公开(公告)号：US06413780B1

公开(公告)日：2002-07-02

申请号：US09415796

申请日：1999-10-11

申请人： Mark C. Bach ,  Daniel Bay ,  Michael K. Carter ,  John M. Clemens ,  Daniel G. Dahlke ,  Charles M. Galitz ,  Robert C. Gray ,  Folim Halaka ,  Steve Herchenbach ,  Ronald E. Kukla ,  Curtis J. Pepe ,  Mark Pierce ,  Scott G. Safar ,  Julius Toth ,  Gary Zuck

发明人： Mark C. Bach ,  Daniel Bay ,  Michael K. Carter ,  John M. Clemens ,  Daniel G. Dahlke ,  Charles M. Galitz ,  Robert C. Gray ,  Folim Halaka ,  Steve Herchenbach ,  Ronald E. Kukla ,  Curtis J. Pepe ,  Mark Pierce ,  Scott G. Safar ,  Julius Toth ,  Gary Zuck

IPC分类号： G01N3502

CPC分类号： B01L7/52 ,  G01N35/02 ,  G01N2035/00366 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998

摘要： A method of performing a determination of an item of interest in a sample using a single structure is disclosed. A sample is provided accessible to the single structure. A first container for processing the sample is placed in a first process path on the single structure. The sample is transferred to the first container in the first process path. A reagent is added to the first container in the first process path. Contents of the first container is mixed in the first process path. The item of interest in the sample is separated from the contents of the first container in the first process path. The separated item of interest in the sample is transferred from the first container in the first process path to a second container in a second process path on the single structure. Contents of the second container is brought to a first temperature different from a temperature of the first process path in the second process path. The item of interest in the second container is detected in the second process path.

摘要翻译： 公开了使用单一结构来对样本中的感兴趣项目进行确定的方法。 单个结构可访问的样本。 用于处理样品的第一容器被放置在单个结构上的第一处理路径中。 将样品转移到第一个过程路径中的第一个容器。 在第一处理路径中将试剂添加到第一容器中。 第一个容器的内容在第一个进程路径中混合。 样本中的感兴趣的项目与第一处理路径中的第一容器的内容分离。 将样品中分离的物品从第一处理路径中的第一容器转移到单个结构上的第二处理路径中的第二容器。 使第二容器的内容物达到与第二处理路径中的第一处理路径的温度不同的第一温度。 在第二处理路径中检测第二容器中的感兴趣的项目。

公开(公告)号：US08357543B2

公开(公告)日：2013-01-22

申请号：US12486215

申请日：2009-06-17

申请人： Scott G. Safar ,  Stephen L. Herchenbach ,  Chadwick M. Dunn ,  Charles M. Galitz ,  Julius J. Toth ,  Ronald E. Kukla ,  Michael G. Lowery ,  Eric B. Shain

发明人： Scott G. Safar ,  Stephen L. Herchenbach ,  Chadwick M. Dunn ,  Charles M. Galitz ,  Julius J. Toth ,  Ronald E. Kukla ,  Michael G. Lowery ,  Eric B. Shain

IPC分类号： G01N1/18 ,  B01D21/00 ,  B01L3/00

CPC分类号： G01N35/1004 ,  B01L3/50255 ,  B01L3/5082 ,  B01L99/00 ,  B01L2200/0668 ,  B01L2400/049 ,  B01L2400/0655 ,  B01L2400/0688 ,  G01N35/0098 ,  G01N35/1065 ,  Y10T137/0391 ,  Y10T137/0396 ,  Y10T436/25375 ,  Y10T436/2575

摘要： A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.

公开(公告)号：US07815866B2

公开(公告)日：2010-10-19

申请号：US12486074

申请日：2009-06-17

申请人： Scott G. Safar ,  Stephen L. Herchenbach ,  Chadwick M. Dunn ,  Charles M. Galitz ,  Julius J. Toth ,  Ronald E. Kukla ,  Michael G. Lowery ,  Eric B. Shain

发明人： Scott G. Safar ,  Stephen L. Herchenbach ,  Chadwick M. Dunn ,  Charles M. Galitz ,  Julius J. Toth ,  Ronald E. Kukla ,  Michael G. Lowery ,  Eric B. Shain

IPC分类号： B01L9/00 ,  B01L99/00

CPC分类号： G01N35/1004 ,  B01L3/50255 ,  B01L3/5082 ,  B01L99/00 ,  B01L2200/0668 ,  B01L2400/049 ,  B01L2400/0655 ,  B01L2400/0688 ,  G01N35/0098 ,  G01N35/1065 ,  Y10T137/0391 ,  Y10T137/0396 ,  Y10T436/25375 ,  Y10T436/2575

摘要： A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.

摘要翻译： 具有底部排放开口的反应容器，其通过流体的表面张力支撑选定的未压缩流体的头部。 装置处理区域包括支撑隔离排列的反应容器，与其支撑的容器的排放开口连通的通道，以及用于选择性地通过排放开口排出流体的压力源。 通常，水平条形磁体被支撑用于在容器列之间选择的垂直运动。 分配头具有可选择性地定位在X选择的反应容器上的X个排出口。 计量泵机构选择性地将X选定量的流体计量为批量供应（其中X为至少四个），并且选择性地将计量的所选量通过排放开口泵送到选定的反应容器。 还包括使用压力源从容器中抽取流体并移动磁体以形成分析物颗粒的方法。

公开(公告)号：US08728311B2

公开(公告)日：2014-05-20

申请号：US13486143

申请日：2012-06-01

申请人： Scott G. Safar ,  Charles M. Galitz ,  Stephen L. Herchenbach ,  Chadwick M. Dunn ,  Larry L. McDowell

发明人： Scott G. Safar ,  Charles M. Galitz ,  Stephen L. Herchenbach ,  Chadwick M. Dunn ,  Larry L. McDowell

IPC分类号： B01L3/00 ,  B01D35/06 ,  B03C1/02

CPC分类号： B01L3/5085 ,  B01D35/06 ,  B01L3/5082 ,  B01L9/06 ,  B01L2300/0848 ,  B03C1/02 ,  B03C1/0332 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N35/0098 ,  G01N2035/00564 ,  G01N2035/103 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/25375 ,  Y10T436/2575

摘要： Magnetic handling structure comprising a retractable magnet and a probe for the manipulation of magnetic particles in biological samples and methods of handling magnetic particles in biological samples.

摘要翻译： 磁性处理结构包括可伸缩磁体和用于在生物样品中操纵磁性颗粒的探针和处理生物样品中的磁性颗粒的方法。

公开(公告)号：US08211301B2

公开(公告)日：2012-07-03

申请号：US12660930

申请日：2010-03-04

申请人： Scott G. Safar ,  Charles M. Galitz ,  Stephen L. Herchenbach ,  Chadwick M. Dunn ,  Larry L. McDowell

发明人： Scott G. Safar ,  Charles M. Galitz ,  Stephen L. Herchenbach ,  Chadwick M. Dunn ,  Larry L. McDowell

IPC分类号： B03C1/02 ,  C12P19/34 ,  C12Q1/68

CPC分类号： B01L3/5085 ,  B01D35/06 ,  B01L3/5082 ,  B01L9/06 ,  B01L2300/0848 ,  B03C1/02 ,  B03C1/0332 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N35/0098 ,  G01N2035/00564 ,  G01N2035/103 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/25375 ,  Y10T436/2575

摘要： Magnetic handling structure (1a) comprising a retractable magnet (4) and a probe (3) for the manipulation of magnetic particles in biological samples and methods of handling magnetic particles in biological samples.

摘要翻译： 磁性处理结构（1a）包括用于操纵生物样品中的磁性颗粒的可伸缩磁体（4）和探针（3）以及处理生物样品中的磁性颗粒的方法。

公开(公告)号：US07718072B2

公开(公告)日：2010-05-18

申请号：US10512033

申请日：2003-04-25

申请人： Scott G. Safar ,  Charles M. Galitz ,  Stephen L. Herchenbach ,  Chadwick M. Dunn ,  Larry L. McDowell

发明人： Scott G. Safar ,  Charles M. Galitz ,  Stephen L. Herchenbach ,  Chadwick M. Dunn ,  Larry L. McDowell

IPC分类号： B03C1/00 ,  C12Q1/68

CPC分类号： B01L3/5085 ,  B01D35/06 ,  B01L3/5082 ,  B01L9/06 ,  B01L2300/0848 ,  B03C1/02 ,  B03C1/0332 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N35/0098 ,  G01N2035/00564 ,  G01N2035/103 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/25375 ,  Y10T436/2575

摘要： Magnetic handling structure (1a) comprising a retractable magnet (4) and a probe (3) for the manipulation of magnetic particles in biological samples and methods of handling magnetic particles in biological samples.

摘要翻译： 磁性处理结构（1a）包括用于操纵生物样品中的磁性颗粒的可伸缩磁体（4）和探针（3）以及处理生物样品中的磁性颗粒的方法。

公开(公告)号：US20120269702A1

公开(公告)日：2012-10-25

申请号：US13486143

申请日：2012-06-01

申请人： Scott G. Safar ,  Charles M. Galitz ,  Stephen L. Herchenbach ,  Chadwick M. Dunn ,  Larry L. McDowell

发明人： Scott G. Safar ,  Charles M. Galitz ,  Stephen L. Herchenbach ,  Chadwick M. Dunn ,  Larry L. McDowell

IPC分类号： G01N1/40 ,  B01L3/02

CPC分类号： B01L3/5085 ,  B01D35/06 ,  B01L3/5082 ,  B01L9/06 ,  B01L2300/0848 ,  B03C1/02 ,  B03C1/0332 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N35/0098 ,  G01N2035/00564 ,  G01N2035/103 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/25375 ,  Y10T436/2575

摘要： Magnetic handling structure comprising a retractable magnet and a probe for the manipulation of magnetic particles in biological samples and methods of handling magnetic particles in biological samples.

摘要翻译： 磁性处理结构包括可伸缩磁体和用于在生物样品中操纵磁性颗粒的探针和处理生物样品中的磁性颗粒的方法。

公开(公告)号：US20100227387A1

公开(公告)日：2010-09-09

申请号：US12660930

申请日：2010-03-04

申请人： Scott G. Safar ,  Charles M. Galitz ,  Stephen L. Herchenbach ,  Chadwick M. Dunn ,  Larry L. McDowell

发明人： Scott G. Safar ,  Charles M. Galitz ,  Stephen L. Herchenbach ,  Chadwick M. Dunn ,  Larry L. McDowell

IPC分类号： C12M1/00 ,  B03C1/02 ,  B01L3/00 ,  B01L3/02

CPC分类号： B01L3/5085 ,  B01D35/06 ,  B01L3/5082 ,  B01L9/06 ,  B01L2300/0848 ,  B03C1/02 ,  B03C1/0332 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N35/0098 ,  G01N2035/00564 ,  G01N2035/103 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/25375 ,  Y10T436/2575

摘要： Magnetic handling structure (1a) comprising a retractable magnet (4) and a probe (3) for the manipulation of magnetic particles in biological samples and methods of handling magnetic particles in biological samples.

公开(公告)号：US20080092646A1

公开(公告)日：2008-04-24

申请号：US11584404

申请日：2006-10-20

申请人： Folim G. Halaka ,  Ronald E. Kukla ,  Scott G. Safar

发明人： Folim G. Halaka ,  Ronald E. Kukla ,  Scott G. Safar

IPC分类号： G01F23/26

CPC分类号： G01F23/268

摘要： An apparatus and method for determining the level of liquid in a container in an analytical instrument, typically an automated analytical instrument in a laboratory. The apparatus comprises: (a) an electrically conductive support; (b) an electrically conductive platform rising up from said electrically conductive support, said platform capable of supporting at least one container that is capable of containing a liquid, said platform having an area less than that of the electrically conductive support; (c) an electrically conductive element, such as, for example, the electrically conductive tip of a probe, the distance between the electrically conductive platform and the electrically conductive element capable of being reduced or increased by relative movement between the electrically conductive element and the electrically conductive platform; and (d) a capacitance sensor coupled to the electrically conductive element (c) and arranged to provide an electrical signal representing the capacitance.

摘要翻译： 用于确定分析仪器中的容器中的液体液位的装置和方法，通常是实验室中的自动分析仪器。 该装置包括：（a）导电支撑件; （b）从所述导电支撑件上升的导电平台，所述平台能够支撑能够容纳液体的至少一个容器，所述平台的面积小于所述导电支撑件的面积; （c）导电元件，例如探针的导电尖端，导电平台与导电元件之间的距离能够通过导电元件和导电元件之间的相对移动而减小或增加 导电平台; 和（d）耦合到所述导电元件（c）并且被布置成提供表示所述电容的电信号的电容传感器。

公开(公告)号：US07814788B2

公开(公告)日：2010-10-19

申请号：US11584404

申请日：2006-10-20

申请人： Folim G. Halaka ,  Ronald E. Kukla ,  Scott G. Safar

发明人： Folim G. Halaka ,  Ronald E. Kukla ,  Scott G. Safar

IPC分类号： G01G23/26

CPC分类号： G01F23/268

摘要： An apparatus and method for determining the level of liquid in a container in an analytical instrument, typically an automated analytical instrument in a laboratory. The apparatus comprises: (a) an electrically conductive support; (b) an electrically conductive platform rising up from said electrically conductive support, said platform capable of supporting at least one container that is capable of containing a liquid, said platform having an area less than that of the electrically conductive support; (c) an electrically conductive element, such as, for example, the electrically conductive tip of a probe, the distance between the electrically conductive platform and the electrically conductive element capable of being reduced or increased by relative movement between the electrically conductive element and the electrically conductive platform; and (d) a capacitance sensor coupled to the electrically conductive element (c) and arranged to provide an electrical signal representing the capacitance.

摘要翻译： 用于确定分析仪器中的容器中的液体液位的装置和方法，通常是实验室中的自动分析仪器。 该装置包括：（a）导电支撑件; （b）从所述导电支撑件上升的导电平台，所述平台能够支撑能够容纳液体的至少一个容器，所述平台的面积小于所述导电支撑件的面积; （c）导电元件，例如探针的导电尖端，导电平台与导电元件之间的距离能够通过导电元件和导电元件之间的相对移动而减小或增加 导电平台; 和（d）耦合到所述导电元件（c）并且被布置成提供表示所述电容的电信号的电容传感器。