAs基异质结构的选择性组成失调的方法

    公开(公告)号：US5346856A

    公开(公告)日：1994-09-13

    申请号：US60073

    申请日：1993-05-10

    申请人： Kenneth A. Jones ,  Howard S. Lee

    发明人： Kenneth A. Jones ,  Howard S. Lee

    IPC分类号： H01L21/18 ,  H01S5/042 ,  H01S5/20 ,  H01L21/20

    CPC分类号： H01L21/182 ,  H01S5/20 ,  H01S5/0421 ,  H01S5/0425 ,  H01S5/2059

    摘要： A method for producing a buried heterostructure active devices and a passive waveguide by providing a heterostructure substrate such as a superlattice having at least one planar GaAs layer and at least one AlGaAs layer adjacent to it. A single crystal germanium layer is epitaxially deposited on the superlattice substrate. A layer of gold is deposited on the germanium layer. The gold and germanium layers are imagewise patterned and selected portions etched away. The patterned substrate is encapsulated in a compatible, heat resistant encapsulating material. The encapsulated substrate is then annealed at a temperature of up to about 350.degree. C.

    摘要翻译： 通过提供具有至少一个平面GaAs层和与其邻近的至少一个AlGaAs层的超晶格等异质结构衬底来制造掩埋异质结构有源器件和无源波导的方法。 单晶锗层外延沉积在超晶格基底上。 一层金沉积在锗层上。 金和锗层是成像图案的，并且选择的部分被蚀刻掉。 图案化衬底被封装在相容的耐热封装材料中。 然后将封装的衬底在高达约350℃的温度下退火