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公开(公告)号：US08367614B2
公开(公告)日：2013-02-05
申请号：US13161098
申请日：2011-06-15
CPC分类号： A61K38/018 , A23L33/175 , A23L33/18 , A23L33/19 , A61K31/198 , A61K35/20
摘要： There is provided a rheumatoid arthritis inhibitor for oral intake that has an inhibitory effect on rheumatoid arthritis and is excellent in safety. The rheumatoid arthritis inhibitor for oral intake of the present invention contains, as an active component, a casein hydrolysate containing free amino acids and peptides obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, or a mixture of free amino acids and peptides contained in the hydrolysate.
摘要翻译： 提供了对类风湿性关节炎具有抑制作用的口服摄入类风湿性关节炎抑制剂，安全性优异。 本发明的口服类风湿关节炎抑制剂作为活性成分含有含有游离氨基酸的酪蛋白水解物和通过水解动物乳酪蛋白得到的肽，其平均链长度不得大于2.1 氨基酸残基或游离氨基酸和包含在水解产物中的肽的混合物。
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公开(公告)号：US20100167979A1
公开(公告)日：2010-07-01
申请号：US12278880
申请日：2007-02-09
CPC分类号： A61K38/018 , A23L33/175 , A23L33/18 , A23L33/19 , A61K31/198 , A61K35/20
摘要： There is provided a rheumatoid arthritis inhibitor for oral intake that has an inhibitory effect on rheumatoid arthritis and is excellent in safety. The rheumatoid arthritis inhibitor for oral intake of the present invention contains, as an active component, a casein hydrolysate containing free amino acids and peptides obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, or a mixture of free amino acids and peptides contained in the hydrolysate.
摘要翻译： 提供了对类风湿性关节炎具有抑制作用的口服摄入类风湿性关节炎抑制剂，安全性优异。 本发明的口服类风湿关节炎抑制剂作为活性成分含有含有游离氨基酸的酪蛋白水解物和通过水解动物乳酪蛋白得到的肽，其平均链长度不得大于2.1 氨基酸残基或游离氨基酸和包含在水解产物中的肽的混合物。
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公开(公告)号：US09067972B2
公开(公告)日：2015-06-30
申请号：US12874610
申请日：2010-09-02
申请人： Kazuhito Ohsawa , Naoto Uchida , Hidehiko Baba , Michio Hatori , Kohji Ohki
发明人： Kazuhito Ohsawa , Naoto Uchida , Hidehiko Baba , Michio Hatori , Kohji Ohki
CPC分类号： C07K5/101 , A61K38/00 , C07K5/0808 , C07K5/1016 , C07K7/06
摘要： The present invention provides a peptide and a composition which are suitable for oral ingestion, and which have a skin aging-inhibiting activity, a collagen-production promoting activity, an epidermal turnover promoting activity, and a cutaneous cell-proliferating effect. The present invention also provides a medicament and a functional food which have a skin aging-inhibiting activity, a collagen-production promoting activity, and a cutaneous cell-proliferation promoting activity. The present invention provides a composition including at least one peptide of Asn-lle-Pro-Pro-Leu, lle-Pro-Pro-Leu, lle-Pro-Pro, Pro-Val-Val-Val-Pro-Pro, Val-Pro-Pro-Phe, Val-Pro-Pro, Phe-Pro-Pro-Gln, and Leu-Pro-Pro-Thr.
摘要翻译： 本发明提供适合于口服摄取，具有皮肤老化抑制活性，胶原产生促进活性，表皮转换促进活性和皮肤细胞增殖效果的肽和组合物。 本发明还提供了具有皮肤老化抑制活性，胶原产生促进活性和皮肤细胞增殖促进活性的药物和功能性食品。 本发明提供包含至少一种Asn-Lle-Pro-Pro-Leu肽，lle-Pro-Pro-Leu，lle-Pro-Pro，Pro-Val-Val-Val-Pro-Pro，Val- Pro-Pro-Phe，Val-Pro-Pro，Phe-Pro-Pro-Gln和Leu-Pro-Pro-Thr。
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公开(公告)号：US20110092431A1
公开(公告)日：2011-04-21
申请号：US12874610
申请日：2010-09-02
申请人： Kazuhito OHSAWA , Naoto Uchida , Hidehiko Baba , Michio Hatori , Kohji Ohki
发明人： Kazuhito OHSAWA , Naoto Uchida , Hidehiko Baba , Michio Hatori , Kohji Ohki
CPC分类号： C07K5/101 , A61K38/00 , C07K5/0808 , C07K5/1016 , C07K7/06
摘要： The present invention provides a peptide and a composition which are suitable for oral ingestion, and which have a skin aging-inhibiting activity, a collagen-production promoting activity, an epidermal turnover promoting activity, and a cutaneous cell-proliferating effect. The present invention also provides a medicament and a functional food which have a skin aging-inhibiting activity, a collagen-production promoting activity, and a cutaneous cell-proliferation promoting activity. The present invention provides a composition including at least one peptide of Asn-Ile-Pro-Pro-Leu, Ile-Pro-Pro-Leu, Ile-Pro-Pro, Pro-Val-Val-Val-Pro-Pro, Val-Pro-Pro-Phe, Val-Pro-Pro, Phe-Pro-Pro-Gln, and Leu-Pro-Pro-Thr.
摘要翻译： 本发明提供适合于口服摄取，具有皮肤老化抑制活性，胶原产生促进活性，表皮转换促进活性和皮肤细胞增殖效果的肽和组合物。 本发明还提供了具有皮肤老化抑制活性，胶原产生促进活性和皮肤细胞增殖促进活性的药物和功能性食品。 本发明提供包含至少一种Asn-Ile-Pro-Pro-Leu，Ile-Pro-Pro-Leu，Ile-Pro-Pro，Pro-Val-Val-Val-Pro-Pro，Val- Pro-Pro-Phe，Val-Pro-Pro，Phe-Pro-Pro-Gln和Leu-Pro-Pro-Thr。
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