-
公开(公告)号：US20180028664A1
公开(公告)日：2018-02-01
申请号：US15674872
申请日：2017-08-11
Applicant: ModernaTX, Inc.
Inventor： Gilles Besin , Stephen Hoge , Joseph Senn , Kerry Benenato , Staci Sabnis
IPC: A61K47/10 , C12N15/117 , A61K39/39 , C08G65/333 , C08G65/332 , C08G65/335 , A61K31/713 , C08G65/334
CPC classification number: A61K48/0033 , A61K9/127 , A61K31/7115 , A61K31/713 , A61K39/39 , A61K47/10 , A61K47/543 , A61K47/544 , A61K47/60 , A61K47/6929 , A61K48/0066 , A61K2039/55555 , C08G65/3322 , C08G65/3326 , C08G65/33306 , C08G65/3331 , C08G65/33317 , C08G65/33324 , C08G65/3348 , C08G65/3356 , C08G2650/04 , C12N15/117 , C12N15/88 , C12N2310/141 , C12N2310/17 , C12N2320/32
Abstract: This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
-
公开(公告)号：US20220265857A1
公开(公告)日：2022-08-25
申请号：US17583674
申请日：2022-01-25
Applicant: ModernaTX,Inc.
Inventor： Gilles Besin , Stephen Hoge , Joseph Senn , Kerry Benenato , Staci Sabnis
IPC: A61K48/00 , A61K9/127 , C12N15/88 , A61K31/7115 , A61K47/14 , A61K47/18 , A61K47/54 , A61K47/69 , A61K47/60 , A61K31/713 , A61K39/39 , A61K47/10 , C08G65/332 , C08G65/333 , C08G65/334 , C08G65/335 , C12N15/117
Abstract: This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
-
公开(公告)号：US20190117798A1
公开(公告)日：2019-04-25
申请号：US16229509
申请日：2018-12-21
Applicant: ModernaTX, Inc.
Inventor： Gilles Besin , Stephen Hoge , Joseph Senn , Kerry Benenato , Staci Sabnis
IPC: A61K48/00 , C12N15/88 , A61K47/10 , A61K47/54 , A61K31/7115 , A61K9/127 , A61K47/69 , A61K47/60 , A61K39/39 , C08G65/332 , C08G65/333 , C08G65/334 , C08G65/335 , C12N15/117 , A61K31/713
Abstract: This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
-
Patent Agency Ranking
公开(公告)号：US10207010B2
公开(公告)日：2019-02-19
申请号：US15674872
申请日：2017-08-11
Applicant: ModernaTX, Inc.
Inventor： Gilles Besin , Stephen Hoge , Joseph Senn , Kerry Benenato , Staci Sabnis
IPC: C12N15/88 , A61K9/127 , A61K48/00 , A61K47/54 , A61K47/69 , A61K47/60 , A61K31/713 , A61K39/39 , A61K47/10 , C08G65/332 , C08G65/333 , C08G65/334 , C08G65/335 , C12N15/117 , A61K31/7115 , A61K39/00
Abstract: This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
-
公开(公告)号：US11285222B2
公开(公告)日：2022-03-29
申请号：US16599661
申请日：2019-10-11
Applicant: ModernaTX, Inc.
Inventor： Gilles Besin , Stephen Hoge , Joseph Senn , Kerry Benenato , Staci Sabnis
IPC: A61K48/00 , A61K9/127 , C12N15/88 , A61K31/7115 , A61K47/14 , A61K47/18 , A61K47/54 , A61K47/69 , A61K47/60 , A61K31/713 , A61K39/39 , A61K47/10 , C08G65/332 , C08G65/333 , C08G65/334 , C08G65/335 , C12N15/117 , A61K39/00
Abstract: This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
-
公开(公告)号：US10556018B2
公开(公告)日：2020-02-11
申请号：US15674107
申请日：2017-08-10
Applicant: ModernaTX, Inc.
Inventor： Gilles Besin , Stephen Hoge , Joseph Senn , Kerry Benenato , Staci Sabnis
IPC: A61K48/00 , A61K9/127 , C12N15/88 , A61K47/54 , A61K47/69 , A61K47/60 , A61K31/713 , A61K39/39 , A61K47/10 , C08G65/332 , C08G65/333 , C08G65/334 , C08G65/335 , C12N15/117 , A61K31/7115 , A61K47/14 , A61K47/18 , A61K39/00
Abstract: This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
-
公开(公告)号：US20220125899A1
公开(公告)日：2022-04-28
申请号：US17291947
申请日：2019-11-07
Applicant: ModernaTX, Inc.
Inventor： Ted Ashburn , Kristen Hopson , Karen Keating , Joseph Senn , Christine Swenson , Benjamin Breton , Shan Zhong , Maija Garnaas
IPC: A61K39/00 , A61K39/395 , A61K9/51 , A61K31/7105 , A61K48/00 , A61P35/00 , C07K16/28
Abstract: The present application is related to a method of treating a cancer by administering to a human subject multiple doses of a mRNA cancer vaccine formulated as a lipid nanoparticle wherein the cancer vaccine comprises one or more mRNAs each having one or more open reading frames encoding 3-50 peptide epitopes, and wherein each of the peptide epitopes are portions of personalized cancer antigens or portions of cancer hotspot antigens. The present application further relates to a method of treating cancer by combining anti-cancer immunotherapy with the administration of the aforementioned mRNA cancer vaccine.
-
公开(公告)号：US20180147298A1
公开(公告)日：2018-05-31
申请号：US15674107
申请日：2017-08-10
Applicant: ModernaTX, Inc.
Inventor： Gilles Besin , Stephen Hoge , Joseph Senn , Kerry Benenato , Staci Sabnis
Abstract: This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
-
-
-
-
-
-
-
Search Results
8
records
(took 0.037 seconds)
