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1.发明授权Pharmaceutical composition comprising a medicament and 3-oxygermylpropionic acid 失效药物组合物，其包含药物和3-氧基甲基丙酸
公开(公告)号：US5240700A
公开(公告)日：1993-08-31
申请号：US881318
申请日：1992-05-07
申请人： Kiichi Sawai , Masayasu Kurono , Kazumasa Nakano , Kyoichi Asano , Takahiko Mitani , Naohisa Ninomiya , Bunkichi Kato
发明人： Kiichi Sawai , Masayasu Kurono , Kazumasa Nakano , Kyoichi Asano , Takahiko Mitani , Naohisa Ninomiya , Bunkichi Kato
CPC分类号： A61K31/80 , A61K31/28 , A61K33/24 , Y10S424/15 , Y10S514/922
摘要： A composition for inhibiting the degeneration of cells including liver cells by drugs and relieving the toxicity of drugs to internal organs including the liver contains as an essential component a 3-oxygermylpropionic acid polymer which is represented by:[(O.sub.1/2).sub.3 GeCH.sub.2 CH.sub.2 COOH].sub.nwherein n is an integer of at least 1, takes the form of a white acicular crystal and has a melting point of about 230.degree. C. at which it decomposes or coagulates. The present composition may be used with a carrier hydroxypropylcellulose in an amount of 0.005 to 50% by weight relative to 0.005 to 5% by weight of the 3-oxygermylpropionic acid polymer.
摘要翻译： 用于通过药物抑制包括肝细胞在内的细胞变性的组合物，并且缓解药物对包括肝脏在内的器官的毒性的组合物含有：[（O1 / 2）3GeCH2CH2COOH] n的3-氧基甲基丙酸聚合物作为必要组分 其中n为至少为1的整数，呈白色针状晶体的形式，其熔点约为230℃，其分解或凝结。 本发明组合物可与载体羟丙基纤维素一起使用，其含量相对于3-氧基甲基丙酸聚合物的0.005-5重量％为0.005至50重量％。
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公开(公告)号：US5260056A
公开(公告)日：1993-11-09
申请号：US640750
申请日：1991-01-14
申请人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Naohisa Ninomiya , Yoshiro Ishiwata , Syoji Yokochi , Kyoichi Asano , Kaneo Yamada , Masashi Taki , Takashi Meguro , Mikio Minamitani , Takao Matumoto , Yuichi Shiokawa
发明人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Naohisa Ninomiya , Yoshiro Ishiwata , Syoji Yokochi , Kyoichi Asano , Kaneo Yamada , Masashi Taki , Takashi Meguro , Mikio Minamitani , Takao Matumoto , Yuichi Shiokawa
摘要： An organic germanium compound to be effectively used for curing AIDS or making AIDS asymtomatic in various forms is expressed by the following rational formula: ##STR1## wherein n is an integer of 1 or 2 or more, is in the form of a white acicular or needle crystal, shows a solubility of 1.570/100 ml in water at 25.degree. C. and exhibits a melting (decomposition) point of 240.degree. C.
摘要翻译： 有效地用于治疗AIDS或以各种形式产生AIDS的有机锗化合物由以下有理式表示：其中n为1或2或更大的整数，为白色针状或 针状结晶，在25℃的水中的溶解度为1.570 / 100ml，熔点（分解）为240℃。
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公开(公告)号：US4952568A
公开(公告)日：1990-08-28
申请号：US348922
申请日：1989-05-08
申请人： Kiichi Sawai , Masayasu Kurono , Hiromoto Asai , Takahiko Mitani , Kazumasa Nakano , Naohisa Ninomiya
发明人： Kiichi Sawai , Masayasu Kurono , Hiromoto Asai , Takahiko Mitani , Kazumasa Nakano , Naohisa Ninomiya
CPC分类号： A61K31/66 , Y10S514/866
摘要： Remedies, preventives and functional diets for diabetic diseases, esp., diabetes, contain phytic acid or its salt or salts. The salt of phytic acid is a non-toxious metal salt, or a non-toxious salt with an organic base, a basic amino acid or an organic ester residue, and has a compositional form together with or separately from phytic acid.
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4.发明授权Use of orally absorbable motilin preparations to enhance motility of digestive tract 失效使用口服可吸收的胃动素制剂以增强消化道的运动能力
公开(公告)号：US5468728A
公开(公告)日：1995-11-21
申请号：US117653
申请日：1993-09-08
申请人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Makoto Sato , Hiroyuki Oowaki , Bunkichi Kato , Haruo Takahashi
发明人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Makoto Sato , Hiroyuki Oowaki , Bunkichi Kato , Haruo Takahashi
CPC分类号： A61K47/26 , A61K38/2214 , A61K47/20 , A61K9/0043
摘要： A readily absorbable type of motilin preparation containing a motilin-like active substance and a surface active agent is provided, in which the motilin-like active substance is mainly L-leucine-13-motilin-homoserine, and the surface active agent is selected from the group consisting of a bile salt, saponin and a polyethylene glycol higher-alcohol ether for nasal administration purposes and is a peptide lytic enzyme inhibitor for oral administration purposes.
摘要翻译： 提供了含有胃动素样活性物质和表面活性剂的易吸收型胃动素制剂，其中胃动素样活性物质主要是L-亮氨酸-13-促胃动素高丝氨酸，表面活性剂选自 由胆汁盐，皂苷和聚乙二醇高级醇醚组成的组，用于鼻腔给药目的，并且是用于口服给药目的的肽溶解酶抑制剂。
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公开(公告)号：US5211956A
公开(公告)日：1993-05-18
申请号：US346852
申请日：1989-05-03
IPC分类号： A61K31/66
CPC分类号： A61K31/66
摘要： Pharmaceutical compositions for oral administration used for the treatment and prevention of hyperlipemia, obesity and obesity-related diseases contain phytic acid or its salt as a pharmaceutically effective component.
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公开(公告)号：US4929438A
公开(公告)日：1990-05-29
申请号：US310162
申请日：1989-02-15
申请人： Kiichi Sawai , Masayasu Kurono , Hiromiotu Asai , Takahiko Mitani , Naohisa Ninomiya , Takao Sugiyama , Eiji Furukawa , Hisashi Michishita
发明人： Kiichi Sawai , Masayasu Kurono , Hiromiotu Asai , Takahiko Mitani , Naohisa Ninomiya , Takao Sugiyama , Eiji Furukawa , Hisashi Michishita
IPC分类号： A61K31/66 , A61K36/00 , A61K36/899 , A61P25/30
CPC分类号： A61K31/66 , Y10S514/811
摘要： Preventives or remedies for medicinal and alcoholic poisoning contain as a pharmaceutically effective component phytic acid or its salt which may be an innoxious metal salt, or an innoxious salt with an organic base, a basic amino acid or an organic ester residue.
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公开(公告)号：US5166388A
公开(公告)日：1992-11-24
申请号：US549048
申请日：1990-07-06
IPC分类号： A23B7/10 , A23L1/30 , A61K8/00 , A61K8/11 , A61K8/55 , A61K8/97 , A61K31/66 , A61K36/00 , A61K36/899 , A61L15/46 , A61P1/02 , A61Q15/00
摘要： A stabilized composition of phytic acid is obtained by the steps of:heating and drying rice bran de-fatted by pressing;adding acidic water of pH 3 to 5 to the dried rice bran, stirring the solution and completing the stirring before the pH of the solution reaches 5.7; andheating the thus obtained liquid extract to solidify protein components, followed by the removal of the solid matters by filtration. This composition is advantageously used for removing uraroma and body odor.
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公开(公告)号：US5089265A
公开(公告)日：1992-02-18
申请号：US427228
申请日：1989-10-24
IPC分类号： A61K31/66 , A61K47/02 , A61K47/26 , A61K47/30 , A61K47/36 , A61K47/38 , A61K47/46 , A61P3/06 , A61P3/08 , A61P7/06 , A61P9/00 , A61P25/28 , C07F9/117
摘要： A stabilized phytic acid composition is provided, which comprises phytic acid or its salt and at least one stabilizer selected from the group consisting of a product obtained by the lactic fermentation and ripening of rice bran, a water-soluble polymer capable of forming a film and an additive capable of absorbing water.
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公开(公告)号：US5041429A
公开(公告)日：1991-08-20
申请号：US354553
申请日：1989-05-22
申请人： Kiichi Sawai , Masayasu Kurono , Hiromoto Asai , Takahiko Mitani , Motohide Hayashi , Tunematu Suzuki , Naohisa Ninomiya
发明人： Kiichi Sawai , Masayasu Kurono , Hiromoto Asai , Takahiko Mitani , Motohide Hayashi , Tunematu Suzuki , Naohisa Ninomiya
IPC分类号： A61K31/66
CPC分类号： A61K31/66
摘要： Phytic acid or at least one of its salts is used as an effective component for cell activators in a hypoxic state, circulatory ameliorators, dementia remedies and edible compositions.
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公开(公告)号：US5059594A
公开(公告)日：1991-10-22
申请号：US497364
申请日：1990-03-22
申请人： Kiichi Sawai , Masayasu Kurono , Hiromoto Asai , Takahiko Mitani , Naohisa Ninomiya , Tomoo Suzuki
发明人： Kiichi Sawai , Masayasu Kurono , Hiromoto Asai , Takahiko Mitani , Naohisa Ninomiya , Tomoo Suzuki
IPC分类号： A61K31/66 , A61K33/26 , A61K47/12 , A61K47/18 , A61P1/16 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/00 , A61P25/28 , A61P39/02 , B01J20/24 , C07F9/117
CPC分类号： A61K47/183 , A61K31/66 , A61K33/26 , A61K47/12
摘要： A novel composition contains phytic acid and ferric ions as main ingredients and carboxylic acid ions as a dissolution accelerator, and may further include at least one or more or two additives selected from the group consisting of a carboxylic acid or its salt, saccharides, an amino acid or its salt and an organic phosphoric acid or its salt.
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