公开(公告)号：US20070129751A1

公开(公告)日：2007-06-07

申请号：US11355512

申请日：2006-02-16

申请人： Ketan Muni ,  Carlos Fernandez ,  Joshua Makower ,  John Chang ,  William Facteau

发明人： Ketan Muni ,  Carlos Fernandez ,  Joshua Makower ,  John Chang ,  William Facteau

IPC分类号： A61M29/00

CPC分类号： A61B17/24 ,  A61B18/12 ,  A61B2017/22061 ,  A61B2018/00577 ,  A61B2018/00601 ,  A61M25/0041 ,  A61M25/0108 ,  A61M25/09 ,  A61M25/10 ,  A61M25/1002 ,  A61M29/02 ,  A61M31/005 ,  A61M2025/1086 ,  A61M2029/025 ,  A61M2210/0618 ,  A61M2210/0681 ,  A61M2230/005

摘要： Devices, systems and methods wherein a dilator, such as a balloon or other expandable member, is positionable within the frontal sinus ostium and adjacent frontal recess and useable to dilate the frontal sinus ostium and substantially all of the frontal sinus recess without requiring repositioning and repeated re-expansion of the dilator. One balloon catheter device of the invention comprises a catheter body that is less than about 50 cm in length (and in some embodiments less than 25 cm in length and a semi-compliant or non-compliant balloon on the catheter body. The balloon may have a working length of about 12 mm to about 30 mm and a width at its widest point when fully inflated of about 2 mm to about 7 mm. Such balloon may be constructed to withstand inflation pressures of about 12 atmospheres. In some embodiments, the dilator is advanced through or over a guide (e.g., guidewire or guide catheter) that has a preformed shape.

摘要翻译： 装置，系统和方法，其中扩张器，例如气囊或其他可扩张构件，可定位在额窦口和相邻的前额槽内，并且可用于扩张额窦口和基本上所有的额叶窦腔，而不需要重新定位并重复 扩张器重新扩张。 本发明的一个气囊导管装置包括导管主体，其长度小于约50cm（并且在一些实施例中小于25cm长，导管主体上具有半顺应性或非顺应性气囊），球囊可具有 约12毫米至约30毫米的工作长度，当完全膨胀约2毫米至约7毫米时，其最宽点处的宽度可以构造成可承受大约12个大气压的充气压力在一些实施例中，扩张器 通过或超过具有预成形形状的引导件（例如，导丝或引导导管）。

公开(公告)号：US20060106361A1

公开(公告)日：2006-05-18

申请号：US11234395

申请日：2005-09-23

申请人： Ketan Muni ,  Hung Ha ,  Joshua Makower ,  John Morriss ,  John Chang ,  William Facteau ,  Amrish Walke

发明人： Ketan Muni ,  Hung Ha ,  Joshua Makower ,  John Morriss ,  John Chang ,  William Facteau ,  Amrish Walke

IPC分类号： A61M31/00

CPC分类号： A61M31/002 ,  A61B5/064 ,  A61B5/411 ,  A61B5/416 ,  A61B17/24 ,  A61B17/320725 ,  A61B17/320758 ,  A61B17/320783 ,  A61B17/3478 ,  A61B34/20 ,  A61B90/361 ,  A61B2017/22061 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2034/2048 ,  A61B2034/2051 ,  A61B2090/365 ,  A61F2/18 ,  A61F2/82 ,  A61F2/92 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2250/0039 ,  A61M25/007 ,  A61M25/10 ,  A61M31/00 ,  A61M2025/004 ,  A61M2025/1052

摘要： Devices and methods for delivering drugs and other therapeutic or diagnostic substances to desired locations within the bodies of human or non-human animal subjects. An implantable delivery device comprising a reservoir is initianlly attached to a deliver catheter or delivery tool and is introduced into the body and positioned at a desired site. A therapeutic or diagnostic substance is then introduced into the reservoir and the delivery catheter or deliver tool is then removed, leaving the implantable delivery device implanted within the body. The substance is then delivered from the reservoir at a rate that causes the desire diagnostic or therapeutic effect. Also provided are substance eluting stents that elute substance from a selected surface of the stent (e.g., the outer surface) but not from another surface of the stent (e.g., the inner surface).

摘要翻译： 将药物和其他治疗或诊断物质递送到人类或非人类动物受试者体内所需位置的装置和方法。 包括储存器的可植入递送装置初始地附接到递送导管或递送工具，并且被引入体内并且定位在期望的位置。 然后将治疗或诊断物质引入储存器中，然后移出输送导管或递送工具，使植入式输送装置植入体内。 然后将物质以引起期望诊断或治疗效果的速率从储存器输送。 还提供了从支架的选定表面（例如外表面）洗脱物质而不从支架的另一表面（例如，内表面）洗脱物质的物质洗脱支架。

公开(公告)号：US20070135789A1

公开(公告)日：2007-06-14

申请号：US11655794

申请日：2007-01-18

申请人： John Chang ,  Joshua Makower ,  Julia Vrany ,  John Morriss ,  Ketan Muni ,  Isaac Kim ,  Hung Ha ,  William Facteau ,  Amrish Walke

发明人： John Chang ,  Joshua Makower ,  Julia Vrany ,  John Morriss ,  Ketan Muni ,  Isaac Kim ,  Hung Ha ,  William Facteau ,  Amrish Walke

IPC分类号： A61K9/02 ,  A61M31/00

CPC分类号： A61M29/00 ,  A61B1/233 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/1657 ,  A61B17/1688 ,  A61B17/24 ,  A61B17/320016 ,  A61B17/320725 ,  A61B34/20 ,  A61B2017/00292 ,  A61B2017/246 ,  A61B2034/2051 ,  A61B2090/3764 ,  A61B2503/40 ,  A61M25/0041 ,  A61M25/0054 ,  A61M25/0662 ,  A61M25/09 ,  A61M25/1002 ,  A61M29/02 ,  A61M2025/0008 ,  A61M2025/1079 ,  A61M2029/025 ,  A61M2210/0618 ,  A61M2210/1028

摘要： Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.) into the paranasal sinuses or other structures in the ear, nose or throat. Specific devices (e.g., tubular guides, guidewires, balloon catheters, tubular sheaths) are provided as are methods for manufacturing and using such devices to treat disorders of the ear, nose or throat.

摘要翻译： 使用具有柔性或刚性器械的微创方法诊断和/或治疗鼻窦炎和其他耳朵，鼻子和喉咙疾病。 各种方法和装置用于重建或改变耳朵，鼻子或喉咙中的窦口或导管或其他解剖结构的形状，尺寸或构型; 植入装置，细胞或组织; 从耳朵，鼻子或喉咙去除物质; 提供诊断或治疗物质或执行其他诊断或治疗程序。 可以使用引入装置（例如，引导导管，管，导线，细长探针，其它细长构件）来促进工作装置（例如，导管例如球囊导管，导线，组织切割或重塑装置，用于植入元件如支架的装置， 电外科装置，能量发射装置，用于递送诊断或治疗剂，物质输送植入物，范围等的装置）到耳鼻窦或耳朵，鼻子或喉咙中的其他结构中。 提供特定装置（例如，管状引导件，导丝，气囊导管，管状护套），制造和使用这种装置来治疗耳朵，鼻子或喉咙的障碍的方法。

公开(公告)号：US20060210605A1

公开(公告)日：2006-09-21

申请号：US11150847

申请日：2005-06-10

申请人： John Chang ,  Joshua Makower ,  Julia Vrany ,  John Morriss ,  Ketan Muni ,  Isaac Kim ,  Hung Ha ,  William Facteau ,  Amrish Walke

发明人： John Chang ,  Joshua Makower ,  Julia Vrany ,  John Morriss ,  Ketan Muni ,  Isaac Kim ,  Hung Ha ,  William Facteau ,  Amrish Walke

IPC分类号： A61M31/00

CPC分类号： A61M29/00 ,  A61B1/233 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/1657 ,  A61B17/1688 ,  A61B17/24 ,  A61B17/320016 ,  A61B17/320725 ,  A61B34/20 ,  A61B2017/00292 ,  A61B2017/246 ,  A61B2034/2051 ,  A61B2090/3764 ,  A61B2503/40 ,  A61M25/0041 ,  A61M25/0054 ,  A61M25/0662 ,  A61M25/09 ,  A61M25/1002 ,  A61M29/02 ,  A61M2025/0008 ,  A61M2025/1079 ,  A61M2029/025 ,  A61M2210/0618 ,  A61M2210/1028

摘要： Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.) into the paranasal sinuses or other structures in the ear, nose or throat. Specific devices (e.g., tubular guides, guidewires, balloon catheters, tubular sheaths) are provided as are methods for manufacturing and using such devices to treat disorders of the ear, nose or throat.

公开(公告)号：US08425488B2

公开(公告)日：2013-04-23

申请号：US11749733

申请日：2007-05-16

申请人： Anton Clifford ,  Greg Liu ,  John Morriss ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

发明人： Anton Clifford ,  Greg Liu ,  John Morriss ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

IPC分类号： A61M31/00 ,  A61M1/00 ,  A61M3/02 ,  A61M3/00 ,  A61N1/30

CPC分类号： A61M31/00 ,  A61B5/0077 ,  A61B2017/00787 ,  A61F11/002 ,  A61F2230/0039 ,  A61F2230/0052 ,  A61F2250/0039 ,  A61M2210/0662 ,  A61N1/30 ,  A61N1/306

摘要： Systems and methods for treating a patient having a head with a first ear and a second ear, function by mounting a support structure to the head of the patient; aligning the support structure with a target tissue in an ear canal of the first ear; stabilizing the support structure relative to the target tissue by injecting a material into the canal and hardening the material; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear.

摘要翻译： 用于治疗患有具有第一耳朵和第二耳朵的头部的患者的系统和方法通过将支撑结构安装到患者的头部而起作用; 将支撑结构与第一耳的耳道中的目标组织对准; 通过将材料注入到管道中并使材料硬化来相对于目标组织稳定支撑结构; 以及当所述装置由所述支撑系统支撑时启动装置，使得所述装置治疗性地改造所述第一耳朵的目标组织。

公开(公告)号：US20080262509A1

公开(公告)日：2008-10-23

申请号：US11749726

申请日：2007-05-16

申请人： Anton Clifford ,  Greg Liu ,  John Morris ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

发明人： Anton Clifford ,  Greg Liu ,  John Morris ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

IPC分类号： A61F11/00 ,  A61N1/30

CPC分类号： A61M31/00 ,  A61B5/0077 ,  A61B2017/00787 ,  A61F11/002 ,  A61F2230/0039 ,  A61F2230/0052 ,  A61F2250/0039 ,  A61M2210/0662 ,  A61N1/30 ,  A61N1/306

摘要： Systems and methods for treating a patient having a head with a first ear and a second ear function by mounting a support system to the head of the patient so that the support system is aligned with a target tissue of the first ear; applying a therapeutic agent to the first ear by energizing an iontophoresis electrode supported by the support system; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear.

摘要翻译： 用于通过将支撑系统安装到患者的头部来治疗具有第一耳朵和第二耳朵功能的头部的患者的系统和方法，使得所述支撑系统与所述第一耳朵的目标组织对准; 通过对由所述支撑系统支撑的离子电渗电极通电来将治疗剂施加到所述第一耳朵; 以及当所述装置由所述支撑系统支撑时启动装置，使得所述装置治疗性地改造所述第一耳朵的目标组织。

公开(公告)号：US20120310145A1

公开(公告)日：2012-12-06

申请号：US13587806

申请日：2012-08-16

申请人： Anton Clifford ,  Greg Liu ,  John Morriss ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

发明人： Anton Clifford ,  Greg Liu ,  John Morriss ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

IPC分类号： A61N1/30

CPC分类号： A61M31/00 ,  A61B5/0077 ,  A61B2017/00787 ,  A61F11/002 ,  A61F2230/0039 ,  A61F2230/0052 ,  A61F2250/0039 ,  A61M2210/0662 ,  A61N1/30 ,  A61N1/306

摘要： Systems and methods for treating a patient having a head with a first ear and a second ear function by mounting a support system to the head of the patient so that the support system is aligned with a target tissue of the first ear; applying a therapeutic agent to the first car by energizing an iontophoresis electrode supported by the support system; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear.

摘要翻译： 用于通过将支撑系统安装到患者的头部来治疗具有第一耳朵和第二耳朵功能的头部的患者的系统和方法，使得所述支撑系统与所述第一耳朵的目标组织对准; 通过激励由所述支撑系统支撑的离子电渗电极向所述第一轿厢施加治疗剂; 以及当所述装置由所述支撑系统支撑时启动装置，使得所述装置治疗性地改造所述第一耳朵的目标组织。

公开(公告)号：US09216112B2

公开(公告)日：2015-12-22

申请号：US11749725

申请日：2007-05-16

申请人： Anton Clifford ,  Joshua Makower ,  William Facteau

发明人： Anton Clifford ,  Joshua Makower ,  William Facteau

IPC分类号： A61F11/00 ,  A61M31/00 ,  A61N1/30 ,  A61B5/00 ,  A61B17/00

CPC分类号： A61M31/00 ,  A61B5/0077 ,  A61B2017/00787 ,  A61F11/002 ,  A61F2230/0039 ,  A61F2230/0052 ,  A61F2250/0039 ,  A61M2210/0662 ,  A61N1/30 ,  A61N1/306

摘要： Systems and methods for bilateral treatment of a patient having a head with a first ear and a second ear function by aligning a first device with a target tissue of the first ear; aligning a second device with a target tissue of the second ear; and therapeutically remodeling, with synchronization, the target tissues of the first and second ear with the first and second aligned devices, respectively.

摘要翻译： 用于通过将第一装置与第一耳朵的目标组织对准来双侧治疗具有第一耳朵和第二耳朵功能的患者的患者的系统和方法; 将第二装置与第二耳朵的目标组织对准; 以及分别与第一和第二对准的装置分别对第一和第二耳朵的目标组织进行同步化的治疗重塑。

公开(公告)号：US20080262468A1

公开(公告)日：2008-10-23

申请号：US11749733

申请日：2007-05-16

申请人： Anton Clifford ,  Greg Liu ,  John Morriss ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

发明人： Anton Clifford ,  Greg Liu ,  John Morriss ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

IPC分类号： A61M31/00

CPC分类号： A61M31/00 ,  A61B5/0077 ,  A61B2017/00787 ,  A61F11/002 ,  A61F2230/0039 ,  A61F2230/0052 ,  A61F2250/0039 ,  A61M2210/0662 ,  A61N1/30 ,  A61N1/306

摘要： Systems and methods for treating a patient having a head with a first ear and a second ear, function by mounting a support structure to the head of the patient; aligning the support structure with a target tissue in an ear canal of the first ear; stabilizing the support structure relative to the target tissue by injecting a material into the canal and hardening the material; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear.

摘要翻译： 用于治疗患有具有第一耳朵和第二耳朵的头部的患者的系统和方法通过将支撑结构安装到患者的头部而起作用; 将支撑结构与第一耳的耳道中的目标组织对准; 通过将材料注入到管道中并使材料硬化来相对于目标组织稳定支撑结构; 以及当所述装置由所述支撑系统支撑时启动装置，使得所述装置治疗性地改造所述第一耳朵的目标组织。

公开(公告)号：US08249700B2

公开(公告)日：2012-08-21

申请号：US11749726

申请日：2007-05-16

申请人： Anton Clifford ,  Greg Liu ,  John Morris ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

发明人： Anton Clifford ,  Greg Liu ,  John Morris ,  Joshua Makower ,  William Facteau ,  Eric Goldfarb ,  John Y. Chang

IPC分类号： A61N1/30

CPC分类号： A61M31/00 ,  A61B5/0077 ,  A61B2017/00787 ,  A61F11/002 ,  A61F2230/0039 ,  A61F2230/0052 ,  A61F2250/0039 ,  A61M2210/0662 ,  A61N1/30 ,  A61N1/306

摘要： Systems and methods for treating a patient having a head with a first ear and a second ear function by mounting a support system to the head of the patient so that the support system is aligned with a target tissue of the first ear; applying a therapeutic agent to the first ear by energizing an iontophoresis electrode supported by the support system; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear.

摘要翻译： 用于通过将支撑系统安装到患者的头部来治疗具有第一耳朵和第二耳朵功能的头部的患者的系统和方法，使得所述支撑系统与所述第一耳朵的目标组织对准; 通过对由所述支撑系统支撑的离子电渗电极通电来将治疗剂施加到所述第一耳朵; 以及当所述装置由所述支撑系统支撑时启动装置，使得所述装置治疗性地改造所述第一耳朵的目标组织。