专利检索 ap:("Lata Jayaraman" OR "Rolf Ryseck" OR "Matthew Lorenzi" OR "David Bol") AND inv:"Lata Jayaraman" 第 1 页

1.

发明申请
PRMTs as modifiers of the p53 pathway and methods of use 审中-公开

公开(公告)号：US20060024665A1

公开(公告)日：2006-02-02

申请号：US11241347

申请日：2005-09-30

申请人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke , Rolf Ryseck , Lata Jayaraman , David Bol , Matthew Lorenzi

发明人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke , Rolf Ryseck , Lata Jayaraman , David Bol , Matthew Lorenzi

IPC分类号： C12Q1/00 , C12Q1/48

CPC分类号： G01N33/6872 , C12Q1/42 , G01N33/57496 , G01N2500/00

摘要： Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.

2.

发明申请
Human coactivator-associated arginine methyltransferase 1 (hCARM1) 审中-公开
标题翻译：人共激活因子相关精氨酸甲基转移酶1（hCARM1）

公开(公告)号：US20050196753A1

公开(公告)日：2005-09-08

申请号：US10449370

申请日：2003-05-30

申请人： Lata Jayaraman , Rolf Ryseck , Matthew Lorenzi , David Bol

发明人： Lata Jayaraman , Rolf Ryseck , Matthew Lorenzi , David Bol

IPC分类号： C07H21/04 , C12N5/06 , C12N9/10 , C12P21/02 , C12Q1/68 , G01N33/53

CPC分类号： C12N9/1007

摘要： Human coactivator-associated arginine methyltransferase 1 (hCARM1) polynucleotides and polypeptides. Also provided are expression vectors, recombinant host cells and processes for producing recombinant host cells, processes for producing said polypeptides, and methods for identifying substances that are capable of interacting with a coactivator-associated arginine methyltransferase 1 molecule.

摘要翻译： 人共激活因子相关的精氨酸甲基转移酶1（hCARM1）多核苷酸和多肽。还提供了表达载体，重组宿主细胞和用于产生重组宿主细胞的方法，用于产生所述多肽的方法，以及用于鉴定能够与共激活因子相关的精氨酸甲基转移酶1分子相互作用的物质的方法。

3.

发明申请
PRMTs as modifiers of the p53 pathway and methods of use 有权
标题翻译： PRMTs作为p53途径的修饰物和使用方法

公开(公告)号：US20050186566A9

公开(公告)日：2005-08-25

申请号：US10164278

申请日：2002-06-05

申请人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke , Rolf Ryseck , Lata Jayaraman , David Bol , Matthew Lorenzi

发明人： Lori Friedman , Gregory Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke , Rolf Ryseck , Lata Jayaraman , David Bol , Matthew Lorenzi

IPC分类号： C12Q1/68 , G01N33/574 , C12Q1/48

CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2333/4739 , G01N2500/10

摘要： Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.

摘要翻译： 人PRMT基因被鉴定为p53途径的调节剂，因此是与缺陷型p53功能相关的病症的治疗靶点。提供了鉴定p53调节剂的方法，包括筛选调节PRMT活性的试剂。

4.

发明授权
PRMTs as modifiers of the p53 pathway and methods of use 有权

公开(公告)号：US07049088B2

公开(公告)日：2006-05-23

申请号：US10164278

申请日：2002-06-05

申请人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke , Rolf Peter Ryseck , Lata Jayaraman , David K. Bol , Matthew Lorenzi

发明人： Lori Friedman , Gregory D. Plowman , Marcia Belvin , Helen Francis-Lang , Danxi Li , Roel P. Funke , Rolf Peter Ryseck , Lata Jayaraman , David K. Bol , Matthew Lorenzi

IPC分类号： C12Q1/48 , C12N9/10

CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2333/4739 , G01N2500/10

摘要： Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.