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公开(公告)号：US08367614B2
公开(公告)日：2013-02-05
申请号：US13161098
申请日：2011-06-15
CPC分类号： A61K38/018 , A23L33/175 , A23L33/18 , A23L33/19 , A61K31/198 , A61K35/20
摘要： There is provided a rheumatoid arthritis inhibitor for oral intake that has an inhibitory effect on rheumatoid arthritis and is excellent in safety. The rheumatoid arthritis inhibitor for oral intake of the present invention contains, as an active component, a casein hydrolysate containing free amino acids and peptides obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, or a mixture of free amino acids and peptides contained in the hydrolysate.
摘要翻译： 提供了对类风湿性关节炎具有抑制作用的口服摄入类风湿性关节炎抑制剂，安全性优异。 本发明的口服类风湿关节炎抑制剂作为活性成分含有含有游离氨基酸的酪蛋白水解物和通过水解动物乳酪蛋白得到的肽，其平均链长度不得大于2.1 氨基酸残基或游离氨基酸和包含在水解产物中的肽的混合物。
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公开(公告)号：US20100167979A1
公开(公告)日：2010-07-01
申请号：US12278880
申请日：2007-02-09
CPC分类号： A61K38/018 , A23L33/175 , A23L33/18 , A23L33/19 , A61K31/198 , A61K35/20
摘要： There is provided a rheumatoid arthritis inhibitor for oral intake that has an inhibitory effect on rheumatoid arthritis and is excellent in safety. The rheumatoid arthritis inhibitor for oral intake of the present invention contains, as an active component, a casein hydrolysate containing free amino acids and peptides obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, or a mixture of free amino acids and peptides contained in the hydrolysate.
摘要翻译： 提供了对类风湿性关节炎具有抑制作用的口服摄入类风湿性关节炎抑制剂，安全性优异。 本发明的口服类风湿关节炎抑制剂作为活性成分含有含有游离氨基酸的酪蛋白水解物和通过水解动物乳酪蛋白得到的肽，其平均链长度不得大于2.1 氨基酸残基或游离氨基酸和包含在水解产物中的肽的混合物。
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公开(公告)号：US09067972B2
公开(公告)日：2015-06-30
申请号：US12874610
申请日：2010-09-02
申请人： Kazuhito Ohsawa , Naoto Uchida , Hidehiko Baba , Michio Hatori , Kohji Ohki
发明人： Kazuhito Ohsawa , Naoto Uchida , Hidehiko Baba , Michio Hatori , Kohji Ohki
CPC分类号： C07K5/101 , A61K38/00 , C07K5/0808 , C07K5/1016 , C07K7/06
摘要： The present invention provides a peptide and a composition which are suitable for oral ingestion, and which have a skin aging-inhibiting activity, a collagen-production promoting activity, an epidermal turnover promoting activity, and a cutaneous cell-proliferating effect. The present invention also provides a medicament and a functional food which have a skin aging-inhibiting activity, a collagen-production promoting activity, and a cutaneous cell-proliferation promoting activity. The present invention provides a composition including at least one peptide of Asn-lle-Pro-Pro-Leu, lle-Pro-Pro-Leu, lle-Pro-Pro, Pro-Val-Val-Val-Pro-Pro, Val-Pro-Pro-Phe, Val-Pro-Pro, Phe-Pro-Pro-Gln, and Leu-Pro-Pro-Thr.
摘要翻译： 本发明提供适合于口服摄取，具有皮肤老化抑制活性，胶原产生促进活性，表皮转换促进活性和皮肤细胞增殖效果的肽和组合物。 本发明还提供了具有皮肤老化抑制活性，胶原产生促进活性和皮肤细胞增殖促进活性的药物和功能性食品。 本发明提供包含至少一种Asn-Lle-Pro-Pro-Leu肽，lle-Pro-Pro-Leu，lle-Pro-Pro，Pro-Val-Val-Val-Pro-Pro，Val- Pro-Pro-Phe，Val-Pro-Pro，Phe-Pro-Pro-Gln和Leu-Pro-Pro-Thr。
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4.发明授权Composition for improving brain function and method for improving brain function 有权用于改善脑功能的组合物和改善脑功能的方法公开(公告)号：US08895512B2
公开(公告)日：2014-11-25
申请号：US13233490
申请日：2011-09-15
申请人： Kazuhito Ohsawa , Naoto Uchida , Kohji Ohki
发明人： Kazuhito Ohsawa , Naoto Uchida , Kohji Ohki
CPC分类号： A61K38/05
摘要： The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, Phe-Pro.
摘要翻译： 本发明提供可以以小剂量口服摄取以改善脑功能的组合物，以及改善脑功能的方法。 本发明是一种用于改善脑功能的组合物，其包含Phe-Pro作为活性成分。
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5.发明申请METHOD FOR ENZYMATICALLY PREPARING PEPTIDES FOR USE IN IMPROVEMENT OF BRAIN FUNCTION 有权用于精确制备用于改善脑功能的肽的方法公开(公告)号：US20120329722A1
公开(公告)日：2012-12-27
申请号：US13495581
申请日：2012-06-13
申请人： Naoto Uchida , Hiroaki Goto , Kazuhito Ohsawa , Kohji Ohki
发明人： Naoto Uchida , Hiroaki Goto , Kazuhito Ohsawa , Kohji Ohki
CPC分类号： C12P21/06 , A23C9/1209 , A23C9/1307 , A23J3/325 , A23J3/344 , A23L33/18 , A23L33/19 , A23V2002/00 , A61K38/018 , A61K38/10 , A61K38/1709 , C07K14/4732 , C12Y304/15 , C12Y304/15001 , C12Y304/15004 , C12Y304/16 , C12Y304/17 , C12Y304/17001 , C12Y304/21019 , Y02P20/52 , A23V2200/322 , A23V2250/55
摘要： The invention provides a method for preparing a peptide for improving brain function, comprising hydrolyzing milk casein with an enzymatic catalyst comprising a protease to produce a hydrolysate comprising: (i) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 1 or a variant thereof; (ii) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 2 or a variant thereof; or (iii) a mixture of the peptides of (i) and (ii), wherein the production yield of each of the peptides is 2% or more, or the total production yield of the mixture is 10% or more. The invention also provides a food or drink or a pharmaceutical composition containing the hydrolysate.
摘要翻译： 本发明提供了一种制备用于改善脑功能的肽的方法，包括用包含蛋白酶的酶催化剂水解乳酪蛋白以产生水解产物，其包含：（i）由SEQ ID NO：1所示氨基酸序列组成的肽或 其变体; （ii）由SEQ ID NO：2所示的氨基酸序列或其变体构成的肽; 或（iii）（i）和（ii）的肽的混合物，其中各肽的产率为2％以上，混合物的总产量为10％以上。 本发明还提供了含有水解产物的食品或饮料或药物组合物。
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6.发明授权Composition for improving brain function and method for improving brain function 有权用于改善脑功能的组合物和改善脑功能的方法公开(公告)号：US08343925B2
公开(公告)日：2013-01-01
申请号：US12890174
申请日：2010-09-24
申请人： Kazuhito Ohsawa , Naoto Uchida , Kohji Ohki
发明人： Kazuhito Ohsawa , Naoto Uchida , Kohji Ohki
CPC分类号： A61K38/06
摘要： The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, the composition comprising, as an active ingredient, Xaa-Pro-Pro (wherein Xaa represents Ile, Leu or Ser).
摘要翻译： 本发明提供可以以小剂量口服摄取以改善脑功能的组合物，以及改善脑功能的方法。 本发明是用于改善脑功能的组合物，该组合物包含作为活性成分的Xaa-Pro-Pro（其中Xaa表示Ile，Leu或Ser）。
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7.发明申请COMPOSITION FOR REGULATING AUTONOMIC NERVOUS ACTIVITY AND METHOD FOR REGULATING AUTONOMIC NERVE 审中-公开用于调节自发性神经活性的组合物和用于调节自主神经的方法公开(公告)号：US20120015882A1
公开(公告)日：2012-01-19
申请号：US13245449
申请日：2011-09-26
申请人： Naoto Uchida , Kazuhito Ohsawa , Kohji Ohki , Yasunori Nakamura , Hidehiko Baba
发明人： Naoto Uchida , Kazuhito Ohsawa , Kohji Ohki , Yasunori Nakamura , Hidehiko Baba
CPC分类号： A61K38/05
摘要： The present invention provides an orally ingestible composition and a method for regulating an autonomic nervous activity. In particular, the present invention provides an orally ingestible composition capable of suppressing an increase in a sympathetic nervous activity, and an orally ingestible composition capable of promoting a parasympathetic nervous activity. The present invention is a composition for regulating an autonomic nervous activity, comprising, as an active ingredient, Tyr-Pro or a salt thereof.
摘要翻译： 本发明提供口服摄取组合物和调节自主神经活性的方法。 特别地，本发明提供能够抑制交感神经活性增加的口服摄取性组合物和能够促进副交感神经活动的口服摄取性组合物。 本发明是用于调节自主神经活性的组合物，其包含Tyr-Pro或其盐作为活性成分。
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8.发明授权Method for enzymatically preparing peptides for use in improvement of brain function 有权用于酶促制备用于改善脑功能的肽的方法公开(公告)号：US09523109B2
公开(公告)日：2016-12-20
申请号：US13495581
申请日：2012-06-13
申请人： Naoto Uchida , Hiroaki Goto , Kazuhito Ohsawa , Kohji Ohki
发明人： Naoto Uchida , Hiroaki Goto , Kazuhito Ohsawa , Kohji Ohki
IPC分类号： C12P21/06 , A61P25/00 , A61K38/01 , A61K38/10 , A61K38/17 , C07K14/47 , A23C9/12 , A23C9/13 , A23J3/32 , A23J3/34
CPC分类号： C12P21/06 , A23C9/1209 , A23C9/1307 , A23J3/325 , A23J3/344 , A23L33/18 , A23L33/19 , A23V2002/00 , A61K38/018 , A61K38/10 , A61K38/1709 , C07K14/4732 , C12Y304/15 , C12Y304/15001 , C12Y304/15004 , C12Y304/16 , C12Y304/17 , C12Y304/17001 , C12Y304/21019 , Y02P20/52 , A23V2200/322 , A23V2250/55
摘要： The invention provides a method for preparing a peptide for improving brain function, comprising hydrolyzing milk casein with an enzymatic catalyst comprising a protease to produce a hydrolysate comprising: (i) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 1 or a variant thereof; (ii) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 2 or a variant thereof; or (iii) a mixture of the peptides of (i) and (ii), wherein the production yield of each of the peptides is 2% or more, or the total production yield of the mixture is 10% or more. The invention also provides a food or drink or a pharmaceutical composition containing the hydrolysate.
摘要翻译： 本发明提供了一种制备用于改善脑功能的肽的方法，包括用包含蛋白酶的酶催化剂水解乳酪蛋白以产生水解产物，其包含：（i）由SEQ ID NO：1所示氨基酸序列组成的肽或 其变体; （ii）由SEQ ID NO：2所示的氨基酸序列或其变体构成的肽; 或（iii）（i）和（ii）的肽的混合物，其中各肽的产率为2％以上，混合物的总产量为10％以上。 本发明还提供了含有水解产物的食品或饮料或药物组合物。
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9.发明授权Composition for improving brain function and method for improving brain function 有权用于改善脑功能的组合物和改善脑功能的方法公开(公告)号：US08916524B2
公开(公告)日：2014-12-23
申请号：US13233922
申请日：2011-09-15
申请人： Kazuhito Ohsawa , Naoto Uchida , Kohji Ohki
发明人： Kazuhito Ohsawa , Naoto Uchida , Kohji Ohki
CPC分类号： A61K38/07 , A61K9/0053 , A61K38/018 , A61K38/08 , C07K5/101 , C07K5/1016 , C07K7/06
摘要： The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, X-Pro-Pro-Y or a salt thereof, wherein X represent Val, Ile or Asn-Ile and Y represent Phe or Leu.
摘要翻译： 本发明提供可以以小剂量口服摄取以改善脑功能的组合物，以及改善脑功能的方法。 本发明是一种用于改善脑功能的组合物，其包含作为活性成分的X-Pro-Pro-Y或其盐，其中X表示Val，Ile或Asn-Ile，Y表示Phe或Leu。
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10.发明申请PROCESS FOR PREPARING CASEIN-DERIVED PEPTIDES BY FERMENTATION OF LACTIC ACID BACTERIA 审中-公开通过发酵乳酸杆菌制备壳衍生肽的方法公开(公告)号：US20120328735A1
公开(公告)日：2012-12-27
申请号：US13495677
申请日：2012-06-13
申请人： Naoto Uchida , Hiroaki Goto , Kazuhito Ohsawa , Kohji Ohki
发明人： Naoto Uchida , Hiroaki Goto , Kazuhito Ohsawa , Kohji Ohki
CPC分类号： A23J3/343 , A23J3/10 , A23L2/66 , A23L33/17 , A23L33/18 , A23V2002/00 , C07K7/08 , C07K14/4732 , C12P21/06 , A23V2200/322 , A23V2250/5424 , A23V2250/55
摘要： The present invention relates to a method for preparing a casein-derived peptide by fermentation of a lactic acid bacterium. The present invention also relates to a composition containing the peptide, and a method for preparing a functional food.
摘要翻译： 本发明涉及通过乳酸菌发酵制备酪蛋白衍生肽的方法。 本发明还涉及含有该肽的组合物及其制备功能性食品的方法。
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