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公开(公告)号：US4929438A
公开(公告)日：1990-05-29
申请号：US310162
申请日：1989-02-15
申请人： Kiichi Sawai , Masayasu Kurono , Hiromiotu Asai , Takahiko Mitani , Naohisa Ninomiya , Takao Sugiyama , Eiji Furukawa , Hisashi Michishita
发明人： Kiichi Sawai , Masayasu Kurono , Hiromiotu Asai , Takahiko Mitani , Naohisa Ninomiya , Takao Sugiyama , Eiji Furukawa , Hisashi Michishita
IPC分类号： A61K31/66 , A61K36/00 , A61K36/899 , A61P25/30
CPC分类号： A61K31/66 , Y10S514/811
摘要： Preventives or remedies for medicinal and alcoholic poisoning contain as a pharmaceutically effective component phytic acid or its salt which may be an innoxious metal salt, or an innoxious salt with an organic base, a basic amino acid or an organic ester residue.
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公开(公告)号：US5118503A
公开(公告)日：1992-06-02
申请号：US359894
申请日：1989-06-01
申请人： Kiichi Sawai , Masayasu Kurono , Hiromoto Asai , Takahiko Mitani , Naohisa Ninomiya , Eiji Furukawa
发明人： Kiichi Sawai , Masayasu Kurono , Hiromoto Asai , Takahiko Mitani , Naohisa Ninomiya , Eiji Furukawa
CPC分类号： A61K8/97 , A61L9/01 , A61Q15/00 , A61K2800/85
摘要： Composition obtained from a rice bran, which comprises a filtrate of lactic fermented and aged material of the rice bran, the filtrate being an odorless pale yellow solution, having a salty taste, and solubility with water and alcohols, or a powderized substance of the filtrate, a process for the preparation of the composition, and use of the composition as a deodorant.
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公开(公告)号：US5260056A
公开(公告)日：1993-11-09
申请号：US640750
申请日：1991-01-14
申请人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Naohisa Ninomiya , Yoshiro Ishiwata , Syoji Yokochi , Kyoichi Asano , Kaneo Yamada , Masashi Taki , Takashi Meguro , Mikio Minamitani , Takao Matumoto , Yuichi Shiokawa
发明人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Naohisa Ninomiya , Yoshiro Ishiwata , Syoji Yokochi , Kyoichi Asano , Kaneo Yamada , Masashi Taki , Takashi Meguro , Mikio Minamitani , Takao Matumoto , Yuichi Shiokawa
摘要： An organic germanium compound to be effectively used for curing AIDS or making AIDS asymtomatic in various forms is expressed by the following rational formula: ##STR1## wherein n is an integer of 1 or 2 or more, is in the form of a white acicular or needle crystal, shows a solubility of 1.570/100 ml in water at 25.degree. C. and exhibits a melting (decomposition) point of 240.degree. C.
摘要翻译： 有效地用于治疗AIDS或以各种形式产生AIDS的有机锗化合物由以下有理式表示：其中n为1或2或更大的整数，为白色针状或 针状结晶，在25℃的水中的溶解度为1.570 / 100ml，熔点（分解）为240℃。
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4.发明授权Uracil derivatives for use as anti-tumor agents having silicon containing side chains 失效尿嘧啶衍生物用作具有含硅侧链的抗肿瘤剂
公开(公告)号：US4868189A
公开(公告)日：1989-09-19
申请号：US140503
申请日：1988-01-04
申请人： Masayasu Kurono , Ryoichi Unno , Hiromoto Kimura , Hiroshi Ozawa , Takahiko Mitani , Takahito Jomori , Masahiko Koketsu , Hisashi Michishita , Kiichi Sawai
发明人： Masayasu Kurono , Ryoichi Unno , Hiromoto Kimura , Hiroshi Ozawa , Takahiko Mitani , Takahito Jomori , Masahiko Koketsu , Hisashi Michishita , Kiichi Sawai
IPC分类号： C07F7/10 , A61K31/695 , A61P35/00 , C07F7/08 , C07F7/18
CPC分类号： C07F7/0812
摘要： An organo-silicone compound of the formula ##STR1## wherein X is a methylene or carbonyl radical, Y is an NH or O, n is an integer, R.sub.1 is a hydrogen atom, halogen atom or alkyl group, R.sub.2, R.sub.3 and R.sub.4 are an alkyl group, alkoxy group, phenyl radical or substituted phenyl radical, respectively, and R.sub.5 is a hydrogen atom or a group of ##STR2## in which X, Y, n, R.sub.2, R.sub.3 and R.sub.4 have the meanings as referred to, and used as an anti-tumor agent or for use in anti-tumor compositions.
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公开(公告)号：US4870062A
公开(公告)日：1989-09-26
申请号：US183575
申请日：1988-04-19
申请人： Masayasu Kurono , Ryoichi Unno , Yukiharu Matsumoto , Yasuaki Kondo , Takahiko Mitani , Takahito Jomori , Hisashi Michishita , Kiichi Sawai
发明人： Masayasu Kurono , Ryoichi Unno , Yukiharu Matsumoto , Yasuaki Kondo , Takahiko Mitani , Takahito Jomori , Hisashi Michishita , Kiichi Sawai
IPC分类号： A61K31/28 , A61K31/282 , A61K31/55 , A61P35/00 , C07F15/00
CPC分类号： C07F15/0093
摘要： A removable rating plug for a circuit breaker provides an active variable impedance in series with a reference resistor between the sensing terminals of the circuit breaker trip circuit to adjust the sensing voltage produced in response to the input current received from current monitors in the protected circuit. The active variable impedance, which is energized by the input current, includes a high gain transistor amplifier, preferably a Darlington transistor, controlled by an operational amplifier. A control circuit includes a pair of reference diodes which match the forward drop across the Darlington transistor when full on, in series with a reference voltage selection circuit which applies a reference voltage to the non-inverting input of the operational amplifier. The voltage at the connection between the Darlington transistor and the reference resistor is fed back to the inverting input of the operational amplifier so that the gain of the amplifier, and therefore the variable impedance in series with the reference resistor, varies with the reference voltage.
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公开(公告)号：US5211956A
公开(公告)日：1993-05-18
申请号：US346852
申请日：1989-05-03
IPC分类号： A61K31/66
CPC分类号： A61K31/66
摘要： Pharmaceutical compositions for oral administration used for the treatment and prevention of hyperlipemia, obesity and obesity-related diseases contain phytic acid or its salt as a pharmaceutically effective component.
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7.发明授权Pharmaceutical composition comprising a medicament and 3-oxygermylpropionic acid 失效药物组合物，其包含药物和3-氧基甲基丙酸
公开(公告)号：US5240700A
公开(公告)日：1993-08-31
申请号：US881318
申请日：1992-05-07
申请人： Kiichi Sawai , Masayasu Kurono , Kazumasa Nakano , Kyoichi Asano , Takahiko Mitani , Naohisa Ninomiya , Bunkichi Kato
发明人： Kiichi Sawai , Masayasu Kurono , Kazumasa Nakano , Kyoichi Asano , Takahiko Mitani , Naohisa Ninomiya , Bunkichi Kato
CPC分类号： A61K31/80 , A61K31/28 , A61K33/24 , Y10S424/15 , Y10S514/922
摘要： A composition for inhibiting the degeneration of cells including liver cells by drugs and relieving the toxicity of drugs to internal organs including the liver contains as an essential component a 3-oxygermylpropionic acid polymer which is represented by:[(O.sub.1/2).sub.3 GeCH.sub.2 CH.sub.2 COOH].sub.nwherein n is an integer of at least 1, takes the form of a white acicular crystal and has a melting point of about 230.degree. C. at which it decomposes or coagulates. The present composition may be used with a carrier hydroxypropylcellulose in an amount of 0.005 to 50% by weight relative to 0.005 to 5% by weight of the 3-oxygermylpropionic acid polymer.
摘要翻译： 用于通过药物抑制包括肝细胞在内的细胞变性的组合物，并且缓解药物对包括肝脏在内的器官的毒性的组合物含有：[（O1 / 2）3GeCH2CH2COOH] n的3-氧基甲基丙酸聚合物作为必要组分 其中n为至少为1的整数，呈白色针状晶体的形式，其熔点约为230℃，其分解或凝结。 本发明组合物可与载体羟丙基纤维素一起使用，其含量相对于3-氧基甲基丙酸聚合物的0.005-5重量％为0.005至50重量％。
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公开(公告)号：US5059594A
公开(公告)日：1991-10-22
申请号：US497364
申请日：1990-03-22
申请人： Kiichi Sawai , Masayasu Kurono , Hiromoto Asai , Takahiko Mitani , Naohisa Ninomiya , Tomoo Suzuki
发明人： Kiichi Sawai , Masayasu Kurono , Hiromoto Asai , Takahiko Mitani , Naohisa Ninomiya , Tomoo Suzuki
IPC分类号： A61K31/66 , A61K33/26 , A61K47/12 , A61K47/18 , A61P1/16 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/00 , A61P25/28 , A61P39/02 , B01J20/24 , C07F9/117
CPC分类号： A61K47/183 , A61K31/66 , A61K33/26 , A61K47/12
摘要： A novel composition contains phytic acid and ferric ions as main ingredients and carboxylic acid ions as a dissolution accelerator, and may further include at least one or more or two additives selected from the group consisting of a carboxylic acid or its salt, saccharides, an amino acid or its salt and an organic phosphoric acid or its salt.
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公开(公告)号：US5166388A
公开(公告)日：1992-11-24
申请号：US549048
申请日：1990-07-06
IPC分类号： A23B7/10 , A23L1/30 , A61K8/00 , A61K8/11 , A61K8/55 , A61K8/97 , A61K31/66 , A61K36/00 , A61K36/899 , A61L15/46 , A61P1/02 , A61Q15/00
摘要： A stabilized composition of phytic acid is obtained by the steps of:heating and drying rice bran de-fatted by pressing;adding acidic water of pH 3 to 5 to the dried rice bran, stirring the solution and completing the stirring before the pH of the solution reaches 5.7; andheating the thus obtained liquid extract to solidify protein components, followed by the removal of the solid matters by filtration. This composition is advantageously used for removing uraroma and body odor.
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公开(公告)号：US5089265A
公开(公告)日：1992-02-18
申请号：US427228
申请日：1989-10-24
IPC分类号： A61K31/66 , A61K47/02 , A61K47/26 , A61K47/30 , A61K47/36 , A61K47/38 , A61K47/46 , A61P3/06 , A61P3/08 , A61P7/06 , A61P9/00 , A61P25/28 , C07F9/117
摘要： A stabilized phytic acid composition is provided, which comprises phytic acid or its salt and at least one stabilizer selected from the group consisting of a product obtained by the lactic fermentation and ripening of rice bran, a water-soluble polymer capable of forming a film and an additive capable of absorbing water.
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