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1.发明授权Method for determination of realistic UV protection factors or broad spectrum indices 有权确定现实紫外线保护因子或广谱指标的方法公开(公告)号：US06820014B2
公开(公告)日：2004-11-16
申请号：US10323088
申请日：2002-12-18
申请人： Louis Ferrero , Marc Pissavini , Leonhard Zastrow
发明人： Louis Ferrero , Marc Pissavini , Leonhard Zastrow
摘要： The invention relates to a new method for determination of realistic UV protection factors or bread spectrum indices of a sunscreen preparation. Realistic UV protection factors are calculable by determination of the theoretical and the experimental UV absorbances of known UV filters in wavelength steps of about 5 nm in the range of 290-400 nm from a definite basic formulation (emulsion, gel etc.) and on a transparent substrate and introducing of the values in a mathematical model. These factors are in conformity with values measured in vivo. The number of the experiments for developing new formulations are significant reduced because only basic formulation, kind and concentration of the filters have to enter.
摘要翻译： 本发明涉及一种用于确定防晒制剂的真实紫外线防护因子或面包光谱指数的新方法。 通过确定已知紫外线滤光片的理论和实验紫外线吸收度可以通过确定在约5nm的范围内的波长步骤在290-400nm范围内从确定的碱性配方（乳液，凝胶等）和在 透明衬底和数值模型中的值的引入。 这些因素与体内测量的值一致。 开发新制剂的实验数量显着减少，因为只有基本配方，过滤器的种类和浓度必须进入。
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2.发明申请公开(公告)号：US20080224059A1
公开(公告)日：2008-09-18
申请号：US11568148
申请日：2005-04-14
IPC分类号： G01J1/42
CPC分类号： G01R33/60
摘要： The invention relates to a method for determining an integral sun protection factor (∫SPF or iSPF) which encompasses both UVA and UVB radiation and can be used for classifying cosmetic and dermatological sunscreens. The method comprises the steps of applying a defined amount of the sunscreen onto a defined area of a skin substrate impregnated with a spin trap, exposing the skin substrate to a defined amount of UVA- and UVB rays by a sun simulator, subjecting the skin substrate exposed to radiation to an electron spin resonance (ESR) measurement, recording the number of free radicals trapped as a real number×1012 free radicals/mg of skin sample, and determining the integral sun protection factor ∫SPF according to the equations (1) and (2) and (8) ∫ S P F = E 0 E ( 1 ) log 10 ( E ) = a · log 10 ( X · 1000 ) + b ( 2 ) E = 10 log 10 ( E ) . ( 8 )
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3.发明授权Multi-phase light screening agent, process for its production and for its application to the skin 失效多相光屏蔽剂，其生产工艺及其在皮肤上的应用
公开(公告)号：US5951967A
公开(公告)日：1999-09-14
申请号：US973605
申请日：1998-01-28
申请人： Karin Golz , Leonhard Zastrow , Klaus Stanzl , Jacques Gerbron , Louis Ferrero
发明人： Karin Golz , Leonhard Zastrow , Klaus Stanzl , Jacques Gerbron , Louis Ferrero
IPC分类号： A61K8/00 , A61K8/03 , A61K8/25 , A61K8/26 , A61K8/29 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/37 , A61K8/41 , A61K8/46 , A61K8/97 , A61K8/98 , A61Q17/04 , A61K7/42 , A61K7/00 , A61K7/44
摘要： A multi-phase sunscreen agent, characterized by at least two phases that are liquid to pasty or gelatinous and separate from each other spontaneously within seconds to less than ten minutes after a brief and gentle mixing process lasting less than one minute without any essential application of force, where at least one phase contains a UV filter.
摘要翻译： PCT No.PCT / DE96 / 01046 Sec。 371日期1998年1月28日 102（e）1998年1月28日PCT PCT 1996年6月7日PCT公布。 公开号WO96 / 41613 日期：1996年12月27日一种多相防晒剂，其特征在于至少两相是液体糊状或凝胶状，并且在持续不到一分钟的短暂且温和的混合过程之后，在数秒至少于十分钟内自发分离 没有任何基本的施加力，其中至少一个相包含UV过滤器。
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公开(公告)号：US6106847A
公开(公告)日：2000-08-22
申请号：US924241
申请日：1997-09-05
申请人： Louis Ferrero , Karin Golz , Leonhard Zastrow , Klaus Stanzl
发明人： Louis Ferrero , Karin Golz , Leonhard Zastrow , Klaus Stanzl
CPC分类号： A61Q17/04 , A61K8/066 , Y10S514/937 , Y10S514/938
摘要： The invention relates to a stable multiple phase emulsion of the O.sub.1 /W/O.sub.2 type with high proportions of the primary O.sub.1 /W emulsion. The new emulsions have an emulsifier-free primary oil-in-water phase consisting of a viscoplastic aqueous gel containing the finely distributed inner oil droplets together with a gelling agent, wherein the thixotropic primary oil-in-water phase has a yield point in the range from 20 to 100 Pa and a plastic viscosity of 0.01 to 0.1 Pa.multidot.s and contains at least one lipophilic agent in the primary oil; and a secondary oil phase in which the primary oil-in-water phase is present together with a lipophilic emulsifier; and wherein the proportion of the inner oily phase is from 10 to 35 % by weight relative to the total weight of the emulsion. The higher proportions of the inner oily phase render possible higher proportions of organic sun protection agents with simultaneous avoidance of skin irritations.
摘要翻译： 本发明涉及具有高比例的主要O1 / W乳液的O1 / W / O2型稳定的多相乳液。 新的乳液具有不含乳化剂的初级水包油相，其由含有细分散的内部油滴的胶粘剂水凝胶与胶凝剂组成，其中触变性初级水包油相具有屈服点 范围为20〜100Pa，塑性粘度为0.01〜0.1Pax，在原油中含有至少一种亲脂性试剂; 和主要油包水相与亲脂性乳化剂一起存在的次级油相; 并且其中所述内部油相的比例相对于所述乳液的总重量为10至35重量％。 内部油相的比例越高，可以提供更高比例的有机防晒剂，同时避免皮肤刺激。
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5.发明授权公开(公告)号：US07567080B2
公开(公告)日：2009-07-28
申请号：US11568148
申请日：2005-04-14
IPC分类号： G01V3/00
CPC分类号： G01R33/60
摘要： The invention relates to a method for determining an integral sun protection factor (∫ SPF or iSPF) which encompasses both UVA and UVB radiation and can be used for classifying cosmetic and dermatological sunscreens. The method comprises the steps of applying a defined amount of the sunscreen onto a defined area of a skin substrate impregnated with a spin trap, exposing the skin substrate to a defined amount of UVA- and UVB rays by a sun simulator, subjecting the skin substrate exposed to radiation to an electron spin resonance (ESR) measurement, recording the number of free radicals trapped as a real number×1012 free radicals/mg of skin sample, and determining the integral sun protection factor ∫ SPF according to the equations (1) and (2) and (8) ∫ S P F = E 0 E ( 1 ) log 10 ( E ) = a · log 10 ( X · 1000 ) + b ( 2 ) E = 10 log 10 ( E ) . ( 8 )
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公开(公告)号：US08425883B2
公开(公告)日：2013-04-23
申请号：US12280185
申请日：2007-02-20
摘要： The invention relates to a cosmetic sun protection product based on W/Si emulsions, which product has improved effectiveness and, despite high content of organic sun protection filters, a very good sensory profile and, in particular, a long-lasting soft touch. The sun protection product includes 22-32 wt. % of a volatile, cyclic silicone oil, 2.0-4.0 wt. % of a non-volatile silicone elastomer, 0.9-2.8 wt. % of an emulsifier, 0.1-0.5 wt. % of an amino acid/fatty acid copolymer, 19-24 wt. % of a mixture of organic UVA and UVB filters at a ratio of from 1:1.5 to 1:1; and cosmetic adjuvants, excipients, active substances and mixtures thereof to make 100 wt. %, the Brookfield viscosity of the sun protection product ranging from 3,000 to 20,000 mPas.
摘要翻译： 本发明涉及一种基于W / Si乳液的化妆品防晒产品，该产品具有改进的效果，并且尽管有机防晒过滤器含量高，但具有非常好的感官特性，特别是持久的柔软触感。 防晒产品包括22-32wt。 ％的挥发性环状硅油，2.0-4.0wt。 ％的非挥发性硅氧烷弹性体，0.9-2.8wt。 ％的乳化剂，0.1-0.5wt。 ％的氨基酸/脂肪酸共聚物，19-24wt。 有机UVA和UVB过滤器的混合物的比例为1:1.5至1:1的比例; 和化妆品佐剂，赋形剂，活性物质及其混合物，以制备100重量％ ％，防晒产品的布鲁克菲尔德粘度为3,000至20,000 mPas。
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公开(公告)号：US07829068B2
公开(公告)日：2010-11-09
申请号：US10570031
申请日：2004-09-08
IPC分类号： A61K8/00 , A61K8/18 , A61K8/02 , A61K9/127 , A61K36/752 , A61K31/70 , A61Q17/04 , A01N65/00 , A01N43/04
摘要： A novel cosmetic bronzing agent based on dihydroxyacetone. the bronzing agent contains 0.1-4.5 wt. % dihydroxyacetone (DHA) mounted in a lamellar structure, 0.15-3.5 wt. % free dihydroxyacetone, whereby the ratio between mounted lamellar DHA and free DHA is located in the region of 1:1.5 -1:0.25 and the total amount of DHA is equal to or less than 5 wt, %, also containing 0.01-10 wt % phospholipids and up to 100 wt % cosmetic auxiliary agents, carrier substances, additional active ingredients and mixtures thereof. The bronzing agent has a particularly durable, even and intensive synergistic action.
摘要翻译： 一种基于二羟丙酮的新型化妆品烫金剂。 烫金剂含有0.1-4.5wt。 ％二羟基丙酮（DHA），其安装在层状结构中，0.15-3.5wt。 ％游离二羟基丙酮，由此安装的层状DHA和游离DHA之间的比例位于1:1.5-1:0.25的范围内，DHA的总量等于或小于5重量％，还含有0.01-10重量％ ％磷脂和高达100重量％的化妆品助剂，载体物质，其它活性成分及其混合物。 烫金剂具有特别耐用，均匀和密集的协同作用。
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公开(公告)号：US20100166687A1
公开(公告)日：2010-07-01
申请号：US12529324
申请日：2008-02-29
CPC分类号： A61K8/72 , A61K8/02 , A61K8/19 , A61K8/25 , A61K8/26 , A61K8/37 , A61K8/40 , A61K8/4946 , A61K8/496 , A61K8/4966 , A61K8/922 , A61K2800/412 , A61K2800/59 , A61K2800/592 , A61Q17/04
摘要： The invention relates to a cosmetic light-protective agent for wavelengths of from 250 to 1400 nm, containing at least methylene bis-benzotriazolyl tetramethylbutylphenol as UVA filter; at least one UVB filter; sea buckthorn oil with a refractive index of from 1.4 to 1.59 and a solid with a d50 of from 3 to 50 μm, selected among citrine, topaz, amethyst, ruby, glass with a refractive index of from 1.500 to 1.599 and mixtures thereof; at least one infrared-absorbing glass with a d50 of from 5 to 50 μm; a free-radical scavenger, and cosmetic adjuvants and/or excipients and optionally further cosmetic active substances. The agent shows an unexpectedly high light absorption and largely prevents skin damage caused by light of 250-1400 nm in wavelength.
摘要翻译： 本发明涉及波长为250〜1400nm的化妆品防晒剂，其至少含有亚甲基双 - 苯并三唑基四甲基丁基苯酚作为UVA过滤器; 至少一个UVB过滤器; 折射率为1.4〜1.59的沙棘油和d50为3〜50μm的固体，选自黄水晶，黄玉，紫水晶，红宝石，折射率为1.500〜1.599的玻璃及其混合物; 至少一种d50为5〜50μm的红外线吸收玻璃; 自由基清除剂和化妆品佐剂和/或赋形剂和任选的其它美容活性物质。 该试剂显示出非常高的光吸收，并且很大程度上可以防止由波长250-1400nm引起的皮肤损伤。
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公开(公告)号：US20100015242A1
公开(公告)日：2010-01-21
申请号：US12438497
申请日：2007-08-24
IPC分类号： A61K36/53 , A61K36/752 , A61K36/82 , A61K35/00 , A61K36/537 , A61P17/00
CPC分类号： A61K8/553 , A61K8/14 , A61K8/22 , A61K8/70 , A61K8/97 , A61K9/06 , A61K9/127 , A61K35/63 , A61K36/00 , A61K47/02 , A61K47/16 , A61K47/24 , A61K47/36 , A61K2800/522 , A61K2800/81 , A61Q17/04 , A61Q19/00 , A61K2300/00
摘要： The invention relates to the use of a composition in the production of a dermatological agent for skin treatment under repeated X-irradiation. The composition includes oxygen-bearing asymmetrical lamellar aggregates of phospholipids and fluorocarbons as well as specific water-soluble antioxidants, said composition having a radical protection factor of at least 4000×1014 radicals/mg.
摘要翻译： 本发明涉及组合物在重复X射线照射下用于皮肤治疗皮肤病药物的生产中的用途。 组合物包括磷脂和碳氟化合物的含氧不对称层状聚集体以及特定的水溶性抗氧化剂，所述组合物具有至少4000×10 14个自由基/毫克的自由基保护因子。
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公开(公告)号：US07303774B2
公开(公告)日：2007-12-04
申请号：US10741335
申请日：2003-12-19
CPC分类号： A61Q19/00 , A61K8/97 , A61K2800/244 , A61Q13/00 , A61Q17/04 , A61Q19/004
摘要： The present invention relates to new cosmetic relax preparations bringing about changing temperature effects on the skin. Said cosmetic contains 0.1-10% by weight of an extract from Papaveraceae and 0.1-10% by weight of an extract from the overground parts of Menthae, along with 80-99.8% by weight of cosmetic auxiliaries, carrier substances, active agents or mixtures thereof.
摘要翻译： 本发明涉及新的化妆品放松制剂，其对皮肤的温度影响变化。 所述化妆品含有0.1-10重量％的来自罂粟科的提取物和0.1-10重量％的来自薄荷地上部分的提取物以及80-99.8重量％的化妆品助剂，载体物质，活性剂或混合物 其中。
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