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公开(公告)号：US10012560B2
公开(公告)日：2018-07-03
申请号：US14405863
申请日：2012-06-08
申请人： Martin Lehmann
发明人： Martin Lehmann
摘要： A coarse-fine two-stage leak detection is carried out on sealed, filled containers loaded into container holders or “pucks”. Failure of the first, coarse leak detection stage, e.g. a pressure-course or impedance or laser-absorption based leak detection stage, causes containers to be rejected together with their corresponding container holders. These are then separated, and the container holder is cleaned and dried before being returned to the system. Any leaking product from inside a grossly leaking container is thus retained within the container holder, thus reducing contamination of subsequent containers and their container holders, preventing such contamination from reaching the fine leak detection stage, e.g. a mass-spectrometer-based leak detection stage.
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公开(公告)号：US20150144538A1
公开(公告)日：2015-05-28
申请号：US14405875
申请日：2012-06-13
申请人： Martin Lehmann
发明人： Martin Lehmann
CPC分类号： B07C5/3416 , B07C5/3427 , B07C5/36 , G01N23/046 , G01N23/083 , G01N23/18 , G01N2223/419
摘要： Method and system for x-ray detection of flaws in containers or their contents wherein containers are conveyed on a circular path around a central axis upon which an x-ray source is situated below the plane of the base of the containers. The x-ray source emits x-ray radiation obliquely upwards through the containers to a plurality of imaging x-ray detectors. Analysis of the images provided by these x-ray detectors determines the presence of a flaw in a container or its contents and is used to command a rejection mechanism to reject the container in question.
摘要翻译： 用于x射线检测容器或其内容物中的瑕疵的方法和系统，其中容器在围绕中心轴线的圆形路径上被输送，在所述中心轴线上X射线源位于容器底部平面的下方。 X射线源通过容器向上倾斜向上发射X射线辐射到多个成像x射线检测器。 由这些X射线探测器提供的图像的分析确定容器或其内容物中是否存在缺陷，并且用于命令拒绝机制来拒绝所述容器。
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公开(公告)号：US09038257B2
公开(公告)日：2015-05-26
申请号：US13665042
申请日：2012-10-31
申请人： Martin Lehmann
发明人： Martin Lehmann
CPC分类号： B65G37/00 , B65G17/12 , B65G17/20 , B65G17/30 , G01M3/00 , G01M3/329 , Y10T29/49764 , Y10T29/49829
摘要： The present invention relates to methods and an apparatuses for loading and unloading objects into/from corresponding cavities in holders at a high count rate. For loading, a plurality of objects are present on an object path which mutually converges with a holder path. For unloading, the object path mutually diverges from the holder path. Integration of this method and apparatus respectively into a method of manufacturing unleaky containers and a corresponding apparatus for leak testing containers is also proposed.
摘要翻译： 本发明涉及用于以高计数率将物体装入和卸载保持器中的相应空腔的方法和装置。 对于装载，多个物体存在于与保持器路径相互收敛的物体路径上。 为了卸载，物体路径从保持器路径相互分开。 还提出了将该方法和装置分别集成到制造不透明容器的方法和用于泄漏测试容器的相应装置。
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4.发明授权Method and system of determining the fiber diameter distribution of a fibrous media 有权确定纤维介质的纤维直径分布的方法和系统公开(公告)号：US08594382B2
公开(公告)日：2013-11-26
申请号：US12889447
申请日：2010-09-24
IPC分类号： G06K9/00
CPC分类号： G06K9/4604 , G06K2209/19 , G06T7/12 , G06T7/62 , G06T2207/30124
摘要： A method and system of determining fiber diameter distribution of a fibrous media is disclosed. The method includes providing at least one digital image representative of the fibrous media, pre-processing the images, binarizing the images, generating virtual lines on the image, solving for fiber fringe points on each of generated line, solving for fiber center points as a mean of the fringe points, generating and growing measurement circles about the fiber center points, repositioning circles and center points to avoid fiber intersections, resizing the repositioned measurement circles to intersect the opposing fringes, and calculating fiber diameters and fiber spacing.
摘要翻译： 公开了一种确定纤维介质的纤维直径分布的方法和系统。 该方法包括提供表示纤维介质的至少一个数字图像，对图像进行预处理，二值化图像，在图像上产生虚拟线，求解每条生成线上的纤维条纹点，求解光纤中心点为 边缘点的平均值，围绕光纤中心点，重新定位圆和中心点产生和增长测量圆以避免光纤交叉，调整重新定位的测量圆与相对条纹相交，以及计算光纤直径和光纤间距。
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5.发明授权Methods for manufacturing unleaky closed containers and leak testing apparatus 有权制造不透明的封闭容器和泄漏检测装置的方法公开(公告)号：US08151631B2
公开(公告)日：2012-04-10
申请号：US12512145
申请日：2009-07-30
申请人： Martin Lehmann
发明人： Martin Lehmann
CPC分类号： G01M3/36
摘要： In a leak testing apparatus and a method for manufacturing unleaky closed containers having first and second flexible wall areas with different flexibility characteristics, a biasing member is moved toward and onto the first flexible area and a force detector monitors a biasing force at the second flexible area. A container is considered unleaky if a difference signal from force measuring signals at first and second points in time fulfills a test criteria. Sampling the biasing force monitored which results in the first force measuring signal includes determining maximum biasing force signal value which occurs during a time span up to and including the first point in time.
摘要翻译： 在泄漏测试装置和用于制造具有不同柔性特性的第一和第二柔性壁区域的不透明的封闭容器的方法中，偏置构件朝向和朝向第一柔性区域移动并且力检测器监测第二柔性区域 。 如果在第一和第二时间点的力测量信号的差分信号满足测试标准，则容器被认为是不透明的。 对所产生的第一力测量信号进行监测的偏压力的采样包括确定在直到并包括第一时间点的时间范围内发生的最大偏置力信号值。
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公开(公告)号：US20080311617A1
公开(公告)日：2008-12-18
申请号：US12091279
申请日：2006-10-25
CPC分类号： C12N9/1022 , C12P17/12 , C12P25/00
摘要： The present invention relates to a improved process for the biotechnological production of compounds for which ribose-5-phosphate, ribulose-5-phosphate or xylulose-5-phosphate is biosynthetic precursor like riboflavin (vitamin B2), FAD, FMN, pyridoxal phosphate (vitamin B6), guanosine, GMP, adenosine, AMP. The invention further pertains to the generation of the organism producing those compounds. It furthermore relates to the generation of mutated transketolases that allow normal growth on glucose but reduced growth on gluconate when introduced into the production strains and to polynucleotides encoding them.
摘要翻译： 本发明涉及核糖-5-磷酸，核酮糖-5-磷酸或木酮糖-5-磷酸是生物合成前体如核黄素（维生素B2），FAD，FMN，吡哆醛磷酸酯（ 维生素B6），鸟苷，GMP，腺苷，AMP。 本发明还涉及产生这些化合物的生物体的产生。 此外，还涉及产生突变的转酮酶，其允许在葡萄糖上正常生长，但当被引入生产菌株中时葡萄糖酸盐的生长减少，以及编码它们的多核苷酸。
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公开(公告)号：US07382819B2
公开(公告)日：2008-06-03
申请号：US11707090
申请日：2007-02-16
申请人： Martin Lehmann , Jean-Noel Fehr , Martin Liechti , Urban Schnell
发明人： Martin Lehmann , Jean-Noel Fehr , Martin Liechti , Urban Schnell
IPC分类号： G01L7/00
CPC分类号： G01L11/02 , G01N21/39 , Y10T29/49 , Y10T29/49845
摘要： A method of monitoring pressure of a gas species up to at most a predetermined maximum pressure value is disclosed. The method includes exposing the gas species to transmission of laser light, periodically modulating the wavelength of the laser light over a wavelength band including at least one absorption line of the gas species, optoelectrically converting the transmitted laser light, thereby generating an electric output signal, performing at least one of first filtering the electric output signal with a filter characteristic having a lower cut-off frequency not lower than a transition frequency and of second filtering the electric output signal with a bandpass filter characteristic having an upper cut-off frequency not higher than the transition frequency and a lower cut-off frequency above the modulation frequency of the periodic wavelength modulation. The output of at least one of the filterings is evaluated as a pressure indicative signal.
摘要翻译： 公开了一种监测气体种类的压力至多达到预定最大压力值的方法。 该方法包括将气体物质暴露于透射激光，周期性地调制激光的波长在包括气体种类的至少一个吸收线的波长带上，光电转换透射的激光，从而产生电输出信号， 执行以具有不低于转换频率的较低截止频率的滤波器特性对所述电输出信号进行第一滤波中的至少一个，并且以具有不高于上限截止频率的带通滤波器特性对所述电输出信号进行第二滤波 超过转换频率和低于周期性波长调制调制频率的较低截止频率。 至少一个过滤器的输出被评估为压力指示信号。
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8.发明授权Methods for manufacturing unleaky closed containers and leak testing apparatus 有权制造不透明的封闭容器和泄漏检测装置的方法公开(公告)号：US07380440B2
公开(公告)日：2008-06-03
申请号：US11221803
申请日：2005-09-09
申请人： Martin Lehmann
发明人： Martin Lehmann
CPC分类号： G01M3/36
摘要： In a leak testing apparatus and a method for manufacturing unleaky closed containers having first and second flexible wall areas with different flexibility characteristics, a biasing member is moved toward and onto the first flexible area and a force detector monitors a biasing force at the second flexible area. A container is considered unleaky if a difference signal from force measuring signals at first and second points in time fulfills a test criteria. Sampling the biasing force monitored which results in the first force measuring signal includes determining maximum biasing force signal value which occurs during a time span up to and including the first point in time.
摘要翻译： 在泄漏测试装置和用于制造具有不同柔性特性的第一和第二柔性壁区域的不透明的封闭容器的方法中，偏置构件朝向和朝向第一柔性区域移动并且力检测器监测第二柔性区域 。 如果在第一和第二时间点的力测量信号的差分信号满足测试标准，则容器被认为是不透明的。 对所产生的第一力测量信号进行监测的偏压力的采样包括确定在直到并包括第一时间点的时间范围内发生的最大偏置力信号值。
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公开(公告)号：US07260981B2
公开(公告)日：2007-08-28
申请号：US11267190
申请日：2005-11-07
申请人： Martin Lehmann
发明人： Martin Lehmann
CPC分类号： G01M3/04 , B65B3/04 , G01M3/22 , G01M3/226 , G01M3/3263 , G01M3/3281 , G01M3/329 , G08B21/20 , Y10T29/49771 , Y10T29/53022
摘要： For leak testing closed containers (9) which are filled with a filling product containing at least one liquid component the container is introduced in a test cavity (1) which is evacuated at least down to vapor pressure of that liquid component. The pressure in the surrounding of the container (9) and thus within test cavity (1) is monitored. Monitoring is performed by a vacuum pressure sensor (7), whereas lowering pressure surrounding the container (9) is performed by a vacuum pump (5). Leakage is detected by monitoring a pressure change in the surrounding of the container which is due to evaporation of liquid emerging from a leak and being evaporated in the low pressure surrounding.
摘要翻译： 对于密封容器（9）的泄漏测试，其中填充有包含至少一种液体组分的填充产品，容器被引入至少抽真空至该液体组分的蒸气压的测试空腔（1）中。 监测容器（9）周围并因此在测试腔（1）内的压力。 通过真空压力传感器（7）进行监视，而通过真空泵（5）执行围绕容器（9）的降低压力。 通过监测容器周围的压力变化来检测泄漏，这是由于泄漏出现的液体蒸发而在低压环境中蒸发。
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10.发明申请Method and apparatus for cleaning containers to be sealed and containing a filler from oxygen gas 审中-公开用于清洁要密封的容器并含有来自氧气的填料的方法和装置公开(公告)号：US20070062162A1
公开(公告)日：2007-03-22
申请号：US11228847
申请日：2005-09-19
申请人： Martin Lehmann
发明人： Martin Lehmann
IPC分类号： B65B31/00
CPC分类号： B65B31/025
摘要： The method of manufacturing a sealed container for containing a non-gaseous filler, which filler is to be protected from Oxygen gas, comprises the following steps in the indicated sequence: 1.) filling said filler into said container; 2.) evacuating said container substantially without evaporating parts of said filler; 3.) filling Nitrogen gas into said container; 4.) sealing the container. The method can be used in-line. The apparatus for cleaning filled containers containing a non-gaseous filler, comprises at least one holder for holding said containers; at least one pump adapted for evacuating said containers; a Nitrogen reservoir for supplying Nitrogen gas to be filled into said containers; a process control unit adapted to allowing for an evacuation of said containers by means of said at least one pump and subsequentially filling said Nitrogen gas into said containers.
摘要翻译： 制造用于容纳非气态填料的密封容器的方法，该填充剂将被保护为氧气，包括以下顺序的以下步骤：1）将所述填料填充到所述容器中; 2.）基本上抽空所述容器而不蒸发所述填料的部分; 3.）将氮气填充到所述容器中; 4.）密封容器。 该方法可以在线使用。 用于清洁包含非气体填充物的填充容器的装置包括至少一个用于保持所述容器的保持器; 至少一个适于抽空所述容器的泵; 用于供应要填充到所述容器中的氮气的氮气储存器; 过程控制单元，其适于通过所述至少一个泵排放所述容器并将所述氮气顺序地填充到所述容器中。
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