公开(公告)号：US20170305903A1

公开(公告)日：2017-10-26

申请号：US15581642

申请日：2017-04-28

Applicant: Novartis AG

Inventor： Dirk BEHNKE ,  David CARCACHE ,  Peter ERTL ,  Manuel KOLLER ,  David ORAIN

IPC: C07D471/04 ,  C07D519/00 ,  A61K31/551

Abstract: The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.

公开(公告)号：US20250092042A1

公开(公告)日：2025-03-20

申请号：US18924066

申请日：2024-10-23

Applicant: NOVARTIS AG

Inventor： Mallesh BUSHABOINA ,  Xin CHEN ,  Atwood Kim CHEUNG ,  Andrew James CULSHAW ,  Timothy Brian HURLEY ,  Nancy LABBE-GIGUERE ,  Wolfgang MILTZ ,  David ORAIN ,  Tajesh PATEL ,  Srinivasan RAJAGOPALAN ,  Till ROEHN ,  David Andrew SANDHAM ,  Gebhard THOMA ,  Ritesh Bhanudasji TICHKULE ,  Rudolf WÄLCHLI

IPC: C07D471/10 ,  A61K45/06 ,  C07D519/00

Abstract: The present invention provides a method for manufacturing a compound of formula (I) or a pharmaceutically acceptable salt thereof; wherein R1 R2, R4 and X1 are defined herein.

公开(公告)号：US20230391782A1

公开(公告)日：2023-12-07

申请号：US18033100

申请日：2021-11-01

Applicant: Novartis AG

Inventor： Thomas Josef TROXLER ,  David ORAIN ,  Pascal FURET ,  Klaus WEIGAND ,  Achim SCHLAPBACH

IPC: C07D487/04 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D405/12

CPC classification number: C07D487/04 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D405/12

Abstract: The present invention relates to novel pyridine-N oxide substituted 2-formamido (N-phenyl and N-pyridyl) acetamide compounds that are Interleukin-17 (IL-17) inhibitors, processes for their preparation, pharmaceutical compositions, and medicaments containing them, and their use in diseases and disorders mediated by IL-17.

公开(公告)号：US20130296332A1

公开(公告)日：2013-11-07

申请号：US13932173

申请日：2013-07-01

Applicant: NOVARTIS AG

Inventor： Hans ALLGEIER ,  Yves AUBERSON ,  David CARCACHE ,  Philipp FLOERSHEIM ,  Christel GUIBOURDENCHE ,  Wolfgang FROESTL ,  Jörg KALLEN ,  Manuel KOLLER ,  Henri MATTES ,  Joachim NOZULAK ,  David ORAIN ,  Johanne RENAUD

IPC: C07D239/96 ,  C07C207/00 ,  C07C229/56 ,  C07D413/04 ,  C07D405/04 ,  C07D403/04 ,  C07C271/58

CPC classification number: C07D239/96 ,  C07C207/00 ,  C07C229/56 ,  C07C229/64 ,  C07C229/66 ,  C07C255/18 ,  C07C265/12 ,  C07C271/58 ,  C07D207/337 ,  C07D231/12 ,  C07D237/08 ,  C07D239/26 ,  C07D241/12 ,  C07D249/06 ,  C07D263/32 ,  C07D307/16 ,  C07D307/54 ,  C07D309/12 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D413/04

Abstract: The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.

Abstract translation: 本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如说明书中所定义，其制备，作为药物的用途，以及含有它们的药物组合物。 此外，公开了用于制备式（I）化合物的中间体和包含式（I）化合物的组合。

公开(公告)号：US20240043425A1

公开(公告)日：2024-02-08

申请号：US18319585

申请日：2023-05-18

Applicant: NOVARTIS AG

Inventor： Mallesh BUSHABOINA ,  Xin CHEN ,  Atwood Kim CHEUNG ,  Andrew James CULSHAW ,  Timothy Brian HURLEY ,  Nancy LABBE-GIGUERE ,  Wolfgang MILTZ ,  David ORAIN ,  Tajesh PATEL ,  Srinivasan RAJAGOPALAN ,  Till ROEHN ,  David Andrew SANDHAM ,  Gebhard THOMA ,  Ritesh Bhanudasji TICHKULE ,  Rudolf WÄLCHLI

IPC: C07D471/10 ,  A61K45/06 ,  C07D519/00

CPC classification number: C07D471/10 ,  C07D519/00 ,  A61K45/06

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof;






wherein R1 R2, R4 and X1 are defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.