公开(公告)号：US20190218496A1

公开(公告)日：2019-07-18

申请号：US16238591

申请日：2019-01-03

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Christopher Brau ,  Nephi JONES ,  Mark SMITH

IPC: C12M1/42 ,  C12M1/00 ,  C12M1/06 ,  C12N5/071

CPC classification number: B01F7/00391 ,  B01F3/04531 ,  B01F7/0005 ,  B01F7/00725 ,  B01F7/24 ,  B01F15/00538 ,  B01F15/00707 ,  B01F15/0085 ,  B01F2003/04673 ,  B01F2015/0011 ,  B01F2015/00603 ,  B01F2215/0073 ,  C12M23/58 ,  C12M27/02 ,  C12M27/06 ,  C12M35/04 ,  C12N5/0602 ,  C12N2527/00

Abstract: The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.