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公开(公告)号：US20100166800A1
公开(公告)日：2010-07-01
申请号：US12640645
申请日：2009-12-17
IPC分类号： A61K39/08 , C07H21/04 , A61P31/04 , A61P31/00 , G01N33/53 , C12N1/20 , C07K14/33 , C12N1/21 , C07K16/12
CPC分类号： A61K39/08 , A61K2039/522 , A61K2039/523 , C07K14/33
摘要： The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin of Clostridium perfringens strain 13, is missing at least nine consecutive amino acid residues including His68. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.
摘要翻译： 本发明公开了表达基本上无毒的α-毒素的减毒产气荚膜梭菌生物体。 表达的α-毒素是相对于产气荚膜梭菌菌株13的成熟α-毒素的α-毒素的缺失突变蛋白缺失至少九个连续的氨基酸残基，包括His68。 本发明还公开了编码突变蛋白的减毒生物，以及这些减毒生物体作为疫苗的用途。
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公开(公告)号：US07807456B2
公开(公告)日：2010-10-05
申请号：US12640645
申请日：2009-12-17
IPC分类号： C12N15/00
CPC分类号： A61K39/08 , A61K2039/522 , A61K2039/523 , C07K14/33
摘要： The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin of Clostridium perfringens strain 13, is missing at least nine consecutive amino acid residues including His68. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.
摘要翻译： 本发明公开了表达基本上无毒的α-毒素的减毒产气荚膜梭菌生物体。 表达的α-毒素是相对于产气荚膜梭菌菌株13的成熟α-毒素的α-毒素的缺失突变蛋白缺失至少九个连续的氨基酸残基，包括His68。 本发明还公开了编码突变蛋白的减毒生物，以及这些减毒生物体作为疫苗的用途。
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公开(公告)号：US07732187B2
公开(公告)日：2010-06-08
申请号：US11734454
申请日：2007-04-12
IPC分类号： C12N1/20
CPC分类号： A61K39/08 , A61K2039/522 , A61K2039/523 , C07K14/33
摘要： The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin of Clostridium perfringens strain 13, is missing at least nine consecutive amino acid residues including His68. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.
摘要翻译： 本发明公开了表达基本上无毒的α-毒素的减毒产气荚膜梭菌生物体。 表达的α-毒素是相对于产气荚膜梭菌菌株13的成熟α-毒素的α-毒素的缺失突变蛋白缺失至少九个连续的氨基酸残基，包括His68。 本发明还公开了编码突变蛋白的减毒生物，以及这些减毒生物体作为疫苗的用途。
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公开(公告)号：US07972604B2
公开(公告)日：2011-07-05
申请号：US12869813
申请日：2010-08-27
IPC分类号： A61K39/02
CPC分类号： A61K39/08 , A61K2039/522 , A61K2039/523 , C07K14/33
摘要： The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin of Clostridium perfringens strain 13, is missing at least nine consecutive amino acid residues including His68. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.
摘要翻译： 本发明公开了表达基本上无毒的α-毒素的减毒产气荚膜梭菌生物体。 表达的α-毒素是相对于产气荚膜梭菌菌株13的成熟α-毒素的α-毒素的缺失突变蛋白缺失至少九个连续的氨基酸残基，包括His68。 本发明还公开了编码突变蛋白的减毒生物，以及这些减毒生物体作为疫苗的用途。
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5.发明授权Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof 失效稳定和生物活性改良猪生长激素及其药物组合物
公开(公告)号：US5849694A
公开(公告)日：1998-12-15
申请号：US553511
申请日：1990-07-16
CPC分类号： C07K14/61 , A61K38/00 , Y10S930/12
摘要： The present invention provides a stable and bioactive recombinant small-loop modified somatotropin which has its small-loop cysteines changed to other amino acids or deleted altogether and a method for producing such a small-loop modified somatotropin. Also provided by the present invention are DNA sequences coding for such small-loop modified somatotropins, plasmids containing such sequences, and organisms containing such plasmids. Furthermore, pharmaceutical compositions including small-loop modified somatotropins and methods for using such pharmaceutical compositions are disclosed.
摘要翻译： 本发明提供一种稳定和生物活性的重组小环修饰生长激素，其小环半胱氨酸改变为其它氨基酸或全部缺失，以及一种生产这种小环修饰生长激素的方法。 本发明还提供了编码这种小环修饰生长激素的DNA序列，含有此类序列的质粒和含有这种质粒的生物体。 此外，公开了包含小环修饰生长激素的药物组合物和使用这种药物组合物的方法。
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