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    Probiotic storage and delivery
    1.
    发明授权
    Probiotic storage and delivery 有权
    益生菌储存和运送

    公开(公告)号：US08871266B2

    公开(公告)日：2014-10-28

    申请号：US10573784

    申请日：2004-03-30

    申请人： Ross Crittenden ,  Luz Sanguansri ,  Mary Ann Augustin

    发明人： Ross Crittenden ,  Luz Sanguansri ,  Mary Ann Augustin

    IPC分类号： C12N1/00 ,  C12N1/04 ,  C12N1/12 ,  C12N11/00 ,  C12N11/16 ,  C12P1/00 ,  C12P1/04 ,  C12P7/00 ,  C12P19/00 ,  C12P39/00 ,  A61K36/064 ,  A61K35/74 ,  A61K47/42 ,  A61K47/26 ,  A61K47/44 ,  A61K9/19

    CPC分类号： A61K47/26 ,  A61K9/19 ,  A61K35/741 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61K36/064 ,  A61K47/42 ,  A61K47/44 ,  Y10S435/822 ,  Y10S435/853 ,  Y10S435/885 ,  Y10S435/886

    摘要： Probiotic microorganisms are micro encapsulated by dispersing the probiotic microorganism in an aqueous suspension of a film forming protein and a carbohydrate; in an oil in water emulsion of a film forming protein and a carbohydrate and a fat; or in an oil which is subsequently dispersed in a film forming protein and a carbohydrate. The emulsion or suspension may be dried to form a powder. The probiotic may be dispersed in oil and then emulsified with the aqueous suspension and then dried to produce an encapsulated oil be dried to produce a powder. Oil suspended probiotics may be preferred where the probiotic is water sensitive. The preferred protein is casein or whey protein and the carbohydrate may be a resistant starch or a saccharide with a reducing sugar group. Where the probiotic is oxygen sensitive the protein carbohydrate is heated to create Maillard reaction products in the encapsulating film.

    摘要翻译： 益生菌微生物通过将益生菌微生物分散在成膜蛋白质和碳水化合物的水悬浮液中来微囊化; 在成膜蛋白质和碳水化合物和脂肪的水包油乳液中; 或随后分散在成膜蛋白质和碳水化合物中的油中。 可以将乳液或悬浮液干燥以形成粉末。 益生菌可以分散在油中，然后用水悬浮液乳化，然后干燥以产生待干燥的包封的油以产生粉末。 在益生菌对水敏感的地方，优选油悬浮的益生菌。 优选的蛋白质是酪蛋白或乳清蛋白，碳水化合物可以是抗性淀粉或具有还原糖基团的糖。 当益生菌对氧敏感时，蛋白质碳水化合物被加热以在封装膜中产生美拉德反应产物。

    Probiotic storage and delivery
    2.
    发明申请
    Probiotic storage and delivery 有权
    益生菌储存和运送

    公开(公告)号：US20070122397A1

    公开(公告)日：2007-05-31

    申请号：US10573784

    申请日：2004-03-30

    申请人： Luz Sanguansri ,  Mary Ann Augustin ,  Ross Crittenden

    发明人： Luz Sanguansri ,  Mary Ann Augustin ,  Ross Crittenden

    IPC分类号： A61K35/74

    CPC分类号： A61K47/26 ,  A61K9/19 ,  A61K35/741 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61K36/064 ,  A61K47/42 ,  A61K47/44 ,  Y10S435/822 ,  Y10S435/853 ,  Y10S435/885 ,  Y10S435/886

    摘要： Probiotic microorganisms are micro encapsulated by dispersing the probiotic microorganism in an aqueous suspension of a film forming protein and a carbohydrate; in an oil in water emulsion of a film forming protein and a carbohydrate and a fat; or in an oil which is subsequently dispersed in a film forming protein and a carbohydrate. The emulsion or suspension may be dried to form a powder. The probiotic may be dispersed in oil and then emulsified with the aqueous suspension and then dried to produce an encapsulated oil be dried to produce a powder. Oil suspended probiotics may be preferred where the probiotic is water sensitive. The preferred protein is casein or whey protein and the carbohydrate may be a resistant starch or a saccharide with a reducing sugar group. Where the probiotic is oxygen sensitive the protein carbohydrate is heated to create Maillard reaction products in the encapsulating film.

    摘要翻译： 益生菌微生物通过将益生菌微生物分散在成膜蛋白质和碳水化合物的水悬浮液中来微囊化; 在成膜蛋白质和碳水化合物和脂肪的水包油乳液中; 或随后分散在成膜蛋白质和碳水化合物中的油中。 可以将乳液或悬浮液干燥以形成粉末。 益生菌可以分散在油中，然后用水悬浮液乳化，然后干燥以产生待干燥的包封的油以产生粉末。 在益生菌对水敏感的地方，优选油悬浮的益生菌。 优选的蛋白质是酪蛋白或乳清蛋白，碳水化合物可以是抗性淀粉或具有还原糖基团的糖。 当益生菌对氧敏感时，蛋白质碳水化合物被加热以在封装膜中产生美拉德反应产物。

    Gi Track Delivery Systems
    3.
    发明申请
    Gi Track Delivery Systems 有权
    Gi跟踪交付系统

    公开(公告)号：US20070218125A1

    公开(公告)日：2007-09-20

    申请号：US10578903

    申请日：2004-11-22

    申请人： Richard Head ,  Luz Sanguansri ,  Mary Ann Augustin

    发明人： Richard Head ,  Luz Sanguansri ,  Mary Ann Augustin

    IPC分类号： A61K9/48

    CPC分类号： A61K9/1623 ,  A23D9/05 ,  A23L33/115 ,  A23V2002/00 ,  A61K9/5036 ,  A23V2200/224 ,  A23V2250/61 ,  A23V2250/54246 ,  A23V2250/28 ,  A23V2250/54252 ,  A23V2250/5118

    摘要： A micro encapsulation material for use with storage unstable, therapeutic and nutritional agents which release the therapeutic and nutritional agents in predetermined locations in the gastro intestinal tract in which the microencapsulation material is formed by combining a food grade treated carbohydrate with a water soluble food grade protein. The therapeutic and nutritional agents form an oil phase which is emulsified with the water dispersed or dissolved encapsulant to encapsulate the therapeutic and nutritional agents. These agents may be oils or oil soluble or oil dispersible. The agents that may be encapsulated Include lipids (oils Including oxygen sensitive oils, fatty acids, triglycerides) and oil soluble and oil dispersible ingredients (including pharmaceuticals, probiotics, protein therapeutics and bioactives). The protein used may include any film forming water soluble protein or hydrolysed protein and includes milk proteins such as casein and its derivatives or whey proteins. The carbohydrate component may be those containing reducing sugar groups, oligosaccharides and starches (raw, modified, resistant, acetylated, proprionated and butyrated starches).

    摘要翻译： 一种用于与储存不稳定，治疗和营养剂一起使用的微包封材料，其通过将食品级处理的碳水化合物与水溶性食品级蛋白质组合而将治疗和营养剂释放在胃肠道中的预定位置，其中形成微胶囊化材料 。 治疗和营养剂形成油相，其被水分散或溶解的密封剂乳化以包封治疗和营养剂。 这些试剂可以是油或油溶性或油分散性。 可以包封的药剂包括脂质（包括氧敏感油，脂肪酸，甘油三酯）和油溶性和油分散性成分（包括药物，益生菌，蛋白质治疗剂和生物活性物质）。 使用的蛋白质可以包括任何成膜水溶性蛋白质或水解蛋白质，并且包括乳蛋白如酪蛋白及其衍生物或乳清蛋白。 碳水化合物组分可以是含有还原糖基团，寡糖和淀粉（生的，改性的，抗性的，乙酰化的，推进的和丁酸的淀粉）的那些。

    Gi track delivery systems
    5.
    发明授权
    Gi track delivery systems 有权
    Gi跟踪传送系统

    公开(公告)号：US09592201B2

    公开(公告)日：2017-03-14

    申请号：US10578903

    申请日：2004-11-22

    申请人： Richard Head ,  Luz Sanguansri ,  Mary Ann Augustin

    发明人： Richard Head ,  Luz Sanguansri ,  Mary Ann Augustin

    IPC分类号： A61K9/48 ,  A61K9/16 ,  A23D9/05 ,  A61K9/50

    CPC分类号： A61K9/1623 ,  A23D9/05 ,  A23L33/115 ,  A23V2002/00 ,  A61K9/5036 ,  A23V2200/224 ,  A23V2250/61 ,  A23V2250/54246 ,  A23V2250/28 ,  A23V2250/54252 ,  A23V2250/5118

    摘要： A micro encapsulation material for use with storage unstable, therapeutic and nutritional agents which release the therapeutic and nutritional agents in predetermined locations in the gastro intestinal tract in which the microencapsulation material is formed by combining a food grade treated carbohydrate with a water soluble food grade protein. The therapeutic and nutritional agents form an oil phase which is emulsified with the water dispersed or dissolved encapsulant to encapsulate the therapeutic and nutritional agents. These agents may be oils or oil soluble or oil dispersible. The agents that may be encapsulated include lipids (oils including oxygen sensitive oils, fatty acids, triglycerides) and oil soluble and oil dispersible ingredients (including pharmaceuticals, probiotics, protein therapeutics and bioactives). The protein used may include any film forming water soluble protein or hydrolyzed protein and includes milk proteins such as casein and its derivatives or whey proteins. The carbohydrate component may be those containing reducing sugar groups, oligosaccharides and starches (raw, modified, resistant, acetylated, proprionylated and butylated starches).

    摘要翻译： 一种用于与储存不稳定，治疗和营养剂一起使用的微包封材料，其通过将食品级处理的碳水化合物与水溶性食品级蛋白质组合而将治疗和营养剂释放在胃肠道中的预定位置，其中形成微胶囊化材料 。 治疗和营养剂形成油相，其被水分散或溶解的密封剂乳化以包封治疗和营养剂。 这些试剂可以是油或油溶性或油分散性。 可以包封的药剂包括脂质（包括氧敏感油，脂肪酸，甘油三酸酯）和油溶性和油分散性成分（包括药物，益生菌，蛋白质治疗剂和生物活性物质）的脂质。 所使用的蛋白质可以包括任何成膜水溶性蛋白质或水解蛋白质，并且包括乳蛋白如酪蛋白及其衍生物或乳清蛋白。 碳水化合物组分可以是含有还原糖基团，寡糖和淀粉（生，修饰，抗性，乙酰化，丙酰化和丁基化淀粉）的那些。